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Conserved domains on  [gi|2017817320|ref|XP_040213560|]
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glycine dehydrogenase (decarboxylating), mitochondrial [Rana temporaria]

Protein Classification

aminomethyl-transferring glycine dehydrogenase( domain architecture ID 1004953)

aminomethyl-transferring glycine dehydrogenase is part of the glycine cleavage system that catalyzes the degradation of glycine

EC:  1.4.4.2
PubMed:  4585091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02414 super family cl31876
glycine dehydrogenase (decarboxylating)
 50-1014 0e+00

glycine dehydrogenase (decarboxylating)


The actual alignment was detected with superfamily member PLN02414:

Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1478.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   50 ASSSSNQRQIERLFPRH------------DDFSERHIGPGDKEKREMMDTLGVQSIDELIDKTVPASIRLsRPLKM---D 114
Cdd:PLN02414     4 ARRLANRGLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIRL-DSMKLskyD 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  115 DQVCENELLETLRNIASKNKIWRSYIGMGYYNCSVPQAILRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITG 194
Cdd:PLN02414    83 EGLTESQMLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  195 MDVANASLLDEGTAAAEAMQLCHRHNKRRK--FYVDSRCHPQTIAVVQTRANYIGVTTELLLPHEMDFSGKDVSGVLFQY 272
Cdd:PLN02414   163 LPMSNASLLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQY 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  273 PDTNGKVEDFTQLVDRAHQNGTLACSATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPG 352
Cdd:PLN02414   243 PATDGEVLDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPG 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  353 RMVGVTRDATGKDVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAG 432
Cdd:PLN02414   323 RIIGVSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLG 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  433 HQLHDEMFFDTLKIHCGcPVKEVLDRAAQRQINFRLYSDGSLGVSIDETIKEKDLDDLLWVFGCESSAELVAENMNEENK 512
Cdd:PLN02414   403 FQVQSLPFFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVD 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  513 GILATAFKRTSKFLAHTVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELAPITWLEFANIHPFVPLD 592
Cdd:PLN02414   482 SSIPSSLARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVD 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  593 QAQGYQQLFRELEKDLCEITGYDNISFQPNSGAQGEYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAGMKIQ 672
Cdd:PLN02414   562 QAQGYQEMFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIV 641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  673 PVEVDKDGSIDVAHLRAMVDKHQDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPADYGSD 752
Cdd:PLN02414   642 VVGTDAKGNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGAD 721

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  753 VSHLNLHKTFCIPHGGGGPGMGPIGVKKHLTPYLPNHPVI----ALQGNDGRSLGTISAAPWGSSAILPISWAYIKMMGA 828
Cdd:PLN02414   722 VCHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptggIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGS 801

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  829 KGLKHATEIAILNANYMAKRLEKHYKILFRGSRGCVAHEFILDVRPFKKSANIEAVDIAKRLQDYGFHAPTMSWPVAGTL 908
Cdd:PLN02414   802 EGLTDASKIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTL 881

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  909 MIEPTESEDKAELDRFCDAMINIRQEIADVEEGRMDSRINPLKMSPHTLTCIASSNWDRPYTREVAAFPLPFVKpESKFW 988
Cdd:PLN02414   882 MIEPTESESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFW 960

                          970       980
                   ....*....|....*....|....*.
gi 2017817320  989 PTIARIDDIYGDQHLVCTCPPMEVYE 1014
Cdd:PLN02414   961 PTTGRVDNVYGDRNLVCTLPSAAEEE 986
 
Name Accession Description Interval E-value
PLN02414 PLN02414
glycine dehydrogenase (decarboxylating)
 50-1014 0e+00

glycine dehydrogenase (decarboxylating)


Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1478.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   50 ASSSSNQRQIERLFPRH------------DDFSERHIGPGDKEKREMMDTLGVQSIDELIDKTVPASIRLsRPLKM---D 114
Cdd:PLN02414     4 ARRLANRGLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIRL-DSMKLskyD 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  115 DQVCENELLETLRNIASKNKIWRSYIGMGYYNCSVPQAILRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITG 194
Cdd:PLN02414    83 EGLTESQMLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  195 MDVANASLLDEGTAAAEAMQLCHRHNKRRK--FYVDSRCHPQTIAVVQTRANYIGVTTELLLPHEMDFSGKDVSGVLFQY 272
Cdd:PLN02414   163 LPMSNASLLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQY 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  273 PDTNGKVEDFTQLVDRAHQNGTLACSATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPG 352
Cdd:PLN02414   243 PATDGEVLDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPG 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  353 RMVGVTRDATGKDVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAG 432
Cdd:PLN02414   323 RIIGVSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLG 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  433 HQLHDEMFFDTLKIHCGcPVKEVLDRAAQRQINFRLYSDGSLGVSIDETIKEKDLDDLLWVFGCESSAELVAENMNEENK 512
Cdd:PLN02414   403 FQVQSLPFFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVD 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  513 GILATAFKRTSKFLAHTVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELAPITWLEFANIHPFVPLD 592
Cdd:PLN02414   482 SSIPSSLARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVD 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  593 QAQGYQQLFRELEKDLCEITGYDNISFQPNSGAQGEYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAGMKIQ 672
Cdd:PLN02414   562 QAQGYQEMFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIV 641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  673 PVEVDKDGSIDVAHLRAMVDKHQDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPADYGSD 752
Cdd:PLN02414   642 VVGTDAKGNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGAD 721

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  753 VSHLNLHKTFCIPHGGGGPGMGPIGVKKHLTPYLPNHPVI----ALQGNDGRSLGTISAAPWGSSAILPISWAYIKMMGA 828
Cdd:PLN02414   722 VCHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptggIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGS 801

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  829 KGLKHATEIAILNANYMAKRLEKHYKILFRGSRGCVAHEFILDVRPFKKSANIEAVDIAKRLQDYGFHAPTMSWPVAGTL 908
Cdd:PLN02414   802 EGLTDASKIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTL 881

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  909 MIEPTESEDKAELDRFCDAMINIRQEIADVEEGRMDSRINPLKMSPHTLTCIASSNWDRPYTREVAAFPLPFVKpESKFW 988
Cdd:PLN02414   882 MIEPTESESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFW 960

                          970       980
                   ....*....|....*....|....*.
gi 2017817320  989 PTIARIDDIYGDQHLVCTCPPMEVYE 1014
Cdd:PLN02414   961 PTTGRVDNVYGDRNLVCTLPSAAEEE 986
gcvP TIGR00461
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ...
 72-1007 0e+00

glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273089 [Multi-domain]  Cd Length: 939  Bit Score: 1305.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   72 RHIGPGDKEKREMMDTLGVQSIDELIDKTVPASIRLSRPLKMDDQVCENELLETLRNIASKNKIWRSYIGMGYYNCSVPQ 151
Cdd:TIGR00461    1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  152 AILRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGMDVANASLLDEGTAAAEAMQLCHRHNKRR--KFYVDS 229
Cdd:TIGR00461   81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKanAFFVAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  230 RCHPQTIAVVQTRANYIGVttELLLPHEMDFS-GKDVSGVLFQYPDTNGKVEDFTQLVDRAHQNGTLACSATDLLALCIL 308
Cdd:TIGR00461  161 DCHPQTIEVIKTRANPFGI--EVIVGDHHTFSfSTDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  309 RPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPGRMVGVTRDATGKDVYRLALQTREQHIRRDKATSNIC 388
Cdd:TIGR00461  239 TPPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNIC 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  389 TAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAGHQLHDEMFFDTLKIHCGCPV-KEVLDRAAQRQINFR 467
Cdd:TIGR00461  319 TAQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGEQSaPAILKAAEGRGINLR 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  468 LYSDGSLGVSIDETIKEKDLDDLLWVFGCESSAELVAENMNEENKGILATAFKRTSKFLAHTVFNSYHSETNIVRYMKRL 547
Cdd:TIGR00461  399 PLVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQL 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  548 ENKDISLVHSMIPLGSCTMKLNSSSELAPITWLEFANIHPFVPLDQAQGYQQLFRELEKDLCEITGYDNISFQPNSGAQG 627
Cdd:TIGR00461  479 ESKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQG 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  628 EYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAGMKIQPVEVDKDGSIDVAHLRAMVDKHQDNLAAIMITYPS 707
Cdd:TIGR00461  559 EYAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPS 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  708 TNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPADYGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLTPYLP 787
Cdd:TIGR00461  639 THGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLP 718

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  788 NHPV---IALQGNDgRSLGTISAAPWGSSAILPISWAYIKMMGAKGLKHATEIAILNANYMAKRLEKHYKILFRGSRGCV 864
Cdd:TIGR00461  719 RHSLnstAELQGED-QSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELV 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  865 AHEFILDVRPFKKSANIEAVDIAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMINIRQEIADVEEGRMD 944
Cdd:TIGR00461  798 AHECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEID 877

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017817320  945 SRINPLKMSPHTLTCIASSNWDRPYTREVAAFPLPFVKpESKFWPTIARIDDIYGDQHLVCTC 1007
Cdd:TIGR00461  878 PADNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
GDC-P pfam02347
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ...
 71-494 0e+00

Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2


Pssm-ID: 396772 [Multi-domain]  Cd Length: 428  Bit Score: 737.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   71 ERHIGPGDKEKREMMDTLGVQSIDELIDKTVPASIRLSRPLKMDDQVCENELLETLRNIASKNKIWRSYIGMGYYNCSVP 150
Cdd:pfam02347    1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  151 QAILRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGMDVANASLLDEGTAAAEAMQLCHRHNKRR--KFYVD 228
Cdd:pfam02347   81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  229 SRCHPQTIAVVQTRANYIGVTTELLLPHEMDFSG-KDVSGVLFQYPDTNGKVEDFTQLVDRAHQNGTLACSATDLLALCI 307
Cdd:pfam02347  161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTDlKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  308 LRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPGRMVGVTRDATGKDVYRLALQTREQHIRRDKATSNI 387
Cdd:pfam02347  241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  388 CTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAGHQLHDEMFFDTLKIHCG-CPVKEVLDRAAQRQINF 466
Cdd:pfam02347  321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400

                          410       420
                   ....*....|....*....|....*...
gi 2017817320  467 RLYSDGSLGVSIDETIKEKDLDDLLWVF 494
Cdd:pfam02347  401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
GcvP2 COG1003
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ...
 509-1006 0e+00

Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440627  Cd Length: 468  Bit Score: 734.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  509 EENKGILATAFKRTSKflahtVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELAPITWLEFANIHPF 588
Cdd:COG1003      8 ADAASLLPEALLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  589 VPLDQAQGYQQLFRELEKDLCEITGYDNISFQPNSGAQGEYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAG 668
Cdd:COG1003     83 QPEETVQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  669 MKIQPVEVDKDGSIDVAHLRAMVDkhqDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPAD 748
Cdd:COG1003    163 FKVVVVKSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGD 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  749 YGSDVSHLNLHKTFCIphggggpgmgpigVKKHLTPYLPNHPVI------ALQGNDGRSLGtISAAPWGSSAILPISWAY 822
Cdd:COG1003    240 MGFDVCHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVkdgdkyRLDYDRPKSIG-RSAAFYGNAGVLVRAYAY 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  823 IKMMGAKGLKHATEIAILNANYMAKRLEKHYKILFRGSRGCvAHEFILDVRPFKKSANIEAVDIAKRLQDYGFHAPTMSW 902
Cdd:COG1003    319 IRMMGAEGLREATEVAVLNANYLAARLKDHYPVLYTGNGRC-AHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYF 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  903 P--VAGTLMIEPTESEDKAELDRFCDAMINIRQEIadveegrmDSRINPLKMSPHTLtciassnwdrpytrevaafplpf 980
Cdd:COG1003    398 PliVPETLMIEPTESESKEELDRFIDAMIAIREEA--------REDPEPLKNAPHTT----------------------- 446

                          490       500
                   ....*....|....*....|....*.
gi 2017817320  981 vkpeskfwpTIARIDDIYGDQHLVCT 1006
Cdd:COG1003    447 ---------PVRRLDEVYADRNLVLT 463
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 119-494 1.48e-172

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 509.85  E-value: 1.48e-172
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  119 ENELLETLRNIASKNKIWR---SYIGMGYYNCSVPQAILRNLLENaGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGM 195
Cdd:cd00613      1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  196 DVANASLLDEGTAAAEAMQLCHRHNK--RRKFYVDSRCHPQTIAVVQTRANYIGVTTELLLPHEM---------DFSGKD 264
Cdd:cd00613     80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  265 VSGVLFQYPDTNGKVEDF-TQLVDRAHQNGTLACSATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVR 343
Cdd:cd00613    160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  344 ENLIRMMPGRMVGVTRDATGKDVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLI 423
Cdd:cd00613    240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017817320  424 LAEGLKRAGHQLH-DEMFFDTLKIHCGCPVKEVLDRAAQRQINFRLYS-------DGSLGVSIDETIKEKDLDDLLWVF 494
Cdd:cd00613    320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPLYGIRAEDLAKALIDGGFHAptmylpvDGTLMIEPTETETKEELDALLEAL 398
 
Name Accession Description Interval E-value
PLN02414 PLN02414
glycine dehydrogenase (decarboxylating)
 50-1014 0e+00

glycine dehydrogenase (decarboxylating)


Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1478.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   50 ASSSSNQRQIERLFPRH------------DDFSERHIGPGDKEKREMMDTLGVQSIDELIDKTVPASIRLsRPLKM---D 114
Cdd:PLN02414     4 ARRLANRGLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIRL-DSMKLskyD 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  115 DQVCENELLETLRNIASKNKIWRSYIGMGYYNCSVPQAILRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITG 194
Cdd:PLN02414    83 EGLTESQMLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  195 MDVANASLLDEGTAAAEAMQLCHRHNKRRK--FYVDSRCHPQTIAVVQTRANYIGVTTELLLPHEMDFSGKDVSGVLFQY 272
Cdd:PLN02414   163 LPMSNASLLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQY 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  273 PDTNGKVEDFTQLVDRAHQNGTLACSATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPG 352
Cdd:PLN02414   243 PATDGEVLDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPG 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  353 RMVGVTRDATGKDVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAG 432
Cdd:PLN02414   323 RIIGVSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLG 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  433 HQLHDEMFFDTLKIHCGcPVKEVLDRAAQRQINFRLYSDGSLGVSIDETIKEKDLDDLLWVFGCESSAELVAENMNEENK 512
Cdd:PLN02414   403 FQVQSLPFFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVD 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  513 GILATAFKRTSKFLAHTVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELAPITWLEFANIHPFVPLD 592
Cdd:PLN02414   482 SSIPSSLARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVD 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  593 QAQGYQQLFRELEKDLCEITGYDNISFQPNSGAQGEYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAGMKIQ 672
Cdd:PLN02414   562 QAQGYQEMFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIV 641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  673 PVEVDKDGSIDVAHLRAMVDKHQDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPADYGSD 752
Cdd:PLN02414   642 VVGTDAKGNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGAD 721

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  753 VSHLNLHKTFCIPHGGGGPGMGPIGVKKHLTPYLPNHPVI----ALQGNDGRSLGTISAAPWGSSAILPISWAYIKMMGA 828
Cdd:PLN02414   722 VCHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptggIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGS 801

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  829 KGLKHATEIAILNANYMAKRLEKHYKILFRGSRGCVAHEFILDVRPFKKSANIEAVDIAKRLQDYGFHAPTMSWPVAGTL 908
Cdd:PLN02414   802 EGLTDASKIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTL 881

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  909 MIEPTESEDKAELDRFCDAMINIRQEIADVEEGRMDSRINPLKMSPHTLTCIASSNWDRPYTREVAAFPLPFVKpESKFW 988
Cdd:PLN02414   882 MIEPTESESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFW 960

                          970       980
                   ....*....|....*....|....*.
gi 2017817320  989 PTIARIDDIYGDQHLVCTCPPMEVYE 1014
Cdd:PLN02414   961 PTTGRVDNVYGDRNLVCTLPSAAEEE 986
gcvP TIGR00461
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ...
 72-1007 0e+00

glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273089 [Multi-domain]  Cd Length: 939  Bit Score: 1305.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   72 RHIGPGDKEKREMMDTLGVQSIDELIDKTVPASIRLSRPLKMDDQVCENELLETLRNIASKNKIWRSYIGMGYYNCSVPQ 151
Cdd:TIGR00461    1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  152 AILRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGMDVANASLLDEGTAAAEAMQLCHRHNKRR--KFYVDS 229
Cdd:TIGR00461   81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKanAFFVAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  230 RCHPQTIAVVQTRANYIGVttELLLPHEMDFS-GKDVSGVLFQYPDTNGKVEDFTQLVDRAHQNGTLACSATDLLALCIL 308
Cdd:TIGR00461  161 DCHPQTIEVIKTRANPFGI--EVIVGDHHTFSfSTDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  309 RPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPGRMVGVTRDATGKDVYRLALQTREQHIRRDKATSNIC 388
Cdd:TIGR00461  239 TPPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNIC 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  389 TAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAGHQLHDEMFFDTLKIHCGCPV-KEVLDRAAQRQINFR 467
Cdd:TIGR00461  319 TAQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGEQSaPAILKAAEGRGINLR 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  468 LYSDGSLGVSIDETIKEKDLDDLLWVFGCESSAELVAENMNEENKGILATAFKRTSKFLAHTVFNSYHSETNIVRYMKRL 547
Cdd:TIGR00461  399 PLVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQL 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  548 ENKDISLVHSMIPLGSCTMKLNSSSELAPITWLEFANIHPFVPLDQAQGYQQLFRELEKDLCEITGYDNISFQPNSGAQG 627
Cdd:TIGR00461  479 ESKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQG 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  628 EYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAGMKIQPVEVDKDGSIDVAHLRAMVDKHQDNLAAIMITYPS 707
Cdd:TIGR00461  559 EYAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPS 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  708 TNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPADYGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLTPYLP 787
Cdd:TIGR00461  639 THGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLP 718

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  788 NHPV---IALQGNDgRSLGTISAAPWGSSAILPISWAYIKMMGAKGLKHATEIAILNANYMAKRLEKHYKILFRGSRGCV 864
Cdd:TIGR00461  719 RHSLnstAELQGED-QSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELV 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  865 AHEFILDVRPFKKSANIEAVDIAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMINIRQEIADVEEGRMD 944
Cdd:TIGR00461  798 AHECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEID 877

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017817320  945 SRINPLKMSPHTLTCIASSNWDRPYTREVAAFPLPFVKpESKFWPTIARIDDIYGDQHLVCTC 1007
Cdd:TIGR00461  878 PADNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
GDC-P pfam02347
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ...
 71-494 0e+00

Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2


Pssm-ID: 396772 [Multi-domain]  Cd Length: 428  Bit Score: 737.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   71 ERHIGPGDKEKREMMDTLGVQSIDELIDKTVPASIRLSRPLKMDDQVCENELLETLRNIASKNKIWRSYIGMGYYNCSVP 150
Cdd:pfam02347    1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  151 QAILRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGMDVANASLLDEGTAAAEAMQLCHRHNKRR--KFYVD 228
Cdd:pfam02347   81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  229 SRCHPQTIAVVQTRANYIGVTTELLLPHEMDFSG-KDVSGVLFQYPDTNGKVEDFTQLVDRAHQNGTLACSATDLLALCI 307
Cdd:pfam02347  161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTDlKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  308 LRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPGRMVGVTRDATGKDVYRLALQTREQHIRRDKATSNI 387
Cdd:pfam02347  241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  388 CTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAGHQLHDEMFFDTLKIHCG-CPVKEVLDRAAQRQINF 466
Cdd:pfam02347  321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400

                          410       420
                   ....*....|....*....|....*...
gi 2017817320  467 RLYSDGSLGVSIDETIKEKDLDDLLWVF 494
Cdd:pfam02347  401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
GcvP2 COG1003
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ...
 509-1006 0e+00

Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440627  Cd Length: 468  Bit Score: 734.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  509 EENKGILATAFKRTSKflahtVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELAPITWLEFANIHPF 588
Cdd:COG1003      8 ADAASLLPEALLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  589 VPLDQAQGYQQLFRELEKDLCEITGYDNISFQPNSGAQGEYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAG 668
Cdd:COG1003     83 QPEETVQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  669 MKIQPVEVDKDGSIDVAHLRAMVDkhqDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPAD 748
Cdd:COG1003    163 FKVVVVKSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGD 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  749 YGSDVSHLNLHKTFCIphggggpgmgpigVKKHLTPYLPNHPVI------ALQGNDGRSLGtISAAPWGSSAILPISWAY 822
Cdd:COG1003    240 MGFDVCHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVkdgdkyRLDYDRPKSIG-RSAAFYGNAGVLVRAYAY 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  823 IKMMGAKGLKHATEIAILNANYMAKRLEKHYKILFRGSRGCvAHEFILDVRPFKKSANIEAVDIAKRLQDYGFHAPTMSW 902
Cdd:COG1003    319 IRMMGAEGLREATEVAVLNANYLAARLKDHYPVLYTGNGRC-AHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYF 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  903 P--VAGTLMIEPTESEDKAELDRFCDAMINIRQEIadveegrmDSRINPLKMSPHTLtciassnwdrpytrevaafplpf 980
Cdd:COG1003    398 PliVPETLMIEPTESESKEELDRFIDAMIAIREEA--------REDPEPLKNAPHTT----------------------- 446

                          490       500
                   ....*....|....*....|....*.
gi 2017817320  981 vkpeskfwpTIARIDDIYGDQHLVCT 1006
Cdd:COG1003    447 ---------PVRRLDEVYADRNLVLT 463
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 67-495 0e+00

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 659.41  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   67 DDFSERHIGPGDKEKREMMDTLGVQSIDELIDKtVPASIRLSRPLKMDDQVCENELLETLRNIASKNKIWRSYIGMGYYN 146
Cdd:COG0403      1 DEFAMRYIPPTEEDRAEMLAAIGVDSLDELFDD-IPAEIRLKRPLDLPEALSEAELLRHLRALAAKNKVLTSFIGAGYYD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  147 CSVPQAIlRNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGMDVANASLLDEGTAAAEAMQLCHRHNKR-RKF 225
Cdd:COG0403     80 HYVPAVV-RNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRsNKV 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  226 YVDSRCHPQTIAVVQTRANYIGVTTELLLPHE--MDFS------GKDVSGVLFQYPDTNGKVEDFTQLVDRAHQNGTLAC 297
Cdd:COG0403    159 LVSEDVHPQTRAVLKTYAEPLGIEVVEVPDEDgvTDLEalkallDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVI 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  298 SATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPGRMVGVTRDATGKDVYRLALQTREQH 377
Cdd:COG0403    239 VAADPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQH 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  378 IRRDKATSNICTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRAGHQL-HDEMFFDTLKIHCGCPVKEVL 456
Cdd:COG0403    319 IRREKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALGVEVpFNGPFFDEFVVRLPKPAAEIN 398

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2017817320  457 DRAAQRQI----NFRLYSDGSLGVSIDETIKEKDLDDLLWVFG 495
Cdd:COG0403    399 AALLEKGIlgglNLRRVDDDTLLVAVTETTTKEDIDALVEALA 441
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 119-494 1.48e-172

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 509.85  E-value: 1.48e-172
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  119 ENELLETLRNIASKNKIWR---SYIGMGYYNCSVPQAILRNLLENaGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGM 195
Cdd:cd00613      1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  196 DVANASLLDEGTAAAEAMQLCHRHNK--RRKFYVDSRCHPQTIAVVQTRANYIGVTTELLLPHEM---------DFSGKD 264
Cdd:cd00613     80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  265 VSGVLFQYPDTNGKVEDF-TQLVDRAHQNGTLACSATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVR 343
Cdd:cd00613    160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  344 ENLIRMMPGRMVGVTRDATGKDVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLI 423
Cdd:cd00613    240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017817320  424 LAEGLKRAGHQLH-DEMFFDTLKIHCGCPVKEVLDRAAQRQINFRLYS-------DGSLGVSIDETIKEKDLDDLLWVF 494
Cdd:cd00613    320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPLYGIRAEDLAKALIDGGFHAptmylpvDGTLMIEPTETETKEELDALLEAL 398
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 537-928 8.17e-160

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 476.72  E-value: 8.17e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  537 ETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELAPITW-LEFANIHPFVPLDQAQGYQQLFRELEKDLCEITGYD 615
Cdd:cd00613      1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILeNEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  616 --NISFQPNSGAQGEYAGLAAIKAYLngkgerHRTVCLIPKSAHGTNPASAQMA----GMKIQPVEVDKDGSIDvahLRA 689
Cdd:cd00613     81 vaNASLQDEATAAAEAAGLAAIRAYH------KRNKVLVPDSAHPTNPAVARTRgeplGIEVVEVPSDEGGTVD---LEA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  690 MVDKHQDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQvGLCRPADYGSDVSHLNLHKTF------- 762
Cdd:cd00613    152 LKEEVSEEVAALMVQYPNTLGVFEDLIKEIADIAHSAGALVYVDGDNLNLT-GLKPPGEYGADIVVGNLQKTGvphgggg 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  763 ------CiphggggpgmgpigVKKHLTPYLPNHPVIALQGNDGRSLGTISAA---------------PWGSSAILPISWA 821
Cdd:cd00613    231 pgagffA--------------VKKELVRFLPGRLVGVTKDAEGNRAFRLALQtreqhirrekatsniCTGQALLALMAAM 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  822 YIKMMGAKGLKHATEIAILNANYMAKRLEKHYKILFRGSRgcVAHEFILDVRPFkksANIEAVDIAKRLQDYGFHAPTMS 901
Cdd:cd00613    297 YIVYLGPEGLKEIAERAHLNANYLAKRLKEVGGVLPFNGP--FFHEFVLRLPPL---YGIRAEDLAKALIDGGFHAPTMY 371

                          410       420
                   ....*....|....*....|....*..
gi 2017817320  902 WPVAGTLMIEPTESEDKAELDRFCDAM 928
Cdd:cd00613    372 LPVDGTLMIEPTETETKEELDALLEAL 398
PRK04366 PRK04366
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
536-958 3.72e-141

aminomethyl-transferring glycine dehydrogenase subunit GcvPB;


Pssm-ID: 235292  Cd Length: 481  Bit Score: 431.46  E-value: 3.72e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  536 SETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNssselaP-----ITWLE-FANIHPFVPLDQAQGYQQLFRELEKDLC 609
Cdd:PRK04366    50 SELEVVRHYTRLSQKNYGVDTGFYPLGSCTMKYN------PkinekVARLPgFAELHPLQPEETVQGALELMYELQEWLK 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  610 EITGYDNISFQPNSGAQGEYAGLAAIKAYLNGKGERHRTVCLIPKSAHGTNPASAQMAGMKIQPVEVDKDGSIDVAHLRA 689
Cdd:PRK04366   124 EITGMDAVTLQPAAGAHGELTGLLMIRAYHEARGDTKRTEVIVPDSAHGTNPASAAMAGFKVVEIPSNEDGLVDLEALKA 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  690 MVDkhqDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVGLCRPADYGSDVSHLNLHKTFCIPHGGG 769
Cdd:PRK04366   204 AVG---EDTAALMLTNPNTLGLFERNILEIAEIVHEAGGLLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFSTPHGGG 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  770 GPGMGPIGVKKHLTPYLPnHPVIA-------LQGNDGRSLGTISAApWGSSAILPISWAYIKMMGAKGLKHATEIAILNA 842
Cdd:PRK04366   281 GPGSGPVGVKEELAPFLP-VPVVEkdgdryrLDYDRPKSIGRVRAF-YGNFGVLVRAYAYIRSLGAEGLREVSEDAVLNA 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  843 NYMAKRLEKHYKILFRGSRgcvAHEFILDVRPFKKSaNIEAVDIAKRLQDYGFHAPTMSWP--VAGTLMIEPTESEDKAE 920
Cdd:PRK04366   359 NYLKARLKDIYDLPYDRPC---MHEFVLSGKKLKET-GVRTLDIAKRLLDYGFHPPTIYFPliVPEALMIEPTETESKET 434

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 2017817320  921 LDRFCDAMINIRQEIADveegrmdsriNP--LKMSPHTLT 958
Cdd:PRK04366   435 LDAFIAAMKQIAEEAKE----------NPelVKEAPHNTP 464
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
78-490 3.75e-130

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 401.44  E-value: 3.75e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320   78 DKEKREMMDTLGVQSIDELIDKtVPASIRLSRPLKMDDQVCENELLETLRNIASKNKIWR---SYIGMGYYNCSVPqAIL 154
Cdd:PRK00451     9 EEDIREMLDAIGVKSIDELFAD-IPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEeypSFLGAGAYDHYIP-AVV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  155 RNLLENAGWVTQYTPYQPEVSQGRLESLLNYQTMVCDITGMDVANASLLDEGTAAAEAMQLCHRHNKRRKFYVDSRCHPQ 234
Cdd:PRK00451    87 DHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVSGAVHPE 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  235 TIAVVQTRANYIGVTTELLlPHE---------MDFSGKDVSGVLFQYPDTNGKVEDFTQLVDRAHQNGTLACSATDLLAL 305
Cdd:PRK00451   167 YREVLKTYLKGQGIEVVEV-PYEdgvtdlealEAAVDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIVGVDPVSL 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  306 CILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLIRMMPGRMVGVTRDATGKDVYRLALQTREQHIRRDKATS 385
Cdd:PRK00451   246 GLLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHIRREKATS 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  386 NICTAQALLANMAAMFCVYHGPNGLKHIARRVHNATLILAEGLKRA-GHQLHDEMFFDTLKIHCGCPVKEVLDRAAQRQI 464
Cdd:PRK00451   326 NICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEIgGVELFDGPFFNEFVVRLPKPAEEVNEALLEKGI 405

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2017817320  465 NF-----RLYS--DGSLGVSIDETIKEKDLDDL 490
Cdd:PRK00451   406 LGgydlgRYYPelGNHLLVCVTEKRTKEDIDAL 438
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 603-763 8.61e-11

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 61.63  E-value: 8.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  603 ELEKDLCEIT--GYDNISFQPnSGAQGEYAGLAAIkaylngkGERHRTVcLIPKSAHGTNPASAQ-MAGMKIQPVEVDKD 679
Cdd:cd01494      4 ELEEKLARLLqpGNDKAVFVP-SGTGANEAALLAL-------LGPGDEV-IVDANGHGSRYWVAAeLAGAKPVPVPVDDA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  680 GSiDVAHLRAMVD-KHQDNLAAIMITYPSTNGVFEEGIRDVCDLIHKHGGQVYLDGANMNAQVG---LCRPADYGsDVSH 755
Cdd:cd01494     75 GY-GGLDVAILEElKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPapgVLIPEGGA-DVVT 152


                   ....*...
gi 2017817320  756 LNLHKTFC 763
Cdd:cd01494    153 FSLHKNLG 160
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
592-763 3.77e-07

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 52.99  E-value: 3.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  592 DQAQGYQQLFRELEKDLCEITGYDNISFQPnSGAQGEyagLAAIKAYLngkgERHRTVCLiPKSAHG---TNPASAQMAG 668
Cdd:pfam01212   25 DEVYGGDPTVNRLEDRVAELFGKEAALFVP-SGTAAN---QLALMAHC----QRGDEVIC-GEPAHIhfdETGGHAELGG 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  669 MKIQPVEVDKDGSIDVAHLRAMVD----KHQDNLAAIMITypSTNG------VFEEGIRDVCDLIHKHGGQVYLDGANM- 737
Cdd:pfam01212   96 VQPRPLDGDEAGNMDLEDLEAAIRevgaDIFPPTGLISLE--NTHNsaggqvVSLENLREIAALAREHGIPVHLDGARFa 173

                          170       180
                   ....*....|....*....|....*..
gi 2017817320  738 NAQVGL-CRPADYGSDVSHLnlhkTFC 763
Cdd:pfam01212  174 NAAVALgVIVKEITSYADSV----TMC 196
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 629-735 8.69e-07

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 52.21  E-value: 8.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  629 YAGLAA---IKAYLNGKGER--HRTVCLIPKSAHGTNPASAQMAGMKIQPVEVDKDGSIDVAHLRAMVDK-HQDNLAAIM 702
Cdd:cd06450     72 LALLAArdrARKRLKAGGGRgiDKLVIVCSDQAHVSVEKAAAYLDVKVRLVPVDEDGRMDPEALEAAIDEdKAEGLNPIM 151

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2017817320  703 I--TYPSTN-GVFEEgIRDVCDLIHKHGGQVYLDGA 735
Cdd:cd06450    152 VvaTAGTTDtGAIDP-LEEIADLAEKYDLWLHVDAA 186
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 664-753 3.94e-06

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 50.41  E-value: 3.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  664 AQMAGMKIqpVEV-DKDGSIDVAHLRAMVDkhqDNLAAIMITYPSTNGVFEEgIRDVCDLIHKHGGQVYLdGANMNAQVG 742
Cdd:COG0403    176 AEPLGIEV--VEVpDEDGVTDLEALKALLD---DDVAGVLVQYPNFFGVIED-LRAIAEAAHAAGALVIV-AADPLSLGL 248

                           90
                   ....*....|.
gi 2017817320  743 LCRPADYGSDV 753
Cdd:COG0403    249 LKPPGELGADI 259
TA_like cd06502
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ...
 592-753 2.26e-04

Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.


Pssm-ID: 99748 [Multi-domain]  Cd Length: 338  Bit Score: 44.63  E-value: 2.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  592 DQAQGYQQLFRELEKDLCEITGYDNISFQPnSGAQGEYAGLAAIKaylngkgERHRTVcLIPKSAHGTNP---ASAQMAG 668
Cdd:cd06502     25 DDVYGEDPTTAKLEARAAELFGKEAALFVP-SGTAANQLALAAHT-------QPGGSV-ICHETAHIYTDeagAPEFLSG 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  669 MKIQPVEvDKDGSIDV----AHLRAMVDKHQDNLAAIMITyPSTNG---VFEEGIRDVCDLIHKHGGQVYLDGANM-NAQ 740
Cdd:cd06502     96 VKLLPVP-GENGKLTPedleAAIRPRDDIHFPPPSLVSLE-NTTEGgtvYPLDELKAISALAKENGLPLHLDGARLaNAA 173

                          170
                   ....*....|....
gi 2017817320  741 VGL-CRPADYGSDV 753
Cdd:cd06502    174 AALgVALKTYKSGV 187
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
594-753 3.37e-04

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 44.36  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  594 AQG-YQQLFrELEKDLCEITGYD--NISFQPNSGAQGEyaglAAIKAY-LNGKgerhRTVcLIPKSAHgtnPASAQM--- 666
Cdd:PRK00451   107 SQGtLQAIF-EYQTMICELTGMDvaNASMYDGATALAE----AALMAVrITKR----KKV-LVSGAVH---PEYREVlkt 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017817320  667 ----AGMKIQPVEVDkDGSIDVAHLRAMVDkhqDNLAAIMITYPSTNGVFEEgIRDVCDLIHKHGGQVYLdGANMNAQVG 742
Cdd:PRK00451   174 ylkgQGIEVVEVPYE-DGVTDLEALEAAVD---DDTAAVVVQYPNFFGVIED-LEEIAEIAHAGGALFIV-GVDPVSLGL 247

                          170
                   ....*....|.
gi 2017817320  743 LCRPADYGSDV 753
Cdd:PRK00451   248 LKPPGEYGADI 258
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
664-735 4.79e-04

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 43.59  E-value: 4.79e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017817320  664 AQMAGMKIQPVEVDKDGSIDVAHLRAMVDkhqDNLAAIMITYPSTNGvfeeG----IRDVCDLIHKHGGQVYLDGA 735
Cdd:COG0520    124 AERTGAEVRVIPLDEDGELDLEALEALLT---PRTKLVAVTHVSNVT----GtvnpVKEIAALAHAHGALVLVDGA 192
SufS_like cd06453
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ...
 664-735 4.47e-03

Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.


Pssm-ID: 99746 [Multi-domain]  Cd Length: 373  Bit Score: 40.53  E-value: 4.47e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017817320  664 AQMAGMKIQPVEVDKDGSIDVAHLRAMVDkhqDNLAAIMITYPSTNGvfeeG----IRDVCDLIHKHGGQVYLDGA 735
Cdd:cd06453    109 AERTGAKLKVVPVDDDGQLDLEALEKLLT---ERTKLVAVTHVSNVL----GtinpVKEIGEIAHEAGVPVLVDGA 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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