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Conserved domains on  [gi|2024456230|ref|XP_040538640|]
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protocadherin Fat 2 isoform X2 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3328-3425 2.97e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 133.98  E-value: 2.97e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3328 PYFADIREDAAVGEIILTVSADDLDGAMNNQITYSIVEGNPLGHFAIQPKSGQISIAKHLDREEISSYSLTVRATDNGHP 3407
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 3408 AQFSDVAVRVHVSDVNDN 3425
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2277-2376 2.96e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 2.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2277 IYTASVSESMPAHTPVVQIIASDKDSGRNKVVSYQILDDGSDatKFFNIDASTGQITTAQALDYEKTQQFRMKVRAADHG 2356
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2357 TPPLSSDALVIVNVTDINDN 2376
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3017-3110 6.12e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 6.12e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3017 YTGRVSEDAQPGHFILKISATDPDVGSNAQITYSLHGPGAEE-FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGGG-- 3093
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 2024456230 3094 RSCQADITLTIEDTNDN 3110
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2803-2903 3.69e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2803 PYKAFVMENMPSGTTVIQVTANDQDTGSDGQVTYSLEAESGKlrGLFTIDGETGWITTLKELDCETQETYRFYVVATDHG 2882
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|.
gi 2024456230 2883 RKvQLSSQTLVEVTVSDENDN 2903
Cdd:cd11304     79 GP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1143-1241 8.18e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 8.18e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1143 VYYASVMENSPPNTSVLQLDALDPDSSSEGKLTFHILTGNPQGLFAINLVTGLISTTsRQLDREYKAEHILEVAVSDNGD 1222
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024456230 1223 PALKSTSRVVIQVLDANDN 1241
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 933-1028 8.34e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 8.34e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  933 NVKVPEDLPVGTILLFLEAFDPDAGSGGEVRYSLV-NDEEMMFHIDKLTGALRLEKELDYEKKDSYNLTVQVRDSGKPvS 1011
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-P 81

                           90
                   ....*....|....*..
gi 2024456230 1012 RSSLCHLEVNVLDVNEN 1028
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1043-1135 1.60e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.60e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1043 VQENSPEGTSVMMVTAKDIDKGKDGEVQYFLREGTGLSVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSA 1122
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85

                           90
                   ....*....|...
gi 2024456230 1123 TEIYIEVTDTNDN 1135
Cdd:cd11304     86 ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1560-1651 8.33e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.79  E-value: 8.33e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1560 HYEAETLDSAAVGTEIVQVRALDQDQGANAEIHYSLQAGNGEGFFSIDPHSGIITVAQKLDPSKQERFTLIVKAEDQGFP 1639
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 2024456230 1640 QLKDSATVHIRI 1651
Cdd:cd11304     81 PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 721-818 7.48e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 7.48e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  721 PRSIDIIENVPINSTIADLSAVDPDTGFNGKLVYVISDGNVDSCFTIDLELGLLQILSPLDHERTSFYILNITVYDLGTP 800
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230  801 QKSSWKLLAVNVLDTNDN 818
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3223-3320 1.18e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3223 EYVAMVKEDVAVGTEVLNLSALTRDNTENTEIKYEIVNGNDHGKFQLNSNTGALYINGSLDFEASHEYYLSIEGTRKGSA 3302
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 3303 SLSDVTMVVINITDINDH 3320
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-563 1.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.79e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  465 SYRGAFDENAPPGTSVLTVRATDEDEGDNGFVTYTIANQKSV-PFVIDPYSGIISTSKSLDYELmQRWYHLRVWASDWGS 543
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREE-QSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 2024456230  544 PfRHETEVYVSLMLSNVNDN 563
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 827-923 1.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.79e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  827 YWVAIPENVVTGTTIAQLKAEDADTDDNGRVKYSLL--TPTDKFAINSVTGEVTVIGALDRELWPYYALKIKARDQPktG 904
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG--G 79

                           90
                   ....*....|....*....
gi 2024456230  905 YQLFSVTDLIVTLEDVNDN 923
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2912-3008 4.88e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.88e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2912 YKGSVIENAEPGQVIVTLSTIDADiSEQNRRVTCYITEGDVLGQFTVDQIEGEwtISSKKPLDREDTEKYLLKVMASDG- 2990
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2991 --KFQATTEVEIFVLDINDN 3008
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1768-1868 1.71e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.71e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1768 IMENAPPQSMVLdesnspLVtHATDADQDSNALLVYEILEPEALKYFTVDPSTGTLTSRADIDYELTPVFHFSVHARDSG 1847
Cdd:cd11304      6 VPENAPPGTVVL------TV-SATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|.
gi 2024456230 1848 NPSLFASkpAKVTIHVKDMND 1868
Cdd:cd11304     79 GPPLSST--ATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3121-3214 5.03e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 5.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3121 VAVFDNTTTKTPIAVVSARDLDEGLNAEVVYSL-SDSANGHFSIEETTGVIRLEKPLKDSQHSAFELTVCATDQGTPqPL 3199
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                           90
                   ....*....|....*
gi 2024456230 3200 SALGTVTVSVVDLNE 3214
Cdd:cd11304     83 SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2075-2164 1.07e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2075 PYYTSVQDGMEPGDVLFQVSATDKDIGNNAAITYSFAE--DYKYFWIDPYLGDISLKKPLDYHALNKYSLRVIAKDNGEP 2152
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 2024456230 2153 PLLAEEEVVISV 2164
Cdd:cd11304     81 PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2177-2269 1.98e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2177 YRVKVPENIPPYTSILHIQAR---SPEGLRLIYNIVEEDSLKLFSTDFKTGVLTVTGQLDYELQTKHSFTVRATDTALGS 2253
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2024456230 2254 FS-EARVEVEVEDINDN 2269
Cdd:cd11304     82 LSsTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2486-2582 6.81e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.81e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2486 TYEAELAENAEVGTKVIELLAIDPDGGPYGTIDYTIINKLADEKFSIDNK-GHITTLQKLDREnsTERVIAIKVMAKDGG 2564
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDRE--EQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2565 G--KVAFCTVKIILTDENDN 2582
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3434-3525 1.74e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 1.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3434 YSVVVQENAPVGTSVLELIMSDRDSPENGPpYSFQITQGNDGKAFDV-TQNGLLVTSSILNRRVKEQYLLQVQVSDSGIP 3512
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 2024456230 3513 PLSSSAFVNIQVT 3525
Cdd:cd11304     81 PLSSTATVTITVL 93
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3802-3923 2.48e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.40  E-value: 2.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3802 MKTHQLHAVVFYANG--TDHAMLEMVHGVLHLGYGCWGNYTGNLSSSRFVSDGEWHSVFLEVKNASVRLLVDGLGNTSLQ 3879
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024456230 3880 LPGTCSTSQGRRDLLFGGLRHPL--QSQRVTRGFRGCLDVLAINGR 3923
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLllPALPVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1454-1552 2.12e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 2.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1454 HYEMRIPEDTPSGREILQVSATDKDKGKG--LIYTIHGSMDPRstrLFQLDPSSGVLTTAEGFSSQPMPQHTLTVMVRDQ 1531
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 2024456230 1532 EVPIKRNFVRVIIHVENCNLH 1552
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 155-250 2.65e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  155 SYKVSIREDTPLKTVVSTLSATDADAGQNAEFYYAL--NTKSDLFTIHPTTGAVVTTGRLNSTHRGRHHLQVLAVDrmrk 232
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD---- 76

                           90
                   ....*....|....*...
gi 2024456230  233 iMEGNGFGNLASLTIQVE 250
Cdd:cd11304     77 -GGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2384-2476 3.38e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 3.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2384 QYEAKVSEMATCGHIVIKVQALDPDSGDTTRLEYVILSGNDHRHFTINSTSGIISMFNRCKKDLESSYSLRVSASDG--- 2460
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 2024456230 2461 VFKSTVPVYINTTNAN 2476
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1252-1337 1.16e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1252 VQLPEREASETPlpVYRLIASDRDQGQNSQVTYTIEEE-EEGIFTINPTTGMVLSRKAF---PASEYNiLTVKATDGGSP 1327
Cdd:cd11304      4 VSVPENAPPGTV--VLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLdreEQSSYT-LTVTATDGGGP 80

                           90
                   ....*....|
gi 2024456230 1328 PLSSHVRLHI 1337
Cdd:cd11304     81 PLSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2698-2795 1.22e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2698 YTFSASEDLPEGSEIGSVKAFAED-----PIIYSLVKGtttesNKDEVFTLDEQTGALKIKKAVDHETTKWYQIDVMAHc 2772
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDsgengEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT- 75

                           90       100
                   ....*....|....*....|...
gi 2024456230 2773 SHQETELVSLVSVNIQVQDINDN 2795
Cdd:cd11304     76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 573-661 7.25e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 7.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  573 SGSIPRDFPVGNPVATVSAIDSDE--LQRIKYEIKSGNELRHFELNPISGVISLRislRDLPSEQPLFYSLKITATDGEN 650
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|.
gi 2024456230  651 YALPTSVNITV 661
Cdd:cd11304     80 PPLSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1665-1755 3.72e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 3.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1665 EYITEISESAAVGSPLIQVS-----TSSSSPVSYEIKDGNGDGVFSMNYQSGLISTQKNLDFEQVSFYQLKVRGTNMAGA 1739
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 1740 FM--DTMVLIYVIDENDN 1755
Cdd:cd11304     81 PLssTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 369-457 2.87e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 2.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  369 VYRVQLSEFSPPGSQVAMVKIT----PVLPNLKYVLRPTPDSTHFKINPHTGLITTVRAMDFHEQSNFQLEVATTNS--- 441
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*...
gi 2024456230  442 --HTSATVVIDIIDCNNH 457
Cdd:cd11304     81 plSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2590-2684 3.92e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 3.92e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2590 EYTLSIQSNVSKGSPVIQVLAYDADEGANADVVYSVdsVEDVSEDIVEINAATGVVKVKESLVGLENRAFNFKVKAEDGR 2669
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 2024456230 2670 PPHWNSLVPVSLQIV 2684
Cdd:cd11304     79 GPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1973-2067 4.15e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 4.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1973 VYTATVMENSTDEKTLTVLGV--KGYQLNEPLFYSLLNG--KERFKMIQASGVLQTKGvKFDREAQDVHEVAVEVKDNRK 2048
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdPDSGENGEVTYSIVSGneDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024456230 2049 PPRVSQATVKVYVEDVNDN 2067
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1356-1446 3.59e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 3.59e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1356 HFNFAVMETDPVNHMVGVISI----EMGPSQVWFNITGGDDDMDFDIEKSTGSMVIARALDARKKSSYNLTVEVTDG--- 1428
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90       100
                   ....*....|....*....|
gi 2024456230 1429 --STTikTQAFIHVIDINQH 1446
Cdd:cd11304     81 plSST--ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-146 2.98e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 2.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   41 YNATIYENSAPKTYVesyvkMGIYKTDPE----WDIRYRIASGDSSGLFKTEEHViGDfcflrIRTRSSntalLNREVKD 116
Cdd:cd11304      2 YEVSVPENAPPGTVV-----LTVSATDPDsgenGEVTYSIVSGNEDGLFSIDPST-GE-----ITTAKP----LDREEQS 66

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2024456230  117 SYMLIIKATEN-TFAYEAWAKVLIHILDRND 146
Cdd:cd11304     67 SYTLTVTATDGgGPPLSSTATVTITVLDVND 97
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4029-4062 5.48e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 54.18  E-value: 5.48e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024456230 4029 ECQD-NPCQNAGRCVSTQGSVRCICPSDYQGDYCT 4062
Cdd:cd00054      4 ECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3538-3622 5.63e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.17  E-value: 5.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3538 EIFITTNEEAFRGGVLGKIHATDRD--PHDTLVYTLVAEVPqEGRFSIGAADGKIIAGNKLPH---GHYLLNVTVSDG-- 3610
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDGgg 79

                           90
                   ....*....|...
gi 2024456230 3611 -TFTATTSVNIHV 3622
Cdd:cd11304     80 pPLSSTATVTITV 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3953-3986 4.82e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 4.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024456230 3953 CSS-NPCLNNGMCSETHGGgYTCICPGLFSGERCE 3986
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3992-4024 1.25e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 1.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024456230 3992 CESK-PCLHGGTCVLSGSGYSCHCPEWYLGDRCE 4024
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1886-1960 1.97e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 1.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1886 VHPGMELLSVQAKDADSE----VTYSIVEGNLDNAFYIHPLTGLVSIlnATGL----GNHHELTVRADDGLYK---STAL 1954
Cdd:pfam00028    9 APVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDIST--TKPLdresIGEYELTVEATDSGGPplsSTAT 86


                   ....*.
gi 2024456230 1955 VKLNLT 1960
Cdd:pfam00028   87 VTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3328-3425 2.97e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 133.98  E-value: 2.97e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3328 PYFADIREDAAVGEIILTVSADDLDGAMNNQITYSIVEGNPLGHFAIQPKSGQISIAKHLDREEISSYSLTVRATDNGHP 3407
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 3408 AQFSDVAVRVHVSDVNDN 3425
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2277-2376 2.96e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 2.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2277 IYTASVSESMPAHTPVVQIIASDKDSGRNKVVSYQILDDGSDatKFFNIDASTGQITTAQALDYEKTQQFRMKVRAADHG 2356
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2357 TPPLSSDALVIVNVTDINDN 2376
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3017-3110 6.12e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 6.12e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3017 YTGRVSEDAQPGHFILKISATDPDVGSNAQITYSLHGPGAEE-FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGGG-- 3093
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 2024456230 3094 RSCQADITLTIEDTNDN 3110
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2803-2903 3.69e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2803 PYKAFVMENMPSGTTVIQVTANDQDTGSDGQVTYSLEAESGKlrGLFTIDGETGWITTLKELDCETQETYRFYVVATDHG 2882
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|.
gi 2024456230 2883 RKvQLSSQTLVEVTVSDENDN 2903
Cdd:cd11304     79 GP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1143-1241 8.18e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 8.18e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1143 VYYASVMENSPPNTSVLQLDALDPDSSSEGKLTFHILTGNPQGLFAINLVTGLISTTsRQLDREYKAEHILEVAVSDNGD 1222
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024456230 1223 PALKSTSRVVIQVLDANDN 1241
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 933-1028 8.34e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 8.34e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  933 NVKVPEDLPVGTILLFLEAFDPDAGSGGEVRYSLV-NDEEMMFHIDKLTGALRLEKELDYEKKDSYNLTVQVRDSGKPvS 1011
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-P 81

                           90
                   ....*....|....*..
gi 2024456230 1012 RSSLCHLEVNVLDVNEN 1028
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1043-1135 1.60e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.60e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1043 VQENSPEGTSVMMVTAKDIDKGKDGEVQYFLREGTGLSVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSA 1122
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85

                           90
                   ....*....|...
gi 2024456230 1123 TEIYIEVTDTNDN 1135
Cdd:cd11304     86 ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1560-1651 8.33e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.79  E-value: 8.33e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1560 HYEAETLDSAAVGTEIVQVRALDQDQGANAEIHYSLQAGNGEGFFSIDPHSGIITVAQKLDPSKQERFTLIVKAEDQGFP 1639
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 2024456230 1640 QLKDSATVHIRI 1651
Cdd:cd11304     81 PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 721-818 7.48e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 7.48e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  721 PRSIDIIENVPINSTIADLSAVDPDTGFNGKLVYVISDGNVDSCFTIDLELGLLQILSPLDHERTSFYILNITVYDLGTP 800
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230  801 QKSSWKLLAVNVLDTNDN 818
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3347-3427 1.03e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.89  E-value: 1.03e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3347 SADDLDGAMNNQITYSIVEGNPLGHFAIQPKSGQISIAKHLDREEISSYSLTVRATDNGHPAQFSDVAVRVHVSDVNDNP 3426
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  3427 P 3427
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3223-3320 1.18e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3223 EYVAMVKEDVAVGTEVLNLSALTRDNTENTEIKYEIVNGNDHGKFQLNSNTGALYINGSLDFEASHEYYLSIEGTRKGSA 3302
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 3303 SLSDVTMVVINITDINDH 3320
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-563 1.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.79e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  465 SYRGAFDENAPPGTSVLTVRATDEDEGDNGFVTYTIANQKSV-PFVIDPYSGIISTSKSLDYELmQRWYHLRVWASDWGS 543
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREE-QSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 2024456230  544 PfRHETEVYVSLMLSNVNDN 563
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 827-923 1.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.79e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  827 YWVAIPENVVTGTTIAQLKAEDADTDDNGRVKYSLL--TPTDKFAINSVTGEVTVIGALDRELWPYYALKIKARDQPktG 904
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG--G 79

                           90
                   ....*....|....*....
gi 2024456230  905 YQLFSVTDLIVTLEDVNDN 923
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3329-3419 2.92e-26

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 105.08  E-value: 2.92e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3329 YFADIREDAAVGEIILTVSADDLDGAMNNQITYSIVEGNPLGHFAIQPKSGQISIAKHLDREEISSYSLTVRATDNGHPA 3408
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024456230 3409 QFSDVAVRVHV 3419
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2297-2378 1.40e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 1.40e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2297 ASDKDSGRNKVVSYQILDDGSDatKFFNIDASTGQITTAQALDYEKTQQFRMKVRAADHGTPPLSSDALVIVNVTDINDN 2376
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD--GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2024456230  2377 PP 2378
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2912-3008 4.88e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.88e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2912 YKGSVIENAEPGQVIVTLSTIDADiSEQNRRVTCYITEGDVLGQFTVDQIEGEwtISSKKPLDREDTEKYLLKVMASDG- 2990
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2991 --KFQATTEVEIFVLDINDN 3008
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1768-1868 1.71e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.71e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1768 IMENAPPQSMVLdesnspLVtHATDADQDSNALLVYEILEPEALKYFTVDPSTGTLTSRADIDYELTPVFHFSVHARDSG 1847
Cdd:cd11304      6 VPENAPPGTVVL------TV-SATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|.
gi 2024456230 1848 NPSLFASkpAKVTIHVKDMND 1868
Cdd:cd11304     79 GPPLSST--ATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3121-3214 5.03e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 5.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3121 VAVFDNTTTKTPIAVVSARDLDEGLNAEVVYSL-SDSANGHFSIEETTGVIRLEKPLKDSQHSAFELTVCATDQGTPqPL 3199
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                           90
                   ....*....|....*
gi 2024456230 3200 SALGTVTVSVVDLNE 3214
Cdd:cd11304     83 SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3035-3112 6.86e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 6.86e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3035 SATDPDVGSNAQITYSLHGPGAEE-FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGGG--RSCQADITLTIEDTNDNA 3111
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  3112 P 3112
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2075-2164 1.07e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2075 PYYTSVQDGMEPGDVLFQVSATDKDIGNNAAITYSFAE--DYKYFWIDPYLGDISLKKPLDYHALNKYSLRVIAKDNGEP 2152
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 2024456230 2153 PLLAEEEVVISV 2164
Cdd:cd11304     81 PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2177-2269 1.98e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2177 YRVKVPENIPPYTSILHIQAR---SPEGLRLIYNIVEEDSLKLFSTDFKTGVLTVTGQLDYELQTKHSFTVRATDTALGS 2253
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2024456230 2254 FS-EARVEVEVEDINDN 2269
Cdd:cd11304     82 LSsTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2822-2905 3.59e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 3.59e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2822 TANDQDTGSDGQVTYSLEAESGKlrGLFTIDGETGWITTLKELDCETQETYRFYVVATDHGRKvQLSSQTLVEVTVSDEN 2901
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDD--GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVN 77


                    ....
gi 2024456230  2902 DNAP 2905
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1057-1137 6.31e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 6.31e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1057 TAKDIDKGKDGEVQYFLREGTGLSVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSATEIYIEVTDTNDNP 1136
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  1137 P 1137
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2486-2582 6.81e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.81e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2486 TYEAELAENAEVGTKVIELLAIDPDGGPYGTIDYTIINKLADEKFSIDNK-GHITTLQKLDREnsTERVIAIKVMAKDGG 2564
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDRE--EQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2565 G--KVAFCTVKIILTDENDN 2582
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2278-2371 1.49e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.67  E-value: 1.49e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2278 YTASVSESMPAHTPVVQIIASDKDSGRNKVVSYQILDDGSDatKFFNIDASTGQITTAQALDYEKTQQFRMKVRAADHGT 2357
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 2024456230 2358 PPLSSDALVIVNVT 2371
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3017-3105 2.20e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 2.20e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3017 YTGRVSEDAQPGHFILKISATDPDVGSNAQITYSLHGPGAEE-FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGG--G 3093
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 2024456230 3094 RSCQADITLTIE 3105
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 740-820 6.27e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 6.27e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   740 SAVDPDTGFNGKLVYVISDGNVDSCFTIDLELGLLQILSPLDHERTSFYILNITVYDLGTPQKSSWKLLAVNVLDTNDNT 819
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230   820 P 820
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1163-1243 1.23e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 1.23e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1163 ALDPDSSSEGKLTFHILTGNPQGLFAINLVTGLIsTTSRQLDREYKAEHILEVAVSDNGDPALKSTSRVVIQVLDANDNP 1242
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  1243 P 1243
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 951-1032 1.83e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 1.83e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   951 AFDPDAGSGGEVRYSLVNDEEM-MFHIDKLTGALRLEKELDYEKKDSYNLTVQVRDSGKPvSRSSLCHLEVNVLDVNENl 1029
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN- 79


                    ...
gi 2024456230  1030 yPP 1032
Cdd:smart00112   80 -AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1789-1871 2.38e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 2.38e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1789 HATDADQDSNALLVYEILEPEALKYFTVDPSTGTLTSRADIDYELTPVFHFSVHARDSGNPSLfaSKPAKVTIHVKDMND 1868
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL--SSTATVTITVLDVND 78


                    ...
gi 2024456230  1869 SPP 1871
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1144-1236 3.09e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 3.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1144 YYASVMENSPPNTSVLQLDALDPDSSSEGKLTFHILTGNPQGLFAINLVTGLISTTsRQLDREYKAEHILEVAVSDNGDP 1223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTT-KPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024456230 1224 ALKSTSRVVIQVL 1236
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2804-2897 8.10e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 8.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2804 YKAFVMENMPSGTTVIQVTANDQDTGSDGQVTYSLEaeSGKLRGLFTIDGETGWITTLKELDCETQETYRFYVVATDHGR 2883
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 2024456230 2884 KvQLSSQTLVEVTV 2897
Cdd:pfam00028   79 P-PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3434-3525 1.74e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 1.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3434 YSVVVQENAPVGTSVLELIMSDRDSPENGPpYSFQITQGNDGKAFDV-TQNGLLVTSSILNRRVKEQYLLQVQVSDSGIP 3512
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 2024456230 3513 PLSSSAFVNIQVT 3525
Cdd:cd11304     81 PLSSTATVTITVL 93
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3802-3923 2.48e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.40  E-value: 2.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3802 MKTHQLHAVVFYANG--TDHAMLEMVHGVLHLGYGCWGNYTGNLSSSRFVSDGEWHSVFLEVKNASVRLLVDGLGNTSLQ 3879
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024456230 3880 LPGTCSTSQGRRDLLFGGLRHPL--QSQRVTRGFRGCLDVLAINGR 3923
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLllPALPVRAGFVGCIRDVRVNGE 126
Cadherin pfam00028
Cadherin domain;
1043-1130 7.23e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 7.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1043 VQENSPEGTSVMMVTAKDIDKGKDGEVQYFLREGTGLSVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSA 1122
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 2024456230 1123 TEIYIEVT 1130
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1454-1552 2.12e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 2.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1454 HYEMRIPEDTPSGREILQVSATDKDKGKG--LIYTIHGSMDPRstrLFQLDPSSGVLTTAEGFSSQPMPQHTLTVMVRDQ 1531
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 2024456230 1532 EVPIKRNFVRVIIHVENCNLH 1552
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1579-1651 2.86e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 2.86e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  1579 RALDQDQGANAEIHYSLQAGNGEGFFSIDPHSGIITVAQKLDPSKQERFTLIVKAEDQGFPQLKDSATVHIRI 1651
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
933-1023 1.15e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 1.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  933 NVKVPEDLPVGTILLFLEAFDPDAGSGGEVRYSLVNDEEM-MFHIDKLTGALRLEKELDYEKKDSYNLTVQVRDSGKPvS 1011
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-P 80

                           90
                   ....*....|..
gi 2024456230 1012 RSSLCHLEVNVL 1023
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1561-1651 1.37e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1561 YEAETLDSAAVGTEIVQVRALDQDQGANAEIHYSLQAGNGEGFFSIDPHSGIITVAQKLDPSKQERFTLIVKAEDQGFPQ 1640
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024456230 1641 LKDSATVHIRI 1651
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
829-918 1.85e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  829 VAIPENVVTGTTIAQLKAEDADTDDNGRVKYSLLT--PTDKFAINSVTGEVTVIGALDRELWPYYALKIKARDQPKTGyq 906
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP-- 80

                           90
                   ....*....|..
gi 2024456230  907 LFSVTDLIVTLE 918
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1768-1863 2.40e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1768 IMENAPPQSMVLdesnsplVTHATDADQDSNALLVYEILEPEALKYFTVDPSTGTLTSRADIDYELTPVFHFSVHARDSG 1847
Cdd:pfam00028    5 VPENAPVGTEVL-------TVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*.
gi 2024456230 1848 NPSLfaSKPAKVTIHV 1863
Cdd:pfam00028   78 GPPL--SSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 155-250 2.65e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  155 SYKVSIREDTPLKTVVSTLSATDADAGQNAEFYYAL--NTKSDLFTIHPTTGAVVTTGRLNSTHRGRHHLQVLAVDrmrk 232
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD---- 76

                           90
                   ....*....|....*...
gi 2024456230  233 iMEGNGFGNLASLTIQVE 250
Cdd:cd11304     77 -GGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 845-925 2.71e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 2.71e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   845 KAEDADTDDNGRVKYSLL--TPTDKFAINSVTGEVTVIGALDRELWPYYALKIKARDQpkTGYQLFSVTDLIVTLEDVND 922
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG--GGPPLSSTATVTITVLDVND 78


                    ...
gi 2024456230   923 NDP 925
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
466-555 3.12e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.12e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  466 YRGAFDENAPPGTSVLTVRATDEDEGDNGFVTYTIANQKSVP-FVIDPYSGIISTSKSLDYELmQRWYHLRVWASDWGSP 544
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRES-IGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 2024456230  545 FRH-ETEVYVSL 555
Cdd:pfam00028   80 PLSsTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2384-2476 3.38e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 3.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2384 QYEAKVSEMATCGHIVIKVQALDPDSGDTTRLEYVILSGNDHRHFTINSTSGIISMFNRCKKDLESSYSLRVSASDG--- 2460
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 2024456230 2461 VFKSTVPVYINTTNAN 2476
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3242-3322 4.77e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 4.77e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3242 SALTRDNTENTEIKYEIVNGNDHGKFQLNSNTGALYINGSLDFEASHEYYLSIEGTRKGSASLSDVTMVVINITDINDHA 3321
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  3322 P 3322
Cdd:smart00112   81 P 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3777-3921 6.39e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 83.62  E-value: 6.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3777 AVRFGGHSYIWY--QHSQVGSWHMHFRMKTHQLHAVVFYA---NGTDHAMLEMVHG--VLHLGYGcWGNYTgnLSSSRFV 3849
Cdd:cd00110      1 GVSFSGSSYVRLptLPAPRTRLSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGrlVLRYDLG-SGSLV--LSSKTPL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024456230 3850 SDGEWHSVFLEVKNASVRLLVDGLGNTSLQLPGTCSTSQGRRDLLFGGL--RHPLQSQRVTRGFRGCLDVLAIN 3921
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLpeDLKSPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1252-1337 1.16e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1252 VQLPEREASETPlpVYRLIASDRDQGQNSQVTYTIEEE-EEGIFTINPTTGMVLSRKAF---PASEYNiLTVKATDGGSP 1327
Cdd:cd11304      4 VSVPENAPPGTV--VLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLdreEQSSYT-LTVTATDGGGP 80

                           90
                   ....*....|
gi 2024456230 1328 PLSSHVRLHI 1337
Cdd:cd11304     81 PLSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2698-2795 1.22e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2698 YTFSASEDLPEGSEIGSVKAFAED-----PIIYSLVKGtttesNKDEVFTLDEQTGALKIKKAVDHETTKWYQIDVMAHc 2772
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDsgengEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT- 75

                           90       100
                   ....*....|....*....|...
gi 2024456230 2773 SHQETELVSLVSVNIQVQDINDN 2795
Cdd:cd11304     76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-565 1.81e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 1.81e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   484 RATDEDEGDNGFVTYTIANQ-KSVPFVIDPYSGIISTSKSLDYELMQRwYHLRVWASDWGSPfRHETEVYVSLMLSNVND 562
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 2024456230   563 NAP 565
Cdd:smart00112   79 NAP 81
LamG smart00282
Laminin G domain;
3797-3923 2.58e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 81.23  E-value: 2.58e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3797 HMHFRMKTHQLHAVVFYA---NGTDHAMLEMVHGVLHLGYGCwGNYTGNLSSSRF-VSDGEWHSVFLEVKNASVRLLVDG 3872
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgskGGGDYLALELRDGRLVLRYDL-GSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  3873 LGNTSLQLPGTCSTSQGRRDLLFGGLRHPLQSQR--VTRGFRGCLDVLAINGR 3923
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPlpVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3137-3217 5.39e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 5.39e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3137 SARDLDEGLNAEVVYSL-SDSANGHFSIEETTGVIRLEKPLKDSQHSAFELTVCATDQGTPqPLSALGTVTVSVVDLNEY 3215
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 2024456230  3216 LP 3217
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2930-3010 6.23e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 6.23e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2930 STIDADiSEQNRRVTCYITEGDVLGQFTVDQIEGEwtISSKKPLDREDTEKYLLKVMASDG---KFQATTEVEIFVLDIN 3006
Cdd:smart00112    1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVN 77


                    ....
gi 2024456230  3007 DNSP 3010
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
3224-3315 6.97e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 6.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3224 YVAMVKEDVAVGTEVLNLSALTRDNTENTEIKYEIVNGNDHGKFQLNSNTGALYINGSLDFEASHEYYLSIEGTRKGSAS 3303
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230 3304 LSDVTMVVINIT 3315
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 573-661 7.25e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 7.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  573 SGSIPRDFPVGNPVATVSAIDSDE--LQRIKYEIKSGNELRHFELNPISGVISLRislRDLPSEQPLFYSLKITATDGEN 650
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|.
gi 2024456230  651 YALPTSVNITV 661
Cdd:cd11304     80 PPLSSTATVTI 90
Cadherin pfam00028
Cadherin domain;
2076-2164 1.92e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2076 YYTSVQDGMEPGDVLFQVSATDKDIGNNAAITYSFAED--YKYFWIDPYLGDISLKKPLDYHALNKYSLRVIAKDNGEPP 2153
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024456230 2154 LLAEEEVVISV 2164
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1665-1755 3.72e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 3.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1665 EYITEISESAAVGSPLIQVS-----TSSSSPVSYEIKDGNGDGVFSMNYQSGLISTQKNLDFEQVSFYQLKVRGTNMAGA 1739
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 1740 FM--DTMVLIYVIDENDN 1755
Cdd:cd11304     81 PLssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
722-813 3.75e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 3.75e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  722 RSIDIIENVPINSTIADLSAVDPDTGFNGKLVYVISDGNVDSCFTIDLELGLLQILSPLDHERTSFYILNITVYDLGTPQ 801
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230  802 KSSWKLLAVNVL 813
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2506-2584 6.21e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 6.21e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2506 AIDPDGGPYGTIDYTIINKLADEKFSID-NKGHITTLQKLDREnsTERVIAIKVMAKDGGG--KVAFCTVKIILTDENDN 2582
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDpETGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                    ..
gi 2024456230  2583 PP 2584
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
3434-3525 1.29e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 1.29e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3434 YSVVVQENAPVGTSVLELIMSDRDSPENGPPySFQITQGNDGKAFDV-TQNGLLVTSSILNRRVKEQYLLQVQVSDSGIP 3512
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI-FYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024456230 3513 PLSSSAFVNIQVT 3525
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 369-457 2.87e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 2.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  369 VYRVQLSEFSPPGSQVAMVKIT----PVLPNLKYVLRPTPDSTHFKINPHTGLITTVRAMDFHEQSNFQLEVATTNS--- 441
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*...
gi 2024456230  442 --HTSATVVIDIIDCNNH 457
Cdd:cd11304     81 plSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3126-3209 3.63e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 3.63e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3126 NTTTKTPIAVVSARDLDEGLNAEVVYS-LSDSANGHFSIEETTGVIRLEKPLKDSQHSAFELTVCATDQGTPqPLSALGT 3204
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTAT 86


                   ....*
gi 2024456230 3205 VTVSV 3209
Cdd:pfam00028   87 VTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2590-2684 3.92e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 3.92e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2590 EYTLSIQSNVSKGSPVIQVLAYDADEGANADVVYSVdsVEDVSEDIVEINAATGVVKVKESLVGLENRAFNFKVKAEDGR 2669
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 2024456230 2670 PPHWNSLVPVSLQIV 2684
Cdd:cd11304     79 GPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1973-2067 4.15e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 4.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1973 VYTATVMENSTDEKTLTVLGV--KGYQLNEPLFYSLLNG--KERFKMIQASGVLQTKGvKFDREAQDVHEVAVEVKDNRK 2048
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdPDSGENGEVTYSIVSGneDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024456230 2049 PPRVSQATVKVYVEDVNDN 2067
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2094-2164 1.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.04e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  2094 SATDKDIGNNAAITYSFA--EDYKYFWIDPYLGDISLKKPLDYHALNKYSLRVIAKDNGEPPLLAEEEVVISV 2164
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2198-2271 1.08e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.08e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230  2198 SPEGLRLIYNIVEEDSLKLFSTDFKTGVLTVTGQLDYELQTKHSFTVRATDTALGSFS-EARVEVEVEDINDNPP 2271
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSsTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1271-1337 7.52e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 7.52e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024456230  1271 ASDRDQGQNSQVTYTI-EEEEEGIFTINPTTGMVLSRKAF---PASEYNiLTVKATDGGSPPLSSHVRLHI 1337
Cdd:smart00112    2 ATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTI 71
Cadherin pfam00028
Cadherin domain;
1252-1338 9.86e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 9.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1252 VQLPEREASETPlpVYRLIASDRDQGQNSQVTYTI-EEEEEGIFTINPTTGMVLSRKAF---PASEYNiLTVKATDGGSP 1327
Cdd:pfam00028    3 ASVPENAPVGTE--VLTVTATDPDLGPNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLdreSIGEYE-LTVEATDSGGP 79

                           90
                   ....*....|.
gi 2024456230 1328 PLSSHVRLHIS 1338
Cdd:pfam00028   80 PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
2912-3003 1.07e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2912 YKGSVIENAEPGQVIVTLSTIDADiSEQNRRVTCYITEGDVLGQFTVDQIEGEwtISSKKPLDREDTEKYLLKVMASDGK 2991
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 2024456230 2992 FQA---TTEVEIFVL 3003
Cdd:pfam00028   78 GPPlssTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2487-2577 1.64e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 1.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2487 YEAELAENAEVGTKVIELLAIDPDGGPYGTIDYTIINKLADEKFSID-NKGHITTLQKLDRENSTERVIAIKVMAKDGGG 2565
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230 2566 KVAFCTVKIILT 2577
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
156-250 1.67e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  156 YKVSIREDTPLKTVVSTLSATDADAGQNAEFYYAL--NTKSDLFTIHPTTGAVVTTGRLNSTHRGRHHLQVLAVDRMRKI 233
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*..
gi 2024456230  234 MEGNgfgnlASLTIQVE 250
Cdd:pfam00028   81 LSST-----ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1356-1446 3.59e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 3.59e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1356 HFNFAVMETDPVNHMVGVISI----EMGPSQVWFNITGGDDDMDFDIEKSTGSMVIARALDARKKSSYNLTVEVTDG--- 1428
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90       100
                   ....*....|....*....|
gi 2024456230 1429 --STTikTQAFIHVIDINQH 1446
Cdd:cd11304     81 plSST--ATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2177-2264 4.01e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 4.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2177 YRVKVPENIPPYTSILHIQARSP-EGL--RLIYNIVEEDSLKLFSTDFKTGVLTVTGQLDYELQTKHSFTVRATDTAL-G 2252
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpP 80

                           90
                   ....*....|..
gi 2024456230 2253 SFSEARVEVEVE 2264
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1999-2069 6.00e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 6.00e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  1999 NEPLFYSLL--NGKERFKMIQASGVLQTKGVkFDREAQDVHEVAVEVKDNRKPPRVSQATVKVYVEDVNDNPP 2069
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
573-661 7.12e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 7.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  573 SGSIPRDFPVGNPVATVSAIDSDE--LQRIKYEIKSGNELRHFELNPISGVISLRISLRdlpSEQPLFYSLKITATDGEN 650
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLD---RESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 2024456230  651 YAL--PTSVNITV 661
Cdd:pfam00028   79 PPLssTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1693-1757 8.86e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 8.86e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024456230  1693 YEIKDGNGDGVFSMNYQSGLISTQKNLDFEQVSFYQLKVRGTNMAGAFM--DTMVLIYVIDENDNVP 1757
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLssTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3454-3532 2.57e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 2.57e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3454 SDRDSPENGPpYSFQITQGNDGKAFDVTQN-GLLVTSSILNRRVKEQYLLQVQVSDSGIPPLSSSAFVNIQVTEQSQYAP 3532
Cdd:smart00112    3 TDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1455-1547 6.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 6.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1455 YEMRIPEDTPSGREILQVSATDKDKG--KGLIYTIhgsMDPRSTRLFQLDPSSGVLTTAEGFSSQPMPQHTLTVMVRDQE 1532
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 2024456230 1533 VPIKRNFVRVIIHVE 1547
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-146 2.98e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 2.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   41 YNATIYENSAPKTYVesyvkMGIYKTDPE----WDIRYRIASGDSSGLFKTEEHViGDfcflrIRTRSSntalLNREVKD 116
Cdd:cd11304      2 YEVSVPENAPPGTVV-----LTVSATDPDsgenGEVTYSIVSGNEDGLFSIDPST-GE-----ITTAKP----LDREEQS 66

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2024456230  117 SYMLIIKATEN-TFAYEAWAKVLIHILDRND 146
Cdd:cd11304     67 SYTLTVTATDGgGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1473-1554 5.66e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.66e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1473 SATDKDKGKG--LIYTIHGSMDPRstrLFQLDPSSGVLTTAEGFSSQPMPQHTLTVMVRDQEVPIKRNFVRVIIHVENCN 1550
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDG---LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 2024456230  1551 LHPP 1554
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1381-1448 5.88e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.88e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024456230  1381 SQVWFNITGGDDDMDFDIEKSTGSMVIARALDARKKSSYNLTVEVTDGSTTIK---TQAFIHVIDINQHRP 1448
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsstATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 395-459 6.30e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 6.30e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   395 NLKYVLRPTPDSTHFKINPHTGLITTVRAMDFHEQSNFQLEVATTNSH-----TSATVVIDIIDCNNHAP 459
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpplsSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2723-2797 7.73e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 7.73e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230  2723 IIYSLVKGtttesNKDEVFTLDEQTGALKIKKAVDHETTKWYQIDVMAhCSHQETELVSLVSVNIQVQDINDNKP 2797
Cdd:smart00112   13 VTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2385-2471 8.36e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2385 YEAKVSEMATCGHIVIKVQALDPDSGDTTRLEYVILSGNDHRHFTINSTSGIISMFNRCKKDLESSYSLRVSASDGVFK- 2463
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|
gi 2024456230 2464 --STVPVYIN 2471
Cdd:pfam00028   81 lsSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2403-2476 4.32e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 4.32e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2403 QALDPDSGDTTRLEYVILSGNDHRHFTINSTSGIIS---MFNRckkDLESSYSLRVSASDG---VFKSTVPVYINTTNAN 2476
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITttkPLDR---EEQPEYTLTVEATDGggpPLSSTATVTITVLDVN 77
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4029-4062 5.48e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 54.18  E-value: 5.48e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024456230 4029 ECQD-NPCQNAGRCVSTQGSVRCICPSDYQGDYCT 4062
Cdd:cd00054      4 ECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3538-3622 5.63e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.17  E-value: 5.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3538 EIFITTNEEAFRGGVLGKIHATDRD--PHDTLVYTLVAEVPqEGRFSIGAADGKIIAGNKLPH---GHYLLNVTVSDG-- 3610
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDGgg 79

                           90
                   ....*....|...
gi 2024456230 3611 -TFTATTSVNIHV 3622
Cdd:cd11304     80 pPLSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
1357-1435 6.16e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 6.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1357 FNFAVMETDPVNHMVGVISI---EMGP-SQVWFNITGGDDDMDFDIEKSTGSMVIARALDARKKSSYNLTVEVTDGSTTI 1432
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ...
gi 2024456230 1433 KTQ 1435
Cdd:pfam00028   81 LSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 174-250 8.07e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 8.07e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024456230   174 SATDADAGQNAEFYYAL--NTKSDLFTIHPTTGAVVTTGRLNSTHRGRHHLQVLAVDRMRKIMEGNgfgnlASLTIQVE 250
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSST-----ATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-661 2.96e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 2.96e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230   590 SAIDSDELQ--RIKYEIKSGNELRHFELNPISGVISLRISL-RdlpsEQPLFYSLKITATDGENYALPTSVNITV 661
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLdR----EEQPEYTLTVEATDGGGPPLSSTATVTI 71
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3953-3986 4.82e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 4.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024456230 3953 CSS-NPCLNNGMCSETHGGgYTCICPGLFSGERCE 3986
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
1974-2062 5.75e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1974 YTATVMENSTDEKTLTVLGVKGYQL--NEPLFYSLLNGKER--FKMIQASGVLQTKGVkFDREAQDVHEVAVEVKDNRKP 2049
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024456230 2050 PRVSQATVKVYVE 2062
Cdd:pfam00028   80 PLSSTATVTITVL 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4030-4060 5.79e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 51.23  E-value: 5.79e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024456230 4030 CQDNPCQNAGRCVSTQGSVRCICPSDYQGDY 4060
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
2591-2683 6.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.69  E-value: 6.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2591 YTLSIQSNVSKGSPVIQVLAYDADEGANADVVYSVdsVEDVSEDIVEINAATGVVKVKESLVGLENRAFNFKVKAEDGRP 2670
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 2024456230 2671 PHWNSLVPVSLQI 2683
Cdd:pfam00028   79 PPLSSTATVTITV 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3992-4024 1.25e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 1.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024456230 3992 CESK-PCLHGGTCVLSGSGYSCHCPEWYLGDRCE 4024
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3953-3984 1.54e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.07  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024456230 3953 CSSNPCLNNGMCSEThGGGYTCICPGLFSGER 3984
Cdd:pfam00008    1 CAPNPCSNGGTCVDT-PGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
1666-1750 1.65e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1666 YITEISESAAVGSPLIQVS-----TSSSSPVSYEIKDGNGDGVFSMNYQSGLISTQKNLDFEQVSFYQLKVRGTNMAGAF 1740
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTatdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230 1741 MD--TMVLIYVI 1750
Cdd:pfam00028   81 LSstATVTITVL 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3992-4022 2.80e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 49.30  E-value: 2.80e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024456230 3992 CESKPCLHGGTCVLSGSGYSCHCPEWYLGDR 4022
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
4029-4062 4.06e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 4.06e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024456230  4029 ECQ-DNPCQNAGRCVSTQGSVRCICPSDYQ-GDYCT 4062
Cdd:smart00179    4 ECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
2698-2790 4.21e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 4.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2698 YTFSASEDLPEGSEIGSVKAfaEDP-------IIYSLVKGtttesNKDEVFTLDEQTGALKIKKAVDHETTKWYQIDVMA 2770
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTA--TDPdlgpngrIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|
gi 2024456230 2771 HcSHQETELVSLVSVNIQVQ 2790
Cdd:pfam00028   74 T-DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
370-452 9.75e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.91  E-value: 9.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  370 YRVQLSEFSPPGSQVAMVKIT----PVLPNLKYVLRPTPDSTHFKINPHTGLITTVRAMDFHEQSNFQLEVATTNSH--- 442
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 2024456230  443 --TSATVVIDII 452
Cdd:pfam00028   81 lsSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3992-4024 1.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 1.41e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024456230  3992 CESK-PCLHGGTCV-LSGSgYSCHCPE-WYLGDRCE 4024
Cdd:smart00179    5 CASGnPCQNGGTCVnTVGS-YRCECPPgYTDGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2610-2684 1.61e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 1.61e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230  2610 AYDADEGANADVVYSVDSveDVSEDIVEINAATGVVKVKESLVGLENRAFNFKVKAEDGRPPHWNSLVPVSLQIV 2684
Cdd:smart00112    2 ATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
1886-1960 1.97e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 1.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1886 VHPGMELLSVQAKDADSE----VTYSIVEGNLDNAFYIHPLTGLVSIlnATGL----GNHHELTVRADDGLYK---STAL 1954
Cdd:pfam00028    9 APVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDIST--TKPLdresIGEYELTVEATDSGGPplsSTAT 86


                   ....*.
gi 2024456230 1955 VKLNLT 1960
Cdd:pfam00028   87 VTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3953-3986 2.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.92e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024456230  3953 CSS-NPCLNNGMCSETHgGGYTCICP-GLFSGERCE 3986
Cdd:smart00179    5 CASgNPCQNGGTCVNTV-GSYRCECPpGYTDGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-149 4.08e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 4.08e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230    66 TDPEWDIRYRIASGDSSGLFkteehvigdfcflRIRTRS---SNTALLNREVKDSYMLIIKATEN-TFAYEAWAKVLIHI 141
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLF-------------SIDPETgeiTTTKPLDREEQPEYTLTVEATDGgGPPLSSTATVTITV 73


                    ....*...
gi 2024456230   142 LDRNDLKP 149
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
41-127 3.28e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 3.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   41 YNATIYENSAPKTYVesyVKMGIYKTD--PEWDIRYRIASGDSSGLFKTEEHViGDfcflrIRTRSSntalLNREVKDSY 118
Cdd:pfam00028    1 YSASVPENAPVGTEV---LTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDT-GD-----ISTTKP----LDRESIGEY 67


                   ....*....
gi 2024456230  119 MLIIKATEN 127
Cdd:pfam00028   68 ELTVEATDS 76
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3328-3425 2.97e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 133.98  E-value: 2.97e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3328 PYFADIREDAAVGEIILTVSADDLDGAMNNQITYSIVEGNPLGHFAIQPKSGQISIAKHLDREEISSYSLTVRATDNGHP 3407
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 3408 AQFSDVAVRVHVSDVNDN 3425
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2277-2376 2.96e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 2.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2277 IYTASVSESMPAHTPVVQIIASDKDSGRNKVVSYQILDDGSDatKFFNIDASTGQITTAQALDYEKTQQFRMKVRAADHG 2356
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2357 TPPLSSDALVIVNVTDINDN 2376
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3017-3110 6.12e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.35  E-value: 6.12e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3017 YTGRVSEDAQPGHFILKISATDPDVGSNAQITYSLHGPGAEE-FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGGG-- 3093
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 2024456230 3094 RSCQADITLTIEDTNDN 3110
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2803-2903 3.69e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 3.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2803 PYKAFVMENMPSGTTVIQVTANDQDTGSDGQVTYSLEAESGKlrGLFTIDGETGWITTLKELDCETQETYRFYVVATDHG 2882
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|.
gi 2024456230 2883 RKvQLSSQTLVEVTVSDENDN 2903
Cdd:cd11304     79 GP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1143-1241 8.18e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 8.18e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1143 VYYASVMENSPPNTSVLQLDALDPDSSSEGKLTFHILTGNPQGLFAINLVTGLISTTsRQLDREYKAEHILEVAVSDNGD 1222
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024456230 1223 PALKSTSRVVIQVLDANDN 1241
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 933-1028 8.34e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 8.34e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  933 NVKVPEDLPVGTILLFLEAFDPDAGSGGEVRYSLV-NDEEMMFHIDKLTGALRLEKELDYEKKDSYNLTVQVRDSGKPvS 1011
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-P 81

                           90
                   ....*....|....*..
gi 2024456230 1012 RSSLCHLEVNVLDVNEN 1028
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1043-1135 1.60e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.60e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1043 VQENSPEGTSVMMVTAKDIDKGKDGEVQYFLREGTGLSVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSA 1122
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85

                           90
                   ....*....|...
gi 2024456230 1123 TEIYIEVTDTNDN 1135
Cdd:cd11304     86 ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1560-1651 8.33e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.79  E-value: 8.33e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1560 HYEAETLDSAAVGTEIVQVRALDQDQGANAEIHYSLQAGNGEGFFSIDPHSGIITVAQKLDPSKQERFTLIVKAEDQGFP 1639
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 2024456230 1640 QLKDSATVHIRI 1651
Cdd:cd11304     81 PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 721-818 7.48e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 7.48e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  721 PRSIDIIENVPINSTIADLSAVDPDTGFNGKLVYVISDGNVDSCFTIDLELGLLQILSPLDHERTSFYILNITVYDLGTP 800
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230  801 QKSSWKLLAVNVLDTNDN 818
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3347-3427 1.03e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.89  E-value: 1.03e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3347 SADDLDGAMNNQITYSIVEGNPLGHFAIQPKSGQISIAKHLDREEISSYSLTVRATDNGHPAQFSDVAVRVHVSDVNDNP 3426
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  3427 P 3427
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3223-3320 1.18e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.18e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3223 EYVAMVKEDVAVGTEVLNLSALTRDNTENTEIKYEIVNGNDHGKFQLNSNTGALYINGSLDFEASHEYYLSIEGTRKGSA 3302
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 3303 SLSDVTMVVINITDINDH 3320
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-563 1.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.79e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  465 SYRGAFDENAPPGTSVLTVRATDEDEGDNGFVTYTIANQKSV-PFVIDPYSGIISTSKSLDYELmQRWYHLRVWASDWGS 543
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREE-QSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 2024456230  544 PfRHETEVYVSLMLSNVNDN 563
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 827-923 1.79e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.79e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  827 YWVAIPENVVTGTTIAQLKAEDADTDDNGRVKYSLL--TPTDKFAINSVTGEVTVIGALDRELWPYYALKIKARDQPktG 904
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG--G 79

                           90
                   ....*....|....*....
gi 2024456230  905 YQLFSVTDLIVTLEDVNDN 923
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3329-3419 2.92e-26

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 105.08  E-value: 2.92e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3329 YFADIREDAAVGEIILTVSADDLDGAMNNQITYSIVEGNPLGHFAIQPKSGQISIAKHLDREEISSYSLTVRATDNGHPA 3408
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024456230 3409 QFSDVAVRVHV 3419
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2297-2378 1.40e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 1.40e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2297 ASDKDSGRNKVVSYQILDDGSDatKFFNIDASTGQITTAQALDYEKTQQFRMKVRAADHGTPPLSSDALVIVNVTDINDN 2376
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDD--GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2024456230  2377 PP 2378
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2912-3008 4.88e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.88e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2912 YKGSVIENAEPGQVIVTLSTIDADiSEQNRRVTCYITEGDVLGQFTVDQIEGEwtISSKKPLDREDTEKYLLKVMASDG- 2990
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2991 --KFQATTEVEIFVLDINDN 3008
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1768-1868 1.71e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.71e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1768 IMENAPPQSMVLdesnspLVtHATDADQDSNALLVYEILEPEALKYFTVDPSTGTLTSRADIDYELTPVFHFSVHARDSG 1847
Cdd:cd11304      6 VPENAPPGTVVL------TV-SATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|.
gi 2024456230 1848 NPSLFASkpAKVTIHVKDMND 1868
Cdd:cd11304     79 GPPLSST--ATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3121-3214 5.03e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 5.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3121 VAVFDNTTTKTPIAVVSARDLDEGLNAEVVYSL-SDSANGHFSIEETTGVIRLEKPLKDSQHSAFELTVCATDQGTPqPL 3199
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                           90
                   ....*....|....*
gi 2024456230 3200 SALGTVTVSVVDLNE 3214
Cdd:cd11304     83 SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3035-3112 6.86e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 6.86e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3035 SATDPDVGSNAQITYSLHGPGAEE-FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGGG--RSCQADITLTIEDTNDNA 3111
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  3112 P 3112
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2075-2164 1.07e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2075 PYYTSVQDGMEPGDVLFQVSATDKDIGNNAAITYSFAE--DYKYFWIDPYLGDISLKKPLDYHALNKYSLRVIAKDNGEP 2152
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 2024456230 2153 PLLAEEEVVISV 2164
Cdd:cd11304     81 PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2177-2269 1.98e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2177 YRVKVPENIPPYTSILHIQAR---SPEGLRLIYNIVEEDSLKLFSTDFKTGVLTVTGQLDYELQTKHSFTVRATDTALGS 2253
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2024456230 2254 FS-EARVEVEVEDINDN 2269
Cdd:cd11304     82 LSsTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2822-2905 3.59e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 3.59e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2822 TANDQDTGSDGQVTYSLEAESGKlrGLFTIDGETGWITTLKELDCETQETYRFYVVATDHGRKvQLSSQTLVEVTVSDEN 2901
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDD--GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVN 77


                    ....
gi 2024456230  2902 DNAP 2905
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1057-1137 6.31e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 6.31e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1057 TAKDIDKGKDGEVQYFLREGTGLSVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSATEIYIEVTDTNDNP 1136
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  1137 P 1137
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2486-2582 6.81e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.81e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2486 TYEAELAENAEVGTKVIELLAIDPDGGPYGTIDYTIINKLADEKFSIDNK-GHITTLQKLDREnsTERVIAIKVMAKDGG 2564
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDRE--EQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2024456230 2565 G--KVAFCTVKIILTDENDN 2582
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2278-2371 1.49e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.67  E-value: 1.49e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2278 YTASVSESMPAHTPVVQIIASDKDSGRNKVVSYQILDDGSDatKFFNIDASTGQITTAQALDYEKTQQFRMKVRAADHGT 2357
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 2024456230 2358 PPLSSDALVIVNVT 2371
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3017-3105 2.20e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 2.20e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3017 YTGRVSEDAQPGHFILKISATDPDVGSNAQITYSLHGPGAEE-FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGG--G 3093
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 2024456230 3094 RSCQADITLTIE 3105
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 740-820 6.27e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 6.27e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   740 SAVDPDTGFNGKLVYVISDGNVDSCFTIDLELGLLQILSPLDHERTSFYILNITVYDLGTPQKSSWKLLAVNVLDTNDNT 819
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230   820 P 820
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1163-1243 1.23e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 1.23e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1163 ALDPDSSSEGKLTFHILTGNPQGLFAINLVTGLIsTTSRQLDREYKAEHILEVAVSDNGDPALKSTSRVVIQVLDANDNP 1242
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  1243 P 1243
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 951-1032 1.83e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 1.83e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   951 AFDPDAGSGGEVRYSLVNDEEM-MFHIDKLTGALRLEKELDYEKKDSYNLTVQVRDSGKPvSRSSLCHLEVNVLDVNENl 1029
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN- 79


                    ...
gi 2024456230  1030 yPP 1032
Cdd:smart00112   80 -AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1789-1871 2.38e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 2.38e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1789 HATDADQDSNALLVYEILEPEALKYFTVDPSTGTLTSRADIDYELTPVFHFSVHARDSGNPSLfaSKPAKVTIHVKDMND 1868
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL--SSTATVTITVLDVND 78


                    ...
gi 2024456230  1869 SPP 1871
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1144-1236 3.09e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 3.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1144 YYASVMENSPPNTSVLQLDALDPDSSSEGKLTFHILTGNPQGLFAINLVTGLISTTsRQLDREYKAEHILEVAVSDNGDP 1223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTT-KPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024456230 1224 ALKSTSRVVIQVL 1236
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2804-2897 8.10e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 8.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2804 YKAFVMENMPSGTTVIQVTANDQDTGSDGQVTYSLEaeSGKLRGLFTIDGETGWITTLKELDCETQETYRFYVVATDHGR 2883
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 2024456230 2884 KvQLSSQTLVEVTV 2897
Cdd:pfam00028   79 P-PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3434-3525 1.74e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 1.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3434 YSVVVQENAPVGTSVLELIMSDRDSPENGPpYSFQITQGNDGKAFDV-TQNGLLVTSSILNRRVKEQYLLQVQVSDSGIP 3512
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 2024456230 3513 PLSSSAFVNIQVT 3525
Cdd:cd11304     81 PLSSTATVTITVL 93
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3802-3923 2.48e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.40  E-value: 2.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3802 MKTHQLHAVVFYANG--TDHAMLEMVHGVLHLGYGCWGNYTGNLSSSRFVSDGEWHSVFLEVKNASVRLLVDGLGNTSLQ 3879
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2024456230 3880 LPGTCSTSQGRRDLLFGGLRHPL--QSQRVTRGFRGCLDVLAINGR 3923
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLllPALPVRAGFVGCIRDVRVNGE 126
Cadherin pfam00028
Cadherin domain;
1043-1130 7.23e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 7.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1043 VQENSPEGTSVMMVTAKDIDKGKDGEVQYFLREGTGLSVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSA 1122
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 2024456230 1123 TEIYIEVT 1130
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1454-1552 2.12e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 2.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1454 HYEMRIPEDTPSGREILQVSATDKDKGKG--LIYTIHGSMDPRstrLFQLDPSSGVLTTAEGFSSQPMPQHTLTVMVRDQ 1531
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 2024456230 1532 EVPIKRNFVRVIIHVENCNLH 1552
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1579-1651 2.86e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 2.86e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  1579 RALDQDQGANAEIHYSLQAGNGEGFFSIDPHSGIITVAQKLDPSKQERFTLIVKAEDQGFPQLKDSATVHIRI 1651
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
933-1023 1.15e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 1.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  933 NVKVPEDLPVGTILLFLEAFDPDAGSGGEVRYSLVNDEEM-MFHIDKLTGALRLEKELDYEKKDSYNLTVQVRDSGKPvS 1011
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-P 80

                           90
                   ....*....|..
gi 2024456230 1012 RSSLCHLEVNVL 1023
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1561-1651 1.37e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1561 YEAETLDSAAVGTEIVQVRALDQDQGANAEIHYSLQAGNGEGFFSIDPHSGIITVAQKLDPSKQERFTLIVKAEDQGFPQ 1640
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024456230 1641 LKDSATVHIRI 1651
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
829-918 1.85e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  829 VAIPENVVTGTTIAQLKAEDADTDDNGRVKYSLLT--PTDKFAINSVTGEVTVIGALDRELWPYYALKIKARDQPKTGyq 906
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP-- 80

                           90
                   ....*....|..
gi 2024456230  907 LFSVTDLIVTLE 918
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1768-1863 2.40e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1768 IMENAPPQSMVLdesnsplVTHATDADQDSNALLVYEILEPEALKYFTVDPSTGTLTSRADIDYELTPVFHFSVHARDSG 1847
Cdd:pfam00028    5 VPENAPVGTEVL-------TVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*.
gi 2024456230 1848 NPSLfaSKPAKVTIHV 1863
Cdd:pfam00028   78 GPPL--SSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 155-250 2.65e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.65e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  155 SYKVSIREDTPLKTVVSTLSATDADAGQNAEFYYAL--NTKSDLFTIHPTTGAVVTTGRLNSTHRGRHHLQVLAVDrmrk 232
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD---- 76

                           90
                   ....*....|....*...
gi 2024456230  233 iMEGNGFGNLASLTIQVE 250
Cdd:cd11304     77 -GGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 845-925 2.71e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 2.71e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   845 KAEDADTDDNGRVKYSLL--TPTDKFAINSVTGEVTVIGALDRELWPYYALKIKARDQpkTGYQLFSVTDLIVTLEDVND 922
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG--GGPPLSSTATVTITVLDVND 78


                    ...
gi 2024456230   923 NDP 925
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
466-555 3.12e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.12e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  466 YRGAFDENAPPGTSVLTVRATDEDEGDNGFVTYTIANQKSVP-FVIDPYSGIISTSKSLDYELmQRWYHLRVWASDWGSP 544
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRES-IGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 2024456230  545 FRH-ETEVYVSL 555
Cdd:pfam00028   80 PLSsTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2384-2476 3.38e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 3.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2384 QYEAKVSEMATCGHIVIKVQALDPDSGDTTRLEYVILSGNDHRHFTINSTSGIISMFNRCKKDLESSYSLRVSASDG--- 2460
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 2024456230 2461 VFKSTVPVYINTTNAN 2476
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3242-3322 4.77e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 4.77e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3242 SALTRDNTENTEIKYEIVNGNDHGKFQLNSNTGALYINGSLDFEASHEYYLSIEGTRKGSASLSDVTMVVINITDINDHA 3321
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024456230  3322 P 3322
Cdd:smart00112   81 P 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3777-3921 6.39e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 83.62  E-value: 6.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3777 AVRFGGHSYIWY--QHSQVGSWHMHFRMKTHQLHAVVFYA---NGTDHAMLEMVHG--VLHLGYGcWGNYTgnLSSSRFV 3849
Cdd:cd00110      1 GVSFSGSSYVRLptLPAPRTRLSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGrlVLRYDLG-SGSLV--LSSKTPL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024456230 3850 SDGEWHSVFLEVKNASVRLLVDGLGNTSLQLPGTCSTSQGRRDLLFGGL--RHPLQSQRVTRGFRGCLDVLAIN 3921
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLpeDLKSPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1252-1337 1.16e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1252 VQLPEREASETPlpVYRLIASDRDQGQNSQVTYTIEEE-EEGIFTINPTTGMVLSRKAF---PASEYNiLTVKATDGGSP 1327
Cdd:cd11304      4 VSVPENAPPGTV--VLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLdreEQSSYT-LTVTATDGGGP 80

                           90
                   ....*....|
gi 2024456230 1328 PLSSHVRLHI 1337
Cdd:cd11304     81 PLSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2698-2795 1.22e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2698 YTFSASEDLPEGSEIGSVKAFAED-----PIIYSLVKGtttesNKDEVFTLDEQTGALKIKKAVDHETTKWYQIDVMAHc 2772
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDsgengEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT- 75

                           90       100
                   ....*....|....*....|...
gi 2024456230 2773 SHQETELVSLVSVNIQVQDINDN 2795
Cdd:cd11304     76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-565 1.81e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.70  E-value: 1.81e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   484 RATDEDEGDNGFVTYTIANQ-KSVPFVIDPYSGIISTSKSLDYELMQRwYHLRVWASDWGSPfRHETEVYVSLMLSNVND 562
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 2024456230   563 NAP 565
Cdd:smart00112   79 NAP 81
LamG smart00282
Laminin G domain;
3797-3923 2.58e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 81.23  E-value: 2.58e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3797 HMHFRMKTHQLHAVVFYA---NGTDHAMLEMVHGVLHLGYGCwGNYTGNLSSSRF-VSDGEWHSVFLEVKNASVRLLVDG 3872
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgskGGGDYLALELRDGRLVLRYDL-GSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  3873 LGNTSLQLPGTCSTSQGRRDLLFGGLRHPLQSQR--VTRGFRGCLDVLAINGR 3923
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPlpVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3137-3217 5.39e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 5.39e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3137 SARDLDEGLNAEVVYSL-SDSANGHFSIEETTGVIRLEKPLKDSQHSAFELTVCATDQGTPqPLSALGTVTVSVVDLNEY 3215
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 2024456230  3216 LP 3217
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2930-3010 6.23e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 6.23e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2930 STIDADiSEQNRRVTCYITEGDVLGQFTVDQIEGEwtISSKKPLDREDTEKYLLKVMASDG---KFQATTEVEIFVLDIN 3006
Cdd:smart00112    1 SATDAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVN 77


                    ....
gi 2024456230  3007 DNSP 3010
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
3224-3315 6.97e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 6.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3224 YVAMVKEDVAVGTEVLNLSALTRDNTENTEIKYEIVNGNDHGKFQLNSNTGALYINGSLDFEASHEYYLSIEGTRKGSAS 3303
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230 3304 LSDVTMVVINIT 3315
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 573-661 7.25e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 7.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  573 SGSIPRDFPVGNPVATVSAIDSDE--LQRIKYEIKSGNELRHFELNPISGVISLRislRDLPSEQPLFYSLKITATDGEN 650
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|.
gi 2024456230  651 YALPTSVNITV 661
Cdd:cd11304     80 PPLSSTATVTI 90
Cadherin pfam00028
Cadherin domain;
2076-2164 1.92e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2076 YYTSVQDGMEPGDVLFQVSATDKDIGNNAAITYSFAED--YKYFWIDPYLGDISLKKPLDYHALNKYSLRVIAKDNGEPP 2153
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024456230 2154 LLAEEEVVISV 2164
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1665-1755 3.72e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 3.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1665 EYITEISESAAVGSPLIQVS-----TSSSSPVSYEIKDGNGDGVFSMNYQSGLISTQKNLDFEQVSFYQLKVRGTNMAGA 1739
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024456230 1740 FM--DTMVLIYVIDENDN 1755
Cdd:cd11304     81 PLssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
722-813 3.75e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 3.75e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  722 RSIDIIENVPINSTIADLSAVDPDTGFNGKLVYVISDGNVDSCFTIDLELGLLQILSPLDHERTSFYILNITVYDLGTPQ 801
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230  802 KSSWKLLAVNVL 813
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2506-2584 6.21e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 6.21e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2506 AIDPDGGPYGTIDYTIINKLADEKFSID-NKGHITTLQKLDREnsTERVIAIKVMAKDGGG--KVAFCTVKIILTDENDN 2582
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDpETGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                    ..
gi 2024456230  2583 PP 2584
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
3434-3525 1.29e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 1.29e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3434 YSVVVQENAPVGTSVLELIMSDRDSPENGPPySFQITQGNDGKAFDV-TQNGLLVTSSILNRRVKEQYLLQVQVSDSGIP 3512
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI-FYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024456230 3513 PLSSSAFVNIQVT 3525
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 369-457 2.87e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 2.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  369 VYRVQLSEFSPPGSQVAMVKIT----PVLPNLKYVLRPTPDSTHFKINPHTGLITTVRAMDFHEQSNFQLEVATTNS--- 441
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*...
gi 2024456230  442 --HTSATVVIDIIDCNNH 457
Cdd:cd11304     81 plSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3126-3209 3.63e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 3.63e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3126 NTTTKTPIAVVSARDLDEGLNAEVVYS-LSDSANGHFSIEETTGVIRLEKPLKDSQHSAFELTVCATDQGTPqPLSALGT 3204
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTAT 86


                   ....*
gi 2024456230 3205 VTVSV 3209
Cdd:pfam00028   87 VTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2590-2684 3.92e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 3.92e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2590 EYTLSIQSNVSKGSPVIQVLAYDADEGANADVVYSVdsVEDVSEDIVEINAATGVVKVKESLVGLENRAFNFKVKAEDGR 2669
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*
gi 2024456230 2670 PPHWNSLVPVSLQIV 2684
Cdd:cd11304     79 GPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1973-2067 4.15e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 4.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1973 VYTATVMENSTDEKTLTVLGV--KGYQLNEPLFYSLLNG--KERFKMIQASGVLQTKGvKFDREAQDVHEVAVEVKDNRK 2048
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdPDSGENGEVTYSIVSGneDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024456230 2049 PPRVSQATVKVYVEDVNDN 2067
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2094-2164 1.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.04e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  2094 SATDKDIGNNAAITYSFA--EDYKYFWIDPYLGDISLKKPLDYHALNKYSLRVIAKDNGEPPLLAEEEVVISV 2164
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2198-2271 1.08e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.08e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230  2198 SPEGLRLIYNIVEEDSLKLFSTDFKTGVLTVTGQLDYELQTKHSFTVRATDTALGSFS-EARVEVEVEDINDNPP 2271
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSsTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1271-1337 7.52e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 7.52e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024456230  1271 ASDRDQGQNSQVTYTI-EEEEEGIFTINPTTGMVLSRKAF---PASEYNiLTVKATDGGSPPLSSHVRLHI 1337
Cdd:smart00112    2 ATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTI 71
Cadherin pfam00028
Cadherin domain;
1252-1338 9.86e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 9.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1252 VQLPEREASETPlpVYRLIASDRDQGQNSQVTYTI-EEEEEGIFTINPTTGMVLSRKAF---PASEYNiLTVKATDGGSP 1327
Cdd:pfam00028    3 ASVPENAPVGTE--VLTVTATDPDLGPNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLdreSIGEYE-LTVEATDSGGP 79

                           90
                   ....*....|.
gi 2024456230 1328 PLSSHVRLHIS 1338
Cdd:pfam00028   80 PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
2912-3003 1.07e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2912 YKGSVIENAEPGQVIVTLSTIDADiSEQNRRVTCYITEGDVLGQFTVDQIEGEwtISSKKPLDREDTEKYLLKVMASDGK 2991
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 2024456230 2992 FQA---TTEVEIFVL 3003
Cdd:pfam00028   78 GPPlssTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2487-2577 1.64e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 1.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2487 YEAELAENAEVGTKVIELLAIDPDGGPYGTIDYTIINKLADEKFSID-NKGHITTLQKLDRENSTERVIAIKVMAKDGGG 2565
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230 2566 KVAFCTVKIILT 2577
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
156-250 1.67e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  156 YKVSIREDTPLKTVVSTLSATDADAGQNAEFYYAL--NTKSDLFTIHPTTGAVVTTGRLNSTHRGRHHLQVLAVDRMRKI 233
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*..
gi 2024456230  234 MEGNgfgnlASLTIQVE 250
Cdd:pfam00028   81 LSST-----ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1356-1446 3.59e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 3.59e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1356 HFNFAVMETDPVNHMVGVISI----EMGPSQVWFNITGGDDDMDFDIEKSTGSMVIARALDARKKSSYNLTVEVTDG--- 1428
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90       100
                   ....*....|....*....|
gi 2024456230 1429 --STTikTQAFIHVIDINQH 1446
Cdd:cd11304     81 plSST--ATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2177-2264 4.01e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 4.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2177 YRVKVPENIPPYTSILHIQARSP-EGL--RLIYNIVEEDSLKLFSTDFKTGVLTVTGQLDYELQTKHSFTVRATDTAL-G 2252
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpP 80

                           90
                   ....*....|..
gi 2024456230 2253 SFSEARVEVEVE 2264
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1999-2069 6.00e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 6.00e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024456230  1999 NEPLFYSLL--NGKERFKMIQASGVLQTKGVkFDREAQDVHEVAVEVKDNRKPPRVSQATVKVYVEDVNDNPP 2069
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
573-661 7.12e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 7.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  573 SGSIPRDFPVGNPVATVSAIDSDE--LQRIKYEIKSGNELRHFELNPISGVISLRISLRdlpSEQPLFYSLKITATDGEN 650
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLD---RESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 2024456230  651 YAL--PTSVNITV 661
Cdd:pfam00028   79 PPLssTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1693-1757 8.86e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 8.86e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024456230  1693 YEIKDGNGDGVFSMNYQSGLISTQKNLDFEQVSFYQLKVRGTNMAGAFM--DTMVLIYVIDENDNVP 1757
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLssTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3454-3532 2.57e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 2.57e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  3454 SDRDSPENGPpYSFQITQGNDGKAFDVTQN-GLLVTSSILNRRVKEQYLLQVQVSDSGIPPLSSSAFVNIQVTEQSQYAP 3532
Cdd:smart00112    3 TDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1455-1547 6.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 6.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1455 YEMRIPEDTPSGREILQVSATDKDKG--KGLIYTIhgsMDPRSTRLFQLDPSSGVLTTAEGFSSQPMPQHTLTVMVRDQE 1532
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 2024456230 1533 VPIKRNFVRVIIHVE 1547
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-146 2.98e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 2.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   41 YNATIYENSAPKTYVesyvkMGIYKTDPE----WDIRYRIASGDSSGLFKTEEHViGDfcflrIRTRSSntalLNREVKD 116
Cdd:cd11304      2 YEVSVPENAPPGTVV-----LTVSATDPDsgenGEVTYSIVSGNEDGLFSIDPST-GE-----ITTAKP----LDREEQS 66

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2024456230  117 SYMLIIKATEN-TFAYEAWAKVLIHILDRND 146
Cdd:cd11304     67 SYTLTVTATDGgGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1473-1554 5.66e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.66e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  1473 SATDKDKGKG--LIYTIHGSMDPRstrLFQLDPSSGVLTTAEGFSSQPMPQHTLTVMVRDQEVPIKRNFVRVIIHVENCN 1550
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDG---LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 2024456230  1551 LHPP 1554
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1381-1448 5.88e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 5.88e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024456230  1381 SQVWFNITGGDDDMDFDIEKSTGSMVIARALDARKKSSYNLTVEVTDGSTTIK---TQAFIHVIDINQHRP 1448
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsstATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 395-459 6.30e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 6.30e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   395 NLKYVLRPTPDSTHFKINPHTGLITTVRAMDFHEQSNFQLEVATTNSH-----TSATVVIDIIDCNNHAP 459
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpplsSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2723-2797 7.73e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 7.73e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230  2723 IIYSLVKGtttesNKDEVFTLDEQTGALKIKKAVDHETTKWYQIDVMAhCSHQETELVSLVSVNIQVQDINDNKP 2797
Cdd:smart00112   13 VTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA-TDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2385-2471 8.36e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2385 YEAKVSEMATCGHIVIKVQALDPDSGDTTRLEYVILSGNDHRHFTINSTSGIISMFNRCKKDLESSYSLRVSASDGVFK- 2463
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|
gi 2024456230 2464 --STVPVYIN 2471
Cdd:pfam00028   81 lsSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2403-2476 4.32e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 4.32e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  2403 QALDPDSGDTTRLEYVILSGNDHRHFTINSTSGIIS---MFNRckkDLESSYSLRVSASDG---VFKSTVPVYINTTNAN 2476
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITttkPLDR---EEQPEYTLTVEATDGggpPLSSTATVTITVLDVN 77
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4029-4062 5.48e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 54.18  E-value: 5.48e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024456230 4029 ECQD-NPCQNAGRCVSTQGSVRCICPSDYQGDYCT 4062
Cdd:cd00054      4 ECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3538-3622 5.63e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.17  E-value: 5.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3538 EIFITTNEEAFRGGVLGKIHATDRD--PHDTLVYTLVAEVPqEGRFSIGAADGKIIAGNKLPH---GHYLLNVTVSDG-- 3610
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDGgg 79

                           90
                   ....*....|...
gi 2024456230 3611 -TFTATTSVNIHV 3622
Cdd:cd11304     80 pPLSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
1357-1435 6.16e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 6.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1357 FNFAVMETDPVNHMVGVISI---EMGP-SQVWFNITGGDDDMDFDIEKSTGSMVIARALDARKKSSYNLTVEVTDGSTTI 1432
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ...
gi 2024456230 1433 KTQ 1435
Cdd:pfam00028   81 LSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 174-250 8.07e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 8.07e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024456230   174 SATDADAGQNAEFYYAL--NTKSDLFTIHPTTGAVVTTGRLNSTHRGRHHLQVLAVDRMRKIMEGNgfgnlASLTIQVE 250
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSST-----ATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-661 2.96e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 2.96e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230   590 SAIDSDELQ--RIKYEIKSGNELRHFELNPISGVISLRISL-RdlpsEQPLFYSLKITATDGENYALPTSVNITV 661
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLdR----EEQPEYTLTVEATDGGGPPLSSTATVTI 71
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3953-3986 4.82e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 4.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024456230 3953 CSS-NPCLNNGMCSETHGGgYTCICPGLFSGERCE 3986
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4029-4062 5.41e-08

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 51.32  E-value: 5.41e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024456230 4029 ECQD-NPCQNAGRCVSTQGSVRCICPSDYQGD-YCT 4062
Cdd:cd00053      1 ECAAsNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
Cadherin pfam00028
Cadherin domain;
1974-2062 5.75e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1974 YTATVMENSTDEKTLTVLGVKGYQL--NEPLFYSLLNGKER--FKMIQASGVLQTKGVkFDREAQDVHEVAVEVKDNRKP 2049
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024456230 2050 PRVSQATVKVYVE 2062
Cdd:pfam00028   80 PLSSTATVTITVL 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4030-4060 5.79e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 51.23  E-value: 5.79e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024456230 4030 CQDNPCQNAGRCVSTQGSVRCICPSDYQGDY 4060
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
2591-2683 6.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.69  E-value: 6.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2591 YTLSIQSNVSKGSPVIQVLAYDADEGANADVVYSVdsVEDVSEDIVEINAATGVVKVKESLVGLENRAFNFKVKAEDGRP 2670
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 2024456230 2671 PHWNSLVPVSLQI 2683
Cdd:pfam00028   79 PPLSSTATVTITV 91
Laminin_G_1 pfam00054
Laminin G domain;
3803-3923 1.02e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 53.47  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3803 KTHQLHAVVFY---ANGTDHAMLEMVHGVLHLGYGCwGNYTGNLSSSRFVSDGEWHSVFLEVKNASVRLLVDGLGNTSLQ 3879
Cdd:pfam00054    2 RTTEPSGLLLYngtQTERDFLALELRDGRLEVSYDL-GSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2024456230 3880 LPGTcSTSQG--RRDLLFGGLRHPLQSQR---VTRGFRGCLDVLAINGR 3923
Cdd:pfam00054   81 SPLG-ATTDLdvDGPLYVGGLPSLGVKKRrlaISPSFDGCIRDVIVNGK 128
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3992-4024 1.25e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 1.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024456230 3992 CESK-PCLHGGTCVLSGSGYSCHCPEWYLGDRCE 4024
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3953-3984 1.54e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.07  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024456230 3953 CSSNPCLNNGMCSEThGGGYTCICPGLFSGER 3984
Cdd:pfam00008    1 CAPNPCSNGGTCVDT-PGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
1666-1750 1.65e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1666 YITEISESAAVGSPLIQVS-----TSSSSPVSYEIKDGNGDGVFSMNYQSGLISTQKNLDFEQVSFYQLKVRGTNMAGAF 1740
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTatdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024456230 1741 MD--TMVLIYVI 1750
Cdd:pfam00028   81 LSstATVTITVL 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3992-4022 2.80e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 49.30  E-value: 2.80e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024456230 3992 CESKPCLHGGTCVLSGSGYSCHCPEWYLGDR 4022
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
4029-4062 4.06e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 4.06e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024456230  4029 ECQ-DNPCQNAGRCVSTQGSVRCICPSDYQ-GDYCT 4062
Cdd:smart00179    4 ECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
2698-2790 4.21e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 4.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2698 YTFSASEDLPEGSEIGSVKAfaEDP-------IIYSLVKGtttesNKDEVFTLDEQTGALKIKKAVDHETTKWYQIDVMA 2770
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTA--TDPdlgpngrIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|
gi 2024456230 2771 HcSHQETELVSLVSVNIQVQ 2790
Cdd:pfam00028   74 T-DSGGPPLSSTATVTITVL 92
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3991-4024 5.35e-07

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 48.63  E-value: 5.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024456230 3991 PCE-SKPCLHGGTCVLSGSGYSCHCPEWYLGD-RCE 4024
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF smart00181
Epidermal growth factor-like domain;
4029-4061 5.91e-06

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 45.59  E-value: 5.91e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2024456230  4029 ECQD-NPCQNaGRCVSTQGSVRCICPSDYQGD-YC 4061
Cdd:smart00181    1 ECASgGPCSN-GTCINTPGSYTCSCPPGYTGDkRC 34
Cadherin pfam00028
Cadherin domain;
370-452 9.75e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.91  E-value: 9.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230  370 YRVQLSEFSPPGSQVAMVKIT----PVLPNLKYVLRPTPDSTHFKINPHTGLITTVRAMDFHEQSNFQLEVATTNSH--- 442
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 2024456230  443 --TSATVVIDII 452
Cdd:pfam00028   81 lsSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3992-4024 1.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 1.41e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024456230  3992 CESK-PCLHGGTCV-LSGSgYSCHCPE-WYLGDRCE 4024
Cdd:smart00179    5 CASGnPCQNGGTCVnTVGS-YRCECPPgYTDGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2610-2684 1.61e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 1.61e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024456230  2610 AYDADEGANADVVYSVDSveDVSEDIVEINAATGVVKVKESLVGLENRAFNFKVKAEDGRPPHWNSLVPVSLQIV 2684
Cdd:smart00112    2 ATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3953-3986 1.82e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.39  E-value: 1.82e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024456230 3953 CS-SNPCLNNGMCSETHGGgYTCICPGLFSGE-RCE 3986
Cdd:cd00053      2 CAaSNPCSNGGTCVNTPGS-YRCVCPPGYTGDrSCE 36
Cadherin pfam00028
Cadherin domain;
1886-1960 1.97e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 1.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 1886 VHPGMELLSVQAKDADSE----VTYSIVEGNLDNAFYIHPLTGLVSIlnATGL----GNHHELTVRADDGLYK---STAL 1954
Cdd:pfam00028    9 APVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDIST--TKPLdresIGEYELTVEATDSGGPplsSTAT 86


                   ....*.
gi 2024456230 1955 VKLNLT 1960
Cdd:pfam00028   87 VTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3953-3986 2.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.92e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024456230  3953 CSS-NPCLNNGMCSETHgGGYTCICP-GLFSGERCE 3986
Cdd:smart00179    5 CASgNPCQNGGTCVNTV-GSYRCECPpGYTDGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-149 4.08e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 4.08e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230    66 TDPEWDIRYRIASGDSSGLFkteehvigdfcflRIRTRS---SNTALLNREVKDSYMLIIKATEN-TFAYEAWAKVLIHI 141
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLF-------------SIDPETgeiTTTKPLDREEQPEYTLTVEATDGgGPPLSSTATVTITV 73


                    ....*...
gi 2024456230   142 LDRNDLKP 149
Cdd:smart00112   74 LDVNDNAP 81
EGF smart00181
Epidermal growth factor-like domain;
3991-4024 6.67e-05

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 42.50  E-value: 6.67e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024456230  3991 PCESK-PCLHGgTCVLSGSGYSCHCPEWYLGD-RCE 4024
Cdd:smart00181    1 ECASGgPCSNG-TCINTPGSYTCSCPPGYTGDkRCE 35
Cadherin pfam00028
Cadherin domain;
41-127 3.28e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 3.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230   41 YNATIYENSAPKTYVesyVKMGIYKTD--PEWDIRYRIASGDSSGLFKTEEHViGDfcflrIRTRSSntalLNREVKDSY 118
Cdd:pfam00028    1 YSASVPENAPVGTEV---LTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDT-GD-----ISTTKP----LDRESIGEY 67


                   ....*....
gi 2024456230  119 MLIIKATEN 127
Cdd:pfam00028   68 ELTVEATDS 76
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 3997-4015 5.92e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.62  E-value: 5.92e-04
                           10
                   ....*....|....*....
gi 2024456230 3997 CLHGGTCVLSGSGYSCHCP 4015
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCP 19
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1080-1135 6.65e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.95  E-value: 6.65e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024456230 1080 SVFSIEKDTGTIRTIGPLDREGTSHYWLTVLALDLGTVPLSSATEIYIEVTDTNDN 1135
Cdd:cd00031     43 SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 4035-4061 9.16e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 9.16e-04
                           10        20
                   ....*....|....*....|....*..
gi 2024456230 4035 CQNAGRCVSTQGsvRCICPSDYQGDYC 4061
Cdd:pfam07974    2 CSGRGTCVNQCG--KCVCDSGYQGATC 26
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3018-3110 1.04e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.18  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 3018 TGRVSEDAQPGHFILKISAtdpDVGSNAQITYSLHGPGAEE----FRLGPHTGELTTSAPLDREQKPTYHLVAKATDGGG 3093
Cdd:cd00031      3 DGSAVEGRSRGSFRVSIPT---DLIASSGEIIKISAAGKEAlpswLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                           90
                   ....*....|....*....
gi 2024456230 3094 RSCQADITLTIE--DTNDN 3110
Cdd:cd00031     80 NVPQTSSVFSIEvyDENDN 98
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 4030-4061 1.33e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 1.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024456230 4030 CQDNP--C-QNAgRCVSTQGSVRCICPSDYQGD--YC 4061
Cdd:pfam12947    1 CSDNNggChPNA-TCTNTGGSFTCTCNDGYTGDgvTC 36
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2808-2903 1.48e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.79  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024456230 2808 VMENMPSGTTVIQVTAN-DQDTGSDGQVTyslEAESGKLRGLFTIDGETGWITTLKELDCETQETYRFYVVA-TDHGRKV 2885
Cdd:cd00031      6 AVEGRSRGSFRVSIPTDlIASSGEIIKIS---AAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAaSLGANVP 82

                           90
                   ....*....|....*...
gi 2024456230 2886 QLSSQtlVEVTVSDENDN 2903
Cdd:cd00031     83 QTSSV--FSIEVYDENDN 98
EGF smart00181
Epidermal growth factor-like domain;
3947-3986 2.08e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 2.08e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024456230  3947 CSPTGACSSNPCLNNGmcsethgGGYTCICPGLFSG-ERCE 3986
Cdd:smart00181    2 CASGGPCSNGTCINTP-------GSYTCSCPPGYTGdKRCE 35
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4035-4056 5.60e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.93  E-value: 5.60e-03
                           10        20
                   ....*....|....*....|..
gi 2024456230 4035 CQNAGRCVSTQGSVRCICPSDY 4056
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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