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Conserved domains on  [gi|1958768788|ref|XP_038963241|]
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histone-lysine N-methyltransferase SMYD1 isoform X4 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 7-222 2.47e-142

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


:

Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 404.49  E-value: 2.47e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD-------RLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEH 79
Cdd:cd10526     1 EGVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVFGkapneniRLAARILWRIEREGGGLKEGELVSIEDLQDHLED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  80 FGEEEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNN 159
Cdd:cd10526    81 FSEEEKKDLREDVHSFLDYWPYQSQQFSMEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNN 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768788 160 GnheavksmfhtqmRIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYYFDCSCEHCQK 222
Cdd:cd10526   161 G-------------RIELRALGKISEGDELTVSYIDFLNTSEDRKEQLKKQYYFDCTCEHCTK 210
 
Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 7-222 2.47e-142

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 404.49  E-value: 2.47e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD-------RLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEH 79
Cdd:cd10526     1 EGVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVFGkapneniRLAARILWRIEREGGGLKEGELVSIEDLQDHLED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  80 FGEEEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNN 159
Cdd:cd10526    81 FSEEEKKDLREDVHSFLDYWPYQSQQFSMEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNN 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768788 160 GnheavksmfhtqmRIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYYFDCSCEHCQK 222
Cdd:cd10526   161 G-------------RIELRALGKISEGDELTVSYIDFLNTSEDRKEQLKKQYYFDCTCEHCTK 210
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 7-198 2.43e-13

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 66.59  E-value: 2.43e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788    7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERaysavvfdrlaarimwrveregtglteGCLVSVDDLQnhvehfgEEEQK 86
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYV---------------------------GEIITSEEAE-------ERPKA 46

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   87 ELRVDVDTFlqywppqsqqfsmqYISHIFGVINCNGFtlsdqrglqavgvGIFPNLGLVNHDCWPNCTVIFNNGNHEavk 166
Cdd:smart00317  47 YDTDGAKAF--------------YLFDIDSDLCIDAR-------------RKGNLARFINHSCEPNCELLFVEVNGD--- 96

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1958768788  167 smfhtqMRIELRALGKISEGEELTVSYIDFLH 198
Cdd:smart00317  97 ------DRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 144-193 3.32e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 51.37  E-value: 3.32e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958768788 144 LVNHDCWPNCTVIFNNGNHEavksmfhtqMRIELRALGKISEGEELTVSY 193
Cdd:pfam00856  74 FINHSCDPNCEVRVVYVNGG---------PRIVIFALRDIKPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
123-220 2.39e-07

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 49.57  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 123 FTLSDQRGLQAVGVGifpNLG-LVNHDCWPNCTVIFNNGnheavksmfhtqmRIELRALGKISEGEELTVSYIDFLHlsE 201
Cdd:COG2940    60 FELDDDGVIDGALGG---NPArFINHSCDPNCEADEEDG-------------RIFIVALRDIAAGEELTYDYGLDYD--E 121

                          90
                  ....*....|....*....
gi 1958768788 202 ERrqqlkkqyyFDCSCEHC 220
Cdd:COG2940   122 EE---------YPCRCPNC 131
 
Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 7-222 2.47e-142

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 404.49  E-value: 2.47e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD-------RLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEH 79
Cdd:cd10526     1 EGVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVFGkapneniRLAARILWRIEREGGGLKEGELVSIEDLQDHLED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  80 FGEEEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNN 159
Cdd:cd10526    81 FSEEEKKDLREDVHSFLDYWPYQSQQFSMEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNN 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768788 160 GnheavksmfhtqmRIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYYFDCSCEHCQK 222
Cdd:cd10526   161 G-------------RIELRALGKISEGDELTVSYIDFLNTSEDRKEQLKKQYYFDCTCEHCTK 210
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 7-222 1.75e-109

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 320.91  E-value: 1.75e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD----RLAARIMWRVEREGTGlTEGCLVSVDDLQNHVEHFGE 82
Cdd:cd19167     1 GQVERFCSPGKGRGLRALKPFEPGDLIFSERPYAYVLTPpehvRLTGRILYKQHIRKTR-TSGKLLSVYDLESHVEKLDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  83 EEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQrGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNh 162
Cdd:cd19167    80 EKKDGLRSDVATLHQFMSKDLQLPDAAYLVELFGKVNCNGFTISDE-ELQHVGVGIYPQAALLNHSCCPNCIVTFNGPN- 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 163 eavksmfhtqmrIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYYFDCSCEHCQK 222
Cdd:cd19167   158 ------------IEVRAVQEIEPGEEVFHSYIDLLYPTEERRDQLRDQYFFLCQCADCQT 205
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 8-221 7.11e-55

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 181.02  E-value: 7.11e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   8 NVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD-----RLAARIMWRVEREGTGLTEGcLVSVDDLQNHVEHFGE 82
Cdd:cd19203     2 KVEKFETAEKGRGLRAVTPLKPGELVLKADPFAYTVCNppdsvRLEGRIIFKLLDKAPSESEK-LYSFYDLQSNINKLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  83 EEQKELRVDVDTFLQYWPPQSQQFSmQYIS-----HIFGVINCNGFTLSDQRgLQAVGVGIFPNLGLVNHDCWPNCTVIF 157
Cdd:cd19203    81 DRKEGLRQLAMVLQHYLREEIQDAS-QLPPafdifELFAKVTCNSFTICDAE-MQEVGVGLYPSASLLNHSCDPNCVIVF 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768788 158 NNgnheavksmfhtqMRIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYYFDCSCEHCQ 221
Cdd:cd19203   159 NG-------------PHLLLRAIREIEVGEELTISYIDMLMPSEERRKQLRDQYCFECDCFRCQ 209
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 7-220 5.42e-35

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 128.79  E-value: 5.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD----RLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGE 82
Cdd:cd19202     1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVLTPsetvRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  83 EEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRgLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNh 162
Cdd:cd19202    81 EKKDLIQSDIAALHHFYSKHLEFPDNDSLVVLFAQVNCNGFTIEDEE-LSHLGSAIFPDVALMNHSCCPNVIVTYKGTL- 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768788 163 eavksmfhtqmrIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYYFDCSCEHC 220
Cdd:cd19202   159 ------------AEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQEC 204
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 121-220 5.40e-29

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 109.77  E-value: 5.40e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 121 NGFTLSDQRGlqAVGVGIFPNLGLVNHDCWPNCTVIFNNGNheavksmfhtqmRIELRALGKISEGEELTVSYIDFLHLS 200
Cdd:cd20071    37 NSFSLTDGLN--EIGVGLFPLASLLNHSCDPNAVVVFDGNG------------TLRVRALRDIKAGEELTISYIDPLLPR 102

                          90       100
                  ....*....|....*....|
gi 1958768788 201 EERRQQLKKQYYFDCSCEHC 220
Cdd:cd20071   103 TERRRELLEKYGFTCSCPRC 122
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 9-220 2.64e-23

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 97.37  E-value: 2.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   9 VEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFDRLAArimwrveregtgltegcLVSVDDLQNHVEHFgEEEQKEL 88
Cdd:cd10536     8 VSLRYSEEKGRFLVATRDIKAGEVLIVEKPYASVLLPYSSD-----------------YRSVYNLVTHTENR-SPEDLFQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  89 RVDVDTFL-----QYWPPQSQQFSMQYIS------------HIFGVINCNGFTLSDQRGLQA-----------VGVGIFP 140
Cdd:cd10536    70 RALTAVFLakclqLSGYFLLWEASTELNGeepesilgglllRHLQQLQCNAHAITELQTTSSgsqvdtskqvrIATAIYP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 141 NLGLVNHDCWPNCTVIFNNGNheavksmfhtqmrIELRALGKISEGEELTVSY-IDFLHLS-EERRQQLKKQYYFDCSCE 218
Cdd:cd10536   150 TLSLLNHSCDPNTIRSFYGNT-------------IVVRATRPIKKGEEITICYgPHFSRMKrSERQRLLKEQYFFDCSCE 216


                  ..
gi 1958768788 219 HC 220
Cdd:cd10536   217 AC 218
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 7-198 2.43e-13

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 66.59  E-value: 2.43e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788    7 ENVEVFTSEGKGRGLKATKEFWAADVIFAERaysavvfdrlaarimwrveregtglteGCLVSVDDLQnhvehfgEEEQK 86
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYV---------------------------GEIITSEEAE-------ERPKA 46

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   87 ELRVDVDTFlqywppqsqqfsmqYISHIFGVINCNGFtlsdqrglqavgvGIFPNLGLVNHDCWPNCTVIFNNGNHEavk 166
Cdd:smart00317  47 YDTDGAKAF--------------YLFDIDSDLCIDAR-------------RKGNLARFINHSCEPNCELLFVEVNGD--- 96

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1958768788  167 smfhtqMRIELRALGKISEGEELTVSYIDFLH 198
Cdd:smart00317  97 ------DRIVIFALRDIKPGEELTIDYGSDYA 122
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 8-221 8.05e-11

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 62.33  E-value: 8.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788   8 NVEV-FTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD--------------------------RLAARIMWRV----- 55
Cdd:cd10521     1 HVEVrFIDAAKGRGLFATRDFKKGDIIFEEKPLVCAQFLwnelhplnklqeawrnmhyppetasiMLIARMIATVkqakd 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788  56 -EREGTGLTEGCLVSVDDlQNHVEH--FGEEEQKELRVDVDTFLQ--YWPPQSQQFSMQYISHIFGVI------------ 118
Cdd:cd10521    81 kDEWLKLFSQFCSATANE-EEHIAHklLGKQFQGQLELLRQLFTEalYEERLSQWFTPEGFRSLFALVgtngqgigtssl 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 119 -----NCNGFTLSDQRG---------------------LQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHeavksmfhtq 172
Cdd:cd10521   160 svwvhNCDALELPEQEReeldafidqlyvdiekesgefLNCEGSGLYLLQSCCNHSCVPNAEITFPENNF---------- 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958768788 173 mRIELRALGKISEGEELTVSYID--FLHLSEERRQQ-LKKQYYFDCSCEHCQ 221
Cdd:cd10521   230 -TLSLKALRDIQEGEEICISYLDecQRERSRHSRQKiLRENYLFICNCPKCE 280
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 144-193 3.32e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 51.37  E-value: 3.32e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958768788 144 LVNHDCWPNCTVIFNNGNHEavksmfhtqMRIELRALGKISEGEELTVSY 193
Cdd:pfam00856  74 FINHSCDPNCEVRVVYVNGG---------PRIVIFALRDIKPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
123-220 2.39e-07

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 49.57  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 123 FTLSDQRGLQAVGVGifpNLG-LVNHDCWPNCTVIFNNGnheavksmfhtqmRIELRALGKISEGEELTVSYIDFLHlsE 201
Cdd:COG2940    60 FELDDDGVIDGALGG---NPArFINHSCDPNCEADEEDG-------------RIFIVALRDIAAGEELTYDYGLDYD--E 121

                          90
                  ....*....|....*....
gi 1958768788 202 ERrqqlkkqyyFDCSCEHC 220
Cdd:COG2940   122 EE---------YPCRCPNC 131
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 144-222 7.56e-07

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 48.43  E-value: 7.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 144 LVNHDCWPNCtvIFNNgnheavksmfHTQMRIELRALGKISEGEELTVSYidflhlSEErrqqlkkqyYF-----DCSCE 218
Cdd:cd10524    79 FINHDCRPNC--KFVP----------TGKSTACVKVLRDIEPGEEITVYY------GDN---------YFgenneECECE 131


                  ....
gi 1958768788 219 HCQK 222
Cdd:cd10524   132 TCER 135
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 144-222 2.26e-05

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 44.21  E-value: 2.26e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768788 144 LVNHDCWPNCtvifnngnhEAVKSMFHTQMRIELRALGKISEGEELTVSYiDFLHLSEERRQQLKkqyyfdCSCEHCQK 222
Cdd:cd19174    75 FVNHSCDPNC---------EMQKWSVNGVYRIGLFALKDIPAGEELTYDY-NFHSFNVEKQQPCK------CGSPNCRG 137
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 123-193 6.47e-05

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 41.08  E-value: 6.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768788 123 FTLSD-QRGlQAVGVGIFpnlglVNHDCWPNCtvifnngnhEAVKSMFHTQMRIELRALGKISEGEELTVSY 193
Cdd:cd08161    15 FATRDiPKG-EVIGLARF-----INHSCEPNC---------EFEEVYVGGKPRVFIVALRDIKAGEELTVDY 71
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 100-193 6.01e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 39.16  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768788 100 PPQSQQFSMQYishifGVINCNGFTLSDQRGLQAVGVGifpnlGLVNHDCWPNCTVIFNNGNHeavksmfhtqmRIELRA 179
Cdd:cd10540    34 LPKEEYQHLCK-----TVLDHYVFSWGDGCLALALGYG-----SMFNHSYTPNAEYEIDFENQ-----------TIVFYA 92

                          90
                  ....*....|....
gi 1958768788 180 LGKISEGEELTVSY 193
Cdd:cd10540    93 LRDIEAGEELTINY 106
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 145-193 1.62e-03

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 38.39  E-value: 1.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958768788 145 VNHDCWPNCtvifnngnhEAVKSMFHTQMRIELRALGKISEGEELTVSY 193
Cdd:cd10531    77 INHSCEPNC---------ETQKWIVNGEYRIGIFALRDIPAGEELTFDY 116
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 146-198 6.72e-03

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 36.91  E-value: 6.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958768788 146 NHDCWPNCtvifnngnhEAVKSMFHTQMRIELRALGKISEGEELTVSY-IDFLH 198
Cdd:cd19173    80 NHSCQPNC---------ETQKWTVNGDTRVGLFAVRDIPAGEELTFNYnLDCLG 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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