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Conserved domains on  [gi|1958642817|ref|XP_038958153|]
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insulin-like growth factor 1 receptor isoform X3 [Rattus norvegicus]

Protein Classification

FU and Recep_L_domain domain-containing protein( domain architecture ID 12013543)

protein containing domains FU, Recep_L_domain, and FN3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
175-330 5.39e-61

Furin-like cysteine rich region;


:

Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 204.21  E-value: 5.39e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  175 PKECGDLCPGTLEEKPMCEKttinneyNYRCWTTNRCQKMCPSVCGKRaCTENNECCHPECLGSCHTPDDnTTCVACRHY 254
Cdd:pfam00757    1 NRECGDVCPGTMEKCHSCCN-------NGYCWGPGHCQKVCPEQCKKR-CTKPGECCHEQCLGGCTGPND-SDCLACRHF 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642817  255 YYKGVCVPACPPGTYRFeGWRCVDRDFCaniPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPK 330
Cdd:pfam00757   72 NDEGTCVDQCPPGTYQF-GWRCVTFKEC---PKSHLPGYNPLVIHNGECVRECPSGYTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 353-468 1.24e-37

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 136.59  E-value: 1.24e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  353 GCTILKGNLLINIRRGNNIaSELENFMGLIEVVTGYVKIRHShALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQL 432
Cdd:pfam01030    1 NCTVIYGNLEITLIDENND-SELLSFLSNVEEITGYLLIANT-NLVSLSFLPNLRIIRGRNLFDDNYALYILDNPNLTEL 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958642817  433 WDWNHRNLTvrSGKMYFAFNPKLCVSEIYRMEEVTG 468
Cdd:pfam01030   79 GLPSLKEIT--SGGVYIHNNPKLCYTETEILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 51-161 3.11e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 123.88  E-value: 3.11e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817   51 NCTVIEGFLHILLISKAEDYRSYR-FPKLTVITEYLLLFRVaGLESLgDLFPNLTVIRGWKLFY-NYALVIFEMTNLKDI 128
Cdd:pfam01030    1 NCTVIYGNLEITLIDENNDSELLSfLSNVEEITGYLLIANT-NLVSL-SFLPNLRIIRGRNLFDdNYALYILDNPNLTEL 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958642817  129 GLYNLRNITRGAIRIEKNADLCYLST-IDWSLIL 161
Cdd:pfam01030   79 GLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 837-926 2.43e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  837 PGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYgGAKLNRLNPG-NYTARIQATSLSGN 915
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGtEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 1958642817  916 GSWTDPVFFYV 926
Cdd:cd00063     83 SPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
494-647 1.27e-06

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  494 LRFTSTTTwkNRIIITWhryRPPDYRDLISFTVYYKEA---PFKNVTEYDGqdacgsNSWnmVDVDLPPNKEgepgillh 570
Cdd:COG3401    239 LTATADTP--GSVTLSW---DPVTESDATGYRVYRSNSgdgPFTKVATVTT------TSY--TDTGLTNGTT-------- 297

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642817  571 glkpwtqYAVYVKAVTltmveNDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTlpNGNLSYYIV 647
Cdd:COG3401    298 -------YYYRVTAVD-----AAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASS--DADVTGYNV 360
 
Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
175-330 5.39e-61

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 204.21  E-value: 5.39e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  175 PKECGDLCPGTLEEKPMCEKttinneyNYRCWTTNRCQKMCPSVCGKRaCTENNECCHPECLGSCHTPDDnTTCVACRHY 254
Cdd:pfam00757    1 NRECGDVCPGTMEKCHSCCN-------NGYCWGPGHCQKVCPEQCKKR-CTKPGECCHEQCLGGCTGPND-SDCLACRHF 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642817  255 YYKGVCVPACPPGTYRFeGWRCVDRDFCaniPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPK 330
Cdd:pfam00757   72 NDEGTCVDQCPPGTYQF-GWRCVTFKEC---PKSHLPGYNPLVIHNGECVRECPSGYTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 353-468 1.24e-37

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 136.59  E-value: 1.24e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  353 GCTILKGNLLINIRRGNNIaSELENFMGLIEVVTGYVKIRHShALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQL 432
Cdd:pfam01030    1 NCTVIYGNLEITLIDENND-SELLSFLSNVEEITGYLLIANT-NLVSLSFLPNLRIIRGRNLFDDNYALYILDNPNLTEL 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958642817  433 WDWNHRNLTvrSGKMYFAFNPKLCVSEIYRMEEVTG 468
Cdd:pfam01030   79 GLPSLKEIT--SGGVYIHNNPKLCYTETEILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 51-161 3.11e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 123.88  E-value: 3.11e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817   51 NCTVIEGFLHILLISKAEDYRSYR-FPKLTVITEYLLLFRVaGLESLgDLFPNLTVIRGWKLFY-NYALVIFEMTNLKDI 128
Cdd:pfam01030    1 NCTVIYGNLEITLIDENNDSELLSfLSNVEEITGYLLIANT-NLVSL-SFLPNLRIIRGRNLFDdNYALYILDNPNLTEL 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958642817  129 GLYNLRNITRGAIRIEKNADLCYLST-IDWSLIL 161
Cdd:pfam01030   79 GLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 230-277 1.17e-09

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 54.83  E-value: 1.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958642817  230 CCHPECLGsCHTPDdNTTCVACRHYYYK--GVCVPACPPGTYR-FEGWRCV 277
Cdd:cd00064      1 PCHPSCAT-CTGPG-PDQCTSCRHGFYLdgGTCVSECPEGTYAdTEGGVCL 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 837-926 2.43e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  837 PGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYgGAKLNRLNPG-NYTARIQATSLSGN 915
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGtEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 1958642817  916 GSWTDPVFFYV 926
Cdd:cd00063     83 SPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
837-919 7.89e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 7.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  837 PGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKY---GSQVEDQRECVSRQEYRkyggAKLNRLNPG-NYTARIQATSL 912
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTS----VTLTGLKPGtEYEVRVQAVNG 78


                   ....*..
gi 1958642817  913 SGNGSWT 919
Cdd:pfam00041   79 GGEGPPS 85
FU smart00261
Furin-like repeats;
227-269 8.41e-08

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 49.43  E-value: 8.41e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958642817   227 NNEC--CHPECLGsCHTPDdNTTCVACRHYYYK--GVCVPACPPGTY 269
Cdd:smart00261    1 DGECkpCHPECAT-CTGPG-PDDCTSCKHGFFLdgGKCVSECPPGTY 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 837-916 8.28e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 8.28e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817   837 PGPVTWEPRPENSIFLKW--PEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYggaKLNRLNPG-NYTARIQATSLS 913
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWepPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSY---TLTGLKPGtEYEFRVRAVNGA 80


                    ...
gi 1958642817   914 GNG 916
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
494-647 1.27e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  494 LRFTSTTTwkNRIIITWhryRPPDYRDLISFTVYYKEA---PFKNVTEYDGqdacgsNSWnmVDVDLPPNKEgepgillh 570
Cdd:COG3401    239 LTATADTP--GSVTLSW---DPVTESDATGYRVYRSNSgdgPFTKVATVTT------TSY--TDTGLTNGTT-------- 297

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642817  571 glkpwtqYAVYVKAVTltmveNDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTlpNGNLSYYIV 647
Cdd:COG3401    298 -------YYYRVTAVD-----AAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASS--DADVTGYNV 360
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 494-607 1.60e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  494 LRFTSTTtwKNRIIITWHRyRPPDYRDLISFTVYYKEApfknvteydgqdacGSNSWNMVDVDLPPNKEgepgILLHGLK 573
Cdd:cd00063      7 LRVTDVT--STSVTLSWTP-PEDDGGPITGYVVEYREK--------------GSGDWKEVEVTPGSETS----YTLTGLK 65

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958642817  574 PWTQYAVYVKAVtltmveNDHIRGAKSEILYIRT 607
Cdd:cd00063     66 PGTEYEFRVRAV------NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 494-586 2.56e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 2.56e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817   494 LRFTSTTtwKNRIIITWhryRPPDYRDLISFTVYYKEapfknvtEYDGQDAcgsnSWNMVDVDLPPNKegepgILLHGLK 573
Cdd:smart00060    7 LRVTDVT--STSVTLSW---EPPPDDGITGYIVGYRV-------EYREEGS----EWKEVNVTPSSTS-----YTLTGLK 65

                            90
                    ....*....|...
gi 1958642817   574 PWTQYAVYVKAVT 586
Cdd:smart00060   66 PGTEYEFRVRAVN 78
fn3 pfam00041
Fibronectin type III domain;
494-586 1.41e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  494 LRFTSTTTwkNRIIITWHryrPPDY--RDLISFTVYYKEApfknvteyDGQDAcgsnsWNMVDVDLPPNkegepGILLHG 571
Cdd:pfam00041    6 LTVTDVTS--TSLTVSWT---PPPDgnGPITGYEVEYRPK--------NSGEP-----WNEITVPGTTT-----SVTLTG 62

                           90
                   ....*....|....*
gi 1958642817  572 LKPWTQYAVYVKAVT 586
Cdd:pfam00041   63 LKPGTEYEVRVQAVN 77
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
209-312 2.18e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 41.55  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  209 NRCQKMCPSVCGKRACTENNEC-CHPECLGSCHTPDDNTTCVACRHyyykgvCVPACPPGTYRF-EGWRCVDRDFCanip 286
Cdd:COG4624     53 RCCLCCCCCCRCCVAISCIQVRgIIIIDKRGPSIIRDKEKCKNCYP------CVRACPVKAIKVdDGKAEIDEEKC---- 122

                           90       100
                   ....*....|....*....|....*.
gi 1958642817  287 naessdsdgfvIHDGECMQECPSGFI 312
Cdd:COG4624    123 -----------ISCGQCVAVCPFGAI 137
 
Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
175-330 5.39e-61

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 204.21  E-value: 5.39e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  175 PKECGDLCPGTLEEKPMCEKttinneyNYRCWTTNRCQKMCPSVCGKRaCTENNECCHPECLGSCHTPDDnTTCVACRHY 254
Cdd:pfam00757    1 NRECGDVCPGTMEKCHSCCN-------NGYCWGPGHCQKVCPEQCKKR-CTKPGECCHEQCLGGCTGPND-SDCLACRHF 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642817  255 YYKGVCVPACPPGTYRFeGWRCVDRDFCaniPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPK 330
Cdd:pfam00757   72 NDEGTCVDQCPPGTYQF-GWRCVTFKEC---PKSHLPGYNPLVIHNGECVRECPSGYTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 353-468 1.24e-37

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 136.59  E-value: 1.24e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  353 GCTILKGNLLINIRRGNNIaSELENFMGLIEVVTGYVKIRHShALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQL 432
Cdd:pfam01030    1 NCTVIYGNLEITLIDENND-SELLSFLSNVEEITGYLLIANT-NLVSLSFLPNLRIIRGRNLFDDNYALYILDNPNLTEL 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958642817  433 WDWNHRNLTvrSGKMYFAFNPKLCVSEIYRMEEVTG 468
Cdd:pfam01030   79 GLPSLKEIT--SGGVYIHNNPKLCYTETEILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 51-161 3.11e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 123.88  E-value: 3.11e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817   51 NCTVIEGFLHILLISKAEDYRSYR-FPKLTVITEYLLLFRVaGLESLgDLFPNLTVIRGWKLFY-NYALVIFEMTNLKDI 128
Cdd:pfam01030    1 NCTVIYGNLEITLIDENNDSELLSfLSNVEEITGYLLIANT-NLVSL-SFLPNLRIIRGRNLFDdNYALYILDNPNLTEL 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958642817  129 GLYNLRNITRGAIRIEKNADLCYLST-IDWSLIL 161
Cdd:pfam01030   79 GLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 230-277 1.17e-09

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 54.83  E-value: 1.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958642817  230 CCHPECLGsCHTPDdNTTCVACRHYYYK--GVCVPACPPGTYR-FEGWRCV 277
Cdd:cd00064      1 PCHPSCAT-CTGPG-PDQCTSCRHGFYLdgGTCVSECPEGTYAdTEGGVCL 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 837-926 2.43e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  837 PGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYgGAKLNRLNPG-NYTARIQATSLSGN 915
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGtEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 1958642817  916 GSWTDPVFFYV 926
Cdd:cd00063     83 SPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
837-919 7.89e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 7.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  837 PGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKY---GSQVEDQRECVSRQEYRkyggAKLNRLNPG-NYTARIQATSL 912
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTS----VTLTGLKPGtEYEVRVQAVNG 78


                   ....*..
gi 1958642817  913 SGNGSWT 919
Cdd:pfam00041   79 GGEGPPS 85
FU smart00261
Furin-like repeats;
227-269 8.41e-08

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 49.43  E-value: 8.41e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958642817   227 NNEC--CHPECLGsCHTPDdNTTCVACRHYYYK--GVCVPACPPGTY 269
Cdd:smart00261    1 DGECkpCHPECAT-CTGPG-PDDCTSCKHGFFLdgGKCVSECPPGTY 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 837-916 8.28e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 8.28e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817   837 PGPVTWEPRPENSIFLKW--PEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYggaKLNRLNPG-NYTARIQATSLS 913
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWepPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSY---TLTGLKPGtEYEFRVRAVNGA 80


                    ...
gi 1958642817   914 GNG 916
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
494-647 1.27e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.31  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  494 LRFTSTTTwkNRIIITWhryRPPDYRDLISFTVYYKEA---PFKNVTEYDGqdacgsNSWnmVDVDLPPNKEgepgillh 570
Cdd:COG3401    239 LTATADTP--GSVTLSW---DPVTESDATGYRVYRSNSgdgPFTKVATVTT------TSY--TDTGLTNGTT-------- 297

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642817  571 glkpwtqYAVYVKAVTltmveNDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTlpNGNLSYYIV 647
Cdd:COG3401    298 -------YYYRVTAVD-----AAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASS--DADVTGYNV 360
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 494-607 1.60e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  494 LRFTSTTtwKNRIIITWHRyRPPDYRDLISFTVYYKEApfknvteydgqdacGSNSWNMVDVDLPPNKEgepgILLHGLK 573
Cdd:cd00063      7 LRVTDVT--STSVTLSWTP-PEDDGGPITGYVVEYREK--------------GSGDWKEVEVTPGSETS----YTLTGLK 65

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958642817  574 PWTQYAVYVKAVtltmveNDHIRGAKSEILYIRT 607
Cdd:cd00063     66 PGTEYEFRVRAV------NGGGESPPSESVTVTT 93
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 235-317 7.45e-05

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 42.80  E-value: 7.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  235 CLGSCHTPDDNTtCVACRHYYY----------KGVCVPACPPGTYRFEGW--------------RCVDRDFCANIPNaes 290
Cdd:pfam15913    1 CSGCVLCSEENG-CLTCQPRLFlllerngirqYGVCLHSCPPGYFGIRGQevnrctkckaenceSCFSKDFCTKCKE--- 76

                           90       100
                   ....*....|....*....|....*...
gi 1958642817  291 sdsdGFVIHDGECMQECPSGFI-RNSTQ 317
Cdd:pfam15913   77 ----GFYLHKGKCLDTCPEGTAaQNSTM 100
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 494-586 2.56e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 2.56e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817   494 LRFTSTTtwKNRIIITWhryRPPDYRDLISFTVYYKEapfknvtEYDGQDAcgsnSWNMVDVDLPPNKegepgILLHGLK 573
Cdd:smart00060    7 LRVTDVT--STSVTLSW---EPPPDDGITGYIVGYRV-------EYREEGS----EWKEVNVTPSSTS-----YTLTGLK 65

                            90
                    ....*....|...
gi 1958642817   574 PWTQYAVYVKAVT 586
Cdd:smart00060   66 PGTEYEFRVRAVN 78
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 224-282 4.80e-04

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 38.84  E-value: 4.80e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642817  224 CTENNEC--CHPECLGSCHTPDDNTTCVAcrhyyykgVCVP--ACPPGTYRFEGWRCVDRDFC 282
Cdd:cd19941      1 CPPNEVYseCGSACPPTCANPNAPPPCTK--------QCVEgcFCPEGYVRNSGGKCVPPSQC 55
fn3 pfam00041
Fibronectin type III domain;
494-586 1.41e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  494 LRFTSTTTwkNRIIITWHryrPPDY--RDLISFTVYYKEApfknvteyDGQDAcgsnsWNMVDVDLPPNkegepGILLHG 571
Cdd:pfam00041    6 LTVTDVTS--TSLTVSWT---PPPDgnGPITGYEVEYRPK--------NSGEP-----WNEITVPGTTT-----SVTLTG 62

                           90
                   ....*....|....*
gi 1958642817  572 LKPWTQYAVYVKAVT 586
Cdd:pfam00041   63 LKPGTEYEVRVQAVN 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 612-656 1.65e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958642817  612 PSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDG 656
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD 45
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
209-312 2.18e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 41.55  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  209 NRCQKMCPSVCGKRACTENNEC-CHPECLGSCHTPDDNTTCVACRHyyykgvCVPACPPGTYRF-EGWRCVDRDFCanip 286
Cdd:COG4624     53 RCCLCCCCCCRCCVAISCIQVRgIIIIDKRGPSIIRDKEKCKNCYP------CVRACPVKAIKVdDGKAEIDEEKC---- 122

                           90       100
                   ....*....|....*....|....*.
gi 1958642817  287 naessdsdgfvIHDGECMQECPSGFI 312
Cdd:COG4624    123 -----------ISCGQCVAVCPFGAI 137
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 224-282 7.28e-03

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 35.83  E-value: 7.28e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642817  224 CTENNE--CCHPECLGSCHTPDDNTTCVAcrhyyykgVCVP--ACPPGTYRFEGWRCVDRDFC 282
Cdd:pfam01826    1 CPANEVysECGSACPPTCANLSPPDVCPE--------PCVEgcVCPPGFVRNSGGKCVPPSDC 55
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 231-332 7.83e-03

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 37.74  E-value: 7.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642817  231 CHPECLGS-CHTPDDnTTCVACRHYYYKGVCVPACP-----PGTYRFEGwRCV----------DRDFCaNIPNAESSDSD 294
Cdd:pfam14843    2 CDPLCSSEgCWGPGP-DQCLSCRNFSRGGTCVESCNilqgePREYVVNS-TCVpchpeclpqnGTATC-SGPGADNCTKC 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958642817  295 GFVIHDGECMQECPSG-------FIRNSTQSMYCIPCEGPCPKVC 332
Cdd:pfam14843   79 AHFRDGPHCVSSCPSGvlgendlIWKYADANGVCQPCHPNCTQGC 123
fn3 pfam00041
Fibronectin type III domain;
619-650 9.41e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 36.24  E-value: 9.41e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958642817  619 LSASN-SSSQLIVKWNPPTLPNGNLSYYIVRWQ 650
Cdd:pfam00041    6 LTVTDvTSTSLTVSWTPPPDGNGPITGYEVEYR 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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