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Conserved domains on  [gi|1958756535|ref|XP_038954388|]
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stromelysin-3 isoform X1 [Rattus norvegicus]

Protein Classification

M10A family metallopeptidase( domain architecture ID 11995186)

M10A family metallopeptidase similar to matrix metalloproteinases with a C-terminal hemopexin repeat-containing domain that may be endopeptidases that degrade various components of the extracellular matrix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 135-324 1.00e-65

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 205.24  E-value: 1.00e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535 135 PEVCET-SFDAVSTIRGELFFFKAGFVWRLrSGQLQPGYPALASRHWQGLPSPVDAAFEDAQ-GQIWFFQGAQYWVYDGE 212
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRL-SPGKPPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535 213 -KPVLGPAPLSKLGLQGSP--VHAALVWGPEKnKIYFFRGGDYWRFHPRTQRVDNPVPRRT-TDWRGVPSEIDAAFQDAE 288
Cdd:cd00094    80 nLEPGYPKPISDLGFPPTVkqIDAALRWPDNG-KTYFFKGDKYWRYDEKTQKMDPGYPKLIeTDFPGVPDKVDAAFRWLD 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958756535 289 GYAYFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDC 324
Cdd:cd00094   159 GYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 1-102 1.90e-49

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


:

Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 162.40  E-value: 1.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535   1 MIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDK---GTDLLQVAAHEFGHVLGLQHTTAAKALM 77
Cdd:pfam00413  53 MIGFGRGDHGDGYPFDGPGGVLAHAFFPGPGLGGDIHFDDDETWTVGSDpphGINLFLVAAHEIGHALGLGHSSDPGAIM 132

                          90       100
                  ....*....|....*....|....*..
gi 1958756535  78 SPFYTFRYP--LSLSPDDRRGIQHLYG 102
Cdd:pfam00413 133 YPTYSPLDSkkFRLSQDDIKGIQQLYG 159
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 135-324 1.00e-65

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 205.24  E-value: 1.00e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535 135 PEVCET-SFDAVSTIRGELFFFKAGFVWRLrSGQLQPGYPALASRHWQGLPSPVDAAFEDAQ-GQIWFFQGAQYWVYDGE 212
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRL-SPGKPPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535 213 -KPVLGPAPLSKLGLQGSP--VHAALVWGPEKnKIYFFRGGDYWRFHPRTQRVDNPVPRRT-TDWRGVPSEIDAAFQDAE 288
Cdd:cd00094    80 nLEPGYPKPISDLGFPPTVkqIDAALRWPDNG-KTYFFKGDKYWRYDEKTQKMDPGYPKLIeTDFPGVPDKVDAAFRWLD 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958756535 289 GYAYFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDC 324
Cdd:cd00094   159 GYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 1-102 1.90e-49

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 162.40  E-value: 1.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535   1 MIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDK---GTDLLQVAAHEFGHVLGLQHTTAAKALM 77
Cdd:pfam00413  53 MIGFGRGDHGDGYPFDGPGGVLAHAFFPGPGLGGDIHFDDDETWTVGSDpphGINLFLVAAHEIGHALGLGHSSDPGAIM 132

                          90       100
                  ....*....|....*....|....*..
gi 1958756535  78 SPFYTFRYP--LSLSPDDRRGIQHLYG 102
Cdd:pfam00413 133 YPTYSPLDSkkFRLSQDDIKGIQQLYG 159
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 1-102 4.39e-48

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 158.91  E-value: 4.39e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535   1 MIDFTRYWHGDNLPFDGPGGILAHAFFPKTHReGDVHFDYDETWTIGD--KGTDLLQVAAHEFGHVLGLQHTTAAKALMS 78
Cdd:cd04278    54 RISFARGNHGDGYPFDGPGGTLAHAFFPGGIG-GDIHFDDDEQWTLGSdsGGTDLFSVAAHEIGHALGLGHSSDPDSIMY 132

                          90       100
                  ....*....|....*....|....*
gi 1958756535  79 PFYTFRYPL-SLSPDDRRGIQHLYG 102
Cdd:cd04278   133 PYYQGPVPKfKLSQDDIRGIQALYG 157
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 1-102 1.67e-15

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 72.38  E-value: 1.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535    1 MIDFTRYWHGdnlPFdgpggiLAHAFFPKthreGDVHFDyDETWTIGDkgtdllQVAAHEFGHVLGLQHTTAAKA---LM 77
Cdd:smart00235  52 YISFGSGDSG---CT------LSHAGRPG----GDQHLS-LGNGCINT------GVAAHELGHALGLYHEQSRSDrdnYM 111

                           90       100
                   ....*....|....*....|....*..
gi 1958756535   78 SPFYTF--RYPLSLSPDDRRGIQHLYG 102
Cdd:smart00235 112 YINYTNidTRNFDLSEDDSLGIPYDYG 138
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 142-185 5.46e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.39  E-value: 5.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958756535  142 FDAVSTIR-GELFFFKAGFVWRLRSGQLQPGYPALASRHWQGLPS 185
Cdd:smart00120   1 IDAAFELRdGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 142-185 1.96e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 46.79  E-value: 1.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958756535 142 FDAVSTIR-GELFFFKAGFVWRLRSGQLQPGYPALASrHWQGLPS 185
Cdd:pfam00045   1 IDAAFEDRdGKTYFFKGRKYWRFDPQRVEPGYPKLIS-DFPGLPC 44
COG1913 COG1913
Predicted Zn-dependent protease [General function prediction only];
53-96 2.46e-03

Predicted Zn-dependent protease [General function prediction only];


Pssm-ID: 441517  Cd Length: 175  Bit Score: 38.40  E-value: 2.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958756535  53 LLQVAAHEFGHVLGLQHTTAAKALMspfytfRYPLSLSPDDRRG 96
Cdd:COG1913   123 VLKEAVHELGHLFGLGHCPNPRCVM------HFSNSLEELDRKP 160
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 135-324 1.00e-65

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 205.24  E-value: 1.00e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535 135 PEVCET-SFDAVSTIRGELFFFKAGFVWRLrSGQLQPGYPALASRHWQGLPSPVDAAFEDAQ-GQIWFFQGAQYWVYDGE 212
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRL-SPGKPPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535 213 -KPVLGPAPLSKLGLQGSP--VHAALVWGPEKnKIYFFRGGDYWRFHPRTQRVDNPVPRRT-TDWRGVPSEIDAAFQDAE 288
Cdd:cd00094    80 nLEPGYPKPISDLGFPPTVkqIDAALRWPDNG-KTYFFKGDKYWRYDEKTQKMDPGYPKLIeTDFPGVPDKVDAAFRWLD 158

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958756535 289 GYAYFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDC 324
Cdd:cd00094   159 GYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 1-102 1.90e-49

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 162.40  E-value: 1.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535   1 MIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDK---GTDLLQVAAHEFGHVLGLQHTTAAKALM 77
Cdd:pfam00413  53 MIGFGRGDHGDGYPFDGPGGVLAHAFFPGPGLGGDIHFDDDETWTVGSDpphGINLFLVAAHEIGHALGLGHSSDPGAIM 132

                          90       100
                  ....*....|....*....|....*..
gi 1958756535  78 SPFYTFRYP--LSLSPDDRRGIQHLYG 102
Cdd:pfam00413 133 YPTYSPLDSkkFRLSQDDIKGIQQLYG 159
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 1-102 4.39e-48

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 158.91  E-value: 4.39e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535   1 MIDFTRYWHGDNLPFDGPGGILAHAFFPKTHReGDVHFDYDETWTIGD--KGTDLLQVAAHEFGHVLGLQHTTAAKALMS 78
Cdd:cd04278    54 RISFARGNHGDGYPFDGPGGTLAHAFFPGGIG-GDIHFDDDEQWTLGSdsGGTDLFSVAAHEIGHALGLGHSSDPDSIMY 132

                          90       100
                  ....*....|....*....|....*
gi 1958756535  79 PFYTFRYPL-SLSPDDRRGIQHLYG 102
Cdd:cd04278   133 PYYQGPVPKfKLSQDDIRGIQALYG 157
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 1-102 1.67e-15

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 72.38  E-value: 1.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535    1 MIDFTRYWHGdnlPFdgpggiLAHAFFPKthreGDVHFDyDETWTIGDkgtdllQVAAHEFGHVLGLQHTTAAKA---LM 77
Cdd:smart00235  52 YISFGSGDSG---CT------LSHAGRPG----GDQHLS-LGNGCINT------GVAAHELGHALGLYHEQSRSDrdnYM 111

                           90       100
                   ....*....|....*....|....*..
gi 1958756535   78 SPFYTF--RYPLSLSPDDRRGIQHLYG 102
Cdd:smart00235 112 YINYTNidTRNFDLSEDDSLGIPYDYG 138
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 8-102 4.45e-11

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 60.55  E-value: 4.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535   8 WHGDNLPFDGPGGILAHAFFPKTHREGDV---HFDYDETWTIGDKGTDLLQVAAHEFGHVLGLQHTTAAKA-LMSPFY-- 81
Cdd:cd04279    56 FFDRPPPVGGAGGGLARAGFPLISDGNRKlfnRTDINLGPGQPRGAENLQAIALHELGHALGLWHHSDRPEdAMYPSQgq 135

                          90       100
                  ....*....|....*....|.
gi 1958756535  82 TFRYPLSLSPDDRRGIQHLYG 102
Cdd:cd04279   136 GPDGNPTLSARDVATLKRLYG 156
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 142-185 5.46e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.39  E-value: 5.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958756535  142 FDAVSTIR-GELFFFKAGFVWRLRSGQLQPGYPALASRHWQGLPS 185
Cdd:smart00120   1 IDAAFELRdGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 16-101 5.65e-08

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 51.75  E-value: 5.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535  16 DGPGGILAHAFFPKT--HREGDVHFDYDETWTIgdkgtDLLQVAAHEFGHVLGLQH--------------------TTAA 73
Cdd:cd00203    62 DFDGGTGGWAYLGRVcdSLRGVGVLQDNQSGTK-----EGAQTIAHELGHALGFYHdhdrkdrddyptiddtlnaeDDDY 136

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958756535  74 KALMSPFYTFR---YPLSLSPDDRRGIQHLY 101
Cdd:cd00203   137 YSVMSYTKGSFsdgQRKDFSQCDIDQINKLY 167
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 142-185 1.96e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 46.79  E-value: 1.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958756535 142 FDAVSTIR-GELFFFKAGFVWRLRSGQLQPGYPALASrHWQGLPS 185
Cdd:pfam00045   1 IDAAFEDRdGKTYFFKGRKYWRFDPQRVEPGYPKLIS-DFPGLPC 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 231-278 6.56e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 45.25  E-value: 6.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958756535 231 VHAALVWGPekNKIYFFRGGDYWRFHPrtQRVDNPVPRRTTDWRGVPS 278
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDP--QRVEPGYPKLISDFPGLPC 44
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 16-102 7.01e-07

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 48.95  E-value: 7.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756535  16 DGPGGILAHAFFPK----THREGDVHFDYDETWTIGDKGTDLLQVAAHEFGHVLGLQH-----------TTAAKA----- 75
Cdd:cd04277    72 DPDGNTAGYAYYPGsgsgTAYGGDIWFNSSYDTNSDSPGSYGYQTIIHEIGHALGLEHpgdynggdpvpPTYALDsreyt 151

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958756535  76 LMS--------PFYTFRYPLSLSPDDRRGIQHLYG 102
Cdd:cd04277   152 VMSynsgygngASAGGGYPQTPMLLDIAALQYLYG 186
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 187-224 2.22e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 43.71  E-value: 2.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958756535 187 VDAAFEDAQGQIWFFQGAQYWVYDGEKPVLG-PAPLSKL 224
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGyPKLISDF 39
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 280-322 4.58e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.00  E-value: 4.58e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958756535  280 IDAAFQDAEGYAYFLRGHLYWKFDPVKVKvlESFPRPIGPDFF 322
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVD--PGYPKLISSFFP 41
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 231-278 1.30e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.84  E-value: 1.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958756535  231 VHAALVWgpEKNKIYFFRGGDYWRFHPrtQRVDNPVPRR-TTDWRGVPS 278
Cdd:smart00120   1 IDAAFEL--RDGKTYFFKGDKYWRFDP--KRVDPGYPKLiSSFFPGLPC 45
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 187-224 5.24e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 39.92  E-value: 5.24e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958756535  187 VDAAFEDAQGQIWFFQGAQYWVYDGEKPVLG-PAPLSKL 224
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGyPKLISSF 39
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 280-317 5.56e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.86  E-value: 5.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958756535 280 IDAAFQDAEGYAYFLRGHLYWKFDPvkVKVLESFPRPI 317
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDP--QRVEPGYPKLI 36
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 31-75 3.23e-04

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 40.56  E-value: 3.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958756535  31 HREGDVHFD--YDETWTIGDKGTDLLQVAAHEFGHVLGLQHTTAAKA 75
Cdd:cd04268    70 PLTGEILLArvYLYSSFVEYSGARLRNTAEHELGHALGLRHNFAASD 116
COG1913 COG1913
Predicted Zn-dependent protease [General function prediction only];
53-96 2.46e-03

Predicted Zn-dependent protease [General function prediction only];


Pssm-ID: 441517  Cd Length: 175  Bit Score: 38.40  E-value: 2.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958756535  53 LLQVAAHEFGHVLGLQHTTAAKALMspfytfRYPLSLSPDDRRG 96
Cdd:COG1913   123 VLKEAVHELGHLFGLGHCPNPRCVM------HFSNSLEELDRKP 160
ZnMc_MMP_like_2 cd04276
Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase ...
 53-82 7.06e-03

Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239803  Cd Length: 197  Bit Score: 37.30  E-value: 7.06e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958756535  53 LLQVAAHEFGHVLGLQHTTAAKALMSPFYT 82
Cdd:cd04276   116 LRYLLAHEVGHTLGLRHNFKASSDGSNEEL 145
Peptidase_M54 cd11375
Peptidase family M54, also called archaemetzincins or archaelysins; Peptidase M54 ...
 53-96 8.02e-03

Peptidase family M54, also called archaemetzincins or archaelysins; Peptidase M54 (archaemetzincin or archaelysin) is a zinc-dependent aminopeptidase that contains the consensus zinc-binding sequence HEXXHXXGXXH/D and a conserved Met residue at the active site, and is thus classified as a metzincin. Archaemetzincins, first identified in archaea, are also found in bacteria and eukaryotes, including two human members, archaemetzincin-1 and -2 (AMZ1 and AMZ2). AMZ1 is mainly found in the liver and heart while AMZ2 is primarily expressed in testis and heart; both have been reported to degrade synthetic substrates and peptides. The Peptidase M54 family contains an extended metzincin concensus sequence of HEXXHXXGX3CX4CXMX17CXXC such that a second zinc ion is bound to four cysteines, thus resembling a zinc finger. Phylogenetic analysis of this family reveals a complex evolutionary process involving a series of lateral gene transfer, gene loss and genetic duplication events.


Pssm-ID: 213029  Cd Length: 173  Bit Score: 36.51  E-value: 8.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958756535  53 LLQVAAHEFGHVLGLQHTTAAKALMSPfytfryPLSLSPDDRRG 96
Cdd:cd11375   123 LLKEAVHELGHLFGLDHCPYYACVMNF------SNSLEETDRKP 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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