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Conserved domains on  [gi|1958667812|ref|XP_038944979|]
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glypican-2 isoform X1 [Rattus norvegicus]

Protein Classification

glypican family protein( domain architecture ID 10471748)

glypican family protein is a cell surface proteoglycan that bears heparan sulfate, similar to human glypican-1 that binds alpha-4 (V) collagen and participates in Schwann cell myelination

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
22-437 0e+00

Glypican;


:

Pssm-ID: 460084  Cd Length: 554  Bit Score: 631.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812  22 HGSEAKVvRSCAETRQVLGARGYSLNLIPPSLISGEHLQICPQEYTCCSSETEQKLIRDAEVTFRGLVEDSGSFLIHTLA 101
Cdd:pfam01153  12 DPASGKA-RSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 102 ARHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDYYEKSGEGLDDTLADFWAQLLERAFPLLHPQ 181
Cdd:pfam01153  91 TNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 182 YSFPPDFLLCLTRLTSTadgsLQPFGDSPRRLRLQITRALVAARALVQGLETGRNVVSEALKVPMLEGCRQALMRLIGCP 261
Cdd:pfam01153 171 YHFSDDYLECLSKQTEQ----LKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 262 LCRGVPSLMPCRGFCLNVAHGCLSSRG-LEPEWGGYLDGLLLLAEKLQGPFSFELAAESIGVKISEGLMHLQENSVKVSA 340
Cdd:pfam01153 247 HCRGLPSVKPCYNYCLNVMRGCLANQAdLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTA 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 341 KVFQECGTPHPVQSRNRRAPAPREETSRSWRSSAEEERPTTAAGTNLHRLVWELRERLSRVRGFWAGLPVTVCGDSRMAA 420
Cdd:pfam01153 327 KVFQGCGTPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAA 406

                         410
                  ....*....|....*..
gi 1958667812 421 DLSQEAApCWTGVGRGR 437
Cdd:pfam01153 407 DPTNEDK-CWNGQTKGR 422
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
22-437 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 631.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812  22 HGSEAKVvRSCAETRQVLGARGYSLNLIPPSLISGEHLQICPQEYTCCSSETEQKLIRDAEVTFRGLVEDSGSFLIHTLA 101
Cdd:pfam01153  12 DPASGKA-RSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 102 ARHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDYYEKSGEGLDDTLADFWAQLLERAFPLLHPQ 181
Cdd:pfam01153  91 TNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 182 YSFPPDFLLCLTRLTSTadgsLQPFGDSPRRLRLQITRALVAARALVQGLETGRNVVSEALKVPMLEGCRQALMRLIGCP 261
Cdd:pfam01153 171 YHFSDDYLECLSKQTEQ----LKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 262 LCRGVPSLMPCRGFCLNVAHGCLSSRG-LEPEWGGYLDGLLLLAEKLQGPFSFELAAESIGVKISEGLMHLQENSVKVSA 340
Cdd:pfam01153 247 HCRGLPSVKPCYNYCLNVMRGCLANQAdLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTA 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 341 KVFQECGTPHPVQSRNRRAPAPREETSRSWRSSAEEERPTTAAGTNLHRLVWELRERLSRVRGFWAGLPVTVCGDSRMAA 420
Cdd:pfam01153 327 KVFQGCGTPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAA 406

                         410
                  ....*....|....*..
gi 1958667812 421 DLSQEAApCWTGVGRGR 437
Cdd:pfam01153 407 DPTNEDK-CWNGQTKGR 422
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
22-437 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 631.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812  22 HGSEAKVvRSCAETRQVLGARGYSLNLIPPSLISGEHLQICPQEYTCCSSETEQKLIRDAEVTFRGLVEDSGSFLIHTLA 101
Cdd:pfam01153  12 DPASGKA-RSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 102 ARHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDYYEKSGEGLDDTLADFWAQLLERAFPLLHPQ 181
Cdd:pfam01153  91 TNHRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 182 YSFPPDFLLCLTRLTSTadgsLQPFGDSPRRLRLQITRALVAARALVQGLETGRNVVSEALKVPMLEGCRQALMRLIGCP 261
Cdd:pfam01153 171 YHFSDDYLECLSKQTEQ----LKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 262 LCRGVPSLMPCRGFCLNVAHGCLSSRG-LEPEWGGYLDGLLLLAEKLQGPFSFELAAESIGVKISEGLMHLQENSVKVSA 340
Cdd:pfam01153 247 HCRGLPSVKPCYNYCLNVMRGCLANQAdLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTA 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667812 341 KVFQECGTPHPVQSRNRRAPAPREETSRSWRSSAEEERPTTAAGTNLHRLVWELRERLSRVRGFWAGLPVTVCGDSRMAA 420
Cdd:pfam01153 327 KVFQGCGTPKPTPYRSTRSSSPEEKKKRGFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAA 406

                         410
                  ....*....|....*..
gi 1958667812 421 DLSQEAApCWTGVGRGR 437
Cdd:pfam01153 407 DPTNEDK-CWNGQTKGR 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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