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Conserved domains on  [gi|1958762855|ref|XP_038961320|]
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WD repeat, SAM and U-box domain-containing protein 1 isoform X4 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-257 2.38e-56

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 2.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGSpVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:COG2319   231 WDLATGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 161 GDLTVWD-DRMRCLHSEKAHDLGITCCSFSSQplsgGEhglqlyRLASCGQDCEIKLWVVSFTRVLGfelkyrsTLSGHC 239
Cdd:COG2319   310 GTVRLWDlATGKLLRTLTGHTGAVRSVAFSPD----GK------TLASGSDDGTVRLWDLATGELLR-------TLTGHT 372

                         250
                  ....*....|....*...
gi 1958762855 240 APVLACAFSHDGQMLASG 257
Cdd:COG2319   373 GAVTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-257 2.38e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 2.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGSpVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:COG2319   231 WDLATGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 161 GDLTVWD-DRMRCLHSEKAHDLGITCCSFSSQplsgGEhglqlyRLASCGQDCEIKLWVVSFTRVLGfelkyrsTLSGHC 239
Cdd:COG2319   310 GTVRLWDlATGKLLRTLTGHTGAVRSVAFSPD----GK------TLASGSDDGTVRLWDLATGELLR-------TLTGHT 372

                         250
                  ....*....|....*...
gi 1958762855 240 APVLACAFSHDGQMLASG 257
Cdd:COG2319   373 GAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-258 5.60e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.17  E-value: 5.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   4 LIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVLW 81
Cdd:cd00200    43 LLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETGECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  82 SAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSGG 161
Cdd:cd00200   121 DVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 162 DLTVWDDRM-RCLHSEKAHDLGITCCSFSSQPlsggehglqlYRLASCGQDCEIKLWvvsftRVLGFELKYrsTLSGHCA 240
Cdd:cd00200   200 TIKLWDLSTgKCLGTLRGHENGVNSVAFSPDG----------YLLASGSEDGTIRVW-----DLRTGECVQ--TLSGHTN 262

                         250
                  ....*....|....*...
gi 1958762855 241 PVLACAFSHDGQMLASGY 258
Cdd:cd00200   263 SVTSLAWSPDGKRLASGS 280
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 55-179 1.28e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.31  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  55 YAVHCCSFSPSghVLASCSTDGTTVLWSAHSGHTLTVLEqpggSPVRVCC--FSPDS-TYLASGAADGSVVLWNAHSYKL 131
Cdd:PLN00181  579 WSIDYSSADPT--LLASGSDDGSVKLWSINQGVSIGTIK----TKANICCvqFPSESgRSLAFGSADHKVYYYDLRNPKL 652

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958762855 132 YRCGSVKDSSLVACAFSPDGGLLVTGSSGGDLTVWDDRMRC-------LHSEKAH 179
Cdd:PLN00181  653 PLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSIsginetpLHSFMGH 707
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-82 1.07e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958762855   46 PHSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVLWS 82
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Frtz pfam11768
WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable ...
 87-167 9.14e-05

WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.


Pssm-ID: 432059  Cd Length: 544  Bit Score: 43.34  E-value: 9.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  87 HTLTVLEQPGGSPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACafSPDGGLLVTGSSGGDLTVW 166
Cdd:pfam11768 249 ECVSVTRIPLRSPVISCARNHAEDKLLLGCEDSSLILYEGHRKITLLAQAAVTPHLIRW--HPAGAIILVCSAQGELQIF 326


                  .
gi 1958762855 167 D 167
Cdd:pfam11768 327 D 327
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-257 2.38e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 2.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGSpVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:COG2319   231 WDLATGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 161 GDLTVWD-DRMRCLHSEKAHDLGITCCSFSSQplsgGEhglqlyRLASCGQDCEIKLWVVSFTRVLGfelkyrsTLSGHC 239
Cdd:COG2319   310 GTVRLWDlATGKLLRTLTGHTGAVRSVAFSPD----GK------TLASGSDDGTVRLWDLATGELLR-------TLTGHT 372

                         250
                  ....*....|....*...
gi 1958762855 240 APVLACAFSHDGQMLASG 257
Cdd:COG2319   373 GAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
3-257 1.99e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 1.99e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFSS--TLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLL--RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:COG2319   189 WDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 161 GDLTVWD-DRMRCLHSEKAHDLGITCCSFSSQplsgGEhglqlyRLASCGQDCEIKLWVVSFTRVLGfelkyrsTLSGHC 239
Cdd:COG2319   268 GTVRLWDlATGELLRTLTGHSGGVNSVAFSPD----GK------LLASGSDDGTVRLWDLATGKLLR-------TLTGHT 330

                         250
                  ....*....|....*...
gi 1958762855 240 APVLACAFSHDGQMLASG 257
Cdd:COG2319   331 GAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
3-217 2.38e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:COG2319   273 WDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958762855 161 GDLTVWD-DRMRCLHSEKAHDLGITCCSFSSQplsgGEhglqlyRLASCGQDCEIKLW 217
Cdd:COG2319   352 GTVRLWDlATGELLRTLTGHTGAVTSVAFSPD----GR------TLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-258 5.60e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.17  E-value: 5.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   4 LIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVLW 81
Cdd:cd00200    43 LLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETGECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  82 SAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSGG 161
Cdd:cd00200   121 DVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 162 DLTVWDDRM-RCLHSEKAHDLGITCCSFSSQPlsggehglqlYRLASCGQDCEIKLWvvsftRVLGFELKYrsTLSGHCA 240
Cdd:cd00200   200 TIKLWDLSTgKCLGTLRGHENGVNSVAFSPDG----------YLLASGSEDGTIRVW-----DLRTGECVQ--TLSGHTN 262

                         250
                  ....*....|....*...
gi 1958762855 241 PVLACAFSHDGQMLASGY 258
Cdd:cd00200   263 SVTSLAWSPDGKRLASGS 280
WD40 COG2319
WD40 repeat [General function prediction only];
4-257 1.78e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 1.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   4 LIHTLADHGDDVSCCAFSSTLLATCSLDKTIRLYSLSDFAELPHSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVLWSA 83
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  84 HSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSGGDL 163
Cdd:COG2319   108 ATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 164 TVWD-DRMRCLHSEKAHDLGITCCSFSSQplsgGEhglqlyRLASCGQDCEIKLWVVSFTRVLGfelkyrsTLSGHCAPV 242
Cdd:COG2319   187 RLWDlATGKLLRTLTGHTGAVRSVAFSPD----GK------LLASGSADGTVRLWDLATGKLLR-------TLTGHSGSV 249

                         250
                  ....*....|....*
gi 1958762855 243 LACAFSHDGQMLASG 257
Cdd:COG2319   250 RSVAFSPDGRLLASG 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-257 4.11e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 4.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   4 LIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDfAELPHSpLKFHTYAVHCCSFSPSGHVLASCSTDGTTVLW 81
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLET-GELLRT-LKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  82 SAHSGHTLTVLEQpGGSPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSGG 161
Cdd:cd00200    79 DLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 162 DLTVWDDR-MRCLHSEKAHDLGITCCSFSSQplsggehglqLYRLASCGQDCEIKLWVVSFTRVLGfelkyrsTLSGHCA 240
Cdd:cd00200   158 TIKLWDLRtGKCVATLTGHTGEVNSVAFSPD----------GEKLLSSSSDGTIKLWDLSTGKCLG-------TLRGHEN 220

                         250
                  ....*....|....*..
gi 1958762855 241 PVLACAFSHDGQMLASG 257
Cdd:cd00200   221 GVNSVAFSPDGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
3-167 2.19e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 2.19e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:COG2319   315 WDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                  ....*..
gi 1958762855 161 GDLTVWD 167
Cdd:COG2319   394 GTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-217 2.63e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.84  E-value: 2.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:cd00200   162 WDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958762855 161 GDLTVWDDRM-RCLHSEKAHDLGITCCSFSSQPLsggehglqlyRLASCGQDCEIKLW 217
Cdd:cd00200   241 GTIRVWDLRTgECVQTLSGHTNSVTSLAWSPDGK----------RLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-167 1.80e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 1.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFaELPHSpLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:cd00200   126 KCLTTLRGHTDWVNSVAFSpdGTFVASSSQDGTIKLWDLRTG-KCVAT-LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  81 WSAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSG 160
Cdd:cd00200   204 WDLSTGKCLGTLRGHEN-GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*..
gi 1958762855 161 GDLTVWD 167
Cdd:cd00200   283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
19-257 4.87e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 4.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  19 AFSSTLLATCSLDKTIRLYSLSDFAELPhsPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVLWSAHSGHTLTVLeQPGGS 98
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLL--LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  99 PVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACAFSPDGGLLVTGSSGGDLTVWD-DRMRCLHSEK 177
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 178 AHDLGITCCSFSSQplsgGEhglqlyRLASCGQDCEIKLWVVSftrvlgfELKYRSTLSGHCAPVLACAFSHDGQMLASG 257
Cdd:COG2319   160 GHSGAVTSVAFSPD----GK------LLASGSDDGTVRLWDLA-------TGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
3-128 5.20e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 5.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYSLSDFAELphSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVL 80
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958762855  81 WSAHSGHTLTVLEQPGGsPVRVCCFSPDSTYLASGAADGSVVLWNAHS 128
Cdd:COG2319   357 WDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 55-179 1.28e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.31  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  55 YAVHCCSFSPSghVLASCSTDGTTVLWSAHSGHTLTVLEqpggSPVRVCC--FSPDS-TYLASGAADGSVVLWNAHSYKL 131
Cdd:PLN00181  579 WSIDYSSADPT--LLASGSDDGSVKLWSINQGVSIGTIK----TKANICCvqFPSESgRSLAFGSADHKVYYYDLRNPKL 652

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958762855 132 YRCGSVKDSSLVACAFSPDGGLLVTGSSGGDLTVWDDRMRC-------LHSEKAH 179
Cdd:PLN00181  653 PLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSIsginetpLHSFMGH 707
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-82 1.07e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958762855   46 PHSPLKFHTYAVHCCSFSPSGHVLASCSTDGTTVLWS 82
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 3-38 5.83e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 5.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958762855    3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYS 38
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
Frtz pfam11768
WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable ...
 87-167 9.14e-05

WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.


Pssm-ID: 432059  Cd Length: 544  Bit Score: 43.34  E-value: 9.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855  87 HTLTVLEQPGGSPVRVCCFSPDSTYLASGAADGSVVLWNAHSYKLYRCGSVKDSSLVACafSPDGGLLVTGSSGGDLTVW 166
Cdd:pfam11768 249 ECVSVTRIPLRSPVISCARNHAEDKLLLGCEDSSLILYEGHRKITLLAQAAVTPHLIRW--HPAGAIILVCSAQGELQIF 326


                  .
gi 1958762855 167 D 167
Cdd:pfam11768 327 D 327
WD40 pfam00400
WD domain, G-beta repeat;
3-38 2.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958762855   3 KLIHTLADHGDDVSCCAFS--STLLATCSLDKTIRLYS 38
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
50-82 2.20e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.20e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958762855  50 LKFHTYAVHCCSFSPSGHVLASCSTDGTTVLWS 82
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-259 2.24e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 172 CLHSEKAHDLGITCCSFSSQPLsggehglqlyRLASCGQDCEIKLWVVSFTRVLgfelkyrSTLSGHCAPVLACAFSHDG 251
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK----------LLATGSGDGTIKVWDLETGELL-------RTLKGHTGPVRDVAASADG 63


                  ....*...
gi 1958762855 252 QMLASGYM 259
Cdd:cd00200    64 TYLASGSS 71
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 139-217 3.83e-04

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 41.29  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762855 139 DSSLVACAFSPDGGLLVTGSSGGDLTVW------DDRMRCLHSEKAHDLGITCCSF-----SSQPLSggehglQLYRLA- 206
Cdd:pfam16529 186 HSLLVDAAFSPDGTALATASLDGEVKFFqiylfdNRNPRCLHEWKPHDGKPLSSLFfldnhKKPPEV------QFWRFAi 259

                          90
                  ....*....|..
gi 1958762855 207 -SCGQDCEIKLW 217
Cdd:pfam16529 260 tGADNNSELKLW 271
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-125 5.25e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 5.25e-04
                           10        20
                   ....*....|....*....|....*...
gi 1958762855   98 SPVRVCCFSPDSTYLASGAADGSVVLWN 125
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-125 2.02e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958762855  98 SPVRVCCFSPDSTYLASGAADGSVVLWN 125
Cdd:pfam00400  12 GSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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