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Conserved domains on  [gi|2034291595|ref|XP_041376194|]
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uncharacterized protein LOC121388767 [Gigantopelta aegis]

Protein Classification

kelch-like protein( domain architecture ID 1003721)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 13-124 9.58e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18245:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 111  Bit Score: 96.25  E-value: 9.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVEEAvhLETVIDALYTG 92
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEV--MEEILDYIYTG 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  93 KLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18245    79 QIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
PHA03098 super family cl33709
kelch-like protein; Provisional
 24-296 1.09e-16

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 83.66  E-value: 1.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  24 GRFCDVQLTVNTKN--IPVHRSVLAACSPYFSGMFSGNFLESDkgmsvVNLSSVVEEavhLETVIDALYTGKLKLDDFNI 101
Cdd:PHA03098    7 QKFCDESIIIVNGGgiIKVHKIILSSSSEYFKKMFKNNFKENE-----INLNIDYDS---FNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 102 AVITQLASFLMIDSLKELCIGFLGDNLHLQTCVRYYILADMYGVEEVEKVAFNIIESRFHDYFIFQdDLLQTSPHHLCRL 181
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP-DFIYLSKNELIKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 182 F---EKNVQRYcDVrqVANLLLRWDKYKKDVERthtalslfKSICvgLELPTLEnlVNYLeTYHIPKSLVSEFLQIVHST 258
Cdd:PHA03098  158 LsddKLNVSSE-DV--VLEIIIKWLTSKKNNKY--------KDIC--LILKVLR--ITFL-SEEGIKKLKRWKLRIKKKK 221

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2034291595 259 IsnvsglalarqtptcstqTVNDKCSSGLVVCKEDSQD 296
Cdd:PHA03098  222 I------------------VFNKRCIKIIYSKKYNLNK 241
 
Name Accession Description Interval E-value
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-124 9.58e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 96.25  E-value: 9.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVEEAvhLETVIDALYTG 92
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEV--MEEILDYIYTG 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  93 KLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18245    79 QIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 17-124 2.82e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 89.24  E-value: 2.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  17 MNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgMSVVNLSSVVEEAVHLetVIDALYTGKLkL 96
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESS--VSEITLDDVSPEDFEA--LLEFMYTGKL-I 75

                          90       100
                  ....*....|....*....|....*...
gi 2034291595  97 DDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 28-128 1.57e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.81  E-value: 1.57e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   28 DVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEavHLETVIDALYTGKLKLDDFNIAVITQL 107
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK--SEIYLDDVSPE--DFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 2034291595  108 ASFLMIDSLKELCIGFLGDNL 128
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 24-296 1.09e-16

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 83.66  E-value: 1.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  24 GRFCDVQLTVNTKN--IPVHRSVLAACSPYFSGMFSGNFLESDkgmsvVNLSSVVEEavhLETVIDALYTGKLKLDDFNI 101
Cdd:PHA03098    7 QKFCDESIIIVNGGgiIKVHKIILSSSSEYFKKMFKNNFKENE-----INLNIDYDS---FNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 102 AVITQLASFLMIDSLKELCIGFLGDNLHLQTCVRYYILADMYGVEEVEKVAFNIIESRFHDYFIFQdDLLQTSPHHLCRL 181
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP-DFIYLSKNELIKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 182 F---EKNVQRYcDVrqVANLLLRWDKYKKDVERthtalslfKSICvgLELPTLEnlVNYLeTYHIPKSLVSEFLQIVHST 258
Cdd:PHA03098  158 LsddKLNVSSE-DV--VLEIIIKWLTSKKNNKY--------KDIC--LILKVLR--ITFL-SEEGIKKLKRWKLRIKKKK 221

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2034291595 259 IsnvsglalarqtptcstqTVNDKCSSGLVVCKEDSQD 296
Cdd:PHA03098  222 I------------------VFNKRCIKIIYSKKYNLNK 241
PHA02713 PHA02713
hypothetical protein; Provisional
 6-137 1.09e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 48.47  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   6 DGGHFESLLHQMNNARQEGRFCDVQLTV-NTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgMSVVNLSSVVEEAVhlET 84
Cdd:PHA02713    5 DIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDL-VTRVNLQMFDKDAV--KN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2034291595  85 VIDALYTgkLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCVRYY 137
Cdd:PHA02713   82 IVQYLYN--RHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMY 132
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 133-239 4.10e-05

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 42.92  E-value: 4.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 133 CVRYYILADMYGVEEVEKVAFNIIESRFHDyFIFQDDLLQTSPHHLCRLFEKNVQRYCDVRQVANLLLRWDKYKKDVERT 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLE-VAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKK 79

                          90       100
                  ....*....|....*....|....*..
gi 2034291595 213 HTALsLFKsiCVGLELPTLENLVNYLE 239
Cdd:pfam07707  80 HLPE-LLS--AVRLPLLSPQYLLNLVE 103
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 129-183 3.41e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 38.80  E-value: 3.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2034291595 129 HLQTCVRYYILADMYGVEEVEKVAFNIIESRFHDyFIFQDDLLQTSPHHLCRLFE 183
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEE-VSKSEEFLELSVELLLELLS 54
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 133-237 1.95e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 38.09  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  133 CVRYYILADMYGVEEVEKVAFNIIESRFHDyFIFQDDLLQTSPHHLCRLFEKNVQRYCDVRQVANLLLRWDKYKKDVERT 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSE-VSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRRE 79

                           90       100
                   ....*....|....*....|....*
gi 2034291595  213 HTALSLFksiCVGLELPTLENLVNY 237
Cdd:smart00875  80 HLPELLE---HVRLPLLSPDYLLEV 101
 
Name Accession Description Interval E-value
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-124 9.58e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 96.25  E-value: 9.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVEEAvhLETVIDALYTG 92
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEV--MEEILDYIYTG 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  93 KLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18245    79 QIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-129 4.21e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 94.91  E-value: 4.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKEN--SEVEFQCIDETA--LQAIVEY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLH 129
Cdd:cd18257    77 AYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLD 117
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-134 7.25e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 91.40  E-value: 7.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  17 MNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVhlETVIDALYTGKLKL 96
Cdd:cd18237    12 MNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKS--SEVELKDAEPDII--ELLVEFAYTARISV 87

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2034291595  97 DDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18237    88 NSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-136 8.02e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 91.17  E-value: 8.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnfLESDKGMSVVNLSSVVEEAVhlETVIDA 88
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSS--DSDGESILTVKLDGLDPDAV--EVLVNY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCVRY 136
Cdd:cd18306    77 AYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 17-124 2.82e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 89.24  E-value: 2.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  17 MNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgMSVVNLSSVVEEAVHLetVIDALYTGKLkL 96
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESS--VSEITLDDVSPEDFEA--LLEFMYTGKL-I 75

                          90       100
                  ....*....|....*....|....*...
gi 2034291595  97 DDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 3.70e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 89.39  E-value: 3.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVveEAVHLETVIDA 88
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK--DVVQIHGV--EPDIFHILLDF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18256    79 IYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-134 1.60e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 87.35  E-value: 1.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  10 FESLLHQMnnaRQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgMSVVNLSSVVEEAVhlETVIDAL 89
Cdd:cd18238     2 SFKVLHQF---YENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESK--QDSITIKDIDEEAV--ELLVDFA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2034291595  90 YTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18238    75 YTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCL 119
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-133 1.62e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 87.45  E-value: 1.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVveEAVHLETVIDA 88
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQ--DEIELKGV--SAKGLKHILDF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18255    77 AYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 2.03e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 87.52  E-value: 2.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESdkGMSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18265     6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKES--RQAVVEIQKVSAAA--MEVLLDY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18265    82 MYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-111 6.24e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 84.53  E-value: 6.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  26 FCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESdkGMSVVNLSSVVEEAvhLETVIDALYTGKLKLDDFNIAVIT 105
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKES--SSSEIELDDVSPEA--FEALLDYIYTGELELSEENVEELL 76


                  ....*.
gi 2034291595 106 QLASFL 111
Cdd:cd18186    77 AAADKL 82
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-124 9.65e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 85.02  E-value: 9.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  16 QMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgMSVVNLSSVveEAVHLETVIDALYTGKLK 95
Cdd:cd18247     9 VMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESK--QDEITMQGI--EPSALEALINFAYSGRIA 84

                          90       100
                  ....*....|....*....|....*....
gi 2034291595  96 LDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18247    85 IDTSNVQSLLVGASFLQLQSVKDACCEFL 113
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-135 1.32e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 85.27  E-value: 1.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKG-MSVVNLSSvveEAVHleTVI 86
Cdd:cd18271     6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGsVTISNLSP---KAVK--AFL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2034291595  87 DALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCVR 135
Cdd:cd18271    81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQ 129
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-134 3.58e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 84.11  E-value: 3.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   1 MEYHLDGgHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESdkgmsvvnLSSVVE--- 77
Cdd:cd18259     8 LDFCLPS-HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVES--------ISARVEikd 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2034291595  78 -EAVHLETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18259    79 vDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-129 5.64e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 83.25  E-value: 5.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVID 87
Cdd:cd18235     3 QHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRA--NRVTLQDVDGKA--LLLLID 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLH 129
Cdd:cd18235    79 YVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLH 120
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-134 6.47e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 83.88  E-value: 6.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVhLETVID 87
Cdd:cd18267    22 SYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQD--SEVNFHDSIHPEV-LELLLD 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18267    99 YAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 145
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-133 8.60e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 82.49  E-value: 8.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   7 GGHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVI 86
Cdd:cd18242     2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGK--SEVELQGLTAST--MEILL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2034291595  87 DALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18242    78 DFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-134 9.63e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 83.33  E-value: 9.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   1 MEYHLDGGHFESLLHQMNNARQEGRFCDVQLTVNTKN--------IPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNL 72
Cdd:cd18273     1 PEELEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQ--ETVTI 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2034291595  73 SSVveEAVHLETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18273    79 HDV--DSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCV 138
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 28-128 1.57e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.81  E-value: 1.57e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   28 DVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEavHLETVIDALYTGKLKLDDFNIAVITQL 107
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK--SEIYLDDVSPE--DFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 2034291595  108 ASFLMIDSLKELCIGFLGDNL 128
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-133 1.65e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 82.14  E-value: 1.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDALYTG 92
Cdd:cd18268    10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQ--AKVDLKGIDSDV--LDQIVDYVYTG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2034291595  93 KLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18268    86 EILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENC 126
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-133 1.92e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 81.74  E-value: 1.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   6 DGGHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgMSVVNLSSVVEEAvhLETV 85
Cdd:cd18250     1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESR--ADRVVLHGVSAEI--LGLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2034291595  86 IDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18250    77 LDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-133 4.60e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 80.45  E-value: 4.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  18 NNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDALYTGKLKLD 97
Cdd:cd18240     9 NELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEK--KVYKIPGVSPEM--MELIIEYAYTRTVPIT 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  98 DFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18240    85 AENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-124 6.36e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 80.71  E-value: 6.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   7 GGHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLES-DKGMSVVNLSSvveeaVHLETV 85
Cdd:cd18266     6 ADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAhQKEVELVGASY-----IGLKAV 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2034291595  86 IDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18266    81 IDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYL 119
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-129 2.05e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 78.61  E-value: 2.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVveEAVHLETVIDA 88
Cdd:cd18339     4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKA--KKIEIKDV--DGQTLSKLIDY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLH 129
Cdd:cd18339    80 IYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLH 120
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-133 7.93e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 77.59  E-value: 7.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   7 GGHFESLLHQMNNARQEGRFCDVQLTV---NTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMsvVNLSSVVEEA---- 79
Cdd:cd18241     4 SSHCSELSWRQNEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGR--VEMRKWSSEPgpdp 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2034291595  80 VHLETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18241    82 DTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-129 8.03e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 77.03  E-value: 8.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVveEAVHLETVIDA 88
Cdd:cd18338     4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRA--KRVRIKEV--DGWTLKMLIDY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLH 129
Cdd:cd18338    80 VYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLH 120
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-134 8.54e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 76.25  E-value: 8.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  27 CDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgMSVVNLSSVVEEAvhLETVIDALYTGKLKLDDFNIAVITQ 106
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREAT--EEEIKLKDVDPDA--LWTLVQYCYTGRLELKEDNVESLLA 77

                          90       100
                  ....*....|....*....|....*...
gi 2034291595 107 LASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18234    78 TACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 8.56e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 76.78  E-value: 8.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMfsgnfLESDKGMSVVNLSSVveEAVHLETVIDA 88
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNI-----LKKDPSLQRVELNDI--SPLGLATVITY 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18260    74 AYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-124 1.05e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 77.01  E-value: 1.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSgnFLESDKGMSVVNLSSVVEEAVHLETVID 87
Cdd:cd18196     3 GHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT--VAEGDQTMNMIQLDSEVVTAEAFAALID 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18196    81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
PHA03098 PHA03098
kelch-like protein; Provisional
 24-296 1.09e-16

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 83.66  E-value: 1.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  24 GRFCDVQLTVNTKN--IPVHRSVLAACSPYFSGMFSGNFLESDkgmsvVNLSSVVEEavhLETVIDALYTGKLKLDDFNI 101
Cdd:PHA03098    7 QKFCDESIIIVNGGgiIKVHKIILSSSSEYFKKMFKNNFKENE-----INLNIDYDS---FNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 102 AVITQLASFLMIDSLKELCIGFLGDNLHLQTCVRYYILADMYGVEEVEKVAFNIIESRFHDYFIFQdDLLQTSPHHLCRL 181
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDP-DFIYLSKNELIKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 182 F---EKNVQRYcDVrqVANLLLRWDKYKKDVERthtalslfKSICvgLELPTLEnlVNYLeTYHIPKSLVSEFLQIVHST 258
Cdd:PHA03098  158 LsddKLNVSSE-DV--VLEIIIKWLTSKKNNKY--------KDIC--LILKVLR--ITFL-SEEGIKKLKRWKLRIKKKK 221

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2034291595 259 IsnvsglalarqtptcstqTVNDKCSSGLVVCKEDSQD 296
Cdd:PHA03098  222 I------------------VFNKRCIKIIYSKKYNLNK 241
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 1.91e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 76.20  E-value: 1.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVhLETVIDA 88
Cdd:cd18254     5 HPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLD--STVNFHDSLHPEV-LELLLDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18254    82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-134 2.10e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 76.18  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   5 LDGGHFESLLHQMNNARQEGRFCDVQLTVNT-KNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVHLe 83
Cdd:cd18274     1 MDPLHACSILQQLKAMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQ--KEVRIVGVEAESMHL- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2034291595  84 tVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18274    78 -VLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSI 127
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-133 4.74e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 74.87  E-value: 4.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESRE--MLVEINGILAEA--MDCFLQY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18253    77 VYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 8.52e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 74.41  E-value: 8.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVhlETVIDA 88
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ--TEVTIRDIDERAM--ELLIDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18249    82 AYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-133 4.33e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 72.52  E-value: 4.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   1 MEYHL--DGGHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESdkGMSVVNLSSVveE 78
Cdd:cd18264     1 MSYFLaySKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQES--KARVIHLPVV--S 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2034291595  79 AVHLETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18264    77 AAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 5.03e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 72.00  E-value: 5.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18336     2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQ--EEIKMEGVDPDA--LKALVHY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18336    78 AYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCL 123
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-128 5.56e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 71.64  E-value: 5.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   6 DGGHFESLLHQMNNARQEGRFCDVQLTV----NTKNIPVHRSVLAACSPYFSGMFSGNFLESdkGMSVVNLssvveEAVH 81
Cdd:cd18248     1 LEDHTKEAFQIMNELRLSQQLCDVTLKVkyqdPKEEFMAHKVVLASSSPYFKAMFTSGLREC--GMEVVPI-----EGVH 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2034291595  82 ---LETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNL 128
Cdd:cd18248    74 pcvMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 8.69e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 71.60  E-value: 8.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18246    22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQ--THVTLHDIDPQA--LEQLVQY 97

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18246    98 AYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFL 133
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 26-120 1.84e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 69.30  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  26 FCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESdkgmsvvNLSSVVEEAVH---LETVIDALYTGKLKLDDFNIA 102
Cdd:cd18314     6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIES-------NLKEVTLEDVEpeiFETVLKYMYTGQVTLSEENVL 78

                          90
                  ....*....|....*...
gi 2034291595 103 VITQLASFLMIDSLKELC 120
Cdd:cd18314    79 DLLMLASKYQVPDLEKLC 96
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-135 2.58e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 70.03  E-value: 2.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  12 SLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVveEAVHLETVIDALYT 91
Cdd:cd18270    12 SLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ--THVHLRNV--DAATLQIIITYAYT 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2034291595  92 GKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCVR 135
Cdd:cd18270    88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVR 131
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-133 2.71e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 69.83  E-value: 2.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTV--NTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgMSVVNLSSVveEAVHLETVI 86
Cdd:cd18239     6 HSSVVLQGFDQLRGEGLLCDVTLVPgdGDETFPVHRAMMASASDYFKAMFTGGMKEQE--LMCIKLHGV--SKIGLKNII 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2034291595  87 DALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18239    82 DFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-134 2.12e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 67.55  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  24 GRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMsvVNLSSVVEEAVhlETVIDALYTGKLKLDDFNIAV 103
Cdd:cd18340    25 NKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKRE--IVLEDVDPDVM--GKILHYIYTSEIEITEQNVQD 100

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2034291595 104 ITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18340   101 IFAAANMFQIPSIFTVCVSFLQKRLCLSNCL 131
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 2.78e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 67.30  E-value: 2.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESdkGMSVVNLSSVVeeAVHLETVIDA 88
Cdd:cd18261    11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVES--EADEVNLHGVT--SLGLKQALDF 86

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18261    87 AYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYL 122
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 3.35e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 66.50  E-value: 3.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQ--NVYEIDFVSAEA--LTALLDF 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18326    84 AYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-120 3.41e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 66.91  E-value: 3.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEG-RFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNfLESDKGMSVVNLSSVVEEAvhLETVID 87
Cdd:cd18207     9 HSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQ-EGDGGTPRELEMHTISSKV--FGDILD 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2034291595  88 ALYTGKL--KLDDFniAVITQLASFLMIDSLKELC 120
Cdd:cd18207    86 FAYTSRIvvRLESF--PELMTAAKFLLMRSVIDIC 118
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-134 3.76e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 66.66  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  23 EGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMsvVNLSSvVEEAVhLETVIDALYTGKLKLDDFNIA 102
Cdd:cd18269    24 ENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKE--VVLED-VDPDV-MGMILKYLYTSEIDLNDQNVQ 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595 103 VITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18269   100 DIFALASRFQIPSIFTVCVSYLQKRLSLSNCL 131
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 1.12e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 65.21  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVHLetVIDA 88
Cdd:cd18276     4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQ--REVVLHDITAESVSI--ILNY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18276    80 MYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCL 125
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-120 1.48e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 64.39  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFsgnfleSDKGMSVVNLSSVVEEAVHLETVIDA 88
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY------KDTEDNIVFLDQSQVSADGFQKLLEF 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18217    75 IYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 1.61e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 64.50  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGmsVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18198     8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQN--VYEIDFVSPEA--LTALLEF 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18198    84 AYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-123 3.34e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 63.24  E-value: 3.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflesdkGMSV-VNLSSVVEEAVHLetVID 87
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGD-------GTSGsVVLPESFAEVFGL--LLD 71

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGF 123
Cdd:cd18232    72 FFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 4.29e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 63.93  E-value: 4.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18337     6 HAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQ--EEIKMEGVEPNA--LWALVQY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18337    82 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCL 127
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-134 4.89e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 63.45  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKG----MSVVNLSSVVeeavhLETVIDA 88
Cdd:cd18258     4 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGekleLTMSNINADV-----LELLLEF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18258    79 VYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-134 8.36e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 62.94  E-value: 8.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  23 EGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNfLESDKGMSVVnLSSVveEAVHLETVIDALYTGKLKLDDFNIA 102
Cdd:cd18341    24 ENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSE-ESEEKKKEVV-LDNV--DPNIMDMILKYLYSAEIDLNDGNVQ 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595 103 VITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18341   100 DIFALASRFQIPSVFTVCVTYLQKRLSPANCL 131
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-121 9.75e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 62.50  E-value: 9.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  10 FESLLHQmnnaRQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNfLESDKGMSVVNLSSVveEAVHLETVIDAL 89
Cdd:cd18293     3 FLQLHRQ----QNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSE-PPPAGQKVVLELQGL--KAHTLLKLVDFL 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  90 YTGKLKLDDFNIAVITQLASFLMIDSLKELCI 121
Cdd:cd18293    76 YTSELEVSSEEAQDVLAAARRLQISELESLCL 107
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-123 1.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 61.87  E-value: 1.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesdkgMSVVNLSsvVEEAVHLETVIDA 88
Cdd:cd18206     5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQ-------KDVVHLD--ISNAAGLGQVLEF 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGF 123
Cdd:cd18206    76 MYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-128 1.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 62.57  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSG-----NFLESDKGMSVVNLSSVVEEAvhLE 83
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGqasprLVLVSPAGKCVLDLHHVTVTG--FA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2034291595  84 TVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNL 128
Cdd:cd18228    80 PLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-129 1.70e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 61.90  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVveeAVHLETVI-DALYT 91
Cdd:cd18201     8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHLDVV---AVQGFSVIlDFMYS 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2034291595  92 GKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLH 129
Cdd:cd18201    85 GNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-125 1.74e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 61.78  E-value: 1.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSG-----NFLESDKGMSVVNLSSVVEEAvhLE 83
Cdd:cd18327     8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGggggsGDLGAGGGQDVCELDFVGPEA--LG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2034291595  84 TVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLG 125
Cdd:cd18327    86 ALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 2.21e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 61.24  E-value: 2.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflESDKGMSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVG---QADAELNITLPEEVTVKG--FEPLIQF 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18277    85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 3.56e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 60.84  E-value: 3.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSgNFLESDKGMSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18230     4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYC-QVQKTSDQATVTHLDIVTAQG--FKAIIDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18230    81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFI 116
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-128 5.98e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 60.22  E-value: 5.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflESDKGmSVVNLSSVVEEAVHLETVIDA 88
Cdd:cd18194     6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRD---RLDKR-DLVRLNSDIVTAPAFGLLLDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNL 128
Cdd:cd18194    82 MYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 6.15e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 60.35  E-value: 6.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflESDKGMsVVNLSSVVeEAVHLETVIDA 88
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVG---QTENDL-VVSLPEEV-TARGFGPLLQF 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18278    89 AYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-119 6.39e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 59.85  E-value: 6.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  12 SLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFsgnFLesdKGMSVVNLSSVVEEAVhLETVIDALYT 91
Cdd:cd18210     7 SLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQV---LL---KNMSSISLPGVMDPGA-FESVLASAYT 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  92 GKLKLDDFNIAVITQLASFL----MIDSLKEL 119
Cdd:cd18210    80 GKLTMLADEIVNYLTVGSVLqmwhIVDKCTEL 111
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-134 8.68e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 59.86  E-value: 8.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   6 DGGHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLEsdKGMSVVNLSSVveEAVHLETV 85
Cdd:cd18236     4 DTGLSLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKE--KYEEKIIIKGV--DAETMQIL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2034291595  86 IDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18236    80 LDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCV 128
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-131 8.86e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 59.67  E-value: 8.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  12 SLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesdkGMSVVNLsSVVEEAVHLETVIDALYT 91
Cdd:cd18222    11 SVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN------EMSTVSI-SVIKNPTVFEQLLSFCYT 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2034291595  92 GKLKLDDFNIAVITQLASFLMIDSLKELCIGFLgDNLHLQ 131
Cdd:cd18222    84 GRICLQLADIISYLTAASFLQMQHIIDKCTQIL-EGIHFK 122
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 17-128 1.01e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 59.62  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  17 MNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDK---GMSVVNLSSVVEEAVhlETVIDALYTGK 93
Cdd:cd18296     8 PFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEEnngSIPVVTLHDVSPEVF--AIVLYYIYTDD 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2034291595  94 LKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNL 128
Cdd:cd18296    86 TDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-124 1.06e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 59.18  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  25 RFCDVQLTVNTKNIPV--HRSVLAACSPYFSGMFSGNFLESDKGMSVVnLSSvVEEAVHLEtVIDALYTGKLKLDdfNIA 102
Cdd:cd18294    13 EFSDVKFLVGPERQEIfaHKCILAARCEVFRAMFLTGPQKESTQSPLV-LSD-IEPEVFRA-VLEFIYTNCVTLS--NHT 87

                          90       100
                  ....*....|....*....|....*
gi 2034291595 103 VITQLAS---FLMiDSLKELCIGFL 124
Cdd:cd18294    88 VIEVLAAaveYGL-DELRKLCERFI 111
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 14-134 1.07e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 59.44  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  14 LHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVeeAVHLETVIDALYTGK 93
Cdd:cd18263     1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQ--SVVQLPTIP--AKDLRLLISFAYSGI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2034291595  94 LKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18263    77 LHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-121 1.16e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 59.51  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18328     8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQP--YVYEIDFVTPEA--LSAILEF 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCI 121
Cdd:cd18328    84 AYTSTLTITTSNVKHILNAAQMLEIQCIINVCL 116
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 1.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 59.17  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSgNFLESDKGMSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18330     1 YYTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLI-HYIQDSGRHSTASLDIVTSEA--FSIILDF 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18330    78 LYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-115 2.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 58.33  E-value: 2.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYfsgmFSGNFLESDKgmSVVNLSSVVEEAVhLETVIDA 88
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPY----FHDKLLLNDT--NCLVLPSVIEAAA-FENLLQL 73

                          90       100
                  ....*....|....*....|....*..
gi 2034291595  89 LYTGKLKLddfniaVITQLASFLMIDS 115
Cdd:cd18200    74 IYSGRLTL------CMDALPSHLLVAS 94
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 2.39e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 58.90  E-value: 2.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   5 LDGGHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesdkgmsvvNLSSVVEEAVHLET 84
Cdd:cd18243    11 FDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-----------NLVLQGCSSIGLRL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2034291595  85 VIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQ 131
Cdd:cd18243    80 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQ 126
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-123 2.52e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 57.51  E-value: 2.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  26 FCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVEEAVhLETVIDALYTGKLKLDDFNIAVIT 105
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDYLSPET-VEQLLDYFYTGKIVISEKNVEDLL 79

                          90
                  ....*....|....*...
gi 2034291595 106 QLASFLMIDSLKELCIGF 123
Cdd:cd18307    80 KGAKYFNIPRLKDHCVDF 97
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-118 2.59e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 58.50  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   4 HLDGGHF-ESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesdkGMSVVNLSSVVEEAVhL 82
Cdd:cd18289     6 HIEIPNFgNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN------SKSAFELPATVPPAC-F 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  83 ETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKE 118
Cdd:cd18289    79 QQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVE 114
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-134 3.29e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 58.30  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   6 DGGHFESLLHQMNNARQEGRFCDVQLTVNTKNI-PVHRSVLAACSPYFSGMFSGNFLEsdKGMSVVNLsSVVEEAVhLET 84
Cdd:cd18252     1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKE--KSNNVIKL-SGIDHDI-LEA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2034291595  85 VIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18252    77 LVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-126 4.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 58.12  E-value: 4.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgmsVVNLSSVVEEAVHLETVIDA 88
Cdd:cd18325     6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRD----IVHLNSDIVTAPAFSLLLEF 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGD 126
Cdd:cd18325    82 MYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKD 119
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-127 4.43e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 57.54  E-value: 4.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLesdkgmsvVNLSSVVEEAVHLETVID 87
Cdd:cd18216     2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNL--------IHLDQDMVSPTVFQQILD 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2034291595  88 ALYTGKLKLDDF---NIAVITQLASFLMIDSLKELCIGFLGDN 127
Cdd:cd18216    74 FIYTGKLLDSLFeepNLSEVLAAANYLQLPDLAALCRSKLKRG 116
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-120 4.55e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 57.91  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSgMFsgnFLESDKGMSVVNLSSVVEEAVHLETVID 87
Cdd:cd18323     5 DHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MF---YKEQLDKRDLVCINNEIVTAPAFSLLLE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18323    81 FMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC 113
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-134 4.61e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 57.75  E-value: 4.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18335     2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQ--EEIKMEGIDPNA--LWDLVQF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCV 134
Cdd:cd18335    78 AYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCL 123
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-52 4.94e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 57.60  E-value: 4.94e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYF 52
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYF 44
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-120 4.98e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 57.55  E-value: 4.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFsgnfleSDKGM-----SVVNLSSVVEEAvhL 82
Cdd:cd18202     1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELF------IEKGAvssheAVVDLSGFCKSS--F 72

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2034291595  83 ETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18202    73 LPLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-119 6.92e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 57.27  E-value: 6.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  28 DVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVHLetVIDALYTGKLKLDDF-NIAVITQ 106
Cdd:cd18286    19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNS--SEITLTGVSHAAVSF--VLLFIYGGVLDLPDDvNLGELLS 94

                          90
                  ....*....|...
gi 2034291595 107 LASFLMIDSLKEL 119
Cdd:cd18286    95 LADMYGLDGLKDV 107
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-120 8.48e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 56.90  E-value: 8.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYF-SGMFSGNFLESDKGMsvVNlSSVVEEavhletVID 87
Cdd:cd18334     4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFkSLVLHDNLINLDTDM--VN-PTVFRQ------ILD 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2034291595  88 ALYTGKL----KLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18334    75 FIYTGKLltsdQPGEQNFNALLTAASYLQLHDLAALC 111
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-116 1.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 56.34  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflESDKGMSVVNLSSVVEEAVHleTVIDA 88
Cdd:cd18212     6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFAD---EGEVGQSIYMLEGMVAETFG--ALLEF 80

                          90       100
                  ....*....|....*....|....*...
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSL 116
Cdd:cd18212    81 IYTGCLQVGEKSLEQILATAQFLKVNDL 108
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-120 1.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 56.20  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVeeavhLETVIDA 88
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDI-----FEEVLNY 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18204    76 MYTAKISVKKEDVNLMMSSGQILGIRFLDKLC 107
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-120 1.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 55.99  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSsvveeAVHLETVID 87
Cdd:cd18224     8 DHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDFIT-----PANFEKVLS 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18224    83 FIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-124 2.09e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 54.78  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  27 CDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesDKGMSVVNLSSVVeEAVHLETVIDALYTGKLKLDDFNIAVITQ 106
Cdd:cd18955     2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQ----TDGDLVITLPEEV-TVKGFEPLLQFAYTAKLLLSKENVLEVCR 76

                          90
                  ....*....|....*...
gi 2034291595 107 LASFLMIDSLKELCIGFL 124
Cdd:cd18955    77 CAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-120 2.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 56.20  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgmsVVNLSSVVEEAVHLETVIDA 88
Cdd:cd18324     6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRD----IVHLNSDIVTAPAFALLLEF 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18324    82 MYEGKLQFKDLPIEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-124 3.93e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 54.88  E-value: 3.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNfLESDKGMSVVNLSSVVEEavhletVID 87
Cdd:cd18203     7 GHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLN-PSSELQVSLMHSSRVVAD------LLL 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18203    80 SCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGAL 116
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-120 4.60e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 54.49  E-value: 4.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflESDKGMSVVNLSSVVeEAVHLETVIDA 88
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTD---QLKNNVSVINLDPEI-EPEGFRILLDF 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18215    78 MYTSRLNLREGNIMAVMATAMYLQMEHVVDTC 109
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-118 4.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 55.04  E-value: 4.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  12 SLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesdkGMSVVNLSSVVEEAvHLETVIDALYT 91
Cdd:cd18290    13 SILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSS------RSAVVELPAAVQPQ-SFQQILSFCYT 85

                          90       100
                  ....*....|....*....|....*..
gi 2034291595  92 GKLKLDDFNIAVITQLASFLMIDSLKE 118
Cdd:cd18290    86 GRLSMNVGDQFLLMYTAGFLQIQEIME 112
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 4.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 54.35  E-value: 4.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRP-STASFDVFSSDA--FSIILDF 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18199    78 VYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-123 5.45e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 54.21  E-value: 5.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  11 ESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFS-GNFLESDKgmSVVNLSSVVEEAVHLETVIDAL 89
Cdd:cd18292     2 REFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQ--SEIELVEDPECAAVFEKFLRYL 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2034291595  90 YTGKLKLDDFNIAVITQLASFLMIDSLKELCIGF 123
Cdd:cd18292    80 YTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-119 8.34e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 53.67  E-value: 8.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMfsgnFLESDKGMSVVNLSSVVEEAVHLETVIDA 88
Cdd:cd18192     4 HSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMM----FINHQHTTAQLNLSNMKISAECFDLILQF 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMI----DSLKEL 119
Cdd:cd18192    80 MYLGKIMTAPSDFEQLKVAMNYLQLyyipECLEDI 114
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-120 8.46e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 53.78  E-value: 8.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  23 EGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGmsVVNLSSVVEEAVHleTVIDALYTGKLK-LDDFNI 101
Cdd:cd18300     6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAK--EVELPGVSKETFL--ALLEYLYTDQAPiLEDGDC 81

                          90
                  ....*....|....*....
gi 2034291595 102 AVITQLASFLMIDSLKELC 120
Cdd:cd18300    82 VGLIVLANRLCLPRLVALC 100
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-116 1.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 53.34  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDkgmSVVNLSSVveEAVHLETVIDA 88
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQ---SVFQLDFC--EPDAFENVLNY 75

                          90       100
                  ....*....|....*....|....*...
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSL 116
Cdd:cd18209    76 IYSSSLFVEKSSLAAVQELGYSLGISFL 103
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-120 1.16e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 53.68  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFsgnFLESDKGMSVvnlsSVVEEAVHLETVIDA 88
Cdd:cd18214     8 YGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQF---LLNDSREVQI----SILQNSEVGRQLLLS 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18214    81 CYTGVLEFPEMELVNYLTAASFLQMSHIVERC 112
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 1.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 53.32  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflESDKGMSVVNLSSVVeEAVHLETVIDA 88
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSG---RVGEGVSVLTLPSGL-EARGFQLLLDF 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18332    78 MYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 1.35e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 53.29  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVvnlSSVVEEAVHLETVIDA 88
Cdd:cd18329     4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVA---TFDVFSPDTFTIILDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18329    81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 1.81e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 53.28  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18251     6 HSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQ--TEVLIHGVSYNA--MCKILDF 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18251    82 IYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 26-114 1.97e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 51.78  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  26 FCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflESDKgMSVVNLSSVveEAVHLETVIDALYTGKLKLDDFNIAVIT 105
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKET--PPDE-HPVIILPDV--PYSELKALLDFIYTGEVNVSQEQLESLL 75


                  ....*....
gi 2034291595 106 QLASFLMID 114
Cdd:cd18315    76 KLAELLQIK 84
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-132 2.01e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 52.66  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  15 HQMNNARqegrFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGmsVVNLSSVVEEAVHLetVIDALYTGkl 94
Cdd:cd18297     5 HYVNNPE----MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTP--VIEIPDIRYDIFQL--MMQYLYTG-- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2034291595  95 KLDDFNIAVITQL-----ASFLMIDSLKELCIGFLGDNLHLQT 132
Cdd:cd18297    75 GVESLDVAQDDALellraASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-120 2.16e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 52.98  E-value: 2.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYF-SGMFSGNFLESDKGMsvvnlssvVEEAVhLETVI 86
Cdd:cd18333     3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLkSLVVHDNLINLDHEM--------VSPGI-FRLIL 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2034291595  87 DALYTGKL----KLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18333    74 DYIYTGRLsegdPGSEQNLGAVLAAASYLQIPDLVALC 111
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-119 2.66e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 52.63  E-value: 2.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  12 SLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFsgnFLesdKGMSVVNLSSVVEEAVhLETVIDALYT 91
Cdd:cd18227    11 TILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQV---LL---KNSRRIVLPDVMNPRV-FENILLSCYT 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595  92 GKLKLDDFNIAVITQLASFL----MIDSLKEL 119
Cdd:cd18227    84 GRLVLPAPEIVSYLTAASFLqmwhVVDKCTEL 115
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-104 3.34e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 52.24  E-value: 3.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVHLetVIDA 88
Cdd:cd18287     5 HVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQ--SEIELKDTNAEAFKA--LLKY 80

                          90
                  ....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVI 104
Cdd:cd18287    81 IYTGRLTLTDLKEDVL 96
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 3.35e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 52.51  E-value: 3.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflESDKGMSVVNLSSVVEEAVHLETVID 87
Cdd:cd18956     5 EHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRD---RPAGGRDTVRLNGDIVTAPAFGRLLD 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLGD 126
Cdd:cd18956    82 FMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLRE 120
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-124 5.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 51.56  E-value: 5.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  12 SLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSgnfLESDKGMSVvnlsSVVEEAVHLETVIDALYT 91
Cdd:cd18220    11 TVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSA---LSTMSGLSI----SVIKNPNVFEQLLSFCYT 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  92 GKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18220    84 GRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-135 6.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 52.20  E-value: 6.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  22 QEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmSVVNLSSVVEEAVHLetVIDALYTGKLKLDDFNI 101
Cdd:cd18272    28 EDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARN--RVIELKDVSESVFQL--LVDYIYHGTVKLRVEEL 103

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2034291595 102 AVITQLASFLMIDSLKELCIGFLGDNLHLQTCVR 135
Cdd:cd18272   104 QETYEVADMYQLTALFEECSRFLARTVQVRNCLQ 137
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-119 9.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 50.77  E-value: 9.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSgNFLESdkgmSVVNLSSVVEEAV-HLetvID 87
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQ-DFTQE----PLVEIEGVSNMAFrHL---IE 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2034291595  88 ALYTGKLKLDDFNIAV-ITQLASFL-MIDSLKEL 119
Cdd:cd18221    73 FTYTAKLMVQGEEEANdVWKAAEYLqMQEAIKAL 106
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-120 1.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 50.45  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   3 YHLDGGHFE-SLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFsgmfsgnfleSDK---GMSVVNLSSVVeE 78
Cdd:cd18208     1 HSINLHNFSnSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFF----------QDKlllGYSDIEIPSVV-S 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2034291595  79 AVHLETVIDALYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18208    70 VQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDEC 111
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-111 1.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 49.20  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  29 VQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESdkGMSVVNLSSVVEEAvhLETVIDALYTGKLKLDDFNIAVITQLA 108
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRES--GQAEINLRDISPED--FRALLEFLYGGKRDLDASNLLELLEAA 76


                  ...
gi 2034291595 109 SFL 111
Cdd:cd01165    77 NFL 79
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-120 1.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 50.25  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  11 ESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFsgnFLESDKGMSVvnlsSVVEEAVHLETVIDALY 90
Cdd:cd18197    10 DAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQF---LLNQSKQVRI----TILQSAEVGRKLLLSCY 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 2034291595  91 TGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18197    83 TGALEVKKKELLKYLTAASYLQMVHIVEKC 112
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 3.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 49.12  E-value: 3.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNfleSDKGMSVVNLSsvVEEAVHLETVIDA 88
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNS---SSQKNDVFHLD--IKNVGGIGQILDF 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18233    76 MYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-97 4.75e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 48.78  E-value: 4.75e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2034291595  24 GRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFlesdKGMSVVNLSSVVEEAVHLETVIDALYTGKLKLD 97
Cdd:cd18295    17 GSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKW----KDKREINLKHPLVNPDAFRALLQYLYTGRLEIH 86
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 4.90e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 49.08  E-value: 4.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACspyfSGMFSGNFLESDK-GMSVVNLSSVVeEAVHLETVID 87
Cdd:cd18331     7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMAC----SGLFYSIFTDQLKcNLSVINLDPEI-NPEGFNILLD 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18331    82 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-120 6.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 48.32  E-value: 6.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  11 ESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFsgmfsgnfleSDK---GMSVVNLSSVVEEAVhLETVID 87
Cdd:cd18229     3 KSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFF----------HDKlllGHSEIEVPPVVPAQT-VRQLVE 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18229    72 FMYSGSLVVAQSEALQILTAASILQIKTVIDEC 104
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-57 6.86e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 48.25  E-value: 6.86e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFS 57
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFS 49
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-131 8.42e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 48.46  E-value: 8.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMsvVNLSSVVEEAvhLETVIDALYTG 92
Cdd:cd18343     8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNR--VEINDVDPEV--FKEMMRFIYTG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2034291595  93 KL----KLDDFNIAVITQLAsflmIDSLKELCIGFLGDNLHLQ 131
Cdd:cd18343    84 KApnldKMADNLLAAADKYA----LERLKVMCEEALCNNLSVE 122
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 13-119 2.83e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 46.42  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQL-TVNTKNIPVHRSVLAACSPYFSgMFSGNFLESDKGMSVVNlsSVVEEAVhlETVIDALYT 91
Cdd:cd18311     1 FLQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFN-VLEQTCEIVDDTLIMPN--ELQADAV--VPVINFMYT 75

                          90       100
                  ....*....|....*....|....*...
gi 2034291595  92 GKLKLDDFNIAVITQLASFLMIDSLKEL 119
Cdd:cd18311    76 GQLEFEEKSYGKLLRTAKELNMTVLLKL 103
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-120 2.90e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 46.50  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  39 PVHRSVLAACsPYFSGMFSGNFLESDkgMSVVNLS----SVVEEAvhLETVIDALYTGKLKLDDFNIAVITQLASFLMID 114
Cdd:cd18305    28 KLHKIYLCQS-GYFASMFSGSWKESK--ETVINLEipddNITVEA--LNVVFGSLYRDEIEIKPSRVVSILAAATLLQLD 102


                  ....*.
gi 2034291595 115 SLKELC 120
Cdd:cd18305   103 GLIQQC 108
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-132 3.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 46.38  E-value: 3.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  25 RFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMsvVNLSSVVEEAvhLETVIDALYTGKL----KLDDFN 100
Cdd:cd18345    17 AFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNR--VEITDVDHEV--MREMLRFIYTGKApnldKMADDL 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595 101 IAVITQLAsflmIDSLKELCIGFLGDNLHLQT 132
Cdd:cd18345    93 LAAADKYA----LERLKVMCEEALCSNLSVEN 120
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-57 4.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 45.98  E-value: 4.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2034291595   6 DGGHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFS 57
Cdd:cd18219     1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFS 52
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-132 7.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 45.60  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKG-MSVVNLSSVVeeavhLETVIDALYT 91
Cdd:cd18279     5 LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNrVEINDVDPEV-----FKEMMRFIYT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2034291595  92 GKL----KLDDFNIAVITQLAsflmIDSLKELCIGFLGDNLHLQT 132
Cdd:cd18279    80 GKApnldKMADDLLAAADKYA----LERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-119 9.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 45.18  E-value: 9.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQ-EGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesdKGMSVVNLSSVVEEAVHLetVID 87
Cdd:cd18226     4 YNKNLLKYLNDDRQkQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKN-----PNTDAVTLDHVSYSVFQH--LLE 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFL-MIDSLKEL 119
Cdd:cd18226    77 FLYTSEFFVYENEIPLVLEAAKFLdIIDAVKLL 109
PHA02713 PHA02713
hypothetical protein; Provisional
 6-137 1.09e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 48.47  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   6 DGGHFESLLHQMNNARQEGRFCDVQLTV-NTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgMSVVNLSSVVEEAVhlET 84
Cdd:PHA02713    5 DIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDL-VTRVNLQMFDKDAV--KN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2034291595  85 VIDALYTgkLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTCVRYY 137
Cdd:PHA02713   82 IVQYLYN--RHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMY 132
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-73 1.31e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 45.07  E-value: 1.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2034291595  24 GRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSgNFLESDkgmSVVNLS 73
Cdd:cd18309    18 GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFR-SFMPED---NTVNIS 63
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-120 1.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 44.84  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  12 SLLHQMNNARQEGRFCDVQLTVNTKNIP----VHRSVLAACSPYFSGMFSgNFLESDKGMSVVNLSSVveEAVHLETVID 87
Cdd:cd18211    11 NLLNEMHKLRLLGHLCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFL-NEKISDGKNTNVMLNEI--YTADFASFLE 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  88 ALYTGKLKLDDFNIAVITQLASFLMIDSLKELC 120
Cdd:cd18211    88 FVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-133 2.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 44.56  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  22 QEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESD------KGMSVVNLSSVVEeavhletvidALYTGKLK 95
Cdd:cd18244    26 EEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDqdkihlKGLTATGFSHVLQ----------FMYYGTIE 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2034291595  96 LDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQTC 133
Cdd:cd18244    96 LSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-120 2.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 43.76  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  26 FCDVQLT-VNTKNI-PVHRSVLAACSPYFSGMFSGNflesdKGMSVVNLSSVVEEAVHLETVIDALYTGKLKLDDFNIAV 103
Cdd:cd18231    14 LCDVDIVlVRQRSTfPAHKGVLAAYSQFFHSLFTQN-----KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQD 88

                          90
                  ....*....|....*..
gi 2034291595 104 ITQLASFLMIDSLKELC 120
Cdd:cd18231    89 VLNAAAVLQMNDIAASC 105
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-124 3.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 43.40  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  28 DVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVEEAVHLETvidaLYTGKLKLDDFNIAVITQL 107
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRY----LYTDQVDLPPEDAIGLLDL 89

                          90
                  ....*....|....*..
gi 2034291595 108 ASFLMIDSLKELCIGFL 124
Cdd:cd18298    90 ANSYCEERLKKLCEDII 106
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 133-239 4.10e-05

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 42.92  E-value: 4.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 133 CVRYYILADMYGVEEVEKVAFNIIESRFHDyFIFQDDLLQTSPHHLCRLFEKNVQRYCDVRQVANLLLRWDKYKKDVERT 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLE-VAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKK 79

                          90       100
                  ....*....|....*....|....*..
gi 2034291595 213 HTALsLFKsiCVGLELPTLENLVNYLE 239
Cdd:pfam07707  80 HLPE-LLS--AVRLPLLSPQYLLNLVE 103
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-125 4.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 43.00  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFsgmfsGNFLESDKGMSVVNLSSVVEEAvhLETVIDA 88
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQL-----GRQLTNPNPGQWCLGEGISPST--FKQLLDF 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFLG 125
Cdd:cd18218    74 VYGESVEVQPGELRPLLEAARALEVESLEEACWRALG 110
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-114 5.92e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 42.89  E-value: 5.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesdkgmSVVNLSSVVEEAVHLETVIDALYTG 92
Cdd:cd18225    10 LLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDST--------DTISIDASVVSPEEFALLLEMVYTG 81

                          90       100
                  ....*....|....*....|...
gi 2034291595  93 KLKLDDFNIAVITQLA-SFLMID 114
Cdd:cd18225    82 KLPPGKHNFTKIISVAdSLQMFD 104
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 26-120 1.98e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 41.20  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  26 FCDVQL-TVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKgmsvvnlSSVVEEAVH---LETVIDALYTGKL------K 95
Cdd:cd18302     5 LYDVTIvSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASS-------CSALTMPIPsdiLEIILDYLYTDEAsavkesQ 77

                          90       100
                  ....*....|....*....|....*
gi 2034291595  96 LDDFNIAVITqLASFLMIDSLKELC 120
Cdd:cd18302    78 NVEFLCNVLV-IADQLLITRLKEIC 101
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 9-94 2.16e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.04  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGnflesdKGMSVVNLSSVVEEaVHLETVIDA 88
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLG------SNGPLPPLSLEVTP-VGWEAVLTF 73


                  ....*.
gi 2034291595  89 LYTGKL 94
Cdd:cd18262    74 AYTGVL 79
PHA02790 PHA02790
Kelch-like protein; Provisional
 37-222 2.19e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 44.26  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  37 NIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVEEavhLETVIDALYTGKLKLDDFNIAVITQLASFLMIDSL 116
Cdd:PHA02790   32 NIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVCLDLDIHS---LTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595 117 KELCIGFLGDNLHLQTCVRYYILADMYGVEEVEKVAFNIIESRFHDyfiFQDDLLQTSPHHLCRL-FEKNVQRYCDVRQV 195
Cdd:PHA02790  109 IYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLE---LEDDIIDNFDYLSMKLiLESDELNVPDEDYV 185

                         170       180
                  ....*....|....*....|....*..
gi 2034291595 196 ANLLLRWdkYKKDVERTHTALSLFKSI 222
Cdd:PHA02790  186 VDFVIKW--YMKRRNRLGNLLLLIKNV 210
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 129-183 3.41e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 38.80  E-value: 3.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2034291595 129 HLQTCVRYYILADMYGVEEVEKVAFNIIESRFHDyFIFQDDLLQTSPHHLCRLFE 183
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEE-VSKSEEFLELSVELLLELLS 54
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-128 4.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 40.46  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  35 TKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNlssvVEEAVHLeTVIDALYTGKLKLDDFNIAVITQLASFLMID 114
Cdd:cd18282    20 TQRIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIPD----VEPAAFL-NLLRYLYCDEIDLEPDTVLATLYAAKKYLVP 94

                          90
                  ....*....|....
gi 2034291595 115 SLKELCIGFLGDNL 128
Cdd:cd18282    95 HLARACVQFLETSL 108
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-135 5.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.38  E-value: 5.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  25 RFCDVQLTVNTKNIPVHRSVLAACSPYFSgmfsgnfLESDKGMSVVNLSSVVEEAVHleTVIDALYTGK--LKLDDFNIA 102
Cdd:cd18303    17 LYSDITIKLADKSIPAHKFVLAARSEKWS-------NENLASTNELDLSDISYEVVL--ALLRWLYTDEldLTLDDEFLL 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595 103 VITQLASFLMIDSLKELCIGFLGDNLHLQTCVR 135
Cdd:cd18303    88 ELMKAAKRFQLTDLVERCERALMSSVNVDNCIR 120
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-71 5.47e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 40.39  E-value: 5.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2034291595   7 GGHFESLLHQMNNarqegrfCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVN 71
Cdd:cd18280     2 GQHFGALLESEEG-------ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIE 59
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-128 5.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 39.97  E-value: 5.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  28 DVQLTVN----TKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNlssvVEEAVHLeTVIDALYTGKLKLDDFNIAV 103
Cdd:cd18349    10 DVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPD----VEPAAFL-ILLKYMYSDEIDLEADTVLA 84

                          90       100
                  ....*....|....*....|....*
gi 2034291595 104 ITQLASFLMIDSLKELCIGFLGDNL 128
Cdd:cd18349    85 TLYAAKKYIVPALAKACVNFLETSL 109
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 6.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 39.78  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  28 DVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLeSDKGMSVVNLSSVVeeavhletviDALYTGKLKLDDFNIAVITQL 107
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDIL-KVKGLSYATLRLLV----------DYVYSGRMAVSKDNVVEVVAG 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2034291595 108 ASFLMIDSLKELCIGFLGDNLHLQTCvrYYIL 139
Cdd:cd18275    75 ARFLQMPCAAQCAVDAVRAQLCLGNC--YEVL 104
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-91 8.68e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 39.25  E-value: 8.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  22 QEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNfLESDKGMSVVNLSSVveEAVHLETVIDALYT 91
Cdd:cd18285    11 REELHTDVTFYVGSTLFKAHKAILLARVPEFFSHIIGK-LSSLEDQEPINIENL--EASEFKTFLRQVYT 77
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 1.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 39.25  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595   9 HFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNflesDKGMSVVNLSSVVeeavhLETVIDA 88
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN----SQHYTLDFLSPKT-----FQQILEY 71

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2034291595  89 LYTGKLKLDDFNIAVITQLASFLMIDSLKELCIGFL 124
Cdd:cd18205    72 AYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-152 1.19e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 39.56  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  23 EGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLES-DKGMSVVNLSSVVEEAvhletVIDALYTgklklddfni 101
Cdd:cd18358    17 KGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESaNSEVVLPNISKVSMQA-----VLDYLYT---------- 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2034291595 102 aviTQLASFLMIDSLKELCigflgdnLHLQTCVRYYI-LADMYGVEEVEKVA 152
Cdd:cd18358    82 ---KQLSPTADLDPLELIA-------LANRFCLPHLVaLTEQHAVQELTKAS 123
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 128-180 1.75e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 38.02  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2034291595 128 LHLQTCVRYYILADMYGVEEVEKVAFNIIESRFHDyfIFQDDLLQTSPHHLCR 180
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHK--VIQDEEFYTLPFHLVR 51
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 133-237 1.95e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 38.09  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  133 CVRYYILADMYGVEEVEKVAFNIIESRFHDyFIFQDDLLQTSPHHLCRLFEKNVQRYCDVRQVANLLLRWDKYKKDVERT 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSE-VSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRRE 79

                           90       100
                   ....*....|....*....|....*
gi 2034291595  213 HTALSLFksiCVGLELPTLENLVNY 237
Cdd:smart00875  80 HLPELLE---HVRLPLLSPDYLLEV 101
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-56 2.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 38.72  E-value: 2.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2034291595   8 GHFESLLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMF 56
Cdd:cd18213     3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIF 51
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 131-203 2.41e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 37.73  E-value: 2.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2034291595 131 QTCVRYYILADMYGVEEVEKVAFNIIESRFHDYFiFQDDLLQTSPHHLCRLFEK---NVQRYCDVRQVANLLLRWD 203
Cdd:cd18479     4 ENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVY-HQEAFMQLSHDLLIDILSSdnlNVEKEETVREAAMLWLEYN 78
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 10-96 2.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 38.83  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  10 FESLLhqmNNARQEgrFCDVQLTVNT-KNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNLSSVVE------EAvhL 82
Cdd:cd18310     7 LENLL---DSPDLF--YSDAEIIVEGgRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPggivgyDA--F 79

                          90
                  ....*....|....
gi 2034291595  83 ETVIDALYTGKLKL 96
Cdd:cd18310    80 MLVLSYLYSGRLRL 93
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 15-125 4.84e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 37.19  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  15 HQMNNARQEGRFCDVQLTV-NTKNIPVHRSVLAACSPYFSGMFSgnflesdkGMSVVNL-SSVVEEAVHleTVIDALYTG 92
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLFL--------MMTVVTLdSDITPEAFR--RVLEFLYTG 70

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2034291595  93 KLKLDDFNIAVITQLASFLMIDSLKELCIGFLG 125
Cdd:cd18299    71 VLDENEDDLKELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-128 6.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 37.36  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  26 FCDVQLTV----NTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMSVVNlssvVEEAVHLeTVIDALYTGKLKLDDFNI 101
Cdd:cd18347    22 LSDVHFLVgkglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPD----VEPAAFL-ALLKFLYSDEVQIGPETV 96

                          90       100
                  ....*....|....*....|....*..
gi 2034291595 102 AVITQLASFLMIDSLKELCIGFLGDNL 128
Cdd:cd18347    97 MTTLYTAKKYAVPALEAHCVEFLKKNL 123
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 28-120 6.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 37.07  E-value: 6.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  28 DVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESD-KGMSVVNLSSVVeeavhLETVIDALYTGKLKLDDFNIAVITQ 106
Cdd:cd18352    15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEaRDIEIPNIRWEV-----FELMMRFIYTGSVDITNDIAKDLLR 89

                          90
                  ....*....|....
gi 2034291595 107 LASFLMIDSLKELC 120
Cdd:cd18352    90 AADQYLLEGLKRLC 103
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-131 7.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 37.00  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2034291595  13 LLHQMNNARQEGRFCDVQLTVNTKNIPVHRSVLAACSPYFSGMFSGNFLESDKGMsvVNLSSVveEAVHLETVIDALYTG 92
Cdd:cd18342     9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR--VEINDV--EPEVFKEMMCFIYTG 84

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2034291595  93 KLKLDDFNIAVITQLASFLMIDSLKELCIGFLGDNLHLQ 131
Cdd:cd18342    85 KAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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