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Conserved domains on  [gi|1958670570|ref|XP_038946007|]
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transducin beta-like protein 2 isoform X2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-232 3.12e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 3.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgE 100
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------A 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 101 FQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVL 180
Cdd:COG2319   277 TGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKTL 345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958670570 181 ALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 232
Cdd:COG2319   346 ASGSDdGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-232 3.12e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 3.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgE 100
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------A 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 101 FQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVL 180
Cdd:COG2319   277 TGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKTL 345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958670570 181 ALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 232
Cdd:COG2319   346 ASGSDdGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-233 8.52e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 8.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  20 KKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVI-SPCSRFVGSCGFTPDVKVWEVcfgkk 98
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTYLASGSSDKTIRLWDL----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  99 gEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTGRFEEASTMpcRLALSPDTH 178
Cdd:cd00200    81 -ETGECVR--TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTDWVN--SVAFSPDGT 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958670570 179 VLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITG-RFLASCGDRAVRLF 233
Cdd:cd00200   149 FVASSSQdGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGeKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-142 2.46e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958670570  108 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 142
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
109-142 6.36e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 6.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958670570 109 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 142
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-232 3.12e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 3.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgE 100
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------A 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 101 FQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVL 180
Cdd:COG2319   277 TGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKTL 345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958670570 181 ALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 232
Cdd:COG2319   346 ASGSDdGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
12-243 1.03e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 1.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  12 TATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKV 90
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  91 WEVCFGKkgefqevlRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCR 170
Cdd:COG2319   189 WDLATGK--------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA-------TGKLLRT--LTGHSGSVRS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 171 LALSPDTHVLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLF--------HNTPGHR 240
Cdd:COG2319   252 VAFSPDGRLLASGSAdGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSdDGTVRLWdlatgkllRTLTGHT 330


                  ...
gi 1958670570 241 AVV 243
Cdd:COG2319   331 GAV 333
WD40 COG2319
WD40 repeat [General function prediction only];
22-238 4.40e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 4.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAV-ISPCSRFVGSCGFTPDVKVWEVCFGKkge 100
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRLWDLATGK--- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 101 fqeVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVL 180
Cdd:COG2319   154 ---LLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKLL 219

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 181 ALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLFHNTPG 238
Cdd:COG2319   220 ASGSAdGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSaDGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-233 8.52e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 8.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  20 KKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVI-SPCSRFVGSCGFTPDVKVWEVcfgkk 98
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTYLASGSSDKTIRLWDL----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  99 gEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTGRFEEASTMpcRLALSPDTH 178
Cdd:cd00200    81 -ETGECVR--TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTDWVN--SVAFSPDGT 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958670570 179 VLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITG-RFLASCGDRAVRLF 233
Cdd:cd00200   149 FVASSSQdGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGeKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
22-144 1.93e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 1.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgE 100
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL------A 360

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958670570 101 FQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTD 144
Cdd:COG2319   361 TGELLR--TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
22-243 2.51e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 2.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAV-ISPCSRFVGSCGFTPDVKVWEVcfgkkge 100
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVaFSPDGRLLASASADGTVRLWDL------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 101 fQEVLRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVL 180
Cdd:COG2319   108 -ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-------TGKLLRT--LTGHSGAVTSVAFSPDGKLL 177

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958670570 181 ALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLF--------HNTPGHRAVV 243
Cdd:COG2319   178 ASGSDdGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSaDGTVRLWdlatgkllRTLTGHSGSV 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-233 2.82e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 2.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgKKGE 100
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL---RTGK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 101 FQEVLrafelKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKQQdpylLRTGRFEEAStmPCRLALSPDTHVL 180
Cdd:cd00200   169 CVATL-----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC----LGTLRGHENG--VNSVAFSPDGYLL 234

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958670570 181 ALATGT-SIHLFNTRRGEKEEYFECVHGECIAdLTFDITGRFLASCG-DRAVRLF 233
Cdd:cd00200   235 ASGSEDgTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-142 1.42e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570  22 HKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVCFGKkge 100
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE--- 252

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958670570 101 fqevlRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 142
Cdd:cd00200   253 -----CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-238 2.33e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670570 108 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkQQDPYLLRTGRFEEASTmpcrLALSPDTHVLALATGTS 187
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----TGELLRTLKGHTGPVRD----VAASADGTYLASGSSDK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958670570 188 -IHLFNTRRGEKEEYFECvHGECIADLTFDITGRFLASCG-DRAVRLFHNTPG 238
Cdd:cd00200    74 tIRLWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETG 125
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-142 2.46e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958670570  108 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 142
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
109-142 6.36e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 6.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958670570 109 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 142
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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