|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
1-495 |
1.87e-71 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 231.97 E-value: 1.87e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 1 MVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvagnssteeaelmgvdvsnrqtsve 80
Cdd:COG0471 23 LLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL--------------------------------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 81 lifvnedtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpssknQELNKKKYRShhdqmvckCL 160
Cdd:COG0471 70 ------------------------------------------------------------GSEKRSKFGS--------AL 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 161 SLSISYAATIGGLTTIIGTSTSLIFLEHFNNQYpaAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsk 240
Cdd:COG0471 82 LLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT--GIPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 241 KKKTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPgwdsffekkgyrtDATVSVFLGFLLFLIP 320
Cdd:COG0471 147 PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP-------------IAVVALLGAVLLLLTG 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 321 akkpcfgkksdgagqeasrgiepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLS-LSSLPPWAITLL 399
Cdd:COG0471 214 -----------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLL 270
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 400 ACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLG 479
Cdd:COG0471 271 LALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLP 350
|
490
....*....|....*.
gi 1958771240 480 VNVIGLVIVMVAINTW 495
Cdd:COG0471 351 LNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
142-500 |
3.72e-42 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 156.76 E-value: 3.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 142 ELNKKKYRSHHDQMVCKCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWF 221
Cdd:pfam00939 158 PAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI--LGVTITWASWFLAAIPPGVILLLLAPL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 222 WMHWLFLGcnfkETCSLSKKKKTRREELSErrireeyekLGDISYPEMVTAFFFILMTVLWFTREPgfvPGWDsffekkg 301
Cdd:pfam00939 236 LLYVLYPP----EIKSVPDAKAIAKTELKE---------LGPMTFREKALLGLFVLLLLLWIFGGS---LNID------- 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 302 yrtDATVSVFLGFLLFLIPakkpcfgkksdgagqeasrgiepIITWKD-FQKTMPWEIVILVGGGYALASGSKSSGLSTW 380
Cdd:pfam00939 293 ---ATTVAIIGLALMLLLR-----------------------ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEW 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 381 IGHQMLSLSSLPPWAITLLACVLVSIVT--EFVSNPATITIFLPILCTLSETLH-INPLYTLVPVTMSISFA-VMLPVGN 456
Cdd:pfam00939 347 LGNTLSTSLSGFSPAMAFIIILSLFYLShyLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGT 426
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1958771240 457 PPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLF 500
Cdd:pfam00939 427 GPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
157-496 |
5.09e-37 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 140.80 E-value: 5.09e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 157 CKCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNnqYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketc 236
Cdd:cd01115 125 PSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLE--SLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAV--------- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 237 slskkkktrreelserrireeyeklgdisypemvtaFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLL 316
Cdd:cd01115 194 ------------------------------------LIITIVLLAALAAITGLLP--------------VSVAIAIGAIV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 317 FLIpakkpcFGKksdgagqeasrgiepiITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLS-LSSLPPWA 395
Cdd:cd01115 224 LVF------GGV----------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 396 ITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVK 475
Cdd:cd01115 282 ILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAK 361
|
330 340
....*....|....*....|.
gi 1958771240 476 AGLGVNVIGLVIVMVAINTWG 496
Cdd:cd01115 362 VGLPLSILSLVVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
160-495 |
1.19e-36 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 140.94 E-value: 1.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 160 LSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcsls 239
Cdd:TIGR00785 155 LMLGIAYSASIGSSGFLTGSAPNALAAGILSKI--LGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF------------ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 240 kKKKTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFtrepgfvpgwdsfFEKKGYRTDATVSVFLGFLLFLi 319
Cdd:TIGR00785 221 -PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWI-------------FGGSLGINASVVALLAVVLMLF- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 320 pakkpcFGkksdgagqeasrgiepIITWKDFQK-TMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITL 398
Cdd:TIGR00785 286 ------LG----------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAV 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 399 LACVLVSIV--TEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQIKDMVK 475
Cdd:TIGR00785 344 LVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWR 423
|
330 340
....*....|....*....|
gi 1958771240 476 AGLGVNVIGLVIVMVAINTW 495
Cdd:TIGR00785 424 VGAIIGIVGLIVLLLVGTLW 443
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
1-495 |
1.87e-71 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 231.97 E-value: 1.87e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 1 MVLMAGAKPGMLLLCFMCCTTMLSMWLSNTSTTAMVMPIVEAVLQELinaeeeqlvagnssteeaelmgvdvsnrqtsve 80
Cdd:COG0471 23 LLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL--------------------------------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 81 lifvnedtsaadftslmqnkqnlngvpmvtksiktanqqqqkkqhqsqekpgvptpssknQELNKKKYRShhdqmvckCL 160
Cdd:COG0471 70 ------------------------------------------------------------GSEKRSKFGS--------AL 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 161 SLSISYAATIGGLTTIIGTSTSLIFLEHFNNQYpaAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsk 240
Cdd:COG0471 82 LLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT--GIPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 241 KKKTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPgwdsffekkgyrtDATVSVFLGFLLFLIP 320
Cdd:COG0471 147 PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP-------------IAVVALLGAVLLLLTG 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 321 akkpcfgkksdgagqeasrgiepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLS-LSSLPPWAITLL 399
Cdd:COG0471 214 -----------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLL 270
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 400 ACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLG 479
Cdd:COG0471 271 LALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLP 350
|
490
....*....|....*.
gi 1958771240 480 VNVIGLVIVMVAINTW 495
Cdd:COG0471 351 LNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
142-500 |
3.72e-42 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 156.76 E-value: 3.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 142 ELNKKKYRSHHDQMVCKCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWF 221
Cdd:pfam00939 158 PAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI--LGVTITWASWFLAAIPPGVILLLLAPL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 222 WMHWLFLGcnfkETCSLSKKKKTRREELSErrireeyekLGDISYPEMVTAFFFILMTVLWFTREPgfvPGWDsffekkg 301
Cdd:pfam00939 236 LLYVLYPP----EIKSVPDAKAIAKTELKE---------LGPMTFREKALLGLFVLLLLLWIFGGS---LNID------- 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 302 yrtDATVSVFLGFLLFLIPakkpcfgkksdgagqeasrgiepIITWKD-FQKTMPWEIVILVGGGYALASGSKSSGLSTW 380
Cdd:pfam00939 293 ---ATTVAIIGLALMLLLR-----------------------ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEW 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 381 IGHQMLSLSSLPPWAITLLACVLVSIVT--EFVSNPATITIFLPILCTLSETLH-INPLYTLVPVTMSISFA-VMLPVGN 456
Cdd:pfam00939 347 LGNTLSTSLSGFSPAMAFIIILSLFYLShyLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGT 426
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1958771240 457 PPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLF 500
Cdd:pfam00939 427 GPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
157-496 |
5.09e-37 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 140.80 E-value: 5.09e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 157 CKCLSLSISYAATIGGLTTIIGTSTSLIFLEHFNnqYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketc 236
Cdd:cd01115 125 PSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLE--SLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAV--------- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 237 slskkkktrreelserrireeyeklgdisypemvtaFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLL 316
Cdd:cd01115 194 ------------------------------------LIITIVLLAALAAITGLLP--------------VSVAIAIGAIV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 317 FLIpakkpcFGKksdgagqeasrgiepiITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLS-LSSLPPWA 395
Cdd:cd01115 224 LVF------GGV----------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 396 ITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFAVMLPVGNPPNAIVFSYGHCQIKDMVK 475
Cdd:cd01115 282 ILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAK 361
|
330 340
....*....|....*....|.
gi 1958771240 476 AGLGVNVIGLVIVMVAINTWG 496
Cdd:cd01115 362 VGLPLSILSLVVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
160-495 |
1.19e-36 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 140.94 E-value: 1.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 160 LSLSISYAATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcsls 239
Cdd:TIGR00785 155 LMLGIAYSASIGSSGFLTGSAPNALAAGILSKI--LGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF------------ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 240 kKKKTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFtrepgfvpgwdsfFEKKGYRTDATVSVFLGFLLFLi 319
Cdd:TIGR00785 221 -PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWI-------------FGGSLGINASVVALLAVVLMLF- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 320 pakkpcFGkksdgagqeasrgiepIITWKDFQK-TMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITL 398
Cdd:TIGR00785 286 ------LG----------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAV 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 399 LACVLVSIV--TEFVSNPATITIFLPILCTLSETLHINPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQIKDMVK 475
Cdd:TIGR00785 344 LVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWR 423
|
330 340
....*....|....*....|
gi 1958771240 476 AGLGVNVIGLVIVMVAINTW 495
Cdd:TIGR00785 424 VGAIIGIVGLIVLLLVGTLW 443
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
158-492 |
6.34e-24 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 103.48 E-value: 6.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 158 KCLSLSISYAATIGGLTTIIGTSTSLIFLehfnnqypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcs 237
Cdd:cd00625 119 VPLLLALAFAANIGGAATPIGNPPNLIIA--------SLSGLGFLDFLAFMAPPALGLLLLLLGLLYLLF---------- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 238 lsKKKKTRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLLF 317
Cdd:cd00625 181 --RKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLI--------------ALLGALLLLLLL 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 318 LIpakkpcfgkksdgagqeasrgiepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAIT 397
Cdd:cd00625 245 VR------------------------GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAAL 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 398 LLACVLVSIVTEFVSNPATITIFLPILCTLSET-----LHINPLYTLVPVTMSISFAVMLPVGNPPNAIV-FSYGhcqik 471
Cdd:cd00625 301 LLIGLLSALLSNFISNVPTVALLLPIAASLAPPepawlALALGSTLGGNLTLIGSLANLIPLGAAENAGVgISFG----- 375
|
330 340
....*....|....*....|.
gi 1958771240 472 DMVKAGLGVNVIGLVIVMVAI 492
Cdd:cd00625 376 EFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
343-492 |
1.84e-12 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 68.49 E-value: 1.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 343 PIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATITIFLP 422
Cdd:pfam03600 26 GVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIP 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958771240 423 ILCTLSETLHINPLYTLVPVTMSISFA-VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAI 492
Cdd:pfam03600 106 IVLALARRLGLPPSPLLIALAFAANIGgTATPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
159-440 |
2.45e-11 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 65.03 E-value: 2.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 159 CLSLSISYAATIGGLTTIIGTSTSLIFLEHFnnqypaaeVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLgcnfketcsl 238
Cdd:pfam03600 120 PLLIALAFAANIGGTATPIGDPPNIIIASAL--------GLSFGDFGFFMFPPVGVALLLVGLLPLLLIF---------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 239 skkkktRREELSERRIREEYEKLGDISYPEMVTAFFFILMTVLWFtrepgfvpgwdsffekkgyrtdatVSVFLGFLLFL 318
Cdd:pfam03600 182 ------RKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVI------------------------LGFLLLSVLAL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 319 IPAkkpcfgkksdgagqeASRGIEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSslPPWAITL 398
Cdd:pfam03600 232 AGA---------------LLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALA 294
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1958771240 399 LACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLV 440
Cdd:pfam03600 295 LILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
344-467 |
8.26e-10 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 60.91 E-value: 8.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 344 IITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATITIFLPI 423
Cdd:COG1055 41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958771240 424 LCTLSETLHINPlytlVPVTMSISFA-----VMLPVGNPPNAIVFSYGH 467
Cdd:COG1055 121 VLAIARRLGLNP----VPFLIAIVFAaniggAATPIGNPTNIMIASAGG 165
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
358-492 |
1.44e-09 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 59.91 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 358 IVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLY 437
Cdd:cd01115 48 AVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSR 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958771240 438 TLVPVTMSISFAVML-PVGNPPNAIVFSYghcqIKDMVKAGLGVNV---IGLVIVMVAI 492
Cdd:cd01115 128 LLMPLAFAASIGGMLtLIGTPPNLVASGY----LESLGGQGFSFFEftpIGLPLLIIGL 182
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
344-492 |
1.45e-09 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 59.96 E-value: 1.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 344 IITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLaCVLVSIVTEFVSNPATITIFLPI 423
Cdd:cd00625 27 VVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLL-MLLTAALSAFFSNDATAVLLTPI 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958771240 424 LCTLSETLHINPlytLVPVTMSISFA-----VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAI 492
Cdd:cd00625 106 VLALLRKLGLSP---PVPLLLALAFAaniggAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLLGLL 176
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
162-440 |
6.88e-09 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 57.83 E-value: 6.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 162 LSISYAATIGGLTTIIGTSTSLIFLEHFNnqypaaevVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsKK 241
Cdd:COG1055 137 IAIVFAANIGGAATPIGNPTNIMIASAGG--------LSFLDFLANLFPPSLVSLLVTLLVLYLLF------------RK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 242 KKTRREELSErrirEEYEKLGDISYPEMVTAFFFILMTVLWFTREPGFVPGWdsffekkgyrtdatVSVFLGFLLFLIpa 321
Cdd:COG1055 197 ELPAAPDLED----DPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPAL--------------IALLGAAVLLLL-- 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 322 kkpcfgkksdgagqeASRGIEPIItwkdfqKTMPWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLAC 401
Cdd:COG1055 257 ---------------ARVDVREVL------KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLIL 315
|
250 260 270
....*....|....*....|....*....|....*....
gi 1958771240 402 VLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTLV 440
Cdd:COG1055 316 WLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWLAL 354
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
338-490 |
6.31e-07 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 51.87 E-value: 6.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 338 SRGIEPIITWKDfqktmpWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATI 417
Cdd:cd01116 35 SPDLETIVSWVD------WETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTV 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958771240 418 TIFLPILCTLSETLHINPlytlVPVTMSISFA-----VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMV 490
Cdd:cd01116 109 LLMVPVTIRLCEVLGLNP----VPVLISEVIAaniggAATLIGDPPNIMIGSAAGLTFNDFLLHMLPSVVLALVVTFI 182
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
364-492 |
1.52e-06 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 50.15 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 364 GGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPLYTL-VPV 442
Cdd:COG0471 2 GGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFgSAL 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958771240 443 TMSISFA-----VMLPVGNPPNAIV-----------FSYGhcqikDMVKAGLGVNVIGLVIVMVAI 492
Cdd:COG0471 82 LLPIAFAasiggMGTLIGTPPNLIAaglleeatgipISFF-----EWMLVGLPVALVGLLLLWLVL 142
|
|
| DctM |
pfam06808 |
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ... |
357-491 |
1.05e-04 |
|
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.
Pssm-ID: 284275 [Multi-domain] Cd Length: 413 Bit Score: 44.55 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 357 EIVILVGGGYALASGSKSSGLSTWIGHQMLSLSsLPPWAITLLACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPl 436
Cdd:pfam06808 274 AVLFILAAAGIFAGLLTITGVPFKLSDWLLSLG-GGNLLFLILVNLLCLVLGMFLDPTAAIIILVPILAPAAAQLGIDP- 351
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1958771240 437 ytlVPVTMSISFAVMLPVGNPPNAIVFsYGHCQIKDMVKAGLGVNVIGLVIVMVA 491
Cdd:pfam06808 352 ---IHFGVVIVYNGSIGLITPPVGLAL-FVAAGIAKVSFEEVVKGVVPFLFVLVP 402
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
344-467 |
6.83e-03 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 38.79 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 344 IITWKDFqktmpWEIVILVGGGYA-------LASGSKSSGLSTWIGHQMLSLSSLPPWAITLLACVLVSIVTEFVSNPAT 416
Cdd:cd01118 38 LVSPHDA-----LEVWGIVWDVTLtligvilLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGT 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958771240 417 ITIFLPILCTLSETLHINPLYTLvPVTMSISF-----AVMLPVGNPPNAIVFSYGH 467
Cdd:cd01118 113 ALILTPIVIALLRALGAKKNRTL-PFLYACAFiadaaSLPLPISNLVNIVTAGYFG 167
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
162-228 |
6.95e-03 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 38.96 E-value: 6.95e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958771240 162 LSISYAATIGGLTTIIGTSTSLIFLEhfnnqypAAE----VVNFGTWFLFSFPISLIMLVVSWFWMHWLFL 228
Cdd:COG1055 352 LALALGATLGGNLTPIGSAANVIVLG-------IAEkkgiKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
162-436 |
7.63e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 38.77 E-value: 7.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 162 LSISYAATIGGLTTIIGTSTSLIFlehfnnqyPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslSKK 241
Cdd:cd01116 131 ISEVIAANIGGAATLIGDPPNIMI--------GSAAGLTFNDFLLHMLPSVVLALVVTFILLYFLY-----------RNI 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 242 KKTRREELSERRIREEYEKLGDIsyPEMVTAFFFILMTVLWFTRE--PGFVPGWDSFfekkgyrtdatvsvfLGFLLFLI 319
Cdd:cd01116 192 LKAREEDVLALAELEPKYPIKDK--VLLLKSLTILTLVIIGFVLHspLGVSLGWIAL---------------LGALLLLL 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958771240 320 PAKKPCFgkksdgagQEASRGIEpiitwkdfqktmpWEIVILVGGGYALASGSKSSGLSTWIGHQMLSLSSLPPWAITLL 399
Cdd:cd01116 255 LADKLDF--------EDVLSRVE-------------WDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVIL 313
|
250 260 270
....*....|....*....|....*....|....*..
gi 1958771240 400 ACVLVSIVTEFVSNPATITIFLPILCTLSETLHINPL 436
Cdd:cd01116 314 ILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLL 350
|
|
| |
