|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
10-439 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 643.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGV 89
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTL 169
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 170 SVSGFICVGASFVCLVLIKNEPSDVGLPKIEPGTMKGK-KGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLSSYGNPRHVLLLSMMAGMSASMYLFRVTITSDSPk 328
Cdd:cd17343 241 LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSS- 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 329 endlwivalhplavltglteqELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFST 408
Cdd:cd17343 320 ---------------------ELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSY 378
|
410 420 430
....*....|....*....|....*....|.
gi 1985423905 409 IAKHYSWATAFWVAEITCVISTIAFFLLRNI 439
Cdd:cd17343 379 IAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-419 |
3.21e-128 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 375.95 E-value: 3.21e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 18 FVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWS 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 98 STVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP-IVAALMALRYDWRTTLSVSGFIC 176
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 177 VGASFVCLVLIKNEPSDVGLPKIEP--------GTMKGKKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEmpneepdgDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsSYGNPRHVLLLSMMAGMSASMYLFRVTITSDspk 328
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAAN--- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 329 endlwivalhplavltglteqELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFST 408
Cdd:TIGR00881 310 ---------------------PLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGY 368
|
410
....*....|.
gi 1985423905 409 IAKHYSWATAF 419
Cdd:TIGR00881 369 LADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-437 |
8.03e-104 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 313.06 E-value: 8.03e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGV 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTL 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 170 SVSGFICVGASFVCLVLIKNEPsdvglpkiepgtmkgkkgssrddstlaelllsPYLWVLSTGYLVVFGVKTCCTDWGQL 249
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP--------------------------------PYVWVLSLAYAFVYIVRYACLDWGPL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssYGNPRHVLLLSMMAGMSASMYLFRVTITSdspke 329
Cdd:cd17312 209 YLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL--------FGGRRAPIAVIYMLLMTLSLALFWFFPHN----- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 330 ndlwivalhplavltglteqELWILILGAIFGFSSYGPIALFGVIANE-SAPSNLCGTSHAIVALLANVGGFLAGLPFST 408
Cdd:cd17312 276 --------------------KLLSIVLLFLIGFFVGGPINLIGGAAAQdIGRKEAAGTATGFVGLFGYLGASLAGLPLGY 335
|
410 420
....*....|....*....|....*....
gi 1985423905 409 IAKHYSWATAFWVAEITCVISTIAFFLLR 437
Cdd:cd17312 336 IIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
2-447 |
1.26e-70 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 229.98 E-value: 1.26e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 2 VDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:PRK11663 13 IDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 82 SGLLLVGVVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAL 161
Cdd:PRK11663 93 IGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIAL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 162 RYDWRTTLSVSGFICVGASFVCLVLIKNEPSDVGLPKI--------EPGTMKGKKGSSRDDSTLAELLLSPYLWVLSTGY 233
Cdd:PRK11663 173 HYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVgewrhdalELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 234 LVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssYGNPRHVLLLSMMAGMSA 313
Cdd:PRK11663 253 VLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKL--------FNGNRGPMNLIFAAGILL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 314 SMylfrvtitsdspkeNDLWIVALHPLAVLTGLteqelwiliLGAIfGFSSYGPIALFGVIANESAPSNLCGTSHAIVAL 393
Cdd:PRK11663 325 SV--------------GSLWLMPFASYVMQAAC---------FFTI-GFFVFGPQMLIGMAAAECSHKEAAGAATGFVGL 380
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1985423905 394 LANVGGFLAGLPFSTIAKHYSWaTAFWVAeITCVISTIAFFLLRNIRTKMGRVP 447
Cdd:PRK11663 381 FAYLGAALSGYPLAKVLEIWHW-TGFFVV-ISIAAGISALLLLPFLNAQAPREA 432
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-436 |
5.92e-62 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 205.33 E-value: 5.92e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGV 89
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTL 169
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 170 SVSGFICVGASFVCLVLIKNEPsdvglpkiepgtmkgkkgssrddstlaelllsPYLWVLSTGYLVVFGVKTCCTDWGQL 249
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVLVYVVRTAINDWGNL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDravarvgLSSYGNpRHVLLLSMMAGMSASMYLfrvtitsdspke 329
Cdd:cd17488 209 YLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSD-------KLFKGN-RGPMNLIFALGLLVSVGA------------ 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 330 ndLWIVALHPLAVLTGLTeqelwililgAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFSTI 409
Cdd:cd17488 269 --LWLVPVHSYWLLATCF----------FTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKV 336
|
410 420
....*....|....*....|....*..
gi 1985423905 410 AKHYSWATAFWVAEITCVISTIAFFLL 436
Cdd:cd17488 337 IESWGWSGFFIVISIAAAISGLLLLPL 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
10-437 |
6.95e-58 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 195.92 E-value: 6.95e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGV 89
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 90 VNVVF----SWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRY-- 163
Cdd:cd17345 81 INILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 164 -DWRTTLSVSGFICVGASFVCLVLIKNEPSDVGLPKIEpgTMKGKKGSSRDDSTLAE-----------LLLSPYLWVLST 231
Cdd:cd17345 161 gWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIE--EYKGDYPEEADGEEEEQelsaweifvkyVLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 232 G----YLVVFGVktccTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssYGNPRHVLLLSM 307
Cdd:cd17345 239 AnvfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL--------FKGRRAPTGIIF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 308 MAGMSASMYLFrvtitsdspkendlWivalhplavltgLTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTS 387
Cdd:cd17345 307 MILVIVALIVY--------------W------------LAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTA 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1985423905 388 HAIVALLANVGG-FLAGLPFSTIAKHYSWATAFWVAEITCVISTIAFFLLR 437
Cdd:cd17345 361 AGLTGLFGYLGGsVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-437 |
1.44e-51 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 177.75 E-value: 1.44e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 3 DKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSS 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 83 GLLLVGVVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALR 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 163 YDWRTTLSVSGFICVGASFVclvliknepsdvglpkiepgtmkgkkgssrddstlaelllspYLWVLSTGYLVVFGVKTC 242
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL------------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 243 CTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglssYGNPRHVLLLSMMAGMSASMYLFrvti 322
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLL---- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 323 tsdspkendlwivalhplavltGLTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLA 402
Cdd:COG2271 266 ----------------------ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323
|
410 420 430
....*....|....*....|....*....|....*
gi 1985423905 403 GLPFSTIAKHYSWATAFWVAEITCVISTIAFFLLR 437
Cdd:COG2271 324 PLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
2-438 |
4.18e-39 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 146.53 E-value: 4.18e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 2 VDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEiELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:TIGR00712 17 IDPTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSKGELGFALSAISIAYGFSKFIMGSVSDRSNPRVFLP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 82 S---GLLLVGVVNVVFSW-SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGG-LGPIVA 156
Cdd:TIGR00712 96 AgliLSAAVMLLMGFVPWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGiPPLLVL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 157 ALMALRYDWRTTLSVSGFICVGASFVCLVLIKNEPSDVGLPKIEP--------GTMKGKKGSSRDDSTLAELLLSPYLWV 228
Cdd:TIGR00712 176 LGMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEyrndypddYNEKAEQELTAKEIFMQYVLPNKLLWY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 229 LSTGYLVVFGVKTCCTDWGQLFLIQERGqSALVGSSYMSAL-EIGGLVGSIAAGYLSDRAvarvglssYGNPRHVLLLSM 307
Cdd:TIGR00712 256 IAIANVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDKV--------FKGNRGATGVFF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 308 MAGMSASMYLFRVtitsdSPKENDlwivalhplavltgLTEQELWILIlgaifGFSSYGPIALFGVIANESAPSNLCGTS 387
Cdd:TIGR00712 327 MTLVTIAVIVYWM-----NPAGNP--------------LVDMICMIVI-----GFLIYGPVMLIGLHALELAPKKAAGTA 382
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1985423905 388 HAIVALLANVGGFL-AGLPFSTIAKHYSWATAFWVAEITCVISTIAFFLLRN 438
Cdd:TIGR00712 383 AGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMI 434
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
2-431 |
2.10e-33 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 130.99 E-value: 2.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 2 VDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEiELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:PRK11273 19 IDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 82 SGLLLVGVVNVVFSW----SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGL-GPIVA 156
Cdd:PRK11273 98 AGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLpPLLFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 157 ALMALRYDWRTTLSVSGFICVGASFVCLVLIKNEPSDVGLPKIEpgTMKGKKGSSRDDSTLAEL----------LLSPYL 226
Cdd:PRK11273 178 LGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIE--EYKNDYPDDYNEKHEQELtakqifmqyvLPNKLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 227 WVLSTGYLVVFGVKTCCTDWGQLFLiQERGQSALVGSSYMSAL-EIGGLVGSIAAGYLSDRAVArvglssyGNprhvlll 305
Cdd:PRK11273 256 WYIAIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFR-------GN------- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 306 smmAGMSASMYLFRVTITSdspkendlWIVALHPlavlTGLTEQELWILIlgaIFGFSSYGPIALFGVIANESAPSNLCG 385
Cdd:PRK11273 321 ---RGATGVFFMTLVTIAT--------IVYWLNP----AGNPTVDMACMI---VIGFLIYGPVMLIGLHALELAPKKAAG 382
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1985423905 386 TSHAIVALLANVGGFLAGlpfSTI----AKHYSWATAFWVAEITCVISTI 431
Cdd:PRK11273 383 TAAGFTGLFGYLGGSVAA---SAIvgytVDFFGWDGGFMVMIGGSILAVI 429
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-437 |
1.02e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 122.30 E-value: 1.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 9 YRTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVG 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 89 VVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTT 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 169 LSVSGFICVGASFVCLVLIKNEPSDVGLPKiepgtmkgkkgsSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAA------------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssygnPRHVLLLSMMAGMSASMYLFrvtitsdspk 328
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLL---------- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 329 endlwIVALHPLAVLTGLteqelwILILGAIFGFssyGPIALFGVIANESAPSNLcGTSHAIVALLANVGGFLAGLPFST 408
Cdd:COG2223 289 -----ALALGSLWLFLVL------FLLLGLALGG---GNGAVFALVPDIFPTKNA-GAVYGLVGAAGGLGGFLGPLLFGA 353
|
410 420 430
....*....|....*....|....*....|
gi 1985423905 409 IAKHY-SWATAFWVAEITCVISTIAFFLLR 437
Cdd:COG2223 354 LLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-402 |
1.06e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.42 E-value: 1.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 17 MFVGYTLYYFNRKTFSFVMPS-IMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFS 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 96 WSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGFI 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 176 CVGASFVCLVLIKNEPSDVGLPKIEPGTMKGKKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVktcctdwgqlFLIQER 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP----------LYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 256 GQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLssygnprhVLLLSMMAGMSASMYLFRVTITSdspkendlwiv 335
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL--------LLALLLLILAALGLLLLSLTLSS----------- 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1985423905 336 alhplavltglteqeLWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLA 402
Cdd:pfam07690 292 ---------------LWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-436 |
3.89e-24 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 103.03 E-value: 3.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGV 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTL 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 170 SVSGFICVGASFVCLVLIknePSDVGLpkiepgtmkgkkgssrddsTLAELLLSPYLWVLSTgylvvfgvktcctdWGQL 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL---RQVWGL-------------------ALGYFGINYALYGLLT--------------WLPT 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVArvglssyGNPRHVLLLSMMAGMSAsmylfrvtitsdspke 329
Cdd:cd17319 205 YLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR-------GARRLVIIIGLLLAAVG---------------- 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 330 ndlwivalhplAVLTGLTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFSTI 409
Cdd:cd17319 262 -----------LLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
410 420
....*....|....*....|....*...
gi 1985423905 410 AKH-YSWATAFWVAEITCVISTIAFFLL 436
Cdd:cd17319 331 VDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-402 |
2.50e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 100.43 E-value: 2.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 7 SYYRTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLL 86
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 87 VGVVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWR 166
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 167 TTLSVSGFICVGASFVCLVLIKNEPsdvglpkiepgtmkgKKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDW 246
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESR---------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 247 GQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssygnPRHVLLLSMMAGMSASMYLFrvtitsds 326
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLL-------- 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1985423905 327 pkendlwivalhplavltGLTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLA 402
Cdd:COG2814 291 ------------------ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-434 |
6.02e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.81 E-value: 6.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 17 MFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSW 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 97 SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALR--YDWRTTLSVSGF 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 175 ICVGASFVCLVLIKNEPSDVGLPKIEPGTMKGKKGssrddstLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQE 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 255 RGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLssygnprHVLLLSMMAGMSASMYLFRVTItsdspkendlwi 334
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL-------LLIGLLLMALGLALLLLAPSLL------------ 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 335 valhplavltglteqelWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFSTI-AKHY 413
Cdd:cd06174 295 -----------------LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATF 357
|
410 420
....*....|....*....|.
gi 1985423905 414 SWATAFWVAEITCVISTIAFF 434
Cdd:cd06174 358 GLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-437 |
3.46e-20 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 91.92 E-value: 3.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 36 PSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNGLAQG 115
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 116 LGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGFICVGASFVCLVLIKNEPSDVG 195
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 196 LPKIEPGTMKGKKgssrddstlaELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLV 275
Cdd:cd17475 180 ATESASTLLRSLK----------EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 276 GSIAAGYLSDRAVArvglssyGNPRHVLLLSMMAGMSASMYLfrvtitsdspkendLWIVALHPLAVLTGLTeqelwili 355
Cdd:cd17475 250 GRIGLGRVSDRVFG-------GRRRPVLVITAAIAAAALLVL--------------SLLSPGTPLWLLVLLL-------- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 356 lgAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPF-STIAKHYSWATAFWVAeitCVISTIAFF 434
Cdd:cd17475 301 --ILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLAL---ALLLVLAAL 375
|
...
gi 1985423905 435 LLR 437
Cdd:cd17475 376 LLL 378
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
14-295 |
1.00e-16 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 82.02 E-value: 1.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 14 FTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVV 93
Cdd:PRK09556 31 YLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 94 FSWS-----STVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAlrydwrTT 168
Cdd:PRK09556 111 FGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGA------NY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 169 L---SVSGF------ICVGASFVCLVLIKNEPSDVGLPKIEP--GTMKGKKGSSRDDSTLAE-------LLLSPYLWVLS 230
Cdd:PRK09556 185 FfdgHVIGMfifpsiIALIIGFIGLRYGSDSPEELGWGKAEEifGEPISEEDKETESTDMTKwqifveyVLKNPVIWLLC 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1985423905 231 TGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLSS 295
Cdd:PRK09556 265 FANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRALVA 329
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-434 |
4.26e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 73.46 E-value: 4.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 28 RKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLW 107
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 108 FLNGLAQ--GLGWPPCGKVLRKWFEPSQfGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGFICVGASFVCLV 185
Cdd:cd17355 99 GLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 186 LIKNEPSDVGLPKIEPGtmkgkkGSSRDDSTLAELLLSPYLWVLSTGYLVVfGVKTCCTDWGQLFLIQERGQSALVGSSY 265
Cdd:cd17355 178 LLRRRPADLALRAYDDA------SPASPGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 266 MSALEIGGLVGSIAAGYLSDRavarvglssyGNPRHVLLLSMMAGMSAsmylfrvtitsdspkendlwivalhpLAVLTG 345
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDR----------YSPRRLLAASYALRALG--------------------------LALLLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 346 LTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFSTIAKHY-SWATAFWVAEI 424
Cdd:cd17355 295 LPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVA 374
|
410
....*....|
gi 1985423905 425 TCVISTIAFF 434
Cdd:cd17355 375 LGLIAALLVL 384
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-436 |
3.48e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.67 E-value: 3.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 34 VMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 114 QGLGWPPCGKVLRKWFePSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGFICVGASFVCLVLIKNEPSD 193
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 194 vglpkiepgtmkgkKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLiQERGQSALVGSSYMSALEIGG 273
Cdd:COG2807 199 --------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 274 LVGSIAAGYLSDRavarvglssYGNPRHVLLLSMMAGMSAsmylfrvtitsdspkendLWIVALHPLAVLTglteqeLWI 353
Cdd:COG2807 264 IPGSLLVPLLADR---------LGDRRPLLLLLGLLGLAG------------------LLGLLLAPGSLPW------LWA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 354 LILGAIFGFSSYGPIALFGVIANESAP-SNLCGTSHAIVALLANVGGFLAGLPFSTIAkhySWATAFWVAEITCVISTIA 432
Cdd:COG2807 311 VLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVA 387
|
....
gi 1985423905 433 FFLL 436
Cdd:COG2807 388 GLLA 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-437 |
8.63e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.53 E-value: 8.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 13 IFTAMFVGYTLYYfnrkTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNV 92
Cdd:cd17325 1 LSLALFLDMLGYG----IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 93 VFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLsvs 172
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 173 gFICVGASFVCLVLIKnepsdVGLPKIEPGTMKGKKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLI 252
Cdd:cd17325 154 -LVCAALALLALVLAL-----LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 253 QERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssygnPRHVLLLSMMAGMSASMYLFRVTitsdspkeNDL 332
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLLPLA--------TSF 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 333 WIVALhpLAVLTGlteqelwiliLGAIFGFSSYGPIalfgvIANESAPSNLcGTSHAIVALLANVGGFLAGLPFSTIAKH 412
Cdd:cd17325 289 WLLLL--LLALLG----------LGLGLVFPATLAL-----LADIVPPEGR-GTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
410 420
....*....|....*....|....*
gi 1985423905 413 YSWATAFWVAEITCVISTIAFFLLR 437
Cdd:cd17325 351 FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
10-191 |
5.54e-10 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 60.79 E-value: 5.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEE---------------------IELDKDD----LGLITSSQSAAYAISK 64
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEwtpsnsntsielheetwnanpLFPSQDDaalfLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 65 FISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVF------SGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWW 138
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1985423905 139 AILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGFICVGASFVCLVLIKNEP 191
Cdd:cd17342 161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSPP 213
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-434 |
3.46e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 3.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 34 VMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 114 QGLGWPPCGKVLRKwFEPSQFGTWWAILSTSMNLAGGLGPIVAA-LMALRYDWRTTLsvsgFICVGASFVCLVLIKNEPS 192
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAaLVALFGGLGLLI----LLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 193 DVGLPKIEPGTMKGKKGSSRDDSTLAELLLspylwVLSTGYLVVFGVKTCCTdwgqlFLIQERGQSALVGSSYMSALEIG 272
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRALLLLLI-----IVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 273 GLVGSIAAGYLSDRavarvglssyGNPRHVLLLSmMAGMSASMYLFRVTitsdspkendlwivalhplavltglteQELW 352
Cdd:cd17478 243 GAIGTLIGGPLSDR----------FGRRRVIIAS-LLLAAPFLLLFLLT---------------------------PGIW 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 353 ILILGAIFGFSSYGPIALFGVIANESAPSNLcGTSHAIVALLANVGGFLAGLPFSTIAKHYSWATAFWVAEITCVISTIA 432
Cdd:cd17478 285 SYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
..
gi 1985423905 433 FF 434
Cdd:cd17478 364 AF 365
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-434 |
6.28e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 57.63 E-value: 6.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 17 MFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSsglllvgvvNVVFSW 96
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILA---------VGILIW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 97 sSTVTVFSGL-----WFL-----NGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA-LRYDW 165
Cdd:cd17328 75 -SAATLLSSFapnfwQLLlfralVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 166 RTTLSVSGFICVGASFVCLVLIKNEPSDVglpkIEPGTMKGKKGSSRDDStLAELLLSPYLWVLSTGYLVVFGVKTCCTD 245
Cdd:cd17328 154 RWAFRVTGVLGVLLAILLLLFVREPPRGA----AEGGVMAKSTATSFLAD-LKALAKNPSFILSTLGFTAVSFVTGALAF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 246 WGQLFLiqERGQSALVGSSYMSALE------IGGLVGSIAAGYLSDRAVARvglssygNPRHVLLLSMMaGMSASMYLFR 319
Cdd:cd17328 229 WAPTFF--LRAFGVGDLSSADVGLIfgaitcIAGVLGVLLGGILADRLRRK-------TPRADPLVCAV-GLLAAAPFLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 320 VTITSDSPKENDLWIvalhplavltglteqelwILILGAIFGFSSYGPIAlfgVIANESAPSNLCGTSHAIVALLAN--- 396
Cdd:cd17328 299 LALVLALSNLLLAWV------------------LLFLGEFLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllg 357
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1985423905 397 --VGGFLAGLPFSTIAKHY--------SWATAFWVAEITCVISTIAFF 434
Cdd:cd17328 358 daGSPYLIGLISDLLRQNKdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-442 |
1.08e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.79 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 34 VMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 114 QGLGWPPCGKVLRkWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALR---YDWRTTLSVSGFICVGASFVCLVlikne 190
Cdd:COG0738 110 LGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLR----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 191 psdVGLPKIEPGTmkgkKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALE 270
Cdd:COG0738 184 ---SKLPEIEEEE----EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 271 IGGLVGSIAAGYLSDRAvarvglssygNPRHVLLLSMMAGMsasmylfrvtitsdspkendlwivalhpLAVLTGLTEQE 350
Cdd:COG0738 257 GGMTIGRFLGGFLLKRF----------GPVRLLRLSALLAA----------------------------VGLLLALLAPG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 351 LWILILGAI---FGFSSYGPIALfgVIANESAPSNLCGTShAIVALLANVGGFLAGLPFSTIAKHYSWATAFWVAEITCV 427
Cdd:COG0738 299 PWLALIGLAlvgLGLSLMFPTIF--SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYL 375
|
410
....*....|....*
gi 1985423905 428 ISTIAFFLLRNIRTK 442
Cdd:COG0738 376 LILLLALALKRKRRK 390
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-436 |
1.51e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.54 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 14 FTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVV 93
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 94 FSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSG 173
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 174 FICVGASFVCLVLIKNepsdvgLPKIEPGTMKGKKGSSRDD-STLAELLLSPYLWVLSTGYLVVFGVKTCC---TDWGQL 249
Cdd:cd17371 161 LLGALPALLVLFIRRF------VKEPPQWQAARAARRHFADrPSLRELFSPPLLRTTLLASLLATGALGGYygiTTWLPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglssYGNPRHVLLLSMMAGMSASMYLFrvtitsdSPKE 329
Cdd:cd17371 235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF-------LPLS 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 330 NDLwivalhplavltglteqelwILILGAIFGFSSYGPIALFGVIANESAPSNLCGTShaiVALLANVGGFLAGL-PFST 408
Cdd:cd17371 299 PTL--------------------ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATA---QGFCYNVGRIIGALfPFLV 355
|
410 420 430
....*....|....*....|....*....|.
gi 1985423905 409 --IAKHYSWATAF-WVAEITCVISTIAFFLL 436
Cdd:cd17371 356 gfLATSGSLGTAIaVFAAVYYIAGLVLALLL 386
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
10-191 |
1.47e-07 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 53.47 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFV-------------MPSIMEEIE-------LDKDD----LGLITSSQSAAYAISKF 65
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVksvlhpncsalipPPNIVLNNTtwcgwapFDGKNgtelLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 66 ISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSgLWF------LNGLAQGLGWPPCGKVLRKWFEPSQFGTWWA 139
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHS-LWYfvvvqiLAGLFQSTGWPSVVACVGNWFGKGKRGLIMG 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1985423905 140 ILSTSMNLAGGLGPIVAAlMALRYDWRTTLSVSGFICVGASFVC-LVLIKNEP 191
Cdd:cd17344 160 IWNSHTSVGNILGSLIAG-IFVSSAWGLSFIVPGIIIAAMGVLVfLFLVEHPP 211
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-239 |
2.10e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGV 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTL 169
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 170 svsgFICVGASFVCLVLIKNEPSDVGLPKIEPGTMKGKKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGV 239
Cdd:COG0477 172 ----LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-434 |
2.39e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.55 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 50 GLITSSQSAAYAISKFISGVLSDQMSAR--WLFSSGLLLVGVVNVVFSWSSTVTVFSGlwFLNGLAQGLGWPPCGKVLRK 127
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRrlLLVLLLLFILGNLLAALAPSFALLLLAR--ALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 128 WFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGFICVGASFVCLVLIknepsdvglpkiePGTMKGK 207
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL-------------PSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 208 KGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRA 287
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 288 VARVglssygnprhvlLLSMMAGMSASMYLfrvtitsdspkendLWIVALHPLAVLTGLteqelwililgAIFGFSSYGP 367
Cdd:cd17324 262 GRRA------------LLIALLLLAAALLL--------------LTLLGPSPLLLLVGL-----------VLWGLGFFAA 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1985423905 368 IALFGVIANESAPSNLcGTSHAIVALLANVGGFLAGLPFSTIAKHYSWATAFWVAEITCVISTIAFF 434
Cdd:cd17324 305 HSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-434 |
5.07e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.45 E-value: 5.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 14 FTAMFVGYTLYYFNRKTFSFVMPSIMEEIE--LDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVN 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 92 VVFSWSSTVTVFSGLWFLNGLAQGlGWPPCGKVLRKWFEPSQF-GTWWAILSTSMN----LAGGLGPIVAALMALRYDWR 166
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIG-GEYPGASTYVAEFAPSKRrGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 167 TTLSVSGFICVGAsfvclvliknepsdvglpkiepgtmkgkkgssrddstlaeLLLSPYLWVLSTGYLVVFGVKTCCTDW 246
Cdd:cd17316 160 ILFLIGALPALLA----------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 247 GQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssygnPRHVLLLSMMAGMSASMYLFrvtitsds 326
Cdd:cd17316 200 LPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL-------- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 327 pkendlwivalhplavLTGLTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLAN-VGGFLAGLP 405
Cdd:cd17316 261 ----------------FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLI 324
|
410 420
....*....|....*....|....*....
gi 1985423905 406 FSTIAKHYSWATAFWVAEITCVISTIAFF 434
Cdd:cd17316 325 ALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-188 |
7.33e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 7.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 12 VIFTAMFVGYTLYYFNRKTFSFVMPSIM-EEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSAR--WLFSSGLLLVG 88
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 89 VVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTT 168
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|
gi 1985423905 169 LSVSGFICVGASFVCLVLIK 188
Cdd:COG2271 340 FLLLAALALLAALLALLLLR 359
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
32-404 |
2.25e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.66 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 32 SFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNG 111
Cdd:TIGR00895 37 GFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 112 LAQGLGWPPCgKVLRKWFEPSQF-GTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGFICVgasFVCLVLIKNE 190
Cdd:TIGR00895 117 LGLGGLMPNL-NALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPL---LLLLLLMRFL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 191 P------------------------------SDVGLPKIEPGTMKGKKGSSRDDSTLAELLLspyLWVL-STGYLVVFGV 239
Cdd:TIGR00895 193 PesidflvskrpetvrrivnaiapqmqaeaqSALPEQKSTQGTKRSVFKALFQGKTARITVL---LWLLyFMLLVGVYFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 240 ktccTDWGQlFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglssygNPRHVLLLSMMAGMSASMYLFR 319
Cdd:TIGR00895 270 ----TNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGAVFAVLVGST 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 320 VTITSDspkendlwivalhplavltglteqelwILILGAIFGFSSYGPIALFGVIANESAPSNLCGTShaiVALLANVGG 399
Cdd:TIGR00895 335 LFSPTL---------------------------LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGR 384
|
....*
gi 1985423905 400 FLAGL 404
Cdd:TIGR00895 385 LGAII 389
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-286 |
5.21e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.47 E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 35 MPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNGLAQ 114
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 115 GLGwPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP-IVAALMALRYDWRTTLSVSGFICVgASFVCLVLIKNEPsd 193
Cdd:cd17333 99 GIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPlIATSLLTSELSWSWAYLIIGLIYL-LLAILILLTLFPE-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 194 vglpkiEPGTMKGKKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17333 175 ------LPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250
....*....|...
gi 1985423905 274 LVGSIAAGYLSDR 286
Cdd:cd17333 249 TIGRLLGGPISRR 261
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-436 |
2.92e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 34 VMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALrYDWRTTLSVSGFICVgASFVCLVLIKNEPSD 193
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIP-VAFLAILFLLPEPKE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 194 vglpkiepgtmKGKKGSSRDDSTLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17474 179 -----------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 274 LVGSIAAGYLSDRAVarvglssygnPRHVLLLSMMAGMSASMYLFrvtitsdspkendlwivalhplavltGLTEQELWI 353
Cdd:cd17474 248 ALGSLFVGRLLKKRF----------GARRILVIGLLLYALSLLLL--------------------------GFVPSLALL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 354 LILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFSTIAKHYSWATAFWVAEITCVISTIAF 433
Cdd:cd17474 292 LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
...
gi 1985423905 434 FLL 436
Cdd:cd17474 372 ALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-436 |
3.12e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 14 FTAMFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWL-----FSSGLLLVG 88
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 89 VVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTT 168
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 169 LSVSGfICVGASFVCLVLIKNEPSDVGLPKIEPGTMKGKKGssrddstLAELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:cd06173 161 FAINA-LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGGALTVLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglssygNPRHVLLLSMMAGMSASmylfrvtitsdspk 328
Cdd:cd06173 233 LLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLA-------------- 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 329 endLWIVALHPLAVLTglteqelwiLILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFST 408
Cdd:cd06173 288 ---LLVLGLSPSLWLL---------LAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
410 420
....*....|....*....|....*...
gi 1985423905 409 IAKHYSWATAFWVAEITCVISTIAFFLL 436
Cdd:cd06173 356 LADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-213 |
1.20e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 26 FNRKTFSFVMPSIM----EEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVT 101
Cdd:cd17329 10 LNRLGFFMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 102 VFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA-LRYDWRTTLSVSGFICVgas 180
Cdd:cd17329 90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLlYSFRLLFLAAAVLFLLA--- 166
|
170 180 190
....*....|....*....|....*....|...
gi 1985423905 181 FVCLVLIKNEPSDVGLPKIEPGTMKGKKGSSRD 213
Cdd:cd17329 167 ALVLLFLLPETRPKRRAAEKTEILRGYKIVLRD 199
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-311 |
1.24e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.11 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 32 SFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGVVNVVFSWSSTVTVFSGLWFLNG 111
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 112 LAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLsvsgFICVGASFVCLVLIKnep 191
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF----LLGGVPPLILLPLLR--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 192 sdvglpkiepgtmkgkkgssrddSTLAelllspyLWVLS-TGYLVVFGVKTcctdWGQLfLIQERGQSALVGSSYMSALE 270
Cdd:cd17365 172 -----------------------GTLL-------LWVTFfMGLLLVYLLNS----WLPK-LMVEAGYSLSQALTITLLLN 216
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1985423905 271 IGGLVGSIAAGYLSDRavarvglssyGNPRHVLLLSMMAGM 311
Cdd:cd17365 217 IGGVIGSLLLGWLADR----------FGPKRVLALFFALGA 247
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-435 |
4.01e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 4.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 30 TFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARW--LFSSGLLLVGVVNVVFSwSSTVTVFSGLW 107
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKaiLIGGILFGLGFILSAFA-ISLPLLFLGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 108 FLNGLAQGLGWPPCGKVLRKWFePSQFGtwwaiLSTSMNLAG-GLG-----PIVAALMAlRYDWRTTLSVSGFICVGASF 181
Cdd:cd17353 100 VLGGIGAGIGYITPVSTAVKWF-PDKRG-----LATGIVIAGfGLGslifsPLIAYLIN-TVGVPTTFLILGIIFLIIIV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 182 VCLVLIKNEPSDVGLPKIEPGtmKGKKGSSRDDSTLAELLLSPYLWVLstgYLVVFgvktCCTDWGQL-------FLIQE 254
Cdd:cd17353 173 IGAFLIRDPPKGWVPPGVDPL--ANNAENSPRDYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakpIGQEF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 255 RGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglssYGNPRhvlLLSMMAGMSASMYLFRVTITSDspkendlwi 334
Cdd:cd17353 244 AGLDAGIAALAVSILSIFNGGGRPFWGWLSDK---------IGRKN---TLSIAFLIQGVAMFLLPFIGSV--------- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 335 valhplavltglteqELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFSTIAKHYS 414
Cdd:cd17353 303 ---------------AVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367
|
410 420
....*....|....*....|.
gi 1985423905 415 WATAFWVAeitCVISTIAFFL 435
Cdd:cd17353 368 YNAAFIIA---AALSLVALAL 385
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-286 |
1.21e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.08 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 12 VIFTAMFVGYTLYYFNRKTFS--FVMpSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGV 89
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISnaAVM-GMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTsmnlAGGLGPIVAALMALR------- 162
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYA----AAGLGSIFGGLLAYGvfkilgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 163 ---YDWRTTLSVSGFICVGASFVCLVLIKNEPSDVG--------LPKIEPGTMKGKKGSSRDD-STLAELLLSPYLWVLS 230
Cdd:cd17327 160 gglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWflteeekeLAVERLRANQTGKGDQKFKwKQIKEAFKDPRTWLLF 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1985423905 231 TGYLVVFGVKTCCTdwGQLFLIQERGQSALVGSSYMS-ALEIGGLVGSIAAGYLSDR 286
Cdd:cd17327 240 LFFFCSQITNNGIS--NFLPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDR 294
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-188 |
2.14e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 17 MFVGYTLYYFNRKTFSFVMPSIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARW--LFSSGLLLVGVVNVVF 94
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKvlLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 95 SWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALRYDWRTTLSVSGF 174
Cdd:cd17380 84 LAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
170
....*....|....
gi 1985423905 175 ICVGASFVCLVLIK 188
Cdd:cd17380 164 LGLLWALVWLIYLP 177
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
353-436 |
3.71e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 39.57 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985423905 353 ILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALLANVGGFLAGLPFSTIAKHYSWATAFWVAEITCVISTIA 432
Cdd:cd17364 302 FVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIIL 381
|
....
gi 1985423905 433 FFLL 436
Cdd:cd17364 382 TLLF 385
|
|
| |
