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Conserved domains on  [gi|1958643873|ref|XP_038961615|]
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WASP homolog-associated protein with actin, membranes and microtubules isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JMY super family cl24446
Junction-mediating and -regulatory protein; JMY, Junction-mediating and -regulatory protein is ...
 1-130 4.13e-72

Junction-mediating and -regulatory protein; JMY, Junction-mediating and -regulatory protein is also a WASP homolog-associated protein with actin, membranes and microtubules. This middle region is the coiled-coil region that putatively binds microtubules to the scaffold. This ability to interact with microtubules plays a role in membrane tubulation.


The actual alignment was detected with superfamily member pfam15871:

Pssm-ID: 464915  Cd Length: 357  Bit Score: 232.66  E-value: 4.13e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643873   1 MQKQMEQDQRRFGQAAWATAMPRLENLKLMLARETLQLMRAKELCLKHRQAEIQRKVEDLPDQGKNVGVVDELEIQYYET 80
Cdd:pfam15871 228 MQKQMEQDQKRFGKAAWAAAAPRLEKLKYMLAKETLQLMRAKELCLEQKRAEIRKEMESLEEGEKAVAVVDELEIQYYEA 307

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958643873  81 QLELYDVKLEILRNEETILVTRLDSVKRLIAEKQAEVVYYDPCESPEELK 130
Cdd:pfam15871 308 QLELYEVQLEILKNEELLLTAQLDSLRRQIKEKQDEVVYYDTCESPEELK 357
 
Name Accession Description Interval E-value
JMY pfam15871
Junction-mediating and -regulatory protein; JMY, Junction-mediating and -regulatory protein is ...
 1-130 4.13e-72

Junction-mediating and -regulatory protein; JMY, Junction-mediating and -regulatory protein is also a WASP homolog-associated protein with actin, membranes and microtubules. This middle region is the coiled-coil region that putatively binds microtubules to the scaffold. This ability to interact with microtubules plays a role in membrane tubulation.


Pssm-ID: 464915  Cd Length: 357  Bit Score: 232.66  E-value: 4.13e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643873   1 MQKQMEQDQRRFGQAAWATAMPRLENLKLMLARETLQLMRAKELCLKHRQAEIQRKVEDLPDQGKNVGVVDELEIQYYET 80
Cdd:pfam15871 228 MQKQMEQDQKRFGKAAWAAAAPRLEKLKYMLAKETLQLMRAKELCLEQKRAEIRKEMESLEEGEKAVAVVDELEIQYYEA 307

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958643873  81 QLELYDVKLEILRNEETILVTRLDSVKRLIAEKQAEVVYYDPCESPEELK 130
Cdd:pfam15871 308 QLELYEVQLEILKNEELLLTAQLDSLRRQIKEKQDEVVYYDTCESPEELK 357
 
Name Accession Description Interval E-value
JMY pfam15871
Junction-mediating and -regulatory protein; JMY, Junction-mediating and -regulatory protein is ...
 1-130 4.13e-72

Junction-mediating and -regulatory protein; JMY, Junction-mediating and -regulatory protein is also a WASP homolog-associated protein with actin, membranes and microtubules. This middle region is the coiled-coil region that putatively binds microtubules to the scaffold. This ability to interact with microtubules plays a role in membrane tubulation.


Pssm-ID: 464915  Cd Length: 357  Bit Score: 232.66  E-value: 4.13e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958643873   1 MQKQMEQDQRRFGQAAWATAMPRLENLKLMLARETLQLMRAKELCLKHRQAEIQRKVEDLPDQGKNVGVVDELEIQYYET 80
Cdd:pfam15871 228 MQKQMEQDQKRFGKAAWAAAAPRLEKLKYMLAKETLQLMRAKELCLEQKRAEIRKEMESLEEGEKAVAVVDELEIQYYEA 307

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958643873  81 QLELYDVKLEILRNEETILVTRLDSVKRLIAEKQAEVVYYDPCESPEELK 130
Cdd:pfam15871 308 QLELYEVQLEILKNEELLLTAQLDSLRRQIKEKQDEVVYYDTCESPEELK 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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