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Conserved domains on  [gi|2062762281|ref|XP_042112293|]
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integrin beta-4 isoform X1 [Ovis aries]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 37-454 0e+00

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member smart00187:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 423  Bit Score: 571.57  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281    37 SCTECIRVDKDCAYCTDEVFKER---RCNTQAELLAAGCRLQSVVVMESSYEIMEERQID---TTLRRSQVSPQALRVRL 110
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   111 RPGEERHFELQVFEPLESPMDLYILMDFSNSMSDDLDNLKKMGQDLAQVLRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   191 KEPWPN----SDPPFSFKNVISLTEDVEEFRNKLKGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   267 FHYEADGAnvLAGIMRRNDEECHLDPTGTYTQYKMQDYPSVPTLVRLLGQHNIIPIFAVTNYSYSYYERLSSYFPVSSLG 346
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   347 VLQEDSSNIVDLLQEAFNRIRSNLDIRALDSPRGLRTEVTSrMFQKTDTGSFfiRRGEVGTYQVQLRAIEDLDGAHVCql 426
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPG--TRKCEGVKIGDTVSFEVTVTATKC-- 393

                           410       420
                    ....*....|....*....|....*....
gi 2062762281   427 PEADQKGTIHLKP-SFSNGLQMDVGVICD 454
Cdd:smart00187  394 PPEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 627-710 1.96e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 107.36  E-value: 1.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  627 CEDLRSCVQCQAWGTGEKKGRTC-EECSFKVKMVDELKKAEE-VVEHCSFRDEdDDCTYSYTVEGDSapGPNSTVLVQRR 704
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYEDE--SGKYVVHVQKE 77


                   ....*.
gi 2062762281  705 KECPPG 710
Cdd:pfam07965   78 RECPPG 83
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1085 6.15e-24

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


:

Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 97.33  E-value: 6.15e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   991 GIVSFEQPEYLVSSGEHVARIPVVRRILDSGKSQVSYRTQDNTAKGNRDYIPMEGELLFQPGETWKELQVKLLElqemDS 1070
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIID----DD 77

                            90
                    ....*....|....*
gi 2062762281  1071 LLRGpqTRRFYIQLS 1085
Cdd:smart00237   78 IYEK--DETFYVRLS 90
fn3 pfam00041
Fibronectin type III domain;
1685-1770 5.13e-21

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.01  E-value: 5.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1685 SAPGPLVFTALSPDSLQLSWERPRRPDGDILGYLVTCEMAHGGEPATTFLVDGDspESRLTVPGLSENVPYKFKVQAKTT 1764
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 2062762281 1765 QGFGPE 1770
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1571-1661 2.89e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 84.09  E-value: 2.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1571 PNTPTRLVFSALGPTSLKVSWQEPQCERA-LQGYSVEYQLLNGGELHRLNIPSPSQTSVVVEDLLPNHSYVFRVRAQSQE 1649
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 2062762281 1650 GWGPEREGVITI 1661
Cdd:cd00063     81 GESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1129-1209 9.74e-17

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.68  E-value: 9.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPTGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2062762281 1205 EGPYS 1209
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1314 1.07e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDGPKKRTLLIENLRESQPYRYTVK 1300
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 2062762281 1301 ARNGAGWGPEREAI 1314
Cdd:cd00063     76 AVNGGGESPPSESV 89
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 458-486 2.20e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.11  E-value: 2.20e-10
                           10        20
                   ....*....|....*....|....*....
gi 2062762281  458 CELQKEERSSRCSFHGDFMCGHCVCHEGW 486
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 551-574 7.53e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 7.53e-03
                           10        20
                   ....*....|....*....|....*.
gi 2062762281  551 LCNDRGRCSM--GQCVCEPGWTGLSC 574
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 37-454 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 571.57  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281    37 SCTECIRVDKDCAYCTDEVFKER---RCNTQAELLAAGCRLQSVVVMESSYEIMEERQID---TTLRRSQVSPQALRVRL 110
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   111 RPGEERHFELQVFEPLESPMDLYILMDFSNSMSDDLDNLKKMGQDLAQVLRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   191 KEPWPN----SDPPFSFKNVISLTEDVEEFRNKLKGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   267 FHYEADGAnvLAGIMRRNDEECHLDPTGTYTQYKMQDYPSVPTLVRLLGQHNIIPIFAVTNYSYSYYERLSSYFPVSSLG 346
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   347 VLQEDSSNIVDLLQEAFNRIRSNLDIRALDSPRGLRTEVTSrMFQKTDTGSFfiRRGEVGTYQVQLRAIEDLDGAHVCql 426
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPG--TRKCEGVKIGDTVSFEVTVTATKC-- 393

                           410       420
                    ....*....|....*....|....*....
gi 2062762281   427 PEADQKGTIHLKP-SFSNGLQMDVGVICD 454
Cdd:smart00187  394 PPEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 125-370 3.02e-151

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 465.05  E-value: 3.02e-151
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  125 PLESPMDLYILMDFSNSMSDDLDNLKKMGQDLAQVLRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  201 FSFKNVISLTEDVEEFRNKLKGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  281 MRRNDEECHLDPTGTYTQYKMQDYPSVPTLVRLLGQHNIIPIFAVTNYSYSYYERLSSYFPVSSLGVLQEDSSNIVDLLQ 360
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 2062762281  361 EAFNRIRSNL 370
Cdd:pfam00362  239 EAYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 627-710 1.96e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 107.36  E-value: 1.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  627 CEDLRSCVQCQAWGTGEKKGRTC-EECSFKVKMVDELKKAEE-VVEHCSFRDEdDDCTYSYTVEGDSapGPNSTVLVQRR 704
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYEDE--SGKYVVHVQKE 77


                   ....*.
gi 2062762281  705 KECPPG 710
Cdd:pfam07965   78 RECPPG 83
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1085 6.15e-24

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 97.33  E-value: 6.15e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   991 GIVSFEQPEYLVSSGEHVARIPVVRRILDSGKSQVSYRTQDNTAKGNRDYIPMEGELLFQPGETWKELQVKLLElqemDS 1070
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIID----DD 77

                            90
                    ....*....|....*
gi 2062762281  1071 LLRGpqTRRFYIQLS 1085
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
991-1085 1.45e-21

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 90.77  E-value: 1.45e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  991 GIVSFEQPEYLVSSGEHVARIPVVRRILD-SGKSQVSYRTQDNTAKGNRDYIPMEGELLFQPGETWKELQVKLLElqemD 1069
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 2062762281 1070 SLLRGpqTRRFYIQLS 1085
Cdd:pfam03160   78 DVYEG--DENFFVLLS 91
fn3 pfam00041
Fibronectin type III domain;
1685-1770 5.13e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.01  E-value: 5.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1685 SAPGPLVFTALSPDSLQLSWERPRRPDGDILGYLVTCEMAHGGEPATTFLVDGDspESRLTVPGLSENVPYKFKVQAKTT 1764
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 2062762281 1765 QGFGPE 1770
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1571-1661 2.89e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 84.09  E-value: 2.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1571 PNTPTRLVFSALGPTSLKVSWQEPQCERA-LQGYSVEYQLLNGGELHRLNIPSPSQTSVVVEDLLPNHSYVFRVRAQSQE 1649
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 2062762281 1650 GWGPEREGVITI 1661
Cdd:cd00063     81 GESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1574-1654 1.52e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 82.08  E-value: 1.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1574 PTRLVFSALGPTSLKVSWQEP-QCERALQGYSVEYQLLNGGE-LHRLNIPsPSQTSVVVEDLLPNHSYVFRVRAQSQEGW 1651
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEpWNEITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 2062762281 1652 GPE 1654
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1684-1769 4.97e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 4.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1684 PSAPGPLVFTALSPDSLQLSWERPRRPDGDILGYLVTCEMAHGGEPATtfLVDGDSPESRLTVPGLSENVPYKFKVQAKT 1763
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKE--VEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78


                   ....*.
gi 2062762281 1764 TQGFGP 1769
Cdd:cd00063     79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1129-1209 9.74e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.68  E-value: 9.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPTGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2062762281 1205 EGPYS 1209
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1129-1216 5.42e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 5.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPTGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2062762281 1205 EGPYSSPVSCRT 1216
Cdd:cd00063     82 ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1571-1652 8.61e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.11  E-value: 8.61e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1571 PNTPTRLVFSALGPTSLKVSWQEPQcERALQGYSVEYQLLNGGELHRLN--IPSPSQTSVVVEDLLPNHSYVFRVRAQSQ 1648
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2062762281  1649 EGWG 1652
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1314 1.07e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDGPKKRTLLIENLRESQPYRYTVK 1300
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 2062762281 1301 ARNGAGWGPEREAI 1314
Cdd:cd00063     76 AVNGGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1570-1790 1.23e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 1.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1570 VPNTPTRLVFSALGPTSLKVSWQEPQcERALQGYSVEYQLLNGGELHRlnIPSPSQTSVVVEDLLPNHSYVFRVRAQSQE 1649
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1650 GWGPEREGVITIESQVHPqsplcplpgsaftlstPSAPGPLVFTALSPDSLQLSWERPrrPDGDILGYLVTcemaHGGEP 1729
Cdd:COG3401    309 GNESAPSNVVSVTTDLTP----------------PAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTSG 366

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2062762281 1730 ATTF-LVDGDSPESRLTVPGLSENVPYKFKVQAKTTQGFGPEREGIITIESQDGGPFPQLGG 1790
Cdd:COG3401    367 GGTYtKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTA 428
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1684-1768 4.74e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 69.18  E-value: 4.74e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1684 PSAPGPLVFTALSPDSLQLSWERPRRPDGDilGYLVTCEMAHGGEPATTFLVDGDSPESRLTVPGLSENVPYKFKVQAKT 1763
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 2062762281  1764 TQGFG 1768
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1222-1310 6.41e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 6.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1222 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEdnrpIGPMKKVLVDGPkKRTLLIENLRESQPYRYTVKA 1301
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGT-TTSVTLTGLKPGTEYEVRVQA 75


                   ....*....
gi 2062762281 1302 RNGAGWGPE 1310
Cdd:pfam00041   76 VNGGGEGPP 84
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 993-1107 9.79e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.21  E-value: 9.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  993 VSFEQPEYLVSSGEHVARIPVVRRILDSGKS-QVSYRTQDNTAKGNRDYIPMEGELLFQPGETWKELQVKLLElqemDSL 1071
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIID----DDI 477

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1072 LRgpQTRRFYIQLSNPKFG--------------ARLGQPQSATVIIGDRD 1107
Cdd:TIGR00845  478 FE--EDEHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 458-486 2.20e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.11  E-value: 2.20e-10
                           10        20
                   ....*....|....*....|....*....
gi 2062762281  458 CELQKEERSSRCSFHGDFMCGHCVCHEGW 486
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1129-1206 3.27e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 3.27e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1129 GAPQNPNAKAAGSRKIHFNWLPPPGK-PTGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2062762281  1205 EG 1206
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1221-1308 8.18e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 8.18e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNednRPIGPMKKVLVDGPKKRTLLIENLRESQPYRYTVK 1300
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 2062762281  1301 ARNGAGWG 1308
Cdd:smart00060   76 AVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1622-1766 9.77e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 9.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1622 SPSQTSVVVEDLLPNHSYVFRVRAQSQEGWGPEREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1700
Cdd:COG3401    188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2062762281 1701 QLSWERPrrPDGDILGYLVtcemAHGGEPATTFLVDGDSPESRLTVPGLSENVPYKFKVQAKTTQG 1766
Cdd:COG3401    250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 551-574 7.53e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 7.53e-03
                           10        20
                   ....*....|....*....|....*.
gi 2062762281  551 LCNDRGRCSM--GQCVCEPGWTGLSC 574
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 37-454 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 571.57  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281    37 SCTECIRVDKDCAYCTDEVFKER---RCNTQAELLAAGCRLQSVVVMESSYEIMEERQID---TTLRRSQVSPQALRVRL 110
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   111 RPGEERHFELQVFEPLESPMDLYILMDFSNSMSDDLDNLKKMGQDLAQVLRQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   191 KEPWPN----SDPPFSFKNVISLTEDVEEFRNKLKGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   267 FHYEADGAnvLAGIMRRNDEECHLDPTGTYTQYKMQDYPSVPTLVRLLGQHNIIPIFAVTNYSYSYYERLSSYFPVSSLG 346
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   347 VLQEDSSNIVDLLQEAFNRIRSNLDIRALDSPRGLRTEVTSrMFQKTDTGSFfiRRGEVGTYQVQLRAIEDLDGAHVCql 426
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPG--TRKCEGVKIGDTVSFEVTVTATKC-- 393

                           410       420
                    ....*....|....*....|....*....
gi 2062762281   427 PEADQKGTIHLKP-SFSNGLQMDVGVICD 454
Cdd:smart00187  394 PPEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 125-370 3.02e-151

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 465.05  E-value: 3.02e-151
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  125 PLESPMDLYILMDFSNSMSDDLDNLKKMGQDLAQVLRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  201 FSFKNVISLTEDVEEFRNKLKGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  281 MRRNDEECHLDPTGTYTQYKMQDYPSVPTLVRLLGQHNIIPIFAVTNYSYSYYERLSSYFPVSSLGVLQEDSSNIVDLLQ 360
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 2062762281  361 EAFNRIRSNL 370
Cdd:pfam00362  239 EAYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 627-710 1.96e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 107.36  E-value: 1.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  627 CEDLRSCVQCQAWGTGEKKGRTC-EECSFKVKMVDELKKAEE-VVEHCSFRDEdDDCTYSYTVEGDSapGPNSTVLVQRR 704
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYEDE--SGKYVVHVQKE 77


                   ....*.
gi 2062762281  705 KECPPG 710
Cdd:pfam07965   78 RECPPG 83
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 991-1085 6.15e-24

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 97.33  E-value: 6.15e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281   991 GIVSFEQPEYLVSSGEHVARIPVVRRILDSGKSQVSYRTQDNTAKGNRDYIPMEGELLFQPGETWKELQVKLLElqemDS 1070
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIID----DD 77

                            90
                    ....*....|....*
gi 2062762281  1071 LLRGpqTRRFYIQLS 1085
Cdd:smart00237   78 IYEK--DETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
991-1085 1.45e-21

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 90.77  E-value: 1.45e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  991 GIVSFEQPEYLVSSGEHVARIPVVRRILD-SGKSQVSYRTQDNTAKGNRDYIPMEGELLFQPGETWKELQVKLLElqemD 1069
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 2062762281 1070 SLLRGpqTRRFYIQLS 1085
Cdd:pfam03160   78 DVYEG--DENFFVLLS 91
fn3 pfam00041
Fibronectin type III domain;
1685-1770 5.13e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.01  E-value: 5.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1685 SAPGPLVFTALSPDSLQLSWERPRRPDGDILGYLVTCEMAHGGEPATTFLVDGDspESRLTVPGLSENVPYKFKVQAKTT 1764
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 2062762281 1765 QGFGPE 1770
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1571-1661 2.89e-19

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 84.09  E-value: 2.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1571 PNTPTRLVFSALGPTSLKVSWQEPQCERA-LQGYSVEYQLLNGGELHRLNIPSPSQTSVVVEDLLPNHSYVFRVRAQSQE 1649
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 2062762281 1650 GWGPEREGVITI 1661
Cdd:cd00063     81 GESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1574-1654 1.52e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 82.08  E-value: 1.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1574 PTRLVFSALGPTSLKVSWQEP-QCERALQGYSVEYQLLNGGE-LHRLNIPsPSQTSVVVEDLLPNHSYVFRVRAQSQEGW 1651
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpDGNGPITGYEVEYRPKNSGEpWNEITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 2062762281 1652 GPE 1654
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1684-1769 4.97e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 4.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1684 PSAPGPLVFTALSPDSLQLSWERPRRPDGDILGYLVTCEMAHGGEPATtfLVDGDSPESRLTVPGLSENVPYKFKVQAKT 1763
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKE--VEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78


                   ....*.
gi 2062762281 1764 TQGFGP 1769
Cdd:cd00063     79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1129-1209 9.74e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.68  E-value: 9.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPTGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2062762281 1205 EGPYS 1209
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1129-1216 5.42e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 5.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1129 GAPQNPNAKAAGSRKIHFNWLPPP---GKPTGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2062762281 1205 EGPYSSPVSCRT 1216
Cdd:cd00063     82 ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1571-1652 8.61e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.11  E-value: 8.61e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1571 PNTPTRLVFSALGPTSLKVSWQEPQcERALQGYSVEYQLLNGGELHRLN--IPSPSQTSVVVEDLLPNHSYVFRVRAQSQ 1648
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2062762281  1649 EGWG 1652
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1314 1.07e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNrpigpMKKVLVDGPKKRTLLIENLRESQPYRYTVK 1300
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 2062762281 1301 ARNGAGWGPEREAI 1314
Cdd:cd00063     76 AVNGGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1570-1790 1.23e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 1.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1570 VPNTPTRLVFSALGPTSLKVSWQEPQcERALQGYSVEYQLLNGGELHRlnIPSPSQTSVVVEDLLPNHSYVFRVRAQSQE 1649
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1650 GWGPEREGVITIESQVHPqsplcplpgsaftlstPSAPGPLVFTALSPDSLQLSWERPrrPDGDILGYLVTcemaHGGEP 1729
Cdd:COG3401    309 GNESAPSNVVSVTTDLTP----------------PAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTSG 366

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2062762281 1730 ATTF-LVDGDSPESRLTVPGLSENVPYKFKVQAKTTQGFGPEREGIITIESQDGGPFPQLGG 1790
Cdd:COG3401    367 GGTYtKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTA 428
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1684-1768 4.74e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 69.18  E-value: 4.74e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1684 PSAPGPLVFTALSPDSLQLSWERPRRPDGDilGYLVTCEMAHGGEPATTFLVDGDSPESRLTVPGLSENVPYKFKVQAKT 1763
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 2062762281  1764 TQGFG 1768
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1222-1310 6.41e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 6.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1222 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEdnrpIGPMKKVLVDGPkKRTLLIENLRESQPYRYTVKA 1301
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGT-TTSVTLTGLKPGTEYEVRVQA 75


                   ....*....
gi 2062762281 1302 RNGAGWGPE 1310
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1117-1306 1.85e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.34  E-value: 1.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1117 TVSSPPPprgdlGAPQNPNAKAAGSRKIHFNWLPPPGKP-TGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--- 1192
Cdd:COG3401    227 TTPTTPP-----SAPTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgl 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1193 -----YEMKVCAYGAQG-EGPYSSPVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVcYglvnEDNR 1266
Cdd:COG3401    293 tngttYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNV-Y----RSTS 365

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2062762281 1267 PIGPMKKVlVDGPKKRTLLIENLRESQPYRYTVKARNGAG 1306
Cdd:COG3401    366 GGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 993-1107 9.79e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.21  E-value: 9.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  993 VSFEQPEYLVSSGEHVARIPVVRRILDSGKS-QVSYRTQDNTAKGNRDYIPMEGELLFQPGETWKELQVKLLElqemDSL 1071
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIID----DDI 477

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1072 LRgpQTRRFYIQLSNPKFG--------------ARLGQPQSATVIIGDRD 1107
Cdd:TIGR00845  478 FE--EDEHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 28-73 9.99e-12

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 61.41  E-value: 9.99e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2062762281   28 NRCKKAQvKSCTECIRVDKDCAYCTDEVF--KERRCNTQAELLAAGCR 73
Cdd:pfam17205    1 NRCTSAS-TSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 458-486 2.20e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.11  E-value: 2.20e-10
                           10        20
                   ....*....|....*....|....*....
gi 2062762281  458 CELQKEERSSRCSFHGDFMCGHCVCHEGW 486
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1129-1206 3.27e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 3.27e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1129 GAPQNPNAKAAGSRKIHFNWLPPPGK-PTGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1204
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2062762281  1205 EG 1206
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1221-1308 8.18e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 8.18e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  1221 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNednRPIGPMKKVLVDGPKKRTLLIENLRESQPYRYTVK 1300
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 2062762281  1301 ARNGAGWG 1308
Cdd:smart00060   76 AVNGAGEG 83
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 979-1092 6.17e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.88  E-value: 6.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281  979 LVNITIIKEQASGIVSFEQPEYLVSSGEHVARIPVVRRILDSGKSQVSYRTQDNTAK-GNRDYIPMEGELLFQPGETWKE 1057
Cdd:TIGR00845  516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKT 595

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2062762281 1058 LQVKLLELQEMDsllrgpQTRRFYIQLSNPKFGAR 1092
Cdd:TIGR00845  596 IRVKIVDDEEYE------KNDTFFIELGEPRWAKR 624
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1622-1766 9.77e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 9.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1622 SPSQTSVVVEDLLPNHSYVFRVRAQSQEGWGPEREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1700
Cdd:COG3401    188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2062762281 1701 QLSWERPrrPDGDILGYLVtcemAHGGEPATTFLVDGDSPESRLTVPGLSENVPYKFKVQAKTTQG 1766
Cdd:COG3401    250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1114-1306 8.91e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.85  E-value: 8.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1114 MNQTVSSPPPPRGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPT-GYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCD 1192
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGvVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTT 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062762281 1193 YEMKVCAYGAQGEGPYSSPVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGlvnedNRPIGPMK 1272
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRS-----NSGDGPFT 277

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2062762281 1273 KvlVDGPKKRTLLIENLRESQPYRYTVKARNGAG 1306
Cdd:COG3401    278 K--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 551-574 7.53e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 7.53e-03
                           10        20
                   ....*....|....*....|....*.
gi 2062762281  551 LCNDRGRCSM--GQCVCEPGWTGLSC 574
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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