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Conserved domains on  [gi|2129501651|ref|XP_044849815|]
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A-kinase anchor protein 10, mitochondrial isoform X3 [Mauremys mutica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
716-1099 1.55e-106

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 339.58  E-value: 1.55e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  716 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 795
Cdd:COG2319     65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  796 FLWDPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 874
Cdd:COG2319    145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  875 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 954
Cdd:COG2319    219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  955 gpeRLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 1034
Cdd:COG2319    260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501651 1035 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 1099
Cdd:COG2319    336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 43-288 2.29e-89

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


:

Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 284.34  E-value: 2.29e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651   43 LSKTLEQVLQDSVALPYFIQFMALRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSvKQRETTVSSPT 122
Cdd:cd08735      1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPS-LDRKVLESKST 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  123 GLLDERLEDSSTVhllmtktvptnlndrignvqnhllsshdsnnarvlrlgkseagthsvpaeqqdsskltvsnrnspsf 202
Cdd:cd08735     80 DSLSQRLTDDDDE------------------------------------------------------------------- 92

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  203 alkdlsgKLMKSIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVDPNCFVTAQSIVFNAMEQEHFSEFLR 282
Cdd:cd08735     93 -------KSMKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLR 165


                   ....*.
gi 2129501651  283 SHHFCK 288
Cdd:cd08735    166 SHFFCK 171
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 304-424 1.96e-74

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


:

Pssm-ID: 188676  Cd Length: 121  Bit Score: 241.10  E-value: 1.96e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  304 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIE 383
Cdd:cd08721      1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2129501651  384 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08721     81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 540-583 2.95e-17

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


:

Pssm-ID: 214003  Cd Length: 45  Bit Score: 76.32  E-value: 2.95e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2129501651  540 AMKKWVQGNTDEAQEEMAWRIAKMIVNDVMQQAQNDQPLEKVTK 583
Cdd:cd12804      1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEM 44
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 632-692 6.57e-13

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 64.47  E-value: 6.57e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501651  632 LLILFKDEAGE--ILGSPFDVPVDITPEKLQLVCNVLLQKEE---PLPLAFYVHDAEIITSLEKTL 692
Cdd:pfam08154    1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
716-1099 1.55e-106

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 339.58  E-value: 1.55e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  716 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 795
Cdd:COG2319     65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  796 FLWDPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 874
Cdd:COG2319    145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  875 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 954
Cdd:COG2319    219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  955 gpeRLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 1034
Cdd:COG2319    260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501651 1035 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 1099
Cdd:COG2319    336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 43-288 2.29e-89

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 284.34  E-value: 2.29e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651   43 LSKTLEQVLQDSVALPYFIQFMALRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSvKQRETTVSSPT 122
Cdd:cd08735      1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPS-LDRKVLESKST 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  123 GLLDERLEDSSTVhllmtktvptnlndrignvqnhllsshdsnnarvlrlgkseagthsvpaeqqdsskltvsnrnspsf 202
Cdd:cd08735     80 DSLSQRLTDDDDE------------------------------------------------------------------- 92

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  203 alkdlsgKLMKSIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVDPNCFVTAQSIVFNAMEQEHFSEFLR 282
Cdd:cd08735     93 -------KSMKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLR 165


                   ....*.
gi 2129501651  283 SHHFCK 288
Cdd:cd08735    166 SHFFCK 171
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 721-1099 1.59e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 283.84  E-value: 1.59e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  721 CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDP 800
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  801 DTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSSS 879
Cdd:cd00200     81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  880 QDRTIKVWRGQDGILCRTLQGHGHWVNTMAlstdyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrgqgperl 959
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  960 vsgsddftlflwapaedkkalermtghqalinqvlFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSA 1039
Cdd:cd00200    185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651 1040 DSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 1099
Cdd:cd00200    230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 304-424 1.96e-74

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 241.10  E-value: 1.96e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  304 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIE 383
Cdd:cd08721      1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2129501651  384 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08721     81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 301-425 3.26e-25

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 101.58  E-value: 3.26e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651   301 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSqlaakkgQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRL 380
Cdd:smart00315    2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 2129501651   381 EIESNICrEGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 425
Cdd:smart00315   75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 540-583 2.95e-17

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 76.32  E-value: 2.95e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2129501651  540 AMKKWVQGNTDEAQEEMAWRIAKMIVNDVMQQAQNDQPLEKVTK 583
Cdd:cd12804      1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEM 44
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 213-289 2.96e-15

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 73.07  E-value: 2.96e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2129501651   213 KSIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgQVDPNCFVTAQSIVFNAMEQEHFSEFLRSHHFCKY 289
Cdd:smart00315   44 EERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 632-692 6.57e-13

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 64.47  E-value: 6.57e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501651  632 LLILFKDEAGE--ILGSPFDVPVDITPEKLQLVCNVLLQKEE---PLPLAFYVHDAEIITSLEKTL 692
Cdd:pfam08154    1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 301-425 2.07e-10

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 59.17  E-value: 2.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  301 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRL 380
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEF-------KKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2129501651  381 EIESNICREggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 425
Cdd:pfam00615   75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 720-757 2.45e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 2.45e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2129501651   720 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 757
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
720-757 5.77e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 5.77e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2129501651  720 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 757
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 202-283 7.79e-08

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 51.85  E-value: 7.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  202 FALKDLsgKLMKSIE---RDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgqVDPNCFVTAQSIVFNAMEQEHFS 278
Cdd:pfam00615   32 LACEEF--KKADPDEerlKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE---PTRDLFDEAQAEVYELMEKDSYP 106


                   ....*
gi 2129501651  279 EFLRS 283
Cdd:pfam00615  107 RFLKS 111
PTZ00421 PTZ00421
coronin; Provisional
 956-1071 2.01e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 2.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  956 PERLVSGSDDFTLFLWA-PAEDKKA-----LERMTGHQALINQVLFSPDTR-IIASASFDKSIKLWDGRTGKYLTSLRGH 1028
Cdd:PTZ00421    88 PQKLFTASEDGTIMGWGiPEEGLTQnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2129501651 1029 VSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHA 1071
Cdd:PTZ00421   168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
716-1099 1.55e-106

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 339.58  E-value: 1.55e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  716 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 795
Cdd:COG2319     65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  796 FLWDPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 874
Cdd:COG2319    145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  875 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 954
Cdd:COG2319    219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  955 gpeRLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 1034
Cdd:COG2319    260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501651 1035 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 1099
Cdd:COG2319    336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
719-1060 3.85e-93

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 303.37  E-value: 3.85e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  719 TRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLW 798
Cdd:COG2319    110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  799 DPDTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFS 877
Cdd:COG2319    190 DLATGKLL-RTLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLAS 263

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  878 SSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQgpe 957
Cdd:COG2319    264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD---------------------------------------GK--- 301

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  958 RLVSGSDDFTLFLWApAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAW 1037
Cdd:COG2319    302 LLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                          330       340
                   ....*....|....*....|...
gi 2129501651 1038 SADSRLLVSGSSDSTLKVWDAKT 1060
Cdd:COG2319    381 SPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
716-1100 5.23e-91

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 297.59  E-value: 5.23e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  716 RAVTRCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQI 795
Cdd:COG2319     23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  796 FLWDPDTGnQIGRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-L 874
Cdd:COG2319    103 RLWDLATG-LLLRTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkL 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  875 LFSSSQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQ 954
Cdd:COG2319    177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD---------------------------------------GK 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  955 gpeRLVSGSDDFTLFLWaPAEDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQ 1034
Cdd:COG2319    218 ---LLASGSADGTVRLW-DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501651 1035 IAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWRR 1100
Cdd:COG2319    294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 43-288 2.29e-89

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 284.34  E-value: 2.29e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651   43 LSKTLEQVLQDSVALPYFIQFMALRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSvKQRETTVSSPT 122
Cdd:cd08735      1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAHSLNTVKHSSLEEPVSPS-LDRKVLESKST 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  123 GLLDERLEDSSTVhllmtktvptnlndrignvqnhllsshdsnnarvlrlgkseagthsvpaeqqdsskltvsnrnspsf 202
Cdd:cd08735     80 DSLSQRLTDDDDE------------------------------------------------------------------- 92

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  203 alkdlsgKLMKSIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVDPNCFVTAQSIVFNAMEQEHFSEFLR 282
Cdd:cd08735     93 -------KSMKSIERDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLR 165


                   ....*.
gi 2129501651  283 SHHFCK 288
Cdd:cd08735    166 SHFFCK 171
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 721-1099 1.59e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 283.84  E-value: 1.59e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  721 CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDP 800
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  801 DTGNQIgRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSSS 879
Cdd:cd00200     81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  880 QDRTIKVWRGQDGILCRTLQGHGHWVNTMAlstdyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrgqgperl 959
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  960 vsgsddftlflwapaedkkalermtghqalinqvlFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSA 1039
Cdd:cd00200    185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651 1040 DSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 1099
Cdd:cd00200    230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
736-1098 1.38e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.22  E-value: 1.38e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  736 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDPDTGnQIGRVLAGHSK 815
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  816 WITwlcwePLHINPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSSSQDRTIKVWRGQDGIL 894
Cdd:COG2319     80 AVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  895 CRTLQGHGHWVNTMALSTDyvlrtgafepaeasvnpqdmsgtlaelkekaqhrydqvrGQgpeRLVSGSDDFTLFLWApA 974
Cdd:COG2319    155 LRTLTGHSGAVTSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-L 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  975 EDKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLK 1054
Cdd:COG2319    192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 2129501651 1055 VWDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 1098
Cdd:COG2319    272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 304-424 1.96e-74

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 241.10  E-value: 1.96e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  304 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIE 383
Cdd:cd08721      1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2129501651  384 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08721     81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 720-914 6.28e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.02  E-value: 6.28e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  720 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 799
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  800 PDTGnQIGRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSS 878
Cdd:cd00200    164 LRTG-KCVATLTGHTGEVNSVAF-----SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASG 237

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2129501651  879 SQDRTIKVWRGQDGILCRTLQGHGHWVNTMALSTDY 914
Cdd:cd00200    238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 720-888 5.81e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.16  E-value: 5.81e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  720 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 799
Cdd:cd00200    126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  800 PDTGNQIGrVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILTGHTQSVTCVKWGGDG-LLFSS 878
Cdd:cd00200    206 LSTGKCLG-TLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASG 279

                          170
                   ....*....|
gi 2129501651  879 SQDRTIKVWR 888
Cdd:cd00200    280 SADGTIRIWD 289
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 301-425 3.26e-25

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 101.58  E-value: 3.26e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651   301 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSqlaakkgQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRL 380
Cdd:smart00315    2 LESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKK-------AEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLRE 74

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 2129501651   381 EIESNICrEGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 425
Cdd:smart00315   75 KIEENLE-SEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 305-424 5.45e-24

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 97.85  E-value: 5.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  305 LFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKgqydgqEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIES 384
Cdd:cd07440      1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE------ELKSKAKEIYDKYISKDAPKEINIPESIREEIEE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2129501651  385 NICREgGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd07440     75 NLEEP-YPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 212-288 4.02e-20

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 86.68  E-value: 4.02e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2129501651  212 MKSIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEDgqVDPNCFVTAQSIVFNAMEQEHFSEFLRSHHFCK 288
Cdd:cd07440     39 DEELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPY--PDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 540-583 2.95e-17

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 76.32  E-value: 2.95e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2129501651  540 AMKKWVQGNTDEAQEEMAWRIAKMIVNDVMQQAQNDQPLEKVTK 583
Cdd:cd12804      1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEM 44
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 213-289 2.96e-15

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 73.07  E-value: 2.96e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2129501651   213 KSIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgQVDPNCFVTAQSIVFNAMEQEHFSEFLRSHHFCKY 289
Cdd:smart00315   44 EERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 632-692 6.57e-13

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 64.47  E-value: 6.57e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501651  632 LLILFKDEAGE--ILGSPFDVPVDITPEKLQLVCNVLLQKEE---PLPLAFYVHDAEIITSLEKTL 692
Cdd:pfam08154    1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 301-424 4.31e-12

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 65.55  E-value: 4.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  301 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQS--------------------QLAAKKGQYDGQEAQN------ 354
Cdd:cd08735      5 LEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSaawsrirahslntvkhssleEPVSPSLDRKVLESKStdslsq 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  355 ----------------DAMILYDRYFSLQATHPLGFDDFVRLEIESNICREGGPL-PNCFTTPLRQAWTTMEKVFLPGFL 417
Cdd:cd08735     85 rltddddeksmksierDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVdPNCFVEAQSFVFSAMEQDHFTEFL 164


                   ....*..
gi 2129501651  418 SSNLYYK 424
Cdd:cd08735    165 RSHFFCK 171
WD40 COG2319
WD40 repeat [General function prediction only];
994-1099 3.96e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 3.96e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  994 LFSPDTRIIASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHADE 1073
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100
                   ....*....|....*....|....*.
gi 2129501651 1074 VFAVDWSPDGQRVASGGKDKCLRIWR 1099
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWD 106
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 301-425 2.07e-10

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 59.17  E-value: 2.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  301 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRL 380
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEF-------KKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2129501651  381 EIESNICREggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 425
Cdd:pfam00615   75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 720-757 2.45e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 2.45e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2129501651   720 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 757
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1018-1057 4.87e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 4.87e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2129501651  1018 TGKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWD 1057
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
720-757 5.77e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 5.77e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2129501651  720 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 757
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
AKAP10_AKB cd12804
PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of ...
 519-564 1.10e-09

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.


Pssm-ID: 214003  Cd Length: 45  Bit Score: 54.75  E-value: 1.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2129501651  519 FIRESEPEPDvkKSKGSMFSQAMKKWVQGNTDEAQEEMAWRIAKMI 564
Cdd:cd12804      2 FKKWVQPEPD--EAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 218-288 2.19e-09

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 56.20  E-value: 2.19e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2129501651  218 DAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVdPNCFVTAQSIVFNAMEQEHFSEFLRSHHFCK 288
Cdd:cd08721     52 DAMIIYDKYFSLQATEPLGFDDKTRLEVESNICREGGPL-PSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
WD40 pfam00400
WD domain, G-beta repeat;
1019-1057 5.02e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 5.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2129501651 1019 GKYLTSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWD 1057
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 760-799 1.51e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 1.51e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2129501651   760 TETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 799
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1060-1098 4.57e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 4.57e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2129501651  1060 TRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 1098
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 202-283 7.79e-08

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 51.85  E-value: 7.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  202 FALKDLsgKLMKSIE---RDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEdgqVDPNCFVTAQSIVFNAMEQEHFS 278
Cdd:pfam00615   32 LACEEF--KKADPDEerlKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE---PTRDLFDEAQAEVYELMEKDSYP 106


                   ....*
gi 2129501651  279 EFLRS 283
Cdd:pfam00615  107 RFLKS 111
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 850-887 9.71e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 9.71e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2129501651   850 TGRCDKILTGHTQSVTCVKWGGDG-LLFSSSQDRTIKVW 887
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 956-1071 2.01e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.90  E-value: 2.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  956 PERLVSGSDDFTLFLWA-PAEDKKA-----LERMTGHQALINQVLFSPDTR-IIASASFDKSIKLWDGRTGKYLTSLRGH 1028
Cdd:PTZ00421    88 PQKLFTASEDGTIMGWGiPEEGLTQnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2129501651 1029 VSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLAIDLPGHA 1071
Cdd:PTZ00421   168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 pfam00400
WD domain, G-beta repeat;
1067-1098 3.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 3.73e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2129501651 1067 LPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 1098
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
851-887 4.20e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 4.20e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2129501651  851 GRCDKILTGHTQSVTCVKWGGDG-LLFSSSQDRTIKVW 887
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 976-1015 4.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 4.48e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2129501651   976 DKKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWD 1015
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
RGS_SNX14 cd08722
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; ...
 304-423 4.90e-07

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.


Pssm-ID: 188677  Cd Length: 127  Bit Score: 49.65  E-value: 4.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  304 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQ-LAAKKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEI 382
Cdd:cd08722      1 ILDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFNRRiLNPDLTDEEKQSLHKEAQEIYKTYFLPEAPDRIHFPPDIVEEI 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2129501651  383 ESNIcrEGGP-----LPNcfTTPLRQAW----TTMEKVFLPGFLSSNLYY 423
Cdd:cd08722     81 KQIL--EGGPekivkLRT--SRPLFEAYehvySLLESVFCPLFCHSDEYF 126
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 808-847 5.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 5.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2129501651   808 RVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWD 847
Cdd:smart00320    6 KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
977-1015 9.75e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 9.75e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2129501651  977 KKALERMTGHQALINQVLFSPDTRIIASASFDKSIKLWD 1015
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 711-887 1.40e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.20  E-value: 1.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  711 AVFKVRAVTRCTSS---LEGHTEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTE-------TPHFTAKGHRHWVLSIAW 779
Cdd:PTZ00421    54 AVLKHTDYGKLASNppiLLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSF 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  780 SPNGRK-LASGCKNSQIFLWDPDTGnQIGRVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWDTVTGRCDKILT 858
Cdd:PTZ00421   134 HPSAMNvLASAGADMVVNVWDVERG-KAVEVIKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE 207

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2129501651  859 GH--TQSVTCVkWGGDG-----LLFSSSQDRTIKVW 887
Cdd:PTZ00421   208 AHasAKSQRCL-WAKRKdliitLGCSKSQQRQIMLW 242
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 937-1057 1.72e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  937 LAELKEKAQHRYD-QVRGQGPERLVSGSDDFTLFLWAPAEDKKALERMTghQALINQVLFSPDT-RIIASASFDKSIKLW 1014
Cdd:PLN00181   568 VTEMKEHEKRVWSiDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESgRSLAFGSADHKVYYY 645

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2129501651 1015 DGRTGKY-LTSLRGHVSAVYQIAWsADSRLLVSGSSDSTLKVWD 1057
Cdd:PLN00181   646 DLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688
WD40 pfam00400
WD domain, G-beta repeat;
762-799 1.86e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.86e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2129501651  762 TPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 799
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
RGS_RGS3 cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...
 314-424 2.49e-06

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.


Pssm-ID: 188668  Cd Length: 114  Bit Score: 47.56  E-value: 2.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  314 FSEYMEKEDAVNILQFWLAADNF-----QSQLAAKkgqydgqeaqndAMILYDRYFSLQATHPLGFDDFVRLEIESNIcr 388
Cdd:cd08713     14 FRAFLQTEFSEENLEFWLACEEYkkiksQSKMASR------------AKKIFAEYIAIQSCKEVNLDSYTREHTKENL-- 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2129501651  389 eGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08713     80 -QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114
RGS_SNX13 cd08719
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...
 304-424 2.77e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.


Pssm-ID: 188674  Cd Length: 135  Bit Score: 47.79  E-value: 2.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  304 ILFCESALFYFSEYMEKEDAVNILQFWLAADNF----QSQL-AAKKGQYDGQEAQNDAM--------ILYDRYFSLQATH 370
Cdd:cd08719      1 ILVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYrvsaEQQLsELHLRQRGGEHQRSDVYemlraaalNIYDQYLSEKASP 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501651  371 PLGFDDFVRLEIESNIcREGGPLPNCFTTPLRQAWTTMEK--VFLPGFLSSNLYYK 424
Cdd:cd08719     81 RVPLDDSLVKKLLNRL-RNDTPSDLWFDDIQQKVFDIMQEdeRFYPAFKKSPAYVK 135
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 744-920 3.89e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 3.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  744 LASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSP-NGRKLASGCKNSQIFLWDPDTGNQIGRVlaghsKWITWLCW 822
Cdd:PLN00181   548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI-----KTKANICC 622

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  823 EPLHiNPECRYLASASKDCSIRIWDTvtgRCDKI----LTGHTQSVTCVKWGGDGLLFSSSQDRTIKVW------RGQDG 892
Cdd:PLN00181   623 VQFP-SESGRSLAFGSADHKVYYYDL---RNPKLplctMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsiSGINE 698

                          170       180
                   ....*....|....*....|....*....
gi 2129501651  893 ILCRTLQGHGHWVNTMALS-TDYVLRTGA 920
Cdd:PLN00181   699 TPLHSFMGHTNVKNFVGLSvSDGYIATGS 727
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 313-422 3.91e-06

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 46.93  E-value: 3.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  313 YFSEYMEKE-DAVNILqFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIEsnICREgg 391
Cdd:cd08706     13 YFTEFLKKEfSEENIL-FWQACEKF-------KKIPDKKQLVQEAREIYDTFLSSKASSPVNIDSQAQLAEE--MLEE-- 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2129501651  392 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08706     81 PHPDMFQKQQLQIFNLMKFDSYSRFLKSPLY 111
WD40 pfam00400
WD domain, G-beta repeat;
808-847 4.37e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.37e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2129501651  808 RVLAGHSKWITWLCWeplhiNPECRYLASASKDCSIRIWD 847
Cdd:pfam00400    5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 774-901 5.35e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 5.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  774 VLSIAWSP-NGRKLASGCKNSQIFLWD-PDTGNQIGRV-----LAGHSKWITWLCWEPLHINpecrYLASASKDCSIRIW 846
Cdd:PTZ00421    78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501651  847 DTVTGRCDKILTGHTQSVTCVKWGGDGLLF-SSSQDRTIKVWRGQDGILCRTLQGH 901
Cdd:PTZ00421   154 DVERGKAVEVIKCHSDQITSLEWNLDGSLLcTTSKDKKLNIIDPRDGTIVSSVEAH 209
PTZ00421 PTZ00421
coronin; Provisional
 985-1097 5.63e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 5.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  985 GHQALINQVLFSP-DTRIIASASFDKSIKLWD-------GRTGKYLTSLRGHVSAVYQIAWSADSR-LLVSGSSDSTLKV 1055
Cdd:PTZ00421    73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2129501651 1056 WDAKTRKLAIDLPGHADEVFAVDWSPDGQRVASGGKDKCLRI 1097
Cdd:PTZ00421   153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 219-283 5.77e-06

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 46.46  E-value: 5.77e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501651  219 AVNTFTKYISPDAAKPIPITEAMRNDIVAKIcgedGQVDPNCFVTAQSIVFNAMEQEHFSEFLRS 283
Cdd:cd08716     49 ARKLFASYIQPQAPREINIDSPTRKAIIRNI----QEPTQSCFDEAQRIVYMHMERDSYPRFLES 109
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 310-422 1.57e-05

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 45.41  E-value: 1.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  310 ALFYFSEYMEKEDAVNILQFWLAADNFQsQLAAKKGQYDGQEAQNdamiLYDRYFSLQATHPLGFDDfvRLEIESNICRE 389
Cdd:cd08743     20 GVEYFTEFLKKEFSAENVNFWKACERFQ-QIPASDTQQLAQEARK----IYNEFLSSSSQSPVNIDQ--QAWIGEDMLAT 92

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2129501651  390 ggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08743     93 --PSPDMFRAQQLQIFNLMKFDSYARFVKSPLY 123
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 304-424 1.72e-05

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 45.05  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  304 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIE 383
Cdd:cd08723      1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDF-------KKTKSSTEIALKAQMIYSEFIQADAPKEINIDFHTRDLIS 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2129501651  384 SNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08723     74 QNISE---PTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 314-424 1.98e-05

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 44.92  E-value: 1.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  314 FSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEaqndamiLYDRYFSLQATHPLGFDDFVRLEIESNICReggPL 393
Cdd:cd08716     14 YATYLKTEHSDENIEFWLACETYKKIASQRKRISMARK-------LFASYIQPQAPREINIDSPTRKAIIRNIQE---PT 83

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2129501651  394 PNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08716     84 QSCFDEAQRIVYMHMERDSYPRFLESKFYQK 114
RGS_RGS4 cd08714
Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...
 312-422 2.16e-05

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.


Pssm-ID: 188669  Cd Length: 114  Bit Score: 44.87  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  312 FYFSEYMEKedavNIlQFWLAADNFQSQLAAKKGQydgQEAQNdamiLYDRYFSLQATHPLGFDDFVRLEIESNICRegg 391
Cdd:cd08714     17 FLKSEYSEE----NI-DFWVSCEDYKKTKSPSKLS---PKARK----IYEEFISVQATKEVNLDSCTREETSRNMLE--- 81

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2129501651  392 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08714     82 PTISCFDEAQKKIFTLMEKDSYRRFLKSRFY 112
PTZ00420 PTZ00420
coronin; Provisional
 725-799 2.30e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 2.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  725 LEGHTEAVISVAFSPT-GKYLASGSGDTTVRFWDLSTE--------TPHFTAKGHRHWVLSIAWSP-NGRKLASGCKNSQ 794
Cdd:PTZ00420    70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNdesvkeikDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSF 149


                   ....*
gi 2129501651  795 IFLWD 799
Cdd:PTZ00420   150 VNIWD 154
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 1002-1056 3.84e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 3.84e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2129501651 1002 IASASFDKSIKLWDGRTGKYLTSLRGHVSAVYQIAW-SADSRLLVSGSSDSTLKVW 1056
Cdd:PLN00181   548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 993-1087 4.30e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 47.73  E-value: 4.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  993 VLFSPDTRIIASASfDKS--IKLW-----DGRTGKYLTSlrGHVSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLA- 1064
Cdd:COG4946    348 PAWSPDGKSIAYFS-DASgeYELYiapadGSGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRk 424

                           90       100
                   ....*....|....*....|...
gi 2129501651 1065 IDLPGHADEVFAVDWSPDGQRVA 1087
Cdd:COG4946    425 VDTDGYGDGISDLAWSPDSKWLA 447
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 309-424 6.19e-05

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 44.00  E-value: 6.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  309 SALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQ---------NDAMILYDRYFS-------LQATHPL 372
Cdd:cd08729      5 SSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDTENDYSLDSSQsrswidsdkEDIAMIYETYFSdpspslnVPKASRD 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2129501651  373 GFDDFVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08729     85 PIRLFLNAGVNASPNEQYRKARRAVLMAQRAVYEEMEEEDFPEFKKSELFYK 136
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 303-422 8.13e-05

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 43.12  E-value: 8.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  303 DILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEI 382
Cdd:cd08709      3 ELLASKYGVAAFRAFLKSEFSEENIEFWLACEDF-------KKTKSPQKLTSKAKKIYTDFIEKEAPKEINIDFQTKTLI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2129501651  383 ESNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08709     76 AQNIQE---ATSGCFTAAQKRVYSLMENNSYPRFLESEFY 112
RGS_RGS17 cd08744
Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...
 314-422 8.26e-05

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.


Pssm-ID: 188698  Cd Length: 118  Bit Score: 43.18  E-value: 8.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  314 FSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIESNICregGPL 393
Cdd:cd08744     18 FREFLRTEYSEENLLFWLACEDL-------KKEQNKKVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNLL---DPN 87

                           90       100
                   ....*....|....*....|....*....
gi 2129501651  394 PNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08744     88 PHMYEDAQLQIYTLMHRDSFPRFLNSQIY 116
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 989-1098 1.95e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  989 LINQVLFSPDTRIIASASFDKSIKLW-------DGRTGKYLTSLRGHVSAVYQIAWSADSRLLVSGSS-DSTLKVWDAKT 1060
Cdd:PLN00181   485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2129501651 1061 RKLAIDLPGHADEVFAVDW-SPDGQRVASGGKDKCLRIW 1098
Cdd:PLN00181   565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 223-286 2.41e-04

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 41.86  E-value: 2.41e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2129501651  223 FTKYISPDAAKPIPITEAMRNDIVAKIcgedGQVDPNCFVTAQSIVFNAMEQEHFSEFLRSHHF 286
Cdd:cd08715     52 YKEFVQSDAAKQINIDFRTRESTAKKI----KAPTPTCFDEAQKVIYILMERDSYPRFLKSDIY 111
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
953-1090 2.48e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.91  E-value: 2.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  953 GQGPERLVSGSDDFTLFLWAPAEDKKALERMTGHQALINQVLFSPD-TRIIASASFDKSIKLWDGRTGKYLTSLRGHVSA 1031
Cdd:COG3391     33 GGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADgRRLYVANSGSGRVSVIDLATGKVVATIPVGGGP 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2129501651 1032 vYQIAWSAD-SRLLVSGSSDSTLKVWDAKTRKLAIDLPGhADEVFAVDWSPDGQR--VASGG 1090
Cdd:COG3391    113 -RGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPV-GAGPHGIAVDPDGKRlyVANSG 172
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 214-288 3.25e-04

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 41.20  E-value: 3.25e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2129501651  214 SIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKIcgedGQVDPNCFVTAQSIVFNAMEQEHFSEFLRSHHFCK 288
Cdd:cd08723     41 EIALKAQMIYSEFIQADAPKEINIDFHTRDLISQNI----SEPTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
PTZ00421 PTZ00421
coronin; Provisional
 725-848 3.70e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 3.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  725 LEGHTEAVISVAFSPTGK-YLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWDPDTG 803
Cdd:PTZ00421   121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2129501651  804 NQIGRVLA---GHSKWITWLCWEPLHINPECrylaSASKDCSIRIWDT 848
Cdd:PTZ00421   201 TIVSSVEAhasAKSQRCLWAKRKDLIITLGC----SKSQQRQIMLWDT 244
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 976-1087 3.74e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.35  E-value: 3.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  976 DKKALERMTGHQALINQVLFSPD-TRIIASASFDKSIKLW----DGRTGKYLTSLRGHVSAvyqIAWSADSRLLV-SGSS 1049
Cdd:COG0823     19 DGGEPRRLTNSPGIDTSPAWSPDgRRIAFTSDRGGGPQIYvvdaDGGEPRRLTFGGGYNAS---PSWSPDGKRLAfVSRS 95

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2129501651 1050 DSTLKVW--DAKTRKLAIdlpgHADEVFAVDWSPDGQRVA 1087
Cdd:COG0823     96 DGRFDIYvlDLDGGAPRR----LTDGPGSPSWSPDGRRIV 131
RGS_RGS19 cd08745
Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...
 314-422 4.27e-04

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .


Pssm-ID: 188699  Cd Length: 118  Bit Score: 41.20  E-value: 4.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  314 FSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIESNICReggPL 393
Cdd:cd08745     18 FREFLRTEYSEENMLFWLACEEL-------KAEANKHVIDEKARLIYEDYISILSPKEVSLDSRVREGINRKMQE---PS 87

                           90       100
                   ....*....|....*....|....*....
gi 2129501651  394 PNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08745     88 SHTFDDAQLQIYTLMHRDSYPRFLNSPIY 116
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 301-424 6.36e-04

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 40.70  E-value: 6.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  301 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaaKKGQYDgqEAQNDAMILYDRYFSLQATHPLGFDDFVRl 380
Cdd:cd08715      1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDY------KKTESD--LLPCKAEEIYKEFVQSDAAKQINIDFRTR- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2129501651  381 eiESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08715     72 --ESTAKKIKAPTPTCFDEAQKVIYILMERDSYPRFLKSDIYLN 113
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 743-888 6.92e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.58  E-value: 6.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  743 YLASGSGDTTVRFWDLSTETPH-FTAkgHRHWVLSIAWSPNGRKLA-----SGckNSQIFLWDPDTGNQIgRVLAGHSKw 816
Cdd:COG0823      3 FTLSRDGNSDIYVVDLDGGEPRrLTN--SPGIDTSPAWSPDGRRIAftsdrGG--GPQIYVVDADGGEPR-RLTFGGGY- 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2129501651  817 itwlCWEPlHINPECRYLASASKD---CSIRIWDTVTGRcDKILTGHTQSVTcvkWGGDG--LLFSSSQDRTIKVWR 888
Cdd:COG0823     77 ----NASP-SWSPDGKRLAFVSRSdgrFDIYVLDLDGGA-PRRLTDGPGSPS---WSPDGrrIVFSSDRGGRPDLYV 144
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 313-422 1.40e-03

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 39.66  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  313 YFSEYMEKEDAVNILQFWLAADNFQSQLAakkgqYDGQEAQNDAMILYDRYFSLQATHPLGFDDfvRLEIESNICRegGP 392
Cdd:cd08742     13 YFSEFLRKEFSEENILFWQACEYFNHVPA-----HDKKELSYRAREIFSKFLCSKATTPVNIDS--QAQLADDILN--AP 83

                           90       100       110
                   ....*....|....*....|....*....|
gi 2129501651  393 LPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08742     84 HPDMFKEQQLQIFNLMKFDSYTRFLKSPLY 113
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
 312-422 1.54e-03

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 39.37  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  312 FYFSEYMEKedavNILqFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDRYFSLQATHPLGFDDFVRLEIESNICRegg 391
Cdd:cd08718     21 FLRTEYSEE----NML-FWLACEEL-------KKEANKHVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNMLE--- 85

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2129501651  392 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 422
Cdd:cd08718     86 PSPHTFDDAQLQIYTLMHRDSYPRFLNSAIY 116
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 993-1080 2.14e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 2.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  993 VLFSPDTRIIASASFDKSI--------KLWDGrtgkyltSLRGHVSAVYQIAWSADSRLLVSGSSDSTLKVWDAKTRKLA 1064
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELllhrlnwqRVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73

                           90
                   ....*....|....*.
gi 2129501651 1065 IDLPGHADEVFAVDWS 1080
Cdd:pfam12894   74 HHFSAGSDLITCLGWG 89
PTZ00420 PTZ00420
coronin; Provisional
 673-800 2.41e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  673 LPLAFYVHDAEIITSLEKTLvgqvveTERVLDIIYQPQAVFKVRAvTRCTssLEGHTEAVISVAFSPTGKYLASGSG-DT 751
Cdd:PTZ00420    78 LDLQFNPCFSEILASGSEDL------TIRVWEIPHNDESVKEIKD-PQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDS 148

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2129501651  752 TVRFWDLSTETPHFTAKGHRHwVLSIAWSPNGRKLASGCKNSQIFLWDP 800
Cdd:PTZ00420   149 FVNIWDIENEKRAFQINMPKK-LSSLKWNIKGNLLSGTCVGKHMHIIDP 196
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 722-782 2.63e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 2.63e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2129501651  722 TSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTAKGHRHWVLSIAWSPN 782
Cdd:pfam12894   31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 731-881 2.68e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  731 AVISVAFSPTGKYLA-----SGSgdttvrfWDL------STETPHFTAKGHRHWVLSIAWSPNGRKLASGCKNSQIFLWD 799
Cdd:COG4946    344 RERLPAWSPDGKSIAyfsdaSGE-------YELyiapadGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVD 416

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  800 PDTGN--QIGRVLAGH----------SKWITWLCWEPLHINpecrylasaskdcSIRIWDTVTGrcdKI--LTGHTQSVT 865
Cdd:COG4946    417 LASGKvrKVDTDGYGDgisdlawspdSKWLAYSKPGPNQLS-------------QIFLYDVETG---KTvqLTDGRYDDG 480

                          170
                   ....*....|....*...
gi 2129501651  866 CVKWGGDG--LLFSSSQD 881
Cdd:COG4946    481 SPAFSPDGkyLYFLSSRD 498
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
 313-424 2.69e-03

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 38.55  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2129501651  313 YFSEYMEKEDAVNILQFWLAADNFQSqlaAKKGQYDgqeaQNDAMILYDryFSLQATHPLGFDDFVRLEIESNICREGGp 392
Cdd:cd08720     10 YLSQFLERMDSQALIGFWEAVEELRS---ANKSEWH----QLGAEIFYT--FIVEPTAEIKVDKSLRKRIEQFLLGDKG- 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2129501651  393 lPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 424
Cdd:cd08720     80 -PEVFYEVQENVVETLEEKYYPSFVVSDQYKQ 110
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 774-822 3.23e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 3.23e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2129501651  774 VLSIAWSPNGRKLASGCKNSQIFLWDPDTGNQIgRVLAGHSKWITWLCW 822
Cdd:pfam12894   41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDLITCLGW 88
RGS_RGS4 cd08714
Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...
 219-286 6.29e-03

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.


Pssm-ID: 188669  Cd Length: 114  Bit Score: 37.55  E-value: 6.29e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2129501651  219 AVNTFTKYISPDAAKPIPITEAMRNDIVAKICgedgQVDPNCFVTAQSIVFNAMEQEHFSEFLRSHHF 286
Cdd:cd08714     49 ARKIYEEFISVQATKEVNLDSCTREETSRNML----EPTISCFDEAQKKIFTLMEKDSYRRFLKSRFY 112
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 51-82 6.68e-03

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 38.22  E-value: 6.68e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2129501651   51 LQDSVALPYFIQFMALRRMEHLVKFWLEAESF 82
Cdd:cd08729      1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGF 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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