NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1974324231|ref|XP_039189453|]
View 

desmocollin-2-like isoform X2 [Crotalus tigris]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10660623)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-354 1.43e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 249 TFSILENSRSGTFIGQMTATDRDEPgtLHTKLKYRIVGQTPASfrggfLFTVHADSGDISLhTPSLDREKVDRYTVLMEA 328
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG-----LFSIDPSTGEITT-AKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 1974324231 329 RDMGGQSfgLCNTGTVIIEVGDTNDH 354
Cdd:cd11304    75 TDGGGPP--LSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 33-113 5.47e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 88.10  E-value: 5.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231   33 ASKKVILNVPPKLNPDTLIGQVNLNGYLRTPHL-ISTSDPDFIVLDDGSIFTSNAVSLSSGKKTFTILLKNLQNNKQKQI 111
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 1974324231  112 HV 113
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-576 1.21e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 479 IYILDIKECLKVGTVVGHYTASDPETGNSEDIRYRIIK-DPCNWIAIN-NEGQISIAKMLDRDVPDlpshQCNVTVAAVD 556
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDpSTGEITTAKPLDREEQS----SYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1974324231 557 RSG--KSGTGTIVVNLLDENDN 576
Cdd:cd11304    77 GGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
143-253 2.25e-15

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 143 TIMENSL-GPFPMQIQQLSSDSAQNYNITYSISGPGVDqpplNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKtldgy 221
Cdd:pfam00028   4 SVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEAT----- 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1974324231 222 tpeiplvhliriedDNDNPPIFNPDTVTFSIL 253
Cdd:pfam00028  75 --------------DSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-440 7.01e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 362 VYEVFIPENT-VNAEVTKIDVIDKDVrgTPAWHATFNIIKGNEDGSFTIetnrDSNTGTLCIKKGLDYEKTKERRLEIIV 440
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-354 1.43e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 249 TFSILENSRSGTFIGQMTATDRDEPgtLHTKLKYRIVGQTPASfrggfLFTVHADSGDISLhTPSLDREKVDRYTVLMEA 328
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG-----LFSIDPSTGEITT-AKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 1974324231 329 RDMGGQSfgLCNTGTVIIEVGDTNDH 354
Cdd:cd11304    75 TDGGGPP--LSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 33-113 5.47e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 88.10  E-value: 5.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231   33 ASKKVILNVPPKLNPDTLIGQVNLNGYLRTPHL-ISTSDPDFIVLDDGSIFTSNAVSLSSGKKTFTILLKNLQNNKQKQI 111
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 1974324231  112 HV 113
Cdd:smart01055  86 KV 87
Cadherin pfam00028
Cadherin domain;
249-348 8.04e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 8.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 249 TFSILENSRSGTFIGQMTATDRDEPgtLHTKLKYRIVGQTPASFrggflFTVHADSGDISLHTPsLDREKVDRYTVLMEA 328
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKP-LDRESIGEYELTVEA 73

                          90       100
                  ....*....|....*....|
gi 1974324231 329 RDMGGQsfGLCNTGTVIIEV 348
Cdd:pfam00028  74 TDSGGP--PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-356 2.13e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 2.13e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  266 TATDRDEPgtLHTKLKYRIVGQTPASFrggflFTVHADSGDISLHTPsLDREKVDRYTVLMEARDMGGQSfgLCNTGTVI 345
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGL-----FSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVT 70

                           90
                   ....*....|.
gi 1974324231  346 IEVGDTNDHAP 356
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-576 1.21e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 479 IYILDIKECLKVGTVVGHYTASDPETGNSEDIRYRIIK-DPCNWIAIN-NEGQISIAKMLDRDVPDlpshQCNVTVAAVD 556
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDpSTGEITTAKPLDREEQS----SYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1974324231 557 RSG--KSGTGTIVVNLLDENDN 576
Cdd:cd11304    77 GGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
143-253 2.25e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 143 TIMENSL-GPFPMQIQQLSSDSAQNYNITYSISGPGVDqpplNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKtldgy 221
Cdd:pfam00028   4 SVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEAT----- 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1974324231 222 tpeiplvhliriedDNDNPPIFNPDTVTFSIL 253
Cdd:pfam00028  75 --------------DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-241 4.48e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.48e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  161 SDSAQNYNITYSISGPGVDqpplNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKTLDGYTPEIPLVHLIRIEDDNDNP 240
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1974324231  241 P 241
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-239 6.84e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 6.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 139 PVPTTIMENS-LGPFPMQIQQLSSDSAQNYNITYSISGPgvdqPPLNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKt 217
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDSGENGEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT- 75

                          90       100
                  ....*....|....*....|....*..
gi 1974324231 218 lDGYTPeiPL-----VHlIRIEDDNDN 239
Cdd:cd11304    76 -DGGGP--PLsstatVT-ITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
480-571 7.26e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 480 YILDIKECLKVGTVVGHYTASDPETGNSEDIRYRIIKDPC-NWIAINNE-GQISIAKMLDRDVPDlpshQCNVTVAAVDR 557
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDtGDISTTKPLDRESIG----EYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1974324231 558 S--GKSGTGTIVVNLL 571
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-440 7.01e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 362 VYEVFIPENT-VNAEVTKIDVIDKDVrgTPAWHATFNIIKGNEDGSFTIetnrDSNTGTLCIKKGLDYEKTKERRLEIIV 440
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 498-578 2.33e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.33e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  498 TASDPETGNSEDIRYRIIK-DPCNWIAINNE-GQISIAKMLDRDVPDlpshQCNVTVAAVDRSG--KSGTGTIVVNLLDE 573
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQP----EYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 1974324231  574 NDNYP 578
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
363-440 3.69e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 3.69e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1974324231 363 YEVFIPENT-VNAEVTKIDVIDKDVrgTPAWHATFNIIKGNEDGSFTIETNrdsnTGTLCIKKGLDYEKTKERRLEIIV 440
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEA 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-460 1.03e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  381 VIDKDVRgtPAWHATFNIIKGNEDGSFTIetnrDSNTGTLCIKKGLDYEKTKERRLEIIVNNevpyilapNSGPISTSTC 460
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATD--------GGGPPLSSTA 67
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 41-98 9.21e-04

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 39.23  E-value: 9.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1974324231  41 VPPKLNPDTLIGQVNLNGYLRTPHLI-STSDPDFIVLDDGSIFTSNAVSLSSGKKTFTI 98
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTGRKKTLyESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLV 73
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-354 1.43e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 249 TFSILENSRSGTFIGQMTATDRDEPgtLHTKLKYRIVGQTPASfrggfLFTVHADSGDISLhTPSLDREKVDRYTVLMEA 328
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG-----LFSIDPSTGEITT-AKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 1974324231 329 RDMGGQSfgLCNTGTVIIEVGDTNDH 354
Cdd:cd11304    75 TDGGGPP--LSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 33-113 5.47e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 88.10  E-value: 5.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231   33 ASKKVILNVPPKLNPDTLIGQVNLNGYLRTPHL-ISTSDPDFIVLDDGSIFTSNAVSLSSGKKTFTILLKNLQNNKQKQI 111
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 1974324231  112 HV 113
Cdd:smart01055  86 KV 87
Cadherin pfam00028
Cadherin domain;
249-348 8.04e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 8.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 249 TFSILENSRSGTFIGQMTATDRDEPgtLHTKLKYRIVGQTPASFrggflFTVHADSGDISLHTPsLDREKVDRYTVLMEA 328
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKP-LDRESIGEYELTVEA 73

                          90       100
                  ....*....|....*....|
gi 1974324231 329 RDMGGQsfGLCNTGTVIIEV 348
Cdd:pfam00028  74 TDSGGP--PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-356 2.13e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 2.13e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  266 TATDRDEPgtLHTKLKYRIVGQTPASFrggflFTVHADSGDISLHTPsLDREKVDRYTVLMEARDMGGQSfgLCNTGTVI 345
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGL-----FSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVT 70

                           90
                   ....*....|.
gi 1974324231  346 IEVGDTNDHAP 356
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-576 1.21e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 479 IYILDIKECLKVGTVVGHYTASDPETGNSEDIRYRIIK-DPCNWIAIN-NEGQISIAKMLDRDVPDlpshQCNVTVAAVD 556
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDpSTGEITTAKPLDREEQS----SYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1974324231 557 RSG--KSGTGTIVVNLLDENDN 576
Cdd:cd11304    77 GGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
143-253 2.25e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 143 TIMENSL-GPFPMQIQQLSSDSAQNYNITYSISGPGVDqpplNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKtldgy 221
Cdd:pfam00028   4 SVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEAT----- 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1974324231 222 tpeiplvhliriedDNDNPPIFNPDTVTFSIL 253
Cdd:pfam00028  75 --------------DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-241 4.48e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.48e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  161 SDSAQNYNITYSISGPGVDqpplNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKTLDGYTPEIPLVHLIRIEDDNDNP 240
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1974324231  241 P 241
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-239 6.84e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 6.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 139 PVPTTIMENS-LGPFPMQIQQLSSDSAQNYNITYSISGPgvdqPPLNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKt 217
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDSGENGEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT- 75

                          90       100
                  ....*....|....*....|....*..
gi 1974324231 218 lDGYTPeiPL-----VHlIRIEDDNDN 239
Cdd:cd11304    76 -DGGGP--PLsstatVT-ITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
480-571 7.26e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 7.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 480 YILDIKECLKVGTVVGHYTASDPETGNSEDIRYRIIKDPC-NWIAINNE-GQISIAKMLDRDVPDlpshQCNVTVAAVDR 557
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDtGDISTTKPLDRESIG----EYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1974324231 558 S--GKSGTGTIVVNLL 571
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-440 7.01e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 362 VYEVFIPENT-VNAEVTKIDVIDKDVrgTPAWHATFNIIKGNEDGSFTIetnrDSNTGTLCIKKGLDYEKTKERRLEIIV 440
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 498-578 2.33e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.33e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  498 TASDPETGNSEDIRYRIIK-DPCNWIAINNE-GQISIAKMLDRDVPDlpshQCNVTVAAVDRSG--KSGTGTIVVNLLDE 573
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQP----EYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 1974324231  574 NDNYP 578
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
363-440 3.69e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 3.69e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1974324231 363 YEVFIPENT-VNAEVTKIDVIDKDVrgTPAWHATFNIIKGNEDGSFTIETNrdsnTGTLCIKKGLDYEKTKERRLEIIV 440
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEA 73
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-239 3.36e-10

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 57.74  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231 141 PTTIMENSLGPfpMQIQQLSSDSAQNYNITYSISGPGVDQPPlNYFYIEKETGNLFVTCPIDREEYAEFQIICYAKTLDG 220
Cdd:cd00031     3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                          90
                  ....*....|....*....
gi 1974324231 221 YTPEIPLVHLIRIEDDNDN 239
Cdd:cd00031    80 NVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-460 1.03e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974324231  381 VIDKDVRgtPAWHATFNIIKGNEDGSFTIetnrDSNTGTLCIKKGLDYEKTKERRLEIIVNNevpyilapNSGPISTSTC 460
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATD--------GGGPPLSSTA 67
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 41-98 9.21e-04

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 39.23  E-value: 9.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1974324231  41 VPPKLNPDTLIGQVNLNGYLRTPHLI-STSDPDFIVLDDGSIFTSNAVSLSSGKKTFTI 98
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTGRKKTLyESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH