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Conserved domains on  [gi|1958675612|ref|XP_038947715|]
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huntingtin isoform X2 [Rattus norvegicus]

Protein Classification

huntingtin( domain architecture ID 10574822)

huntingtin is a DUF3652 domain-containing protein that may play a role in microtubule-mediated transport or vesicle function

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3652 pfam12372
Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 ...
 1470-1510 3.30e-16

Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.


:

Pssm-ID: 463554  Cd Length: 41  Bit Score: 74.41  E-value: 3.30e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958675612 1470 QIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLR 1510
Cdd:pfam12372    1 AIIGQPRIIQLCDGLMASGQPAVRHEIPALRPILQDTFFYR 41
 
Name Accession Description Interval E-value
DUF3652 pfam12372
Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 ...
 1470-1510 3.30e-16

Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.


Pssm-ID: 463554  Cd Length: 41  Bit Score: 74.41  E-value: 3.30e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958675612 1470 QIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLR 1510
Cdd:pfam12372    1 AIIGQPRIIQLCDGLMASGQPAVRHEIPALRPILQDTFFYR 41
 
Name Accession Description Interval E-value
DUF3652 pfam12372
Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 ...
 1470-1510 3.30e-16

Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.


Pssm-ID: 463554  Cd Length: 41  Bit Score: 74.41  E-value: 3.30e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958675612 1470 QIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLR 1510
Cdd:pfam12372    1 AIIGQPRIIQLCDGLMASGQPAVRHEIPALRPILQDTFFYR 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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