NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2024488129|ref|XP_040522740|]
View 

beta/gamma crystallin domain-containing protein 1 isoform X3 [Gallus gallus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG1 cd23464
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
 1382-1518 2.11e-88

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


:

Pssm-ID: 467342  Cd Length: 137  Bit Score: 283.23  E-value: 2.11e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1382 QKRVYFRLRNKETGKFMSTDGNLDNLNLLRIQAAEDVDSDDQIWLYQDGFIRCRMAEDCCLTIVGNLITPGSKLGLSFER 1461
Cdd:cd23464      1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAEDCCLETVGNLVTAGSKLGLSLEQ 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024488129 1462 NEDKQYWHISPDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEKLTQCWEPLVV 1518
Cdd:cd23464     81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRWEVEIL 137
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1022-1110 4.24e-35

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 128.77  E-value: 4.24e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1022 KVVIYEKPFFEGRHVEVESEIFTLSDkeseektRLSLTSVGSIKVLGGVWVAYEKPGFEGHQYLLEEGEYRDWTDWGGYD 1101
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQE-------RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPN 73


                   ....*....
gi 2024488129 1102 EELQSLRPV 1110
Cdd:pfam00030   74 DRIGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1301-1380 9.87e-29

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 110.66  E-value: 9.87e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1301 IALFEKVGFQGRKIEFTTEVLNLQFLGYNPRIASVQVLGGTWIIYEHSNYRGRQMLLSPNEIPDWYKLSGCC-QIGSLRP 1379
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNdRIGSLRP 81


                   .
gi 2024488129 1380 L 1380
Cdd:pfam00030   82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1118-1201 5.11e-27

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 105.65  E-value: 5.11e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1118 HMIMYSEKDFgsKGSNINVLGIVSNLKDTGYGLRTQSINVLSGVWVAYENPEFTGEQYILDKGLYPNIEAWGGKNCKISS 1197
Cdd:pfam00030    1 KIVLYEKENF--QGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGS 78


                   ....
gi 2024488129 1198 VQPI 1201
Cdd:pfam00030   79 LRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 927-1008 1.88e-20

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 86.78  E-value: 1.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  927 QIDLYTEPEGLGIVTSFFDDTEETGVFGSTQKTCSIKVHWGIWLIYEEPGFQGVPLMLEPGEYPNLAFWEKKEAYIRSMR 1006
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                   ..
gi 2024488129 1007 PL 1008
Cdd:pfam00030   81 PI 82
Crystall super family cl02528
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1214-1292 1.53e-15

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


The actual alignment was detected with superfamily member pfam00030:

Pssm-ID: 470604  Cd Length: 82  Bit Score: 72.91  E-value: 1.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1214 KVQLFSEPEFKGNCQILEKNTGCIDSFT----VKSSKVLGGSCIVFDQEEFSGNQYVLEEGIYPDLMAMGCSSqAALKSL 1289
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGfnsrVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPN-DRIGSL 79


                   ...
gi 2024488129 1290 RII 1292
Cdd:pfam00030   80 RPI 82
Crystall super family cl02528
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 829-917 4.67e-10

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


The actual alignment was detected with superfamily member smart00247:

Pssm-ID: 470604  Cd Length: 82  Bit Score: 57.52  E-value: 4.67e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129   829 KLVIYCESDNQENVIEVFHDVL---DCSSWvlSPTILVKVIRGCWILYEKPNFEGPSIPLEEGELELPDIWGAgeeQNEC 905
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPslqDYGSR--DNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGG---FNDQ 75

                            90
                    ....*....|..
gi 2024488129   906 gslkpavIGSIR 917
Cdd:smart00247   76 -------ISSIR 80
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG1 cd23464
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
 1382-1518 2.11e-88

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467342  Cd Length: 137  Bit Score: 283.23  E-value: 2.11e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1382 QKRVYFRLRNKETGKFMSTDGNLDNLNLLRIQAAEDVDSDDQIWLYQDGFIRCRMAEDCCLTIVGNLITPGSKLGLSFER 1461
Cdd:cd23464      1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAEDCCLETVGNLVTAGSKLGLSLEQ 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024488129 1462 NEDKQYWHISPDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEKLTQCWEPLVV 1518
Cdd:cd23464     81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRWEVEIL 137
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1022-1110 4.24e-35

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 128.77  E-value: 4.24e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1022 KVVIYEKPFFEGRHVEVESEIFTLSDkeseektRLSLTSVGSIKVLGGVWVAYEKPGFEGHQYLLEEGEYRDWTDWGGYD 1101
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQE-------RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPN 73


                   ....*....
gi 2024488129 1102 EELQSLRPV 1110
Cdd:pfam00030   74 DRIGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1301-1380 9.87e-29

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 110.66  E-value: 9.87e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1301 IALFEKVGFQGRKIEFTTEVLNLQFLGYNPRIASVQVLGGTWIIYEHSNYRGRQMLLSPNEIPDWYKLSGCC-QIGSLRP 1379
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNdRIGSLRP 81


                   .
gi 2024488129 1380 L 1380
Cdd:pfam00030   82 I 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1022-1110 1.31e-27

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 107.21  E-value: 1.31e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1022 KVVIYEKPFFEGRHVEVESEIFTLSDkeseektRLSLTSVGSIKVLGGVWVAYEKPGFEGHQYLLEEGEYRDWTDWGGYD 1101
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQD-------YGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFN 73


                    ....*....
gi 2024488129  1102 EELQSLRPV 1110
Cdd:smart00247   74 DQISSIRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1118-1201 5.11e-27

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 105.65  E-value: 5.11e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1118 HMIMYSEKDFgsKGSNINVLGIVSNLKDTGYGLRTQSINVLSGVWVAYENPEFTGEQYILDKGLYPNIEAWGGKNCKISS 1197
Cdd:pfam00030    1 KIVLYEKENF--QGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGS 78


                   ....
gi 2024488129 1198 VQPI 1201
Cdd:pfam00030   79 LRPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1301-1380 1.31e-25

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 101.82  E-value: 1.31e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1301 IALFEKVGFQGRKIEFTTEVLNLQFLGYNPRIASVQVLGGTWIIYEHSNYRGRQMLLSPNEIPDWYKLSGCC-QIGSLRP 1379
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81


                    .
gi 2024488129  1380 L 1380
Cdd:smart00247   82 I 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1118-1201 5.45e-21

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 88.33  E-value: 5.45e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1118 HMIMYSEKDFGskGSNINVLGIVSNLKDTGYGLRTQSINVLSGVWVAYENPEFTGEQYILDKGLYPNIEAWGGKNCKISS 1197
Cdd:smart00247    1 KITLYEDENFQ--GRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISS 78


                    ....
gi 2024488129  1198 VQPI 1201
Cdd:smart00247   79 IRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 927-1008 1.88e-20

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 86.78  E-value: 1.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  927 QIDLYTEPEGLGIVTSFFDDTEETGVFGSTQKTCSIKVHWGIWLIYEEPGFQGVPLMLEPGEYPNLAFWEKKEAYIRSMR 1006
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                   ..
gi 2024488129 1007 PL 1008
Cdd:pfam00030   81 PI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 927-1008 5.82e-16

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 74.08  E-value: 5.82e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129   927 QIDLYTEPEGLGIVTSFFDDTEETGVFGSTQKTCSIKVHWGIWLIYEEPGFQGVPLMLEPGEYPNLAFWEKKEAYIRSMR 1006
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIR 80


                    ..
gi 2024488129  1007 PL 1008
Cdd:smart00247   81 RI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1214-1292 1.53e-15

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 72.91  E-value: 1.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1214 KVQLFSEPEFKGNCQILEKNTGCIDSFT----VKSSKVLGGSCIVFDQEEFSGNQYVLEEGIYPDLMAMGCSSqAALKSL 1289
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGfnsrVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPN-DRIGSL 79


                   ...
gi 2024488129 1290 RII 1292
Cdd:pfam00030   80 RPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1214-1292 1.39e-11

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 61.76  E-value: 1.39e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1214 KVQLFSEPEFKGNCQILEKNTGCIDSF----TVKSSKVLGGSCIVFDQEEFSGNQYVLEEGIYPDLMAMGCSSqAALKSL 1289
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQDYgsrdNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFN-DQISSI 79


                    ...
gi 2024488129  1290 RII 1292
Cdd:smart00247   80 RRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 829-917 4.67e-10

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 57.52  E-value: 4.67e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129   829 KLVIYCESDNQENVIEVFHDVL---DCSSWvlSPTILVKVIRGCWILYEKPNFEGPSIPLEEGELELPDIWGAgeeQNEC 905
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPslqDYGSR--DNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGG---FNDQ 75

                            90
                    ....*....|..
gi 2024488129   906 gslkpavIGSIR 917
Cdd:smart00247   76 -------ISSIR 80
RICIN smart00458
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.
 1391-1513 2.09e-08

Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.


Pssm-ID: 214672 [Multi-domain]  Cd Length: 118  Bit Score: 54.05  E-value: 2.09e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1391 NKETGKFMSTDGNLDNLNLlriqAAEDVDSDDQIW-LYQDGFIRCrMAEDCCLTIVGNLitpGSKLGL-SFERNEDKQYW 1468
Cdd:smart00458    3 SGNTGKCLDVNGNKNPVGL----FDCHGTGGNQLWkLTSDGAIRI-KDTDLCLTANGNT---GSTVTLySCDGTNDNQYW 74

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 2024488129  1469 HISPDGRIYSKmKPKLVLDIKGGTqyDRDHVVVNTVNeEKLTQCW 1513
Cdd:smart00458   75 EVNKDGTIRNP-DSGKCLDVKDGN--TGTKVILWTCS-GNPNQKW 115
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 836-919 5.44e-08

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 51.34  E-value: 5.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  836 SDNQENVIEVFHDVlDCSSwvlsptilVKVIRGCWILYEKPNFEGPSIPLEEGELELPDIWGAGEEQnecgslkpavIGS 915
Cdd:pfam00030   18 TDDCPSLQERGFNS-RVNS--------IRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR----------IGS 78


                   ....
gi 2024488129  916 IRHV 919
Cdd:pfam00030   79 LRPI 82
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG1 cd23464
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
 1382-1518 2.11e-88

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467342  Cd Length: 137  Bit Score: 283.23  E-value: 2.11e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1382 QKRVYFRLRNKETGKFMSTDGNLDNLNLLRIQAAEDVDSDDQIWLYQDGFIRCRMAEDCCLTIVGNLITPGSKLGLSFER 1461
Cdd:cd23464      1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAEDCCLETVGNLVTAGSKLGLSLEQ 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024488129 1462 NEDKQYWHISPDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEKLTQCWEPLVV 1518
Cdd:cd23464     81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRWEVEIL 137
beta-trefoil_Ricin_CRYBG cd23430
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin ...
 1385-1517 1.08e-59

ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin domain-containing protein (CRYBG) family; The CRYBG family includes three members: CRYBG1, CRYBG2, and CRYBG3/vlAKAP. CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG2 is also called absent in melanoma 1-like protein (AIM1L). CRYBG3/vlAKAP, also called very large A-kinase anchor protein, is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). CRYBG proteins belong to the beta/gamma-crystallin family. They all contain a ricin B-type lectin domain with a beta-trefoil fold at the C-terminus. The beta-trefoil fold is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467308 [Multi-domain]  Cd Length: 133  Bit Score: 200.89  E-value: 1.08e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1385 VYFRLRNKETGKFMSTDGNLDNLNLLRIQAAEDVDSDDQIWLYQDGFIRCRMAEDCCLTIVGNLITPGSKLGLSFERNED 1464
Cdd:cd23430      1 VYFRLRNKATGLFLSVNGNLEDLKLLRVQVMPDVGADDQIWYYQEGLIKCRIAEDCCLTVIGSLVTPGSKVGLWLEQNAD 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024488129 1465 KQYWHISPDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEKLTQCWEPLV 1517
Cdd:cd23430     81 RQFWSLKSDGRIYSKLKPNLVLDVKGGTQYDQNHVILNTPSEEKFTQVWEIMV 133
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1022-1110 4.24e-35

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 128.77  E-value: 4.24e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1022 KVVIYEKPFFEGRHVEVESEIFTLSDkeseektRLSLTSVGSIKVLGGVWVAYEKPGFEGHQYLLEEGEYRDWTDWGGYD 1101
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQE-------RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPN 73


                   ....*....
gi 2024488129 1102 EELQSLRPV 1110
Cdd:pfam00030   74 DRIGSLRPI 82
beta-trefoil_Ricin_CRYBG2 cd23465
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
 1382-1514 1.30e-31

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467343  Cd Length: 136  Bit Score: 120.74  E-value: 1.30e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1382 QKRVYFRLRNKETGKFMSTDGNLDNLNLLRIQAAEDVDSDDQIWLYQDGFIRCRMAEDCCLTIVGNlITPGSKLGLSFER 1461
Cdd:cd23465      1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGP-PDNGAKVVLWSET 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024488129 1462 NEDKQYWHISPDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEKLTQCWE 1514
Cdd:cd23465     80 RQPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWD 132
beta-trefoil_Ricin_vlAKAP cd23463
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein ...
 1382-1514 4.72e-31

ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein (vlAKAP) and similar proteins; vlAKAP, also called beta/gamma crystallin domain-containing protein 3 (CRYBG3), is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). vlAKAP belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467341  Cd Length: 136  Bit Score: 119.08  E-value: 4.72e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1382 QKRVYFRLRNKETGKFMSTDGNLDNLNLLRIQAAEDVDSDDQIWLYQDGFIRCRmAEDCCLTIVGNLITPGSKLGLSFER 1461
Cdd:cd23463      1 QPRVYLRIKNRAQGLYLTTEGNLADPRATSVCVSQYNGKDTQIWYYCRGLLKSK-ANDACLDVIGGKDNPGSKVALWTEH 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024488129 1462 NEDKQYWHISPDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEKLTQCWE 1514
Cdd:cd23463     80 GKTHQKWRINEDGTISSHLSDDLVLDLKGGNYYDKDHLIVNNPEEDQQTQKWD 132
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1301-1380 9.87e-29

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 110.66  E-value: 9.87e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1301 IALFEKVGFQGRKIEFTTEVLNLQFLGYNPRIASVQVLGGTWIIYEHSNYRGRQMLLSPNEIPDWYKLSGCC-QIGSLRP 1379
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNdRIGSLRP 81


                   .
gi 2024488129 1380 L 1380
Cdd:pfam00030   82 I 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1022-1110 1.31e-27

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 107.21  E-value: 1.31e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1022 KVVIYEKPFFEGRHVEVESEIFTLSDkeseektRLSLTSVGSIKVLGGVWVAYEKPGFEGHQYLLEEGEYRDWTDWGGYD 1101
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQD-------YGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFN 73


                    ....*....
gi 2024488129  1102 EELQSLRPV 1110
Cdd:smart00247   74 DQISSIRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1118-1201 5.11e-27

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 105.65  E-value: 5.11e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1118 HMIMYSEKDFgsKGSNINVLGIVSNLKDTGYGLRTQSINVLSGVWVAYENPEFTGEQYILDKGLYPNIEAWGGKNCKISS 1197
Cdd:pfam00030    1 KIVLYEKENF--QGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGS 78


                   ....
gi 2024488129 1198 VQPI 1201
Cdd:pfam00030   79 LRPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1301-1380 1.31e-25

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 101.82  E-value: 1.31e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1301 IALFEKVGFQGRKIEFTTEVLNLQFLGYNPRIASVQVLGGTWIIYEHSNYRGRQMLLSPNEIPDWYKLSGCC-QIGSLRP 1379
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81


                    .
gi 2024488129  1380 L 1380
Cdd:smart00247   82 I 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1118-1201 5.45e-21

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 88.33  E-value: 5.45e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1118 HMIMYSEKDFGskGSNINVLGIVSNLKDTGYGLRTQSINVLSGVWVAYENPEFTGEQYILDKGLYPNIEAWGGKNCKISS 1197
Cdd:smart00247    1 KITLYEDENFQ--GRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISS 78


                    ....
gi 2024488129  1198 VQPI 1201
Cdd:smart00247   79 IRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 927-1008 1.88e-20

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 86.78  E-value: 1.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  927 QIDLYTEPEGLGIVTSFFDDTEETGVFGSTQKTCSIKVHWGIWLIYEEPGFQGVPLMLEPGEYPNLAFWEKKEAYIRSMR 1006
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                   ..
gi 2024488129 1007 PL 1008
Cdd:pfam00030   81 PI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 927-1008 5.82e-16

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 74.08  E-value: 5.82e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129   927 QIDLYTEPEGLGIVTSFFDDTEETGVFGSTQKTCSIKVHWGIWLIYEEPGFQGVPLMLEPGEYPNLAFWEKKEAYIRSMR 1006
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIR 80


                    ..
gi 2024488129  1007 PL 1008
Cdd:smart00247   81 RI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 1214-1292 1.53e-15

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 72.91  E-value: 1.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1214 KVQLFSEPEFKGNCQILEKNTGCIDSFT----VKSSKVLGGSCIVFDQEEFSGNQYVLEEGIYPDLMAMGCSSqAALKSL 1289
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGfnsrVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPN-DRIGSL 79


                   ...
gi 2024488129 1290 RII 1292
Cdd:pfam00030   80 RPI 82
beta-trefoil_Ricin_GllA-1 cd23454
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ...
 1386-1514 2.33e-13

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.


Pssm-ID: 467332 [Multi-domain]  Cd Length: 136  Bit Score: 68.50  E-value: 2.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1386 YFRLRNKETGKFMSTDGNLDNLN---LLRIQAAEDVDSddQIWLYQDGFIrCRMAEDCCLTIVGNLITPGSKLGLSFERN 1462
Cdd:cd23454      2 WFFIKSSSNGLVLDVEHGSLKSGakvVLAPLKTKDYES--QLWRYDDGYL-VNKASGLVLDIQGGVVKSGTRLVQSPKKP 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024488129 1463 EDK---QYWHISPDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEK--LTQCWE 1514
Cdd:cd23454     79 SKDannQRWGLTADGYIYLLSNPSLVLGIKGNETREGARVILQERKLQKdaLNQRWT 135
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 1214-1292 1.39e-11

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 61.76  E-value: 1.39e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1214 KVQLFSEPEFKGNCQILEKNTGCIDSF----TVKSSKVLGGSCIVFDQEEFSGNQYVLEEGIYPDLMAMGCSSqAALKSL 1289
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQDYgsrdNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFN-DQISSI 79


                    ...
gi 2024488129  1290 RII 1292
Cdd:smart00247   80 RRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 829-917 4.67e-10

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 57.52  E-value: 4.67e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129   829 KLVIYCESDNQENVIEVFHDVL---DCSSWvlSPTILVKVIRGCWILYEKPNFEGPSIPLEEGELELPDIWGAgeeQNEC 905
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPslqDYGSR--DNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGG---FNDQ 75

                            90
                    ....*....|..
gi 2024488129   906 gslkpavIGSIR 917
Cdd:smart00247   76 -------ISSIR 80
beta-trefoil_Ricin_EW29-like cd23449
ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa ...
 1386-1514 5.01e-10

ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa galactose-binding lectin (EW29) and similar proteins; EW29 is a galactose-binding lectin from the earthworm Lumbricus terrestris. It contains two ricin B-type lectin domains with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The second ricin B-type lectin domain may harbor two sugar-binding pockets in subdomains alpha and gamma. EW29 uses these two sugar-binding sites for its function as a single domain-type hemagglutinin.


Pssm-ID: 467327 [Multi-domain]  Cd Length: 128  Bit Score: 58.84  E-value: 5.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1386 YFRLRNKETGKFMS-TDGNLDNLNLLRIQAAEDVDSDDQIWlYQD---GFIRCRMaEDCCLTIvgnliTPGSKLGLS-FE 1460
Cdd:cd23449      2 YFYIKSKLNGKVLDvEGANAKPGAKVIMWEKKGGAEDNQLW-YEDevtGTIRSKL-NDFCLDA-----SGDKGLILNpYD 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024488129 1461 RNEDKQYWHISpDGRIYSKMKPKLVLDIKGGTQYDRDHVVVNTVNEEKlTQCWE 1514
Cdd:cd23449     75 PSNPKQQWKIS-GNKIQNRSNPDNVLDIKGGSKDDGARLCAWEYNGGP-NQLWD 126
RICIN smart00458
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.
 1391-1513 2.09e-08

Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.


Pssm-ID: 214672 [Multi-domain]  Cd Length: 118  Bit Score: 54.05  E-value: 2.09e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  1391 NKETGKFMSTDGNLDNLNLlriqAAEDVDSDDQIW-LYQDGFIRCrMAEDCCLTIVGNLitpGSKLGL-SFERNEDKQYW 1468
Cdd:smart00458    3 SGNTGKCLDVNGNKNPVGL----FDCHGTGGNQLWkLTSDGAIRI-KDTDLCLTANGNT---GSTVTLySCDGTNDNQYW 74

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 2024488129  1469 HISPDGRIYSKmKPKLVLDIKGGTqyDRDHVVVNTVNeEKLTQCW 1513
Cdd:smart00458   75 EVNKDGTIRNP-DSGKCLDVKDGN--TGTKVILWTCS-GNPNQKW 115
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 1386-1505 4.53e-08

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 53.53  E-value: 4.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1386 YFRLRNKETGKFMSTDGNlDNLNLLRIQAAEDVDSDDQIWLYQD-----GFIRCRmAEDCCLTIVGNLITPGSKLGLSFE 1460
Cdd:cd00161      2 TYRIVNAASGKCLDVAGG-STANGAPVQQWTCNGGANQQWTLTPvgdgyYTIRNV-ASGKCLDVAGGSTANGANVQQWTC 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2024488129 1461 RNEDKQYWHISPDGRIYSKMKPK---LVLDIKGGTQYDRDHVVVNTVN 1505
Cdd:cd00161     80 NGGDNQQWRLEPVGDGYYRIVNKhsgKCLDVSGGSTANGANVQQWTCN 127
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 836-919 5.44e-08

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 51.34  E-value: 5.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129  836 SDNQENVIEVFHDVlDCSSwvlsptilVKVIRGCWILYEKPNFEGPSIPLEEGELELPDIWGAGEEQnecgslkpavIGS 915
Cdd:pfam00030   18 TDDCPSLQERGFNS-RVNS--------IRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR----------IGS 78


                   ....
gi 2024488129  916 IRHV 919
Cdd:pfam00030   79 LRPI 82
beta-trefoil_Ricin_SCDase cd23456
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide ...
 1386-1493 4.54e-06

ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467334 [Multi-domain]  Cd Length: 122  Bit Score: 47.35  E-value: 4.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024488129 1386 YFRLRNKETGKFMSTDGNLDNLNLLRIQAAEdvDSDDQIWLY-QDGFIRCRMAEDCCLTiVGNLITPGSKLGLSFERNED 1464
Cdd:cd23456      2 YFQLKSQASGLCLDVSGGATNGANVVVYDCN--NSNSQKWYYdATGRLHSKANPGKCLD-AGGENSNGANVVLWACNDSA 78

                           90       100
                   ....*....|....*....|....*....
gi 2024488129 1465 KQYWHISpDGRIYSKMKPKLVLDIKGGTQ 1493
Cdd:cd23456     79 NQRWDFD-GNFIRSRNNTNLALDAYGSQG 106
beta-trefoil_Ricin_DCDC1 cd23427
ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein ...
 1423-1486 1.84e-05

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.


Pssm-ID: 467305  Cd Length: 146  Bit Score: 46.15  E-value: 1.84e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024488129 1423 QIWLYQDGFIRCRMAEDCCLTIVGNLITPGSKLGLSFERNED-KQYWHISPDGRIYSKMKPKLVL 1486
Cdd:cd23427     38 QQFVFEDGFISCCSNPNLVLGVQGSELGRGAEVVLVKKKPDDiNQRWILREDGHIMSKPNYDLVL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH