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Conserved domains on  [gi|1985464488|ref|XP_039372930|]
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beta-1,4 N-acetylgalactosaminyltransferase 2-like [Mauremys reevesii]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10455355)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|9445404
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 285-386 3.10e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


:

Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 67.81  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 285 TFLRYHKLRLLIKSI-RQYYPDIKIIVADDSEVPE--KIIEE------NVEHYIMPFGKGWFAGRNLAISQVTTKYYLWV 355
Cdd:pfam00535   6 TYNEEKYLLETLESLlNQTYPNFEIIVVDDGSTDGtvEIAEEyakkdpRVRVIRLPENRGKAGARNAGLRAATGDYIAFL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1985464488 356 DDDYLFTENtKIEKLLDVLERTNLDMVGGSV 386
Cdd:pfam00535  86 DADDEVPPD-WLEKLVEALEEDGADVVVGSR 115
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 285-386 3.10e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 67.81  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 285 TFLRYHKLRLLIKSI-RQYYPDIKIIVADDSEVPE--KIIEE------NVEHYIMPFGKGWFAGRNLAISQVTTKYYLWV 355
Cdd:pfam00535   6 TYNEEKYLLETLESLlNQTYPNFEIIVVDDGSTDGtvEIAEEyakkdpRVRVIRLPENRGKAGARNAGLRAATGDYIAFL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1985464488 356 DDDYLFTENtKIEKLLDVLERTNLDMVGGSV 386
Cdd:pfam00535  86 DADDEVPPD-WLEKLVEALEEDGADVVVGSR 115
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
285-384 3.43e-09

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 56.92  E-value: 3.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 285 TFLRYHKLRLLIKSI-RQYYPDIKIIVADDS------EVPEKIIEENVEHYIMPFGKGWFAGRNLAISQVTTKYYLWVDD 357
Cdd:COG1216    11 TYNRPELLRRCLESLlAQTYPPFEVIVVDNGstdgtaELLAALAFPRVRVIRNPENLGFAAARNLGLRAAGGDYLLFLDD 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1985464488 358 DYLFTENTkIEKLLDV----LERTNLDMVGG 384
Cdd:COG1216    91 DTVVEPDW-LERLLAAacllIRREVFEEVGG 120
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 292-384 3.05e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 50.20  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 292 LRLLIKSI-RQYYPDIKIIVADD--SEVPEKIIEE------NVEHYIMPFGKGWFAGRNLAISQVTTKYYLWVDDDYLFT 362
Cdd:cd00761    12 LERCLESLlAQTYPNFEVIVVDDgsTDGTLEILEEyakkdpRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLLL 91

                          90       100
                  ....*....|....*....|...
gi 1985464488 363 ENtKIEKLLDVLER-TNLDMVGG 384
Cdd:cd00761    92 PD-WLERLVAELLAdPEADAVGG 113
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 279-394 1.99e-03

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 39.59  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 279 VTITTKTFLRYHKLRLLIKSIRQYYPDIKIIVADDSEvpEKIIEE-----------NVEHYIMPFGKGWFAGRNL-AISQ 346
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSD--EKFNENnlkvfknysnpNITYLHYPDLGVPFYEKLLdALEQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1985464488 347 VTTKYYLWVDDDYLFTENTkIEKLLDVLErTNLDMVggSVKGDTYSFQ 394
Cdd:TIGR04440  80 VETPYVVICADDDFIIPSG-LTECLSFLE-ANPDYS--AAQGRYVYFE 123
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 285-386 3.10e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 67.81  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 285 TFLRYHKLRLLIKSI-RQYYPDIKIIVADDSEVPE--KIIEE------NVEHYIMPFGKGWFAGRNLAISQVTTKYYLWV 355
Cdd:pfam00535   6 TYNEEKYLLETLESLlNQTYPNFEIIVVDDGSTDGtvEIAEEyakkdpRVRVIRLPENRGKAGARNAGLRAATGDYIAFL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1985464488 356 DDDYLFTENtKIEKLLDVLERTNLDMVGGSV 386
Cdd:pfam00535  86 DADDEVPPD-WLEKLVEALEEDGADVVVGSR 115
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
285-384 3.43e-09

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 56.92  E-value: 3.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 285 TFLRYHKLRLLIKSI-RQYYPDIKIIVADDS------EVPEKIIEENVEHYIMPFGKGWFAGRNLAISQVTTKYYLWVDD 357
Cdd:COG1216    11 TYNRPELLRRCLESLlAQTYPPFEVIVVDNGstdgtaELLAALAFPRVRVIRNPENLGFAAARNLGLRAAGGDYLLFLDD 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1985464488 358 DYLFTENTkIEKLLDV----LERTNLDMVGG 384
Cdd:COG1216    91 DTVVEPDW-LERLLAAacllIRREVFEEVGG 120
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 292-389 9.44e-09

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 55.48  E-value: 9.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 292 LRLLIKSIR-QYYPDIKIIVADDS---EVPEkIIEE------NVEHYIMPFGKGWFAGRNLAISQVTTKYYLWVDDDYLF 361
Cdd:COG0463    17 LEEALESLLaQTYPDFEIIVVDDGstdGTAE-ILRElaakdpRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADDQL 95

                          90       100
                  ....*....|....*....|....*...
gi 1985464488 362 TENtKIEKLLDVLERTNLDMVGGSVKGD 389
Cdd:COG0463    96 DPE-KLEELVAALEEGPADLVYGSRLIR 122
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 292-384 3.05e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 50.20  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 292 LRLLIKSI-RQYYPDIKIIVADD--SEVPEKIIEE------NVEHYIMPFGKGWFAGRNLAISQVTTKYYLWVDDDYLFT 362
Cdd:cd00761    12 LERCLESLlAQTYPNFEVIVVDDgsTDGTLEILEEyakkdpRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLLL 91

                          90       100
                  ....*....|....*....|...
gi 1985464488 363 ENtKIEKLLDVLER-TNLDMVGG 384
Cdd:cd00761    92 PD-WLERLVAELLAdPEADAVGG 113
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 292-386 5.76e-05

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 45.12  E-value: 5.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 292 LRLLIKSI-RQYYPDIK--IIVADDSEVPE--KIIEE------NVEHYIMPF--GKGWfaGRNLAISQVTTKYYLWVDDD 358
Cdd:COG1215    44 IEETLRSLlAQDYPKEKleVIVVDDGSTDEtaEIARElaaeypRVRVIERPEngGKAA--ALNAGLKAARGDIVVFLDAD 121

                          90       100
                  ....*....|....*....|....*...
gi 1985464488 359 YLFTENTkIEKLLDVLERTNLDMVGGSV 386
Cdd:COG1215   122 TVLDPDW-LRRLVAAFADPGVGASGANL 148
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 279-394 1.99e-03

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 39.59  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 279 VTITTKTFLRYHKLRLLIKSIRQYYPDIKIIVADDSEvpEKIIEE-----------NVEHYIMPFGKGWFAGRNL-AISQ 346
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSD--EKFNENnlkvfknysnpNITYLHYPDLGVPFYEKLLdALEQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1985464488 347 VTTKYYLWVDDDYLFTENTkIEKLLDVLErTNLDMVggSVKGDTYSFQ 394
Cdd:TIGR04440  80 VETPYVVICADDDFIIPSG-LTECLSFLE-ANPDYS--AAQGRYVYFE 123
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 292-376 6.11e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 37.54  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985464488 292 LRLLIKSI-RQYYPDIKIIVAD----DSEVPE-KIIEENVEHYIMPFGKGWFAGRNLAISQVTTKYYLWVDDDYLFTENT 365
Cdd:cd04186    12 LKACLDSLlAQTYPDFEVIVVDnastDGSVELlRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLLLNPDTVVEPGA 91

                          90
                  ....*....|.
gi 1985464488 366 kIEKLLDVLER 376
Cdd:cd04186    92 -LLELLDAAEQ 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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