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Conserved domains on  [gi|1993979193|ref|XP_039619893|]
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alpha-1,2-mannosyltransferase ALG9 isoform X2 [Polypterus senegalus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 17-256 3.76e-75

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 234.18  E-value: 3.76e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  17 TAFKCLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSPAYAIRSYAYLWLHALPAWFHAKVLQTNKVLVF 96
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTSDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGDSKYLVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  97 YFLRCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGW--------FTEK 168
Cdd:pfam03901  81 YAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193 169 NSIAVLGVAAGAIIGWPFSAVLGLPIALDLL--LMKKQWKTFIC--WTLVALVLFL--GPVVAIDSYYYGKLVNAPVNIL 242
Cdd:pfam03901 161 YLKAVLLIAALAILGRPTSALLWLPLVLYLLlrLRGKRLKLFLFlaISLGLLVALLvlGAVILIDSYFYGRFVFTPLNFL 240

                         250
                  ....*....|....
gi 1993979193 243 LYNVFTaHGPDLYG 256
Cdd:pfam03901 241 KYNVLS-NGSSFYG 253
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 17-256 3.76e-75

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 234.18  E-value: 3.76e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  17 TAFKCLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSPAYAIRSYAYLWLHALPAWFHAKVLQTNKVLVF 96
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTSDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGDSKYLVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  97 YFLRCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGW--------FTEK 168
Cdd:pfam03901  81 YAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193 169 NSIAVLGVAAGAIIGWPFSAVLGLPIALDLL--LMKKQWKTFIC--WTLVALVLFL--GPVVAIDSYYYGKLVNAPVNIL 242
Cdd:pfam03901 161 YLKAVLLIAALAILGRPTSALLWLPLVLYLLlrLRGKRLKLFLFlaISLGLLVALLvlGAVILIDSYFYGRFVFTPLNFL 240

                         250
                  ....*....|....
gi 1993979193 243 LYNVFTaHGPDLYG 256
Cdd:pfam03901 241 KYNVLS-NGSSFYG 253
PLN02816 PLN02816
mannosyltransferase
 21-256 3.61e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 50.80  E-value: 3.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  21 CLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSpaYAIRSYaylwLHALPAWFHAKVLQTNKVLVFYFL- 99
Cdd:PLN02816   45 CLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWK--RGIRSY----LHPMLFAFLYKLLQVTGLDTPYIMi 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193 100 ---RCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGWFTEKNSIA---- 172
Cdd:PLN02816  119 kapRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIdypv 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193 173 ----VLGVAAGAIIGWPFSAVLGLPIA-LDLLLMKKQWKTFICWTLVALVLFLGPVVAIDSYYYGKLVNAPVNILLYNvF 247
Cdd:PLN02816  199 nrkwGLVIAALACAIRPTSAVIWLYVGmLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFN-F 277


                  ....*....
gi 1993979193 248 TAHGPDLYG 256
Cdd:PLN02816  278 LSSGGDYYG 286
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 17-256 3.76e-75

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 234.18  E-value: 3.76e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  17 TAFKCLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSPAYAIRSYAYLWLHALPAWFHAKVLQTNKVLVF 96
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTSDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGDSKYLVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  97 YFLRCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGW--------FTEK 168
Cdd:pfam03901  81 YAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193 169 NSIAVLGVAAGAIIGWPFSAVLGLPIALDLL--LMKKQWKTFIC--WTLVALVLFL--GPVVAIDSYYYGKLVNAPVNIL 242
Cdd:pfam03901 161 YLKAVLLIAALAILGRPTSALLWLPLVLYLLlrLRGKRLKLFLFlaISLGLLVALLvlGAVILIDSYFYGRFVFTPLNFL 240

                         250
                  ....*....|....
gi 1993979193 243 LYNVFTaHGPDLYG 256
Cdd:pfam03901 241 KYNVLS-NGSSFYG 253
PLN02816 PLN02816
mannosyltransferase
 21-256 3.61e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 50.80  E-value: 3.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193  21 CLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSpaYAIRSYaylwLHALPAWFHAKVLQTNKVLVFYFL- 99
Cdd:PLN02816   45 CLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWK--RGIRSY----LHPMLFAFLYKLLQVTGLDTPYIMi 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193 100 ---RCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGWFTEKNSIA---- 172
Cdd:PLN02816  119 kapRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIdypv 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979193 173 ----VLGVAAGAIIGWPFSAVLGLPIA-LDLLLMKKQWKTFICWTLVALVLFLGPVVAIDSYYYGKLVNAPVNILLYNvF 247
Cdd:PLN02816  199 nrkwGLVIAALACAIRPTSAVIWLYVGmLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFN-F 277


                  ....*....
gi 1993979193 248 TAHGPDLYG 256
Cdd:PLN02816  278 LSSGGDYYG 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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