NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958759703|ref|XP_038960134|]
View 

solute carrier family 12 member 5 isoform X3 [Rattus norvegicus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
9-1104 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1339.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703    9 NPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENNEGGKKKPV-QAPRMGT 87
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703   88 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 167
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  168 VGLCFYLGTTFAGAMYILGTIEILLAylfpamaIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 247
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  248 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrllnatcdeyftrnn 327
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  328 vtEIQGIPGAASGlikenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 407
Cdd:TIGR00930  271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  408 RSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN---------------------GNLVVGT 466
Cdd:TIGR00930  302 ISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMS 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  467 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEV 545
Cdd:TIGR00930  382 LVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTI 461
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  546 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 625
Cdd:TIGR00930  462 APIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKP 541
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  626 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDqdqnVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLD 705
Cdd:TIGR00930  542 DVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLE 617
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  706 NHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQkEDHQTWRNFIELVRE 785
Cdd:TIGR00930  618 CVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQ-AEPRAWETYIGIIHD 696
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  786 TTAGHLALLVTKNVSMFPGNP--------------------------------------ERFSEGSIDVWWIVHDGGMLM 827
Cdd:TIGR00930  697 AFDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTL 776
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  828 LLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMhesDISAytYEKTLVMEQRSQILKQM 907
Cdd:TIGR00930  777 LLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPF 851
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  908 HLTKNEREREIqsitdesrgsirrknpantrlrlnvpeetacdneekpeeevqlihdqsapscpssspspgeepegegeT 987
Cdd:TIGR00930  852 RLHKTEKDREA--------------------------------------------------------------------K 863
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  988 DPekvHLTWTKDKSAAQKNkgpspvssegikdffsmkpewenlNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPR 1067
Cdd:TIGR00930  864 DP---KMTWTKPWKITDAE------------------------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRK 916
                         1130      1140      1150
                   ....*....|....*....|....*....|....*..
gi 1958759703 1068 NRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1104
Cdd:TIGR00930  917 GSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
9-1104 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1339.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703    9 NPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENNEGGKKKPV-QAPRMGT 87
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703   88 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 167
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  168 VGLCFYLGTTFAGAMYILGTIEILLAylfpamaIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 247
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  248 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrllnatcdeyftrnn 327
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  328 vtEIQGIPGAASGlikenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 407
Cdd:TIGR00930  271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  408 RSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN---------------------GNLVVGT 466
Cdd:TIGR00930  302 ISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMS 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  467 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEV 545
Cdd:TIGR00930  382 LVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTI 461
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  546 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 625
Cdd:TIGR00930  462 APIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKP 541
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  626 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDqdqnVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLD 705
Cdd:TIGR00930  542 DVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLE 617
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  706 NHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQkEDHQTWRNFIELVRE 785
Cdd:TIGR00930  618 CVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQ-AEPRAWETYIGIIHD 696
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  786 TTAGHLALLVTKNVSMFPGNP--------------------------------------ERFSEGSIDVWWIVHDGGMLM 827
Cdd:TIGR00930  697 AFDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTL 776
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  828 LLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMhesDISAytYEKTLVMEQRSQILKQM 907
Cdd:TIGR00930  777 LLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPF 851
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  908 HLTKNEREREIqsitdesrgsirrknpantrlrlnvpeetacdneekpeeevqlihdqsapscpssspspgeepegegeT 987
Cdd:TIGR00930  852 RLHKTEKDREA--------------------------------------------------------------------K 863
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  988 DPekvHLTWTKDKSAAQKNkgpspvssegikdffsmkpewenlNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPR 1067
Cdd:TIGR00930  864 DP---KMTWTKPWKITDAE------------------------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRK 916
                         1130      1140      1150
                   ....*....|....*....|....*....|....*..
gi 1958759703 1068 NRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1104
Cdd:TIGR00930  917 GSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
90-663 1.44e-44

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 168.27  E-value: 1.44e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703   90 GVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 169
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  170 LcFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEdasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLG 249
Cdd:pfam00324   80 W-NYWLSWITVLALELTAASILIQFWELVPDIPYLW--------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  250 CVILSILAIYAGVIksafdppnfpicllgnrtlsrhgfdvcaklawegnetvttrlwGLFCSSRLLNATCDEYFTRNnvt 329
Cdd:pfam00324  145 IKIIAIIGFIIVGI-------------------------------------------ILLSGGNPNDGAIFRYLGDN--- 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  330 eiqgipgaasgLIKENLwSSYLTKGVIverrgmpsvgladgtpvdmdhpYVFSdmtsyftllvgIYFPSVTGIMAGSNRS 409
Cdd:pfam00324  179 -----------GGKNNF-PPGFGKGFI----------------------SVFV-----------IAFFAFTGIELVGIAA 213
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  410 GDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVV------GTLAWPSpwVIVIGSFFST 483
Cdd:pfam00324  214 GEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTAA 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  484 CGAGLQSLTGAPRLLQAISRDGIVPFlqVFGHGKANGEPTWALLLTACICEIGILIASLdeVAPILSMFFLMCYMFVNLA 563
Cdd:pfam00324  292 LSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLI 367
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  564 CAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARY 643
Cdd:pfam00324  368 VWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLL 447
                          570       580
                   ....*....|....*....|
gi 1958759703  644 ALLRLEEGPPHTKNWRPQLL 663
Cdd:pfam00324  448 FLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
98-623 1.28e-32

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 132.33  E-value: 1.28e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703   98 NIFGVILFLRLTWVVGIAG--IMESFCMVFICCsctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 174
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  175 GTTFAGAMYILGTIEiLLAYLFPAMAIFkaedasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 254
Cdd:COG0531    100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  255 ILAIYAGVIkSAFDPPNFpicllgnrtlsrHGFDvcaklawegneTVTTRLWGLFcssrllnatcdeyftrnnvteiqgi 334
Cdd:COG0531    162 LLLFIVVGL-FAFDPANF------------TPFL-----------PAGGGLSGVL------------------------- 192
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  335 pgAASGLIkenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyftllvgiyFPSVTGIMAGSNRSGDLRD 414
Cdd:COG0531    193 --AALALA-----------------------------------------------------FFAFTGFEAIANLAEEAKN 217
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  415 AQKSIPTGTILAIATTSAVYISSVVLFGacieGVVLRDKFGEAVNGNLVVGTLAWPSP--WVIVIGSFFSTCGAGLQSLT 492
Cdd:COG0531    218 PKRNIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASIL 293
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  493 GAPRLLQAISRDGIVPflQVFGH-GKANGEPTWALLLTACICEIGILI--ASLDEVAPILSMFFLMCYMFVNLACAVQtL 569
Cdd:COG0531    294 GASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-R 370
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759703  570 LRTPNWRPRFRYYHWTLSFLGMSLCLALMFIC---SWYYALVAMLIAGLIYKYIEYR 623
Cdd:COG0531    371 RRRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
9-1104 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1339.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703    9 NPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENNEGGKKKPV-QAPRMGT 87
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703   88 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 167
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  168 VGLCFYLGTTFAGAMYILGTIEILLAylfpamaIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 247
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  248 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrllnatcdeyftrnn 327
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  328 vtEIQGIPGAASGlikenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 407
Cdd:TIGR00930  271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  408 RSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN---------------------GNLVVGT 466
Cdd:TIGR00930  302 ISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMS 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  467 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEV 545
Cdd:TIGR00930  382 LVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTI 461
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  546 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 625
Cdd:TIGR00930  462 APIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKP 541
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  626 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDqdqnVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLD 705
Cdd:TIGR00930  542 DVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLE 617
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  706 NHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQkEDHQTWRNFIELVRE 785
Cdd:TIGR00930  618 CVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQ-AEPRAWETYIGIIHD 696
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  786 TTAGHLALLVTKNVSMFPGNP--------------------------------------ERFSEGSIDVWWIVHDGGMLM 827
Cdd:TIGR00930  697 AFDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTL 776
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  828 LLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMhesDISAytYEKTLVMEQRSQILKQM 907
Cdd:TIGR00930  777 LLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPF 851
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  908 HLTKNEREREIqsitdesrgsirrknpantrlrlnvpeetacdneekpeeevqlihdqsapscpssspspgeepegegeT 987
Cdd:TIGR00930  852 RLHKTEKDREA--------------------------------------------------------------------K 863
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  988 DPekvHLTWTKDKSAAQKNkgpspvssegikdffsmkpewenlNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPR 1067
Cdd:TIGR00930  864 DP---KMTWTKPWKITDAE------------------------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRK 916
                         1130      1140      1150
                   ....*....|....*....|....*....|....*..
gi 1958759703 1068 NRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1104
Cdd:TIGR00930  917 GSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
90-663 1.44e-44

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 168.27  E-value: 1.44e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703   90 GVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 169
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  170 LcFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEdasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLG 249
Cdd:pfam00324   80 W-NYWLSWITVLALELTAASILIQFWELVPDIPYLW--------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  250 CVILSILAIYAGVIksafdppnfpicllgnrtlsrhgfdvcaklawegnetvttrlwGLFCSSRLLNATCDEYFTRNnvt 329
Cdd:pfam00324  145 IKIIAIIGFIIVGI-------------------------------------------ILLSGGNPNDGAIFRYLGDN--- 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  330 eiqgipgaasgLIKENLwSSYLTKGVIverrgmpsvgladgtpvdmdhpYVFSdmtsyftllvgIYFPSVTGIMAGSNRS 409
Cdd:pfam00324  179 -----------GGKNNF-PPGFGKGFI----------------------SVFV-----------IAFFAFTGIELVGIAA 213
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  410 GDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVV------GTLAWPSpwVIVIGSFFST 483
Cdd:pfam00324  214 GEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTAA 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  484 CGAGLQSLTGAPRLLQAISRDGIVPFlqVFGHGKANGEPTWALLLTACICEIGILIASLdeVAPILSMFFLMCYMFVNLA 563
Cdd:pfam00324  292 LSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLI 367
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  564 CAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARY 643
Cdd:pfam00324  368 VWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLL 447
                          570       580
                   ....*....|....*....|
gi 1958759703  644 ALLRLEEGPPHTKNWRPQLL 663
Cdd:pfam00324  448 FLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
98-623 1.28e-32

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 132.33  E-value: 1.28e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703   98 NIFGVILFLRLTWVVGIAG--IMESFCMVFICCsctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 174
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  175 GTTFAGAMYILGTIEiLLAYLFPAMAIFkaedasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 254
Cdd:COG0531    100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  255 ILAIYAGVIkSAFDPPNFpicllgnrtlsrHGFDvcaklawegneTVTTRLWGLFcssrllnatcdeyftrnnvteiqgi 334
Cdd:COG0531    162 LLLFIVVGL-FAFDPANF------------TPFL-----------PAGGGLSGVL------------------------- 192
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  335 pgAASGLIkenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyftllvgiyFPSVTGIMAGSNRSGDLRD 414
Cdd:COG0531    193 --AALALA-----------------------------------------------------FFAFTGFEAIANLAEEAKN 217
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  415 AQKSIPTGTILAIATTSAVYISSVVLFGacieGVVLRDKFGEAVNGNLVVGTLAWPSP--WVIVIGSFFSTCGAGLQSLT 492
Cdd:COG0531    218 PKRNIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASIL 293
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  493 GAPRLLQAISRDGIVPflQVFGH-GKANGEPTWALLLTACICEIGILI--ASLDEVAPILSMFFLMCYMFVNLACAVQtL 569
Cdd:COG0531    294 GASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-R 370
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759703  570 LRTPNWRPRFRYYHWTLSFLGMSLCLALMFIC---SWYYALVAMLIAGLIYKYIEYR 623
Cdd:COG0531    371 RRRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
677-1104 5.24e-24

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 106.16  E-value: 5.24e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  677 PQLLSLTSQLKAGKGLTIVGSVLEGTfldnHPQAQRAE--ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGL 754
Cdd:pfam03522    2 PALVDFAHLITKNVSLMICGHVVKGR----LSQKLRSElqKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  755 QHNTVLVGWPRNWR-----------------------------------------------------------QKEDHQT 775
Cdd:pfam03522   78 KPNILLMGYKSDWRtcdkeeleeyfnvihdafdlqyavailrlpegldvshllqdqdteelglgdetnssyaeQSSEEQS 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  776 WRNFIELVRETTAGH-------LALLVTKNVSMFPGNPE------------------------------RFSEGSIDVWW 818
Cdd:pfam03522  158 TSNSKQDDDKSKLSKkdsnlslSPDKSTKNPSGKDSSKSdklkkkspsiilrtasnekeilnnitqfqkKQKKGTIDVWW 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  819 IVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRIT-AEVEVVemheSDISAYTYEKTlvm 897
Cdd:pfam03522  238 LYDDGGLTLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEQRNMASLLSKFRIDySDLTVI----PDITKKPKKET--- 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  898 eqrsqilKQMH--LTKNEREREiqsitdesrgsirrknpantrlrlnvpeetacdnEEKPEEEVQLIhdqsapscpsssp 975
Cdd:pfam03522  311 -------KKFFdeLIEPFRLHE----------------------------------DDKEEESAEKI------------- 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  976 spgeepegegeTDPEKVHLtwtKDKSAAQknkgpspvssegikdffsmkpewenlnqsnvrrmhtaVRLNEVIVNKSRDA 1055
Cdd:pfam03522  337 -----------TDSELEAL---KEKTNRQ-------------------------------------LRLRELLLEHSSDA 365
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1958759703 1056 KLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1104
Cdd:pfam03522  366 NLIVMTLPMPRKGTVSAPLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
372-620 3.16e-14

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 76.19  E-value: 3.16e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  372 PVDMDHPYVFSDMTSYFTLLVGIYFpSVTGIMAGSNRSGdlRDAQKSIPTGTILAIATTSAVYISSVVLFGACI--EGVV 449
Cdd:pfam13520  175 LSGEWHTFFPDGWPGVFAGFLGVLW-SFTGFESAANVSE--EVKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVpdDEIA 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  450 LRD-------KFGEAVNGNLVVGtlawpspwVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEP 522
Cdd:pfam13520  252 LSSglgqvaaLLFQAVGGKWGAI--------IVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSP 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  523 TWALLLTACICEIGILIASLDEVAPI----LSMFFLMCYMFVNLACAVqtLLRTPNWRPRFRYYHWTLSFLGMsLCLALM 598
Cdd:pfam13520  324 IRAIILTAILSLILLLLFLLSPAAYNallsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGI-LFSLFL 400
                          250       260
                   ....*....|....*....|..
gi 1958759703  599 FICSWYYALVAMLIAGLIYKYI 620
Cdd:pfam13520  401 IVALFFPPVGPATGSSLNYAII 422
2A0308 TIGR00911
L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and ...
410-611 4.64e-04

L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273332 [Multi-domain]  Cd Length: 501  Bit Score: 43.97  E-value: 4.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  410 GDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAWPSPwvIVIGsfFSTCGAGL 488
Cdd:TIGR00911  259 EEVKNPYRTLPIAIIISMPIVTFIYVLTNIAYFTVLSPEELLASLAVAVDfGERLLGVMSWAMP--ALVG--LSCFGSVN 334
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759703  489 QSLTGAPRLLQAISRDGIVPFLQVFGHGKANgEPTWALLLTaciCEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQT 568
Cdd:TIGR00911  335 GSLFSSSRLFFVGGREGHLPSLLSMIHVKRL-TPLPSLLIV---CTLTLLMLFSGDIYSLINLISFANWLFNALAVAGLL 410
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1958759703  569 LLR--TPNWRPRFRyyhwtlsflgMSLCLALMFICSWYYALVAML 611
Cdd:TIGR00911  411 WLRykRPEMNRPIK----------VPLFFPVFFLLSCLFLIILSL 445
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH