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Conserved domains on  [gi|2105399015|ref|XP_043895768|]
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beta-1,4-galactosyltransferase 1 [Solea senegalensis]

Protein Classification

beta-1,4-galactosyltransferase( domain architecture ID 10097028)

beta-1,4-galactosyltransferase is responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids

CAZY:  GT7
EC:  2.4.1.-
Gene Ontology:  GO:0016758
PubMed:  15465321
SCOP:  4000687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
b4GalT cd00899
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core ...
 143-360 3.26e-133

Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids; Beta-4-Galactosyltransferase transfers galactose from uridine diphosphogalactose to the terminal beta-N-acetylglucosamine residues, hereby forming the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids. At least seven homologous beta-4-galactosyltransferase isoforms have been identified that use different types of glycoproteins and glycolipids as substrates. Of the seven identified members of the beta-1,4-galactosyltransferase subfamily (beta1,4-Gal-T1 to -T7), b1,4-Gal-T1 is most characterized (biochemically). It is a Golgi-resident type II membrane enzyme with a cytoplasmic domain, membrane spanning region, and a stem region and catalytic domain facing the lumen.


:

Pssm-ID: 132999 [Multi-domain]  Cd Length: 219  Bit Score: 379.23  E-value: 3.26e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 143 QKVAVIIPFRKRDEHLKYWLHYLHPVLQRQQLDYGIYVINQDGDEIFNRAKLLNVGYTEALKEYEYECFVFSDVDLIPMD 222
Cdd:cd00899     2 HKVAIIVPFRNRFEHLLIFLPHLHPFLQRQQLDYRIFVIEQVGNFRFNRAKLLNVGFLEALKDGDWDCFIFHDVDLLPEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 223 DRNTYRCFSQPRHLSVSMDKFGFRLPYYQYFGGVSSMSKEQYMKINGFPNNYWGWGGEDDDIYNRLVSRGMSISRPSGEV 302
Cdd:cd00899    82 DRNLYGCEEGPRHLSVPLDKFHYKLPYKTYFGGVLALTREQFRKVNGFSNAYWGWGGEDDDLYNRIKAAGLKITRPSGDT 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2105399015 303 GKCRMIRHKRDDKNEPNPQRFDRIAHTRETMLKDGINSLSYRVVNTEKFELFTKITVD 360
Cdd:cd00899   162 GRYKMIRHIHDKRNRDNPNRFALLQNSRERDHSDGLNSLKYKVLSIELAPLYTNILVD 219
 
Name Accession Description Interval E-value
b4GalT cd00899
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core ...
 143-360 3.26e-133

Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids; Beta-4-Galactosyltransferase transfers galactose from uridine diphosphogalactose to the terminal beta-N-acetylglucosamine residues, hereby forming the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids. At least seven homologous beta-4-galactosyltransferase isoforms have been identified that use different types of glycoproteins and glycolipids as substrates. Of the seven identified members of the beta-1,4-galactosyltransferase subfamily (beta1,4-Gal-T1 to -T7), b1,4-Gal-T1 is most characterized (biochemically). It is a Golgi-resident type II membrane enzyme with a cytoplasmic domain, membrane spanning region, and a stem region and catalytic domain facing the lumen.


Pssm-ID: 132999 [Multi-domain]  Cd Length: 219  Bit Score: 379.23  E-value: 3.26e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 143 QKVAVIIPFRKRDEHLKYWLHYLHPVLQRQQLDYGIYVINQDGDEIFNRAKLLNVGYTEALKEYEYECFVFSDVDLIPMD 222
Cdd:cd00899     2 HKVAIIVPFRNRFEHLLIFLPHLHPFLQRQQLDYRIFVIEQVGNFRFNRAKLLNVGFLEALKDGDWDCFIFHDVDLLPEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 223 DRNTYRCFSQPRHLSVSMDKFGFRLPYYQYFGGVSSMSKEQYMKINGFPNNYWGWGGEDDDIYNRLVSRGMSISRPSGEV 302
Cdd:cd00899    82 DRNLYGCEEGPRHLSVPLDKFHYKLPYKTYFGGVLALTREQFRKVNGFSNAYWGWGGEDDDLYNRIKAAGLKITRPSGDT 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2105399015 303 GKCRMIRHKRDDKNEPNPQRFDRIAHTRETMLKDGINSLSYRVVNTEKFELFTKITVD 360
Cdd:cd00899   162 GRYKMIRHIHDKRNRDNPNRFALLQNSRERDHSDGLNSLKYKVLSIELAPLYTNILVD 219
Glyco_transf_7N pfam13733
N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of ...
 105-229 4.45e-84

N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 463972  Cd Length: 125  Bit Score: 250.84  E-value: 4.45e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 105 VGPLRVEFNVPVSLDQIKRDNGDVRLGGRFKPRDCEAQQKVAVIIPFRKRDEHLKYWLHYLHPVLQRQQLDYGIYVINQD 184
Cdd:pfam13733   1 VGPLKVNFNSPPTLEEVEKKNPLVQPGGRYKPPDCKARHKVAIIIPYRNREEHLRYLLYHLHPFLQRQQLDYGIYVIEQA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2105399015 185 GDEIFNRAKLLNVGYTEALKEYEYECFVFSDVDLIPMDDRNTYRC 229
Cdd:pfam13733  81 GNGTFNRAKLLNVGFLEALKDYDYDCFIFHDVDLIPEDDRNLYTC 125
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 133-295 1.69e-06

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 48.97  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 133 RFKPRDCEAQQKVAVIIPFRKRDEHLKYWLHYLhpvlqrQQLDYG-----IYVINqDGD------------EIFNRAKLL 195
Cdd:COG1215    19 ARRRRAPADLPRVSVIIPAYNEEAVIEETLRSL------LAQDYPkekleVIVVD-DGStdetaeiarelaAEYPRVRVI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 196 ----NVGYTEAL----KEYEYECFVFSDVDLIPMDD--RNTYRCFSQPRhlsvsmdkfgfrlpyYQYFGGVSSMSKEQYM 265
Cdd:COG1215    92 erpeNGGKAAALnaglKAARGDIVVFLDADTVLDPDwlRRLVAAFADPG---------------VGASGANLAFRREALE 156

                         170       180       190
                  ....*....|....*....|....*....|
gi 2105399015 266 KINGFPNNYWgwgGEDDDIYNRLVSRGMSI 295
Cdd:COG1215   157 EVGGFDEDTL---GEDLDLSLRLLRAGYRI 183
 
Name Accession Description Interval E-value
b4GalT cd00899
Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core ...
 143-360 3.26e-133

Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids; Beta-4-Galactosyltransferase transfers galactose from uridine diphosphogalactose to the terminal beta-N-acetylglucosamine residues, hereby forming the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids. At least seven homologous beta-4-galactosyltransferase isoforms have been identified that use different types of glycoproteins and glycolipids as substrates. Of the seven identified members of the beta-1,4-galactosyltransferase subfamily (beta1,4-Gal-T1 to -T7), b1,4-Gal-T1 is most characterized (biochemically). It is a Golgi-resident type II membrane enzyme with a cytoplasmic domain, membrane spanning region, and a stem region and catalytic domain facing the lumen.


Pssm-ID: 132999 [Multi-domain]  Cd Length: 219  Bit Score: 379.23  E-value: 3.26e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 143 QKVAVIIPFRKRDEHLKYWLHYLHPVLQRQQLDYGIYVINQDGDEIFNRAKLLNVGYTEALKEYEYECFVFSDVDLIPMD 222
Cdd:cd00899     2 HKVAIIVPFRNRFEHLLIFLPHLHPFLQRQQLDYRIFVIEQVGNFRFNRAKLLNVGFLEALKDGDWDCFIFHDVDLLPEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 223 DRNTYRCFSQPRHLSVSMDKFGFRLPYYQYFGGVSSMSKEQYMKINGFPNNYWGWGGEDDDIYNRLVSRGMSISRPSGEV 302
Cdd:cd00899    82 DRNLYGCEEGPRHLSVPLDKFHYKLPYKTYFGGVLALTREQFRKVNGFSNAYWGWGGEDDDLYNRIKAAGLKITRPSGDT 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2105399015 303 GKCRMIRHKRDDKNEPNPQRFDRIAHTRETMLKDGINSLSYRVVNTEKFELFTKITVD 360
Cdd:cd00899   162 GRYKMIRHIHDKRNRDNPNRFALLQNSRERDHSDGLNSLKYKVLSIELAPLYTNILVD 219
Glyco_transf_7N pfam13733
N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of ...
 105-229 4.45e-84

N-terminal region of glycosyl transferase group 7; This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 463972  Cd Length: 125  Bit Score: 250.84  E-value: 4.45e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 105 VGPLRVEFNVPVSLDQIKRDNGDVRLGGRFKPRDCEAQQKVAVIIPFRKRDEHLKYWLHYLHPVLQRQQLDYGIYVINQD 184
Cdd:pfam13733   1 VGPLKVNFNSPPTLEEVEKKNPLVQPGGRYKPPDCKARHKVAIIIPYRNREEHLRYLLYHLHPFLQRQQLDYGIYVIEQA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2105399015 185 GDEIFNRAKLLNVGYTEALKEYEYECFVFSDVDLIPMDDRNTYRC 229
Cdd:pfam13733  81 GNGTFNRAKLLNVGFLEALKDYDYDCFIFHDVDLIPEDDRNLYTC 125
Glyco_transf_7C pfam02709
N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of ...
 234-311 3.05e-38

N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 460659 [Multi-domain]  Cd Length: 78  Bit Score: 131.58  E-value: 3.05e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2105399015 234 RHLSVSMDKFGFRLPYYQYFGGVSSMSKEQYMKINGFPNNYWGWGGEDDDIYNRLVSRGMSISRPSGEVGKCRMIRHK 311
Cdd:pfam02709   1 RHLSVALDKFGYKLPYKTYFGGVLALSREDFERINGFSNGFWGWGGEDDDLYNRLLLAGLEIERPPGDIGRYYMLYHK 78
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 133-295 1.69e-06

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 48.97  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 133 RFKPRDCEAQQKVAVIIPFRKRDEHLKYWLHYLhpvlqrQQLDYG-----IYVINqDGD------------EIFNRAKLL 195
Cdd:COG1215    19 ARRRRAPADLPRVSVIIPAYNEEAVIEETLRSL------LAQDYPkekleVIVVD-DGStdetaeiarelaAEYPRVRVI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2105399015 196 ----NVGYTEAL----KEYEYECFVFSDVDLIPMDD--RNTYRCFSQPRhlsvsmdkfgfrlpyYQYFGGVSSMSKEQYM 265
Cdd:COG1215    92 erpeNGGKAAALnaglKAARGDIVVFLDADTVLDPDwlRRLVAAFADPG---------------VGASGANLAFRREALE 156

                         170       180       190
                  ....*....|....*....|....*....|
gi 2105399015 266 KINGFPNNYWgwgGEDDDIYNRLVSRGMSI 295
Cdd:COG1215   157 EVGGFDEDTL---GEDLDLSLRLLRAGYRI 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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