NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1993979189|ref|XP_039619891|]
View 

alpha-1,2-mannosyltransferase ALG9 isoform X1 [Polypterus senegalus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 60-299 2.54e-82

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 254.21  E-value: 2.54e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189  60 TAFKCLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSPAYAIRSYAYLWLHALPAWFHAKVLQTNKVLVF 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTSDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGDSKYLVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 140 YFLRCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGW--------FTEK 211
Cdd:pfam03901  81 YAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 212 NSIAVLGVAAGAIIGWPFSAVLGLPIALDLL--LMKKQWKTFIC--WTLVALVLFL--GPVVAIDSYYYGKLVNAPVNIL 285
Cdd:pfam03901 161 YLKAVLLIAALAILGRPTSALLWLPLVLYLLlrLRGKRLKLFLFlaISLGLLVALLvlGAVILIDSYFYGRFVFTPLNFL 240

                         250
                  ....*....|....
gi 1993979189 286 LYNVFTaHGPDLYG 299
Cdd:pfam03901 241 KYNVLS-NGSSFYG 253
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 60-299 2.54e-82

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 254.21  E-value: 2.54e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189  60 TAFKCLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSPAYAIRSYAYLWLHALPAWFHAKVLQTNKVLVF 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTSDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGDSKYLVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 140 YFLRCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGW--------FTEK 211
Cdd:pfam03901  81 YAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 212 NSIAVLGVAAGAIIGWPFSAVLGLPIALDLL--LMKKQWKTFIC--WTLVALVLFL--GPVVAIDSYYYGKLVNAPVNIL 285
Cdd:pfam03901 161 YLKAVLLIAALAILGRPTSALLWLPLVLYLLlrLRGKRLKLFLFlaISLGLLVALLvlGAVILIDSYFYGRFVFTPLNFL 240

                         250
                  ....*....|....
gi 1993979189 286 LYNVFTaHGPDLYG 299
Cdd:pfam03901 241 KYNVLS-NGSSFYG 253
PLN02816 PLN02816
mannosyltransferase
 64-299 1.09e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 52.73  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189  64 CLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSpaYAIRSYaylwLHALPAWFHAKVLQTNKVLVFYFL- 142
Cdd:PLN02816   45 CLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWK--RGIRSY----LHPMLFAFLYKLLQVTGLDTPYIMi 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 143 ---RCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGWFTEKNSIA---- 215
Cdd:PLN02816  119 kapRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIdypv 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 216 ----VLGVAAGAIIGWPFSAVLGLPIA-LDLLLMKKQWKTFICWTLVALVLFLGPVVAIDSYYYGKLVNAPVNILLYNvF 290
Cdd:PLN02816  199 nrkwGLVIAALACAIRPTSAVIWLYVGmLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFN-F 277


                  ....*....
gi 1993979189 291 TAHGPDLYG 299
Cdd:PLN02816  278 LSSGGDYYG 286
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 60-299 2.54e-82

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 254.21  E-value: 2.54e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189  60 TAFKCLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSPAYAIRSYAYLWLHALPAWFHAKVLQTNKVLVF 139
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTSDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGDSKYLVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 140 YFLRCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGW--------FTEK 211
Cdd:pfam03901  81 YAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 212 NSIAVLGVAAGAIIGWPFSAVLGLPIALDLL--LMKKQWKTFIC--WTLVALVLFL--GPVVAIDSYYYGKLVNAPVNIL 285
Cdd:pfam03901 161 YLKAVLLIAALAILGRPTSALLWLPLVLYLLlrLRGKRLKLFLFlaISLGLLVALLvlGAVILIDSYFYGRFVFTPLNFL 240

                         250
                  ....*....|....
gi 1993979189 286 LYNVFTaHGPDLYG 299
Cdd:pfam03901 241 KYNVLS-NGSSFYG 253
PLN02816 PLN02816
mannosyltransferase
 64-299 1.09e-07

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 52.73  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189  64 CLVSARFCAALLSNISDCDETFNYWEPTHYLLYGKGFQTWEYSpaYAIRSYaylwLHALPAWFHAKVLQTNKVLVFYFL- 142
Cdd:PLN02816   45 CLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWK--RGIRSY----LHPMLFAFLYKLLQVTGLDTPYIMi 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 143 ---RCLLAFVCCICELYFYKAVCKKFGLHVGRLMLAFLVLSTGMFCSVSAYLPSSFCMYTTVVAMTGWFTEKNSIA---- 215
Cdd:PLN02816  119 kapRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIdypv 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993979189 216 ----VLGVAAGAIIGWPFSAVLGLPIA-LDLLLMKKQWKTFICWTLVALVLFLGPVVAIDSYYYGKLVNAPVNILLYNvF 290
Cdd:PLN02816  199 nrkwGLVIAALACAIRPTSAVIWLYVGmLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFN-F 277


                  ....*....
gi 1993979189 291 TAHGPDLYG 299
Cdd:PLN02816  278 LSSGGDYYG 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH