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Conserved domains on  [gi|2062887737|ref|XP_042103772|]
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lactosylceramide 4-alpha-galactosyltransferase [Ovis aries]

Protein Classification

Gly_transf_sug and Gb3_synth domain-containing protein( domain architecture ID 10517332)

Gly_transf_sug and Gb3_synth domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 224-351 1.43e-60

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


:

Pssm-ID: 428017  Cd Length: 130  Bit Score: 190.53  E-value: 1.43e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737 224 AFERHHEFMAQCMRDFVAHYNGWIWGHQGPQLLTRVFKKWCSIRSLS--ESRACRGVTTLPPEAFYPIPWQNWKKYFEDI 301
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKamERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2062887737 302 SPQELTRLLNATFAVHVWNKKSQGTHFEATSRALLAQLHARYCPTTHKAM 351
Cdd:pfam04572  81 DLEETMKLTKDSYAVHLWNKLSKGEPLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 96-216 2.02e-16

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


:

Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 73.52  E-value: 2.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737  96 FMCSVESAARAHPESPVVVLMKGLpggnasrprhlglsllgcfpnvqMRPLDLEELFRETPlaaWY-AAVQRRWepyLLP 174
Cdd:pfam04488   4 VMKAIESLIKLHPDYCYVVLSDDL-----------------------DFALDINFLKSDTP---WFlEAYSLLP---LFI 54

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2062887737 175 VLSDASRIALLWKFGGIYLDTDFIVLKDLrnltNALGTQSRY 216
Cdd:pfam04488  55 AKSDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERF 92
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 224-351 1.43e-60

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 190.53  E-value: 1.43e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737 224 AFERHHEFMAQCMRDFVAHYNGWIWGHQGPQLLTRVFKKWCSIRSLS--ESRACRGVTTLPPEAFYPIPWQNWKKYFEDI 301
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKamERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2062887737 302 SPQELTRLLNATFAVHVWNKKSQGTHFEATSRALLAQLHARYCPTTHKAM 351
Cdd:pfam04572  81 DLEETMKLTKDSYAVHLWNKLSKGEPLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 96-216 2.02e-16

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 73.52  E-value: 2.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737  96 FMCSVESAARAHPESPVVVLMKGLpggnasrprhlglsllgcfpnvqMRPLDLEELFRETPlaaWY-AAVQRRWepyLLP 174
Cdd:pfam04488   4 VMKAIESLIKLHPDYCYVVLSDDL-----------------------DFALDINFLKSDTP---WFlEAYSLLP---LFI 54

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2062887737 175 VLSDASRIALLWKFGGIYLDTDFIVLKDLrnltNALGTQSRY 216
Cdd:pfam04488  55 AKSDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERF 92
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
177-236 2.73e-08

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 51.81  E-value: 2.73e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2062887737 177 SDASRIALLWKFGGIYLDTDFIVLKDLRNLTNA----LGTQ--SRYVLNGAFLAFERHHEFMAQCM 236
Cdd:COG3774    70 ADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGddlfLGYEdpPPGIISNGFIAAEPGHPFLKKAL 135
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 224-351 1.43e-60

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 190.53  E-value: 1.43e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737 224 AFERHHEFMAQCMRDFVAHYNGWIWGHQGPQLLTRVFKKWCSIRSLS--ESRACRGVTTLPPEAFYPIPWQNWKKYFEDI 301
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKamERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2062887737 302 SPQELTRLLNATFAVHVWNKKSQGTHFEATSRALLAQLHARYCPTTHKAM 351
Cdd:pfam04572  81 DLEETMKLTKDSYAVHLWNKLSKGEPLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 96-216 2.02e-16

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 73.52  E-value: 2.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737  96 FMCSVESAARAHPESPVVVLMKGLpggnasrprhlglsllgcfpnvqMRPLDLEELFRETPlaaWY-AAVQRRWepyLLP 174
Cdd:pfam04488   4 VMKAIESLIKLHPDYCYVVLSDDL-----------------------DFALDINFLKSDTP---WFlEAYSLLP---LFI 54

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2062887737 175 VLSDASRIALLWKFGGIYLDTDFIVLKDLrnltNALGTQSRY 216
Cdd:pfam04488  55 AKSDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERF 92
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
177-236 2.73e-08

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 51.81  E-value: 2.73e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2062887737 177 SDASRIALLWKFGGIYLDTDFIVLKDLRNLTNA----LGTQ--SRYVLNGAFLAFERHHEFMAQCM 236
Cdd:COG3774    70 ADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGddlfLGYEdpPPGIISNGFIAAEPGHPFLKKAL 135
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 80-208 8.96e-03

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 37.65  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737  80 NIFFleTSDRtnpNFLFMCSV--ESAARAHPESP--VVVLMKGLPGGNASRprhlgLSLLGCFPNVQMRPLDL-EELFRE 154
Cdd:COG1442     7 NIVF--AIDD---NYLPGLGVsiASLLENNPDRPydFHILTDGLSDENKER-----LEALAAKYNVSIEFIDVdDELLKD 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062887737 155 TPL------AAWYaavqRRWEPYLLPvlSDASRIallwkfggIYLDTDFIVLKDLRNLTN 208
Cdd:COG1442    77 LPVskhiskATYY----RLLIPELLP--DDYDKV--------LYLDADTLVLGDLSELWD 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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