BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737 108 APEKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISSAVFRTVLDYYKTGIINCPDGIS 187
Cdd:cd18386     1 APEKVTLIVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISCTVFRTVLDYYKTGIINCPDGIS 80

                          90       100
                  ....*....|....*....|....
gi 2024385737 188 IPDLRDTCDYLCINFDFNTIKCQD 211
Cdd:cd18386    81 IPDLRDTCDYLCINFDFNTIKCQD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20); KCTD20, also called potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737 108 APEKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISSAVFRTVLDYYKTGIINCPDGIS 187
Cdd:cd18386     1 APEKVTLIVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISCTVFRTVLDYYKTGIINCPDGIS 80

                          90       100
                  ....*....|....*....|....
gi 2024385737 188 IPDLRDTCDYLCINFDFNTIKCQD 211
Cdd:cd18386    81 IPDLRDTCDYLCINFDFNTIKCQD 104

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737  112 VTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREynftrpNEKGEYEIaEGISSAVFRTVLDYYKTGIINCPDGiSIPDL 191
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE------SDKSEIYL-DDVSPEDFRALLNFLYTGKLDLPEE-NVEEL 73

                   ....*....
gi 2024385737  192 RDTCDYLCI 200
Cdd:smart00225  74 LELADYLQI 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20); KCTD20, also called potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737 108 APEKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISSAVFRTVLDYYKTGIINCPDGIS 187
Cdd:cd18386     1 APEKVTLIVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISCTVFRTVLDYYKTGIINCPDGIS 80

                          90       100
                  ....*....|....*....|....
gi 2024385737 188 IPDLRDTCDYLCINFDFNTIKCQD 211
Cdd:cd18386    81 IPDLRDTCDYLCINFDFNTIKCQD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737 110 EKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISSAVFRTVLDYYKTGIINCPDGISIP 189
Cdd:cd18385     3 ERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCPDGISIP 82

                          90       100
                  ....*....|....*....|....*...
gi 2024385737 190 DLRDTCDYLCINFDFNTIKCQDLSALLH 217
Cdd:cd18385    83 ELREACDYLCISFDYSTIKCRDLSALMH 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737 112 VTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREynFTRPNEKGEYEIAEgiSSAVFRTVLDYYKTGIINCPDGISIPDL 191
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGRE--FTFPNETGEYFIDR--DPTVFRTILNYYRTGKLNCPDGISIPDL 76

                  ....*..
gi 2024385737 192 RDTCDYL 198
Cdd:cd18187    77 REECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737 112 VTLVVDGTRFAVNPQIFTAHPDTMLGRM-------FGPGREYNFTRPnekgeyeiaegisSAVFRTVLDYYKTGIINCPD 184
Cdd:cd18317     1 VVLNVGGTRFELSRSTLLRFPDTRLGKLakeshayDESTNEYFFDRN-------------PEVFEAILDYYRTGELHLPS 67

                          90
                  ....*....|...
gi 2024385737 185 GISIPDLRDTCDY 197
Cdd:cd18317    68 NVCPASFKEELEF 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024385737 112 VTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPG-REYNFTRPNEKGEYEIAEgiSSAVFRTVLDYYKTGIINCPDGIS 187
Cdd:cd18370     1 VTLNVGGTLYSTTLETLTRFPDSMLGAMFRAGtPIPPNLNMQGGGHYFIDR--DGKAFRHILNFLRLGRLDLPRGYG 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024385737 109 PEKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREYNFTRpNEKGEYEIAEgiSSAVFRTVLDYYKTGIINCPDG 185
Cdd:cd18367     2 PEIVELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQELAR-DSKGRYFLDR--DGVLFRYILDYLRNQKLVLPEN 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024385737 112 VTLVVDGTRFAVNPQIFTAHPDTMLGrmfgpGREYNFTRPNEKGEYEIAEgiSSAVFRTVLDYYKTGIINCP 183
Cdd:cd18418     2 IVLNVSGTRFQTWRNTLERYPDTLLG-----SSERDFFYHEETQEYFFDR--DPDIFRHILNFYRTGKLHYP 66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024385737 110 EKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFgPGREYNFTRPNekGEYEIAEgiSSAVFRTVLDYYKTGIINCPDGIS 187
Cdd:cd18375     1 ELVTLNVGGKKFTTRPSTLRRFPDSRLARML-DGKDQDFKVVN--GQFFVDR--DGSLFSYILDYLRTGQLTLPTEFS 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024385737 109 PEKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGRE-YNFTRPNEKGEYEIAEgiSSAVFRTVLDYYKTGIINCPD 184
Cdd:cd18398     2 PEVVELNVGGQVYFTRHATLVSIPHSLLWKMFSPKRDtANDLAKDSKGRFFIDR--DGFLFRYILDYLRDRQVVLPD 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024385737 109 PEKVTLVVDGTRFAVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEgiSSAVFRTVLDYYKTGIINCPDGISI 188
Cdd:cd18414     2 SDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNFDYDPRADEFFFDR--HPGVFAHILNYYRTGKLHCPADVCG 79

                  .
gi 2024385737 189 P 189
Cdd:cd18414    80 P 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024385737 110 EKVTLVVDGTRFAVNPQIFTAHPDTMLGrmfgpGREYNFTRPNEKGEYEIAEgiSSAVFRTVLDYYKTGIINCP 183
Cdd:cd18420    36 EKLIINVSGRRFETWRNTLEKYPDTLLG-----SNEREFFYDEETKEYFFDR--DPDIFRHILNYYRTGKLHYP 102

Ran-binding protein 2, Ran binding domains; RanBP2 (also called E3 SUMO-protein ligase RanBP2, 358 kDa nucleoporin, and nuclear pore complex (NPC) protein Nup358) is a giant nucleoporin that localizes to the cytosolic face of the NPC. RanBP2 contains a leucine-rich region, 8 zinc-finger motifs, a cyclophilin A homologous domain, and 4 RanBDs. Ran is a Ras-like nuclear small GTPase, which regulates receptor-mediated transport between the nucleus and the cytoplasm. RanGTP hydrolysis is stimulated by RanGAP together with the Ran-binding domain containing acessory proteins RanBP1 and RanBP2. These accessory proteins stabilize the active GTP-bound form of Ran. All eukaryotic cells contain RanBP1, but in vertebrates however, the main RanBP seems to be RanBP2. There is no RanBP2 ortholog in yeast. Transport complex disassembly is accomplished by a small ubiquitin-related modifier-1 (SUMO-1)-modified version of RanGAP that is bound to RanBP2. RanBP1 acts as a second line of defense against exported RanGTP-importin complexes which have escaped from dissociation by RanBP2. RanBP2 also interacts with the importin subunit beta-1. RabBD shares structural similarity to the PH domain, but lacks detectable sequence similarity. The members here include human, chicken, frog, tunicates, sea urchins, ticks, sea anemones, and sponges. RanBD repeats 1 and 3 are present in this hierarchy.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2024385737 273 GEEYSQILYS--SKLYRFfkyieNRDVAKavLKERGLKNIRI 312
Cdd:cd13176     2 GEEDEEVLFShrAKLYRF-----DKDVKQ--WKERGVGDIKI 36