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Conserved domains on  [gi|2092229334|ref|XP_043396238|]
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lysophosphatidylcholine acyltransferase 1 isoform X5 [Chelonia mydas]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 12959276)

lysophospholipid acyltransferases of glycerophospholipid biosynthesis catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 55-266 1.71e-100

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


:

Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 300.29  E-value: 1.71e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  55 MRTMWFAGGFHWINVKGRQAlPAEAAILTLAPHSSYFDAIPVT-MTMASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQD 133
Cdd:cd07991     1 ARVLLFAFGFYVIKVHGKPD-PPEAPRIIVANHTSFIDPLILFsDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 134 SRRKTVEEIKRRAQsDGKWPQIMIFPEGTCTNRSCLITFKPGAFIPGVPVQPVVLRYPNKLDTITWTWQGPGALEILWLT 213
Cdd:cd07991    80 DRKKVVEEIKERAT-DPNWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2092229334 214 LCQFHNFVEIEFLPVYIPSeEEKKNPSLYANNVRSVMAEALGVSVTDYTFEDC 266
Cdd:cd07991   159 LTQPANVLEVEFLPVYTPS-EEGEDPKEFANRVRLIMANKLGLPATDWTGEDK 210
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
318-427 2.44e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 47.09  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 318 RVSLKEFAAYLEVPISDTLEN----MFALFVENEDGVIDLREYVTALsvvcrpsktletiqlafkmyesqngtiiennla 393
Cdd:COG5126    49 RISREEFVAGMESLFEATVEPfaraAFDLLDTDGDGKISADEFRRLL--------------------------------- 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2092229334 394 cilkTALGVSELNVTDLFKAIDAEEKGKITYDDF 427
Cdd:COG5126    96 ----TALGVSEEEADELFARLDTDGDGKISFEEF 125
EF-hand_7 pfam13499
EF-hand domain pair;
371-431 5.89e-04

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.39  E-value: 5.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092229334 371 ETIQLAFKMYES-QNGTIIENNLACILKTALG---VSELNVTDLFKAIDAEEKGKITYDDFYRYT 431
Cdd:pfam13499   2 EKLKEAFKLLDSdGDGYLDVEELKKLLRKLEEgepLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 55-266 1.71e-100

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 300.29  E-value: 1.71e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  55 MRTMWFAGGFHWINVKGRQAlPAEAAILTLAPHSSYFDAIPVT-MTMASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQD 133
Cdd:cd07991     1 ARVLLFAFGFYVIKVHGKPD-PPEAPRIIVANHTSFIDPLILFsDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 134 SRRKTVEEIKRRAQsDGKWPQIMIFPEGTCTNRSCLITFKPGAFIPGVPVQPVVLRYPNKLDTITWTWQGPGALEILWLT 213
Cdd:cd07991    80 DRKKVVEEIKERAT-DPNWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2092229334 214 LCQFHNFVEIEFLPVYIPSeEEKKNPSLYANNVRSVMAEALGVSVTDYTFEDC 266
Cdd:cd07991   159 LTQPANVLEVEFLPVYTPS-EEGEDPKEFANRVRLIMANKLGLPATDWTGEDK 210
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 42-255 2.87e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 111.64  E-value: 2.87e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  42 WWRKVVDFLLKAIMRTMWFAGGFHWiNVKGRQALPAEAAILTLAPHSSYFDAIPVTMTM---ASIVMKAESKDIPVWGTL 118
Cdd:COG0204     7 LLRRFRYRLVRLWARLLLRLLGVRV-RVEGLENLPADGPVLIVANHQSWLDILLLLAALprpVRFVAKKELFKIPLLGWL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 119 IKYIRPVFVSRSDQDSRRKTVEEIKRRAQsDGKWpqIMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVLRYPNKL 194
Cdd:COG0204    86 LRALGAIPVDRSKRRAALRALRQAVEALK-AGES--LVIFPEGTRSPDGRLLPFKTGAARlaleAGVPIVPVAIDGTERA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2092229334 195 DTITWtWQGPGAleilwltlcqfhnfVEIEFLPVYIPSEEEKKNPSLYANNVRSVMAEALG 255
Cdd:COG0204   163 LPKGF-LPRPGK--------------VTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLA 208
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 81-190 1.33e-22

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 92.80  E-value: 1.33e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334   81 ILTLAPHSSYFDAI------PVTMTMASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQDSRRKTVEEIKRRAQsDGKWpq 154
Cdd:smart00563   1 ALVVANHQSFLDPLvlsallPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLK-EGEW-- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2092229334  155 IMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVLRY 190
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARlaleAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 67-188 7.19e-21

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 88.10  E-value: 7.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  67 INVKGRQALPAEAAILTLAPHSSYFDAI------PVTMTMASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQDSRRKTVE 140
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVLllslalYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2092229334 141 EIKRRaQSDGKWpqIMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVL 188
Cdd:pfam01553  82 YLVEL-LREGKL--VVIFPEGTRSREGELLPFKKGAFRlaieAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 67-189 1.04e-14

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 70.84  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  67 INVKGRQALPAEAAILTLAPHSSYFDaiPVTMTMA-----SIVMKAESKDIPVWGTLIKYIRPVFVSRSDQ---DSRRKT 138
Cdd:TIGR00530   4 VEVVGPENLPAKSPVLVVANHQSNLD--PLTLSAAfpppiVFIAKKELKWIPFFGIMLWLTGAIFIDRENIraiATALKA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2092229334 139 VEEIKRRAQSdgkwpqIMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVLR 189
Cdd:TIGR00530  82 AIEVLKQGRS------IGVFPEGTRSRGRDILPFKKGAFHiaikAGVPILPVVLS 130
PLN02833 PLN02833
glycerol acyltransferase family protein
 3-194 2.16e-07

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 52.85  E-value: 2.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334   3 LTLFPIR---LFFAAFMMLLAW-PFAFIASMGSAERELERPLSWWrkvvdfllkaiMRTMWFAGGFHWINVKGRQALPAE 78
Cdd:PLN02833   95 GILFPVRvllLAIGWIIFLSAFiPVHFLLKGHKLRKKIERKLVEL-----------ICSAFVASWTGVIKYHGPRPSRRP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  79 AAILtLAPHSSYFDAIPVT-MTMASIVMKAEskdiPVW-----GTLIKYIRPVFVSRSDQDSRRKTVEEIKRRAQSDGKW 152
Cdd:PLN02833  164 KQVF-VANHTSMIDFIVLEqMTPFAVIMQKH----PGWvgflqNTILESVGCIWFNRTEAKDREVVAKKLRDHVQDPDRN 238

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2092229334 153 PqIMIFPEGTCTNRSCLITFKPGAFIPGVPVQPVVLRYpNKL 194
Cdd:PLN02833  239 P-LLIFPEGTCVNNEYTVMFKKGAFELGCTVCPIAIKY-NKI 278
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
318-427 2.44e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 47.09  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 318 RVSLKEFAAYLEVPISDTLEN----MFALFVENEDGVIDLREYVTALsvvcrpsktletiqlafkmyesqngtiiennla 393
Cdd:COG5126    49 RISREEFVAGMESLFEATVEPfaraAFDLLDTDGDGKISADEFRRLL--------------------------------- 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2092229334 394 cilkTALGVSELNVTDLFKAIDAEEKGKITYDDF 427
Cdd:COG5126    96 ----TALGVSEEEADELFARLDTDGDGKISFEEF 125
EF-hand_8 pfam13833
EF-hand domain pair;
383-434 9.38e-05

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 39.99  E-value: 9.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2092229334 383 QNGTIIENNLACILKTAL--GVSELNVTDLFKAIDAEEKGKITYDDFYRYTEMY 434
Cdd:pfam13833   1 EKGVITREELKRALALLGlkDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
PTZ00184 PTZ00184
calmodulin; Provisional
 331-429 4.61e-04

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 40.52  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 331 PISDTLENMFALFVENEDGVIDLREYVTALSVVCRPSKTLETIQLAFKMYESQ-NGTIIENNLACILkTALG--VSELNV 407
Cdd:PTZ00184   44 PTEAELQDMINEVDADGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDgNGFISAAELRHVM-TNLGekLTDEEV 122

                          90       100
                  ....*....|....*....|..
gi 2092229334 408 TDLFKAIDAEEKGKITYDDFYR 429
Cdd:PTZ00184  123 DEMIREADVDGDGQINYEEFVK 144
EF-hand_7 pfam13499
EF-hand domain pair;
371-431 5.89e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.39  E-value: 5.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092229334 371 ETIQLAFKMYES-QNGTIIENNLACILKTALG---VSELNVTDLFKAIDAEEKGKITYDDFYRYT 431
Cdd:pfam13499   2 EKLKEAFKLLDSdGDGYLDVEELKKLLRKLEEgepLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 55-266 1.71e-100

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 300.29  E-value: 1.71e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  55 MRTMWFAGGFHWINVKGRQAlPAEAAILTLAPHSSYFDAIPVT-MTMASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQD 133
Cdd:cd07991     1 ARVLLFAFGFYVIKVHGKPD-PPEAPRIIVANHTSFIDPLILFsDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 134 SRRKTVEEIKRRAQsDGKWPQIMIFPEGTCTNRSCLITFKPGAFIPGVPVQPVVLRYPNKLDTITWTWQGPGALEILWLT 213
Cdd:cd07991    80 DRKKVVEEIKERAT-DPNWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2092229334 214 LCQFHNFVEIEFLPVYIPSeEEKKNPSLYANNVRSVMAEALGVSVTDYTFEDC 266
Cdd:cd07991   159 LTQPANVLEVEFLPVYTPS-EEGEDPKEFANRVRLIMANKLGLPATDWTGEDK 210
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 42-255 2.87e-28

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 111.64  E-value: 2.87e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  42 WWRKVVDFLLKAIMRTMWFAGGFHWiNVKGRQALPAEAAILTLAPHSSYFDAIPVTMTM---ASIVMKAESKDIPVWGTL 118
Cdd:COG0204     7 LLRRFRYRLVRLWARLLLRLLGVRV-RVEGLENLPADGPVLIVANHQSWLDILLLLAALprpVRFVAKKELFKIPLLGWL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 119 IKYIRPVFVSRSDQDSRRKTVEEIKRRAQsDGKWpqIMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVLRYPNKL 194
Cdd:COG0204    86 LRALGAIPVDRSKRRAALRALRQAVEALK-AGES--LVIFPEGTRSPDGRLLPFKTGAARlaleAGVPIVPVAIDGTERA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2092229334 195 DTITWtWQGPGAleilwltlcqfhnfVEIEFLPVYIPSEEEKKNPSLYANNVRSVMAEALG 255
Cdd:COG0204   163 LPKGF-LPRPGK--------------VTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLA 208
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 59-251 7.86e-28

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 109.43  E-value: 7.86e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  59 WFAGGFHWINVKGRQALPAEAAILTLAPHSSYFDAIPVTM-------TMASIVMKAESKDI-PVWGTLikyiRPVFVSRS 130
Cdd:cd06551     6 LNFFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLllerglrRDVYGLMDEELLERyPFFTRL----GAFSVDRD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 131 DQDSRRKTVEEIKRRAQSDGKWpqIMIFPEGTCTNRS-CLITFKPGAFIP----GVPVQPVVLRYPNkldtitwtwqgpg 205
Cdd:cd06551    82 SPRSAAKSLKYVARLLSKPGSV--VWIFPEGTRTRRDkRPLQFKPGVAHLaekaGVPIVPVALRYTF------------- 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2092229334 206 aleilWLTLCQFHNFVEIEFLPVYIPSEEEKKNPSLYANNVRSVMA 251
Cdd:cd06551   147 -----ELFEQFPEIFVRIGPPIPYAETALGEELAAELANRLTRLLD 187
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 58-209 3.18e-24

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 99.27  E-value: 3.18e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  58 MWFAGGFHWINVKGRQALPAEAAILTLAPHSSYFDAIPVTMTM---ASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQDS 134
Cdd:cd07989     3 LLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALprpIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRS 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2092229334 135 RRKTVEEIKRRAQsDGKWpqIMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVLRYPNKLDTITWTWQGPGALEI 209
Cdd:cd07989    83 AREALREAIEALK-EGES--VVIFPEGTRSRDGELLPFKSGAFRlakeAGVPIVPVAISGTWGSLPKGKKLPRPGRVTV 158
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 81-190 1.33e-22

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 92.80  E-value: 1.33e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334   81 ILTLAPHSSYFDAI------PVTMTMASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQDSRRKTVEEIKRRAQsDGKWpq 154
Cdd:smart00563   1 ALVVANHQSFLDPLvlsallPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLK-EGEW-- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2092229334  155 IMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVLRY 190
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARlaleAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 67-188 7.19e-21

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 88.10  E-value: 7.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  67 INVKGRQALPAEAAILTLAPHSSYFDAI------PVTMTMASIVMKAESKDIPVWGTLIKYIRPVFVSRSDQDSRRKTVE 140
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVLllslalYKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2092229334 141 EIKRRaQSDGKWpqIMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVL 188
Cdd:pfam01553  82 YLVEL-LREGKL--VVIFPEGTRSREGELLPFKKGAFRlaieAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 67-189 1.04e-14

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 70.84  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  67 INVKGRQALPAEAAILTLAPHSSYFDaiPVTMTMA-----SIVMKAESKDIPVWGTLIKYIRPVFVSRSDQ---DSRRKT 138
Cdd:TIGR00530   4 VEVVGPENLPAKSPVLVVANHQSNLD--PLTLSAAfpppiVFIAKKELKWIPFFGIMLWLTGAIFIDRENIraiATALKA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2092229334 139 VEEIKRRAQSdgkwpqIMIFPEGTCTNRSCLITFKPGAFI----PGVPVQPVVLR 189
Cdd:TIGR00530  82 AIEVLKQGRS------IGVFPEGTRSRGRDILPFKKGAFHiaikAGVPILPVVLS 130
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 43-193 3.61e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 56.50  E-value: 3.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  43 WRKVVDFLLKaimrtmWFaggFHWINVKGRQALPAEAAILTLAPHS-SYFDAIPVTMTMA---SIVMKAESKDIPVWGTL 118
Cdd:cd07992     1 VRLLSRVILR------IY---FRRITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRrpvRFLAKADLFKNPLIGWL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 119 IKYIRPVFVSRsDQDSRRKTVEEIK--------RRAQSDGKWpqIMIFPEGTCTNRSCLITFKPGAFI----------PG 180
Cdd:cd07992    72 LESFGAIPVYR-PKDLARGGIGKISnaavfdavGEALKAGGA--IGIFPEGGSHDRPRLLPLKAGAARmalealeagqKD 148

                         170
                  ....*....|...
gi 2092229334 181 VPVQPVVLRYPNK 193
Cdd:cd07992   149 VKIVPVGLNYEDK 161
PLN02833 PLN02833
glycerol acyltransferase family protein
 3-194 2.16e-07

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 52.85  E-value: 2.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334   3 LTLFPIR---LFFAAFMMLLAW-PFAFIASMGSAERELERPLSWWrkvvdfllkaiMRTMWFAGGFHWINVKGRQALPAE 78
Cdd:PLN02833   95 GILFPVRvllLAIGWIIFLSAFiPVHFLLKGHKLRKKIERKLVEL-----------ICSAFVASWTGVIKYHGPRPSRRP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  79 AAILtLAPHSSYFDAIPVT-MTMASIVMKAEskdiPVW-----GTLIKYIRPVFVSRSDQDSRRKTVEEIKRRAQSDGKW 152
Cdd:PLN02833  164 KQVF-VANHTSMIDFIVLEqMTPFAVIMQKH----PGWvgflqNTILESVGCIWFNRTEAKDREVVAKKLRDHVQDPDRN 238

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2092229334 153 PqIMIFPEGTCTNRSCLITFKPGAFIPGVPVQPVVLRYpNKL 194
Cdd:PLN02833  239 P-LLIFPEGTCVNNEYTVMFKKGAFELGCTVCPIAIKY-NKI 278
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
318-427 2.44e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 47.09  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 318 RVSLKEFAAYLEVPISDTLEN----MFALFVENEDGVIDLREYVTALsvvcrpsktletiqlafkmyesqngtiiennla 393
Cdd:COG5126    49 RISREEFVAGMESLFEATVEPfaraAFDLLDTDGDGKISADEFRRLL--------------------------------- 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2092229334 394 cilkTALGVSELNVTDLFKAIDAEEKGKITYDDF 427
Cdd:COG5126    96 ----TALGVSEEEADELFARLDTDGDGKISFEEF 125
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 44-189 5.24e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 49.15  E-value: 5.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334   44 RKVVDFLLKAIMrtMWFAGGFHWINVKGRQALPAEAAILTLAPHSSYFDAIPVTMTMA---SIVMKAESKDIPvwgtlik 120
Cdd:PRK08633   408 LLLPDSLLRFLL--LLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWIDWALLQAASPrpiRFVMERSIYEKW------- 478

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  121 YIRPVF-------VSrsdQDSRRKTVEEIkRRAQSDGKwpQIMIFPEGTCTNRSCLITFKPG----AFIPGVPVQPVVLR 189
Cdd:PRK08633   479 YLKWFFklfgvipIS---SGGSKESLEFI-RKALDDGE--VVCIFPEGAITRNGQLNEFKRGfeliVKGTDVPIIPFYIR 552
EF-hand_8 pfam13833
EF-hand domain pair;
383-434 9.38e-05

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 39.99  E-value: 9.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2092229334 383 QNGTIIENNLACILKTAL--GVSELNVTDLFKAIDAEEKGKITYDDFYRYTEMY 434
Cdd:pfam13833   1 EKGVITREELKRALALLGlkDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
PTZ00184 PTZ00184
calmodulin; Provisional
 331-429 4.61e-04

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 40.52  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334 331 PISDTLENMFALFVENEDGVIDLREYVTALSVVCRPSKTLETIQLAFKMYESQ-NGTIIENNLACILkTALG--VSELNV 407
Cdd:PTZ00184   44 PTEAELQDMINEVDADGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDgNGFISAAELRHVM-TNLGekLTDEEV 122

                          90       100
                  ....*....|....*....|..
gi 2092229334 408 TDLFKAIDAEEKGKITYDDFYR 429
Cdd:PTZ00184  123 DEMIREADVDGDGQINYEEFVK 144
EF-hand_7 pfam13499
EF-hand domain pair;
371-431 5.89e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.39  E-value: 5.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092229334 371 ETIQLAFKMYES-QNGTIIENNLACILKTALG---VSELNVTDLFKAIDAEEKGKITYDDFYRYT 431
Cdd:pfam13499   2 EKLKEAFKLLDSdGDGYLDVEELKKLLRKLEEgepLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 75-162 2.59e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 39.14  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092229334  75 LPAEAAILtLAPHSSYFDAIpVTMTMAS---------IVMKAESKDIPV--WGTLI-KYIrpvFVSRS---DQDSRRKTV 139
Cdd:cd07990    21 LPKERALI-ISNHRSEVDWL-VLWMLADrfgrlgrlkIVLKDSLKYPPLggWGWQLgEFI---FLKRKwekDEKTIKRQL 95

                          90       100
                  ....*....|....*....|...
gi 2092229334 140 EEIKRRaqSDGKWpqIMIFPEGT 162
Cdd:cd07990    96 KRLKDS--PEPFW--LLIFPEGT 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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