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Conserved domains on  [gi|1965520073|ref|XP_039103145|]
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conserved oligomeric Golgi complex subunit 5 isoform X4 [Hyaena hyaena]

Protein Classification

conserved oligomeric Golgi complex subunit 5( domain architecture ID 10564031)

conserved oligomeric Golgi complex subunit 5 (COG5) is a component of the conserved oligomeric Golgi complex (COG), and is required for normal Golgi function

Gene Ontology:  GO:0070085|GO:0007030|GO:0048219|GO:0006891|GO:0015031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 35-158 2.22e-36

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


:

Pssm-ID: 192566  Cd Length: 132  Bit Score: 133.20  E-value: 2.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  35 SDFLNEDFDVKTYTSRSIHQA--------VIAEQLAELAQGISQLDKELHLQVVARHEDLLAQATGIESLEGVLQMMQTR 106
Cdd:pfam10392   1 EAFLDPDFDPKSFANALLLATnnnddtplDLSTPLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1965520073 107 IAALQGAVDRMKAKIVEPYNKIVARTAQLARLQVACDLLRRIVRILYLSQRL 158
Cdd:pfam10392  81 LEYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
 
Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 35-158 2.22e-36

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


Pssm-ID: 192566  Cd Length: 132  Bit Score: 133.20  E-value: 2.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  35 SDFLNEDFDVKTYTSRSIHQA--------VIAEQLAELAQGISQLDKELHLQVVARHEDLLAQATGIESLEGVLQMMQTR 106
Cdd:pfam10392   1 EAFLDPDFDPKSFANALLLATnnnddtplDLSTPLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1965520073 107 IAALQGAVDRMKAKIVEPYNKIVARTAQLARLQVACDLLRRIVRILYLSQRL 158
Cdd:pfam10392  81 LEYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 58-224 1.47e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  58 AEQLAELAQGISQLDKELhlqvvARHEDLLAQATG-IESLEGVLQMMQTRIAALQGAVDRMKAKIVEPYNKIVARTAQLA 136
Cdd:COG4942    19 ADAAAEAEAELEQLQQEI-----AELEKELAALKKeEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073 137 RLQVA----CDLLRRIVRILYLSQRLQG-QLQGGSREITKAAQSLNELDYLSQGiDLSGIEVIENDLLFIARARLEVENQ 211
Cdd:COG4942    94 ELRAEleaqKEELAELLRALYRLGRQPPlALLLSPEDFLDAVRRLQYLKYLAPA-RREQAEELRADLAELAALRAELEAE 172

                         170
                  ....*....|...
gi 1965520073 212 AKRLLEQGVETQN 224
Cdd:COG4942   173 RAELEALLAELEE 185
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 54-224 4.88e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073   54 QAVIAEQLAELAQGISQLDKELH-LQVVARHEDLLAQATGIESLEGVLQMMQTRIAALQGAVDRMKAKIVEPYNKIVART 132
Cdd:TIGR02168  208 QAEKAERYKELKAELRELELALLvLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  133 AQLARLQVAC-DLLRRIVRILYLSQRLQGQLQGGSREITKAAQSLNELDYL--SQGIDLSGIEVIENDLlfiaRARLEVE 209
Cdd:TIGR02168  288 KELYALANEIsRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEElaELEEKLEELKEELESL----EAELEEL 363

                          170
                   ....*....|....*
gi 1965520073  210 NQAKRLLEQGVETQN 224
Cdd:TIGR02168  364 EAELEELESRLEELE 378
 
Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 35-158 2.22e-36

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


Pssm-ID: 192566  Cd Length: 132  Bit Score: 133.20  E-value: 2.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  35 SDFLNEDFDVKTYTSRSIHQA--------VIAEQLAELAQGISQLDKELHLQVVARHEDLLAQATGIESLEGVLQMMQTR 106
Cdd:pfam10392   1 EAFLDPDFDPKSFANALLLATnnnddtplDLSTPLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1965520073 107 IAALQGAVDRMKAKIVEPYNKIVARTAQLARLQVACDLLRRIVRILYLSQRL 158
Cdd:pfam10392  81 LEYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
Vps51 pfam08700
Vps51/Vps67; This family includes a presumed domain found in a number of components of ...
 37-119 1.39e-12

Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues.


Pssm-ID: 462568  Cd Length: 86  Bit Score: 63.84  E-value: 1.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  37 FLNEDFDVKTYTSRSIHQAVIAE---QLAELAQGISQLDKELHLQVVARHEDLLAQATGIESLEGVLQMMQTRIAALQGA 113
Cdd:pfam08700   1 LDSPSFDADRYVSELLSKATLEEllqFESSLRSEIERLDSELKQLVYDNYRDLIKAADTISKMKSEMEQLSQKLSELKQA 80


                  ....*.
gi 1965520073 114 VDRMKA 119
Cdd:pfam08700  81 LSKIAS 86
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 58-224 1.47e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  58 AEQLAELAQGISQLDKELhlqvvARHEDLLAQATG-IESLEGVLQMMQTRIAALQGAVDRMKAKIVEPYNKIVARTAQLA 136
Cdd:COG4942    19 ADAAAEAEAELEQLQQEI-----AELEKELAALKKeEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073 137 RLQVA----CDLLRRIVRILYLSQRLQG-QLQGGSREITKAAQSLNELDYLSQGiDLSGIEVIENDLLFIARARLEVENQ 211
Cdd:COG4942    94 ELRAEleaqKEELAELLRALYRLGRQPPlALLLSPEDFLDAVRRLQYLKYLAPA-RREQAEELRADLAELAALRAELEAE 172

                         170
                  ....*....|...
gi 1965520073 212 AKRLLEQGVETQN 224
Cdd:COG4942   173 RAELEALLAELEE 185
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 54-224 4.88e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073   54 QAVIAEQLAELAQGISQLDKELH-LQVVARHEDLLAQATGIESLEGVLQMMQTRIAALQGAVDRMKAKIVEPYNKIVART 132
Cdd:TIGR02168  208 QAEKAERYKELKAELRELELALLvLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  133 AQLARLQVAC-DLLRRIVRILYLSQRLQGQLQGGSREITKAAQSLNELDYL--SQGIDLSGIEVIENDLlfiaRARLEVE 209
Cdd:TIGR02168  288 KELYALANEIsRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEElaELEEKLEELKEELESL----EAELEEL 363

                          170
                   ....*....|....*
gi 1965520073  210 NQAKRLLEQGVETQN 224
Cdd:TIGR02168  364 EAELEELESRLEELE 378
HrpB7 pfam09486
Bacterial type III secretion protein (HrpB7); This entry represents proteins encoded by genes ...
 54-159 5.62e-03

Bacterial type III secretion protein (HrpB7); This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.


Pssm-ID: 370523 [Multi-domain]  Cd Length: 157  Bit Score: 38.19  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1965520073  54 QAVIAEQLAELAQGISQLDKELhlQVVARHEDLLAQATGIES----------------LEGVLQMMQTRIAALQGAVDRM 117
Cdd:pfam09486  28 RAALAQAEAALAAAQAQAEQAR--DRVRAHEERLDDLTTGGSpfsaadylacrayrdvLEGRVGAAEAALAAARQALDAA 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1965520073 118 KAKIvepynkivARTAQ-LARLQVACDLLR-RIVRILYLSQRLQ 159
Cdd:pfam09486 106 EDAV--------AATRRkIARNDAQLDVCReRIARLRRAAERAR 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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