|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
91-335 |
3.63e-23 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 102.70 E-value: 3.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 91 TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNLPH--SLRELHLQDNNIRSVTrDSLSRIPQIEKLHLDDN 168
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 169 SVSTVSiedDAFLDSHQLRLLFLSRNHLSSIPNGLP--HTLEELRLDDNRISTIPlhAFKGLNNLRRLVLDGNllanqRI 246
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 247 AD-DTFSRLQNLSELSLVRNslaappvNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLE 325
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNN-------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
250
....*....|
gi 2038186169 326 NLSQLLLRNN 335
Cdd:COG4886 336 TLTTLALSLS 345
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
65-388 |
2.25e-22 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 102.47 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 65 CRCDNGFIYCNDR-GLTSIPPDIPDDATTLYLQNNQINNagVPTELKTktNVKVIYLYENDLDEFPVNLPHSLRELHLQD 143
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 144 NNIRSVTRdslsRIPQ-IEKLHLDDNSVSTVSiedDAFLDshQLRLLFLSRNHLSSIPNGLPHTLEELRLDDNRIS---- 218
Cdd:PRK15370 251 NRITELPE----RLPSaLQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpe 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 219 TIPLhafkglnNLRRLVLDGNLLANqrIADDTFSRLQNlseLSLVRNSLAAPPVNLPSAhLQKLYLQDNAITHIPYNSLS 298
Cdd:PRK15370 322 TLPP-------GLKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPA 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 299 KmrqLQRLDLSSNNLTALPRGLFDDLENLSQ---LLLRNNPWfcgcnliwlrdwvkARASVVNVRGLMC----QGPEKVR 371
Cdd:PRK15370 389 A---LQIMQASRNNLVRLPESLPHFRGEGPQptrIIVEYNPF--------------SERTIQNMQRLMSsvgyQGPRVLF 451
|
330 340
....*....|....*....|
gi 2038186169 372 GM---AIKDITQELDDCFEG 388
Cdd:PRK15370 452 AMgdfSIVRVTRPLHQAVQG 471
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
91-318 |
2.73e-17 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 81.37 E-value: 2.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 91 TTLYLQNNQINNAGvptELKTKTNVKVIYLYENDLDEFP--VNLPHsLRELHLQDNNIRSVtrDSLSRIPQIEKLHLDDN 168
Cdd:cd21340 5 THLYLNDKNITKID---NLSLCKNLKVLYLYDNKITKIEnlEFLTN-LTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 169 SVSTVsiEDdafLDS-HQLRLLFLSRNHLssiPNGlphtlEELRLDDNRISTIplhafkgLNNLRRLVLDGNllanqria 247
Cdd:cd21340 79 RISVV--EG---LENlTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN-------- 130
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2038186169 248 ddtfsRLQNLSELSLVRNslaappvnlpsahLQKLYLQDNAITHIPY--NSLSKMRQLQRLDLSSNNLTALPR 318
Cdd:cd21340 131 -----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
278-336 |
8.08e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.92 E-value: 8.08e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2038186169 278 HLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNNP 336
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
307-385 |
7.30e-08 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 56.24 E-value: 7.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 307 DLSSNNLTALPRGLFDDLENLSQLLLRNNPWFCGCNLIWLRDWVKAR-ASVVNVRGLMCQGPEKVRGMAIKDITQELDDC 385
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
335-372 |
1.63e-07 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 48.20 E-value: 1.63e-07
10 20 30
....*....|....*....|....*....|....*...
gi 2038186169 335 NPWFCGCNLIWLRDWVKARASVVNVRGLMCQGPEKVRG 372
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG 38
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
61-91 |
9.23e-07 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 45.77 E-value: 9.23e-07
10 20 30
....*....|....*....|....*....|.
gi 2038186169 61 CPYVCRCDNGFIYCNDRGLTSIPPDIPDDAT 91
Cdd:smart00013 2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
61-87 |
3.00e-06 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 44.16 E-value: 3.00e-06
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
446-514 |
4.83e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.52 E-value: 4.83e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038186169 446 LNVKPLTADSIRITWK--SFHPASSFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:smart00060 7 LRVTDVTSTSVTLSWEppPDDGITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
446-514 |
1.08e-03 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 38.55 E-value: 1.08e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2038186169 446 LNVKPLTADSIRITWK-SFHPAS---SFRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTpPPDGNGpitGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
446-513 |
1.10e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 38.63 E-value: 1.10e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2038186169 446 LNVKPLTADSIRITWK----SFHPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPRSTYIICLV 513
Cdd:cd00063 7 LRVTDVTSTSVTLSWTppedDGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
300-323 |
1.18e-03 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 36.56 E-value: 1.18e-03
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
91-335 |
3.63e-23 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 102.70 E-value: 3.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 91 TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNLPH--SLRELHLQDNNIRSVTrDSLSRIPQIEKLHLDDN 168
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 169 SVSTVSiedDAFLDSHQLRLLFLSRNHLSSIPNGLP--HTLEELRLDDNRISTIPlhAFKGLNNLRRLVLDGNllanqRI 246
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 247 AD-DTFSRLQNLSELSLVRNslaappvNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLE 325
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNN-------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
250
....*....|
gi 2038186169 326 NLSQLLLRNN 335
Cdd:COG4886 336 TLTTLALSLS 345
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
91-335 |
1.20e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 101.16 E-value: 1.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 91 TTLYLQNNQinnagvptELKTKTNVKVIYLYENDLDEFPVNLP--HSLRELHLQDNNIRSVTrDSLSRIPQIEKLHLDDN 168
Cdd:COG4886 99 TELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNN 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 169 SVSTVSiedDAFLDSHQLRLLFLSRNHLSSIPNGL--PHTLEELRLDDNRISTIPLhAFKGLNNLRRLVLDGNllanqRI 246
Cdd:COG4886 170 QLTDLP---EELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN-----QL 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 247 AD-DTFSRLQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLE 325
Cdd:COG4886 241 TDlPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320
|
250
....*....|
gi 2038186169 326 NLSQLLLRNN 335
Cdd:COG4886 321 TTLLLLLLLL 330
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
65-388 |
2.25e-22 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 102.47 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 65 CRCDNGFIYCNDR-GLTSIPPDIPDDATTLYLQNNQINNagVPTELKTktNVKVIYLYENDLDEFPVNLPHSLRELHLQD 143
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 144 NNIRSVTRdslsRIPQ-IEKLHLDDNSVSTVSiedDAFLDshQLRLLFLSRNHLSSIPNGLPHTLEELRLDDNRIS---- 218
Cdd:PRK15370 251 NRITELPE----RLPSaLQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpe 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 219 TIPLhafkglnNLRRLVLDGNLLANqrIADDTFSRLQNlseLSLVRNSLAAPPVNLPSAhLQKLYLQDNAITHIPYNSLS 298
Cdd:PRK15370 322 TLPP-------GLKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPA 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 299 KmrqLQRLDLSSNNLTALPRGLFDDLENLSQ---LLLRNNPWfcgcnliwlrdwvkARASVVNVRGLMC----QGPEKVR 371
Cdd:PRK15370 389 A---LQIMQASRNNLVRLPESLPHFRGEGPQptrIIVEYNPF--------------SERTIQNMQRLMSsvgyQGPRVLF 451
|
330 340
....*....|....*....|
gi 2038186169 372 GM---AIKDITQELDDCFEG 388
Cdd:PRK15370 452 AMgdfSIVRVTRPLHQAVQG 471
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
109-346 |
2.72e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 90.76 E-value: 2.72e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 109 LKTKTNVKVIYLYENDLDEFPVNLPHSLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDNSVSTVSIEDDAFLDSHQLRL 188
Cdd:COG4886 21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 189 LFLSRN-HLSSIPNglphtLEELRLDDNRISTIPlHAFKGLNNLRRLVLDGNLLANqriADDTFSRLQNLSELSLVRNSL 267
Cdd:COG4886 101 LDLSGNeELSNLTN-----LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD---LPEPLGNLTNLKSLDLSNNQL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 268 AAPPVNL-PSAHLQKLYLQDNAITHIPyNSLSKMRQLQRLDLSSNNLTALPRGLfDDLENLSQLLLRNN-----PWFCGC 341
Cdd:COG4886 172 TDLPEELgNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGNL 249
|
....*.
gi 2038186169 342 -NLIWL 346
Cdd:COG4886 250 tNLEEL 255
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
91-318 |
2.73e-17 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 81.37 E-value: 2.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 91 TTLYLQNNQINNAGvptELKTKTNVKVIYLYENDLDEFP--VNLPHsLRELHLQDNNIRSVtrDSLSRIPQIEKLHLDDN 168
Cdd:cd21340 5 THLYLNDKNITKID---NLSLCKNLKVLYLYDNKITKIEnlEFLTN-LTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 169 SVSTVsiEDdafLDS-HQLRLLFLSRNHLssiPNGlphtlEELRLDDNRISTIplhafkgLNNLRRLVLDGNllanqria 247
Cdd:cd21340 79 RISVV--EG---LENlTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN-------- 130
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2038186169 248 ddtfsRLQNLSELSLVRNslaappvnlpsahLQKLYLQDNAITHIPY--NSLSKMRQLQRLDLSSNNLTALPR 318
Cdd:cd21340 131 -----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
72-337 |
2.94e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 84.60 E-value: 2.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 72 IYCNDRGLTSIPPDIPDDA--TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNL--PHSLRELHLQDNNIR 147
Cdd:COG4886 141 LDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 148 SVTrDSLSRIPQIEKLHLDDNSVSTVSieddAFLDSHQLRLLFLSRNHLSSIPNGLPHT-LEELRLDDNRISTIPLHAFK 226
Cdd:COG4886 219 DLP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELE 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 227 GLNNLRRLVLDGNLLANQriadDTFSRLQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRL 306
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLL----ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
|
250 260 270
....*....|....*....|....*....|.
gi 2038186169 307 DLSSNNLTALPRGLFDDLENLSQLLLRNNPW 337
Cdd:COG4886 370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
139-335 |
2.48e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.18 E-value: 2.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 139 LHLQDNNIRSVTRDSLSRIPQIEKLHLDDNSVSTvSIEDDAFLDSHQLRLLFLSRNHLS-SIPNGLPHTLEELRLDDNRI 217
Cdd:PLN00113 74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNML 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 218 S-TIPLHaFKGLNNLRRLVLDGNLLANQriADDTFSRLQNLSELSLVRNSLAAP-PVNLPSA-HLQKLYLQDNAIT-HIP 293
Cdd:PLN00113 153 SgEIPND-IGSFSSLKVLDLGGNVLVGK--IPNSLTNLTSLEFLTLASNQLVGQiPRELGQMkSLKWIYLGYNNLSgEIP 229
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2038186169 294 YnSLSKMRQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNN 335
Cdd:PLN00113 230 Y-EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
278-336 |
8.08e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.92 E-value: 8.08e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2038186169 278 HLQKLYLQDNAITHIPYNSLSKMRQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNNP 336
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
139-335 |
1.07e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.11 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 139 LHLQDNNIRSvtrdslsripqIEKLHLddnsvstvsieddafldSHQLRLLFLSRNHLSSIPN--GLPHtLEELRLDDNR 216
Cdd:cd21340 7 LYLNDKNITK-----------IDNLSL-----------------CKNLKVLYLYDNKITKIENleFLTN-LTHLYLQNNQ 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 217 ISTIPlhAFKGLNNLRRLVLDGNLLAnqRIADdtFSRLQNLSELSLVRNSLAAPpvnlpsahlQKLYLQDNAIThipynS 296
Cdd:cd21340 58 IEKIE--NLENLVNLKKLYLGGNRIS--VVEG--LENLTNLEELHIENQRLPPG---------EKLTFDPRSLA-----A 117
|
170 180 190
....*....|....*....|....*....|....*....
gi 2038186169 297 LSKmrQLQRLDLSSNNLTALpRGLFDdLENLSQLLLRNN 335
Cdd:cd21340 118 LSN--SLRVLNISGNNIDSL-EPLAP-LRNLEQLDASNN 152
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
72-326 |
1.37e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 63.80 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 72 IYCNDRGLTSIPPDIPDDA--TTLYLQNNQINNagVPTELKTKTNVKVIYLYENDLDEFPVNLP--HSLRELHLQDNNIR 147
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTnlKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLT 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 148 SVtrDSLSRIPQIEKLHLDDNSVSTVSIEddafLDSHQLRLLFLSRNHLSSIPNGLPHTLEELRLDDNRISTIPLHAFKG 227
Cdd:COG4886 242 DL--PELGNLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 228 LNNLRRLVLDGNLLANQRIADDTFSRLQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPYNSLSKMRQLQRLD 307
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395
|
250
....*....|....*....
gi 2038186169 308 LSSNNLTALPRGLFDDLEN 326
Cdd:COG4886 396 TTAGVLLLTLALLDAVNTE 414
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
92-339 |
2.64e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 62.37 E-value: 2.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 92 TLYLQNNQINNAGVPTELKTKTNVKVIYLYENDLDE-----FPVNLPH--SLRELHLQDNNIRSVTR------DSLSRIP 158
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEeaakaLASALRPqpSLKELCLSLNETGRIPRglqsllQGLTKGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 159 QIEKLHLDDNSVStvsieddaFLDSHQLRLLFLSrnhlssipnglpHTLEELRLDDNRISTIPL-HAFKGLN----NLRR 233
Cdd:cd00116 82 GLQELDLSDNALG--------PDGCGVLESLLRS------------SSLQELKLNNNGLGDRGLrLLAKGLKdlppALEK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 234 LVLDGNLLANQRIAD--DTFSRLQNLSELSLVRNSLAAPPVNL------PSAHLQKLYLQDNAITHIPYNSLS----KMR 301
Cdd:cd00116 142 LVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDAGIRAlaeglkANCNLEVLDLNNNGLTDEGASALAetlaSLK 221
|
250 260 270
....*....|....*....|....*....|....*....
gi 2038186169 302 QLQRLDLSSNNLTALP-RGLFDDLENLSQLLLRNNPWFC 339
Cdd:cd00116 222 SLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
82-335 |
5.51e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 62.94 E-value: 5.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 82 IPPDI--PDDATTLYLQNNQINNAgVPTELKTKTNVKVIYLYENDLD-EFPVNLP--HSLRELHLQDNNIRSVTRDSLSR 156
Cdd:PLN00113 348 IPKNLgkHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTK 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 157 IPQIEKLHLDDNSVSTvSIEDDAFlDSHQLRLLFLSRNHLSSipnGLPHT-----LEELRLDDNRIS-TIPLhAFKGLNN 230
Cdd:PLN00113 427 LPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRNQFSgAVPR-KLGSLSE 500
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 231 LRRLVLDGNLLANQriADDTFSRLQNLSELSLVRNSLAAppvnlpsahlqklylqdnaitHIPyNSLSKMRQLQRLDLSS 310
Cdd:PLN00113 501 LMQLKLSENKLSGE--IPDELSSCKKLVSLDLSHNQLSG---------------------QIP-ASFSEMPVLSQLDLSQ 556
|
250 260
....*....|....*....|....*.
gi 2038186169 311 NNLTA-LPRGLfDDLENLSQLLLRNN 335
Cdd:PLN00113 557 NQLSGeIPKNL-GNVESLVQVNISHN 581
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
206-267 |
8.12e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.84 E-value: 8.12e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2038186169 206 TLEELRLDDNRISTIPLHAFKGLNNLRRLVLDGNLLanQRIADDTFSRLQNLSELSLVRNSL 267
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
69-314 |
1.98e-09 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 60.95 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 69 NGFIYCNDRGLTSIPPDIPDDATTLYLQNNQINN-AGVPTELKT-------KTNVKV-------IYLYENDLDEFPVnLP 133
Cdd:PRK15387 203 NAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELRTlevsgnqLTSLPVlppglleLSIFSNPLTHLPA-LP 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 134 HSLRELHLQDNNIRSVTrdslSRIPQIEKLHLDDNSVSTVSIeddafLDShQLRLLFLSRNHLSSIPNgLPHTLEELRLD 213
Cdd:PRK15387 282 SGLCKLWIFGNQLTSLP----VLPPGLQELSVSDNQLASLPA-----LPS-ELCKLWAYNNQLTSLPT-LPSGLQELSVS 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 214 DNRISTIP-----LHAFKGLNN-----------LRRLVLDGNLLANQRIADdtfsrlQNLSELSLVRNSLAAPPVnLPSA 277
Cdd:PRK15387 351 DNQLASLPtlpseLYKLWAYNNrltslpalpsgLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LPSG 423
|
250 260 270
....*....|....*....|....*....|....*..
gi 2038186169 278 hLQKLYLQDNAITHIPyNSLSKMRQLQRLDLSSNNLT 314
Cdd:PRK15387 424 -LLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPLS 458
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
93-335 |
3.16e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 60.25 E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 93 LYLQNNQINnAGVPTELKTKTNVKVIYLYENDLD-EFPVNLPH--SLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDNS 169
Cdd:PLN00113 193 LTLASNQLV-GQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 170 VSTvSIEDDAFlDSHQLRLLFLSRNHLS-SIPNGLPH--TLEELRLDDNRIS-TIPLhAFKGLNNLRRLVLDGNLLANQR 245
Cdd:PLN00113 272 LSG-PIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQlqNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFSGEI 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 246 IADdtFSRLQNLSELSLVRNSLAA--PPVNLPSAHLQKLYLQDNAI-THIPyNSLSKMRQLQRLDLSSNNLTA-LPRGlF 321
Cdd:PLN00113 349 PKN--LGKHNNLTVLDLSTNNLTGeiPEGLCSSGNLFKLILFSNSLeGEIP-KSLGACRSLRRVRLQDNSFSGeLPSE-F 424
|
250
....*....|....
gi 2038186169 322 DDLENLSQLLLRNN 335
Cdd:PLN00113 425 TKLPLVYFLDISNN 438
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
136-328 |
2.61e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 56.21 E-value: 2.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 136 LRELHLQDNNIR---SVTRDSLSRIPQIEKLHLDDNSVST--VSIEDDAFLD-SHQLRLLFLSRNHLSS-----IPNGLP 204
Cdd:cd00116 83 LQELDLSDNALGpdgCGVLESLLRSSSLQELKLNNNGLGDrgLRLLAKGLKDlPPALEKLVLGRNRLEGasceaLAKALR 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 205 H--TLEELRLDDNRIST--IPL--HAFKGLNNLRRLVLDGNLLANQRIAD--DTFSRLQNLSELSLVRNSLAappvnlpS 276
Cdd:cd00116 163 AnrDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLT-------D 235
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2038186169 277 AHLQKLYLQdnaithipynSLSKMRQLQRLDLSSNNLTA-----LPRGLFD--DLENLS 328
Cdd:cd00116 236 AGAAALASA----------LLSPNISLLTLSLSCNDITDdgakdLAEVLAEkeSLLELD 284
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
230-313 |
3.88e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.22 E-value: 3.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 230 NLRRLVLDGNLLanQRIADDTFSRLQNLselslvrnslaappvnlpsahlQKLYLQDNAITHIPYNSLSKMRQLQRLDLS 309
Cdd:pfam13855 2 NLRSLDLSNNRL--TSLDDGAFKGLSNL----------------------KVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57
|
....
gi 2038186169 310 SNNL 313
Cdd:pfam13855 58 GNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
158-241 |
5.57e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.83 E-value: 5.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 158 PQIEKLHLDDNSVStvSIEDDAFLDSHQLRLLFLSRNhlssipnglphtleelrlddnRISTIPLHAFKGLNNLRRLVLD 237
Cdd:pfam13855 1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNN---------------------LLTTLSPGAFSGLPSLRYLDLS 57
|
....
gi 2038186169 238 GNLL 241
Cdd:pfam13855 58 GNRL 61
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
307-385 |
7.30e-08 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 56.24 E-value: 7.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 307 DLSSNNLTALPRGLFDDLENLSQLLLRNNPWFCGCNLIWLRDWVKAR-ASVVNVRGLMCQGPEKVRGMAIKDITQELDDC 385
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
335-372 |
1.63e-07 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 48.20 E-value: 1.63e-07
10 20 30
....*....|....*....|....*....|....*...
gi 2038186169 335 NPWFCGCNLIWLRDWVKARASVVNVRGLMCQGPEKVRG 372
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG 38
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
135-196 |
2.18e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 2.18e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2038186169 135 SLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDNSVSTvsIEDDAFLDSHQLRLLFLSRNHL 196
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
61-91 |
9.23e-07 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 45.77 E-value: 9.23e-07
10 20 30
....*....|....*....|....*....|.
gi 2038186169 61 CPYVCRCDNGFIYCNDRGLTSIPPDIPDDAT 91
Cdd:smart00013 2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
61-87 |
3.00e-06 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 44.16 E-value: 3.00e-06
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
144-317 |
2.35e-05 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 47.85 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 144 NNIRSVTRDSLSRIPQIEKLHlddnsVSTVSIEDDAFLD----SHQLRLLFLSRNHLSSIPNgLPHTLEELRLDDNRIST 219
Cdd:PRK15387 203 NAVLNVGESGLTTLPDCLPAH-----ITTLVIPDNNLTSlpalPPELRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTH 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 220 IPLHAfkglNNLRRLVLDGNLLANQRIADdtfsrlQNLSELSLVRNSLAAPPVnLPSaHLQKLYLQDNAITHIPynslSK 299
Cdd:PRK15387 277 LPALP----SGLCKLWIFGNQLTSLPVLP------PGLQELSVSDNQLASLPA-LPS-ELCKLWAYNNQLTSLP----TL 340
|
170
....*....|....*...
gi 2038186169 300 MRQLQRLDLSSNNLTALP 317
Cdd:PRK15387 341 PSGLQELSVSDNQLASLP 358
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
91-217 |
2.58e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 47.09 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 91 TTLYLQNNQINNAGV---PTELKTKTNVKVIYLYENDL-DEFPVNL------PHSLRELHLQDNNIRSVTRDSLSRI--- 157
Cdd:COG5238 267 ETLYLSGNQIGAEGAialAKALQGNTTLTSLDLSVNRIgDEGAIALaeglqgNKTLHTLNLAYNGIGAQGAIALAKAlqe 346
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2038186169 158 -PQIEKLHLDDNSVSTVSIEDDA-FLDSH-QLRLLFLSRNHLS-----SIPNGLPHT-LEELRLDDNRI 217
Cdd:COG5238 347 nTTLHSLDLSDNQIGDEGAIALAkYLEGNtTLRELNLGKNNIGkqgaeALIDALQTNrLHTLILDGNLI 415
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
254-335 |
3.04e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.85 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 254 LQNLSELSLVRNSLAAPPVNLPSAHLQKLYLQDNAITHIPynSLSKMRQLQRLDLSSNNLTALPrGLfDDLENLSQLLLR 333
Cdd:cd21340 1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-NL-ENLVNLKKLYLG 76
|
..
gi 2038186169 334 NN 335
Cdd:cd21340 77 GN 78
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
301-335 |
3.05e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 3.05e-04
10 20 30
....*....|....*....|....*....|....*
gi 2038186169 301 RQLQRLDLSSNNLTALPRGLFDDLENLSQLLLRNN 335
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
446-514 |
4.83e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 39.52 E-value: 4.83e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038186169 446 LNVKPLTADSIRITWK--SFHPASSFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:smart00060 7 LRVTDVTSTSVTLSWEppPDDGITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
91-324 |
7.54e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.47 E-value: 7.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 91 TTLYLQNNQINNAGVP---TELKTKTNVKVIYLYENDL-DEFPVNL------PHSLRELHLQDNNIRSVTRDSLSRipqi 160
Cdd:COG5238 211 TTLWLKRNPIGDEGAEilaEALKGNKSLTTLDLSNNQIgDEGVIALaealknNTTVETLYLSGNQIGAEGAIALAK---- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 161 eklHLDDNSvstvsieddafldshQLRLLFLSRNHLS-----SIPNGLPH--TLEELRLDDNRIST---IPL-HAFKGLN 229
Cdd:COG5238 287 ---ALQGNT---------------TLTSLDLSVNRIGdegaiALAEGLQGnkTLHTLNLAYNGIGAqgaIALaKALQENT 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 230 NLRRLVLDGNLLANQRIAddtfsrlqnlselslvrnSLAAPPVNLPSAHlqKLYLQDNAITHIPYNSLSKM---RQLQRL 306
Cdd:COG5238 349 TLHSLDLSDNQIGDEGAI------------------ALAKYLEGNTTLR--ELNLGKNNIGKQGAEALIDAlqtNRLHTL 408
|
250
....*....|....*...
gi 2038186169 307 DLSSNNLTALPRGLFDDL 324
Cdd:COG5238 409 ILDGNLIGAEAQQRLEQL 426
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
446-514 |
1.08e-03 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 38.55 E-value: 1.08e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2038186169 446 LNVKPLTADSIRITWK-SFHPAS---SFRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPRSTYIICLVT 514
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTpPPDGNGpitGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
446-513 |
1.10e-03 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 38.63 E-value: 1.10e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2038186169 446 LNVKPLTADSIRITWK----SFHPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPRSTYIICLV 513
Cdd:cd00063 7 LRVTDVTSTSVTLSWTppedDGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
300-323 |
1.18e-03 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 36.56 E-value: 1.18e-03
|
| LRR_TYP |
smart00369 |
Leucine-rich repeats, typical (most populated) subfamily; |
300-323 |
1.18e-03 |
|
Leucine-rich repeats, typical (most populated) subfamily;
Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 36.56 E-value: 1.18e-03
|
| LRR_9 |
pfam14580 |
Leucine-rich repeat; |
156-271 |
2.96e-03 |
|
Leucine-rich repeat;
Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 39.36 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 156 RIPQIEKLhlddnsvstvsiedDAFLDshQLRLLFLSRNHLSSIpNGLPHT--LEELRLDDNRISTIPLHAFKGLNNLRR 233
Cdd:pfam14580 30 KIPIIENL--------------GATLD--QFDTIDFSDNEIRKL-DGFPLLrrLKTLLLNNNRICRIGEGLGEALPNLTE 92
|
90 100 110
....*....|....*....|....*....|....*....
gi 2038186169 234 LVLDGNLLanQRIAD-DTFSRLQNLSELSLVRNSLAAPP 271
Cdd:pfam14580 93 LILTNNNL--QELGDlDPLASLKKLTFLSLLRNPVTNKP 129
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
278-313 |
5.52e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.30 E-value: 5.52e-03
10 20 30
....*....|....*....|....*....|....*.
gi 2038186169 278 HLQKLYLQDNAITHIPynSLSKMRQLQRLDLSSNNL 313
Cdd:pfam12799 2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
221-340 |
7.40e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 39.41 E-value: 7.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 221 PLHAFKGLN-----NLRRLVLDGNLLANQRIAD---DTFSRLQNLSELSLVRNSL-AAPPVNLPS-AHLQKLYLQDNAIT 290
Cdd:PLN03150 400 QQHPWSGADcqfdsTKGKWFIDGLGLDNQGLRGfipNDISKLRHLQSINLSGNSIrGNIPPSLGSiTSLEVLDLSYNSFN 479
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2038186169 291 HIPYNSLSKMRQLQRLDLSSNNLTA-LPRGLFDDLENLSQLLLRNNPWFCG 340
Cdd:PLN03150 480 GSIPESLGQLTSLRILNLNGNSLSGrVPAALGGRLLHRASFNFTDNAGLCG 530
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
113-168 |
9.46e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.19 E-value: 9.46e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038186169 113 TNVKVIYLYENDL----DEFPVNLPHsLRELHLQDNNIRSVTRDSLSRIPQIEKLHLDDN 168
Cdd:pfam13855 1 PNLRSLDLSNNRLtsldDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
|