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Conserved domains on  [gi|1958661199|ref|XP_038942888|]
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contactin-associated protein 1 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 119-274 3.94e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 119.83  E-value: 3.94e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  119 LYFDGDDAISYRFQRGASQSLwdVFAFSFKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSspiqprpGHTTVS 197
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958661199  198 AGGVLNDLSWHYVRVDRYGREANLTLDGYVH-RFVLNGDFERLNLENEIFIGGLVGAARKN-LAYRHNFRGCIENVIYN 274
Cdd:cd00110     73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1162 9.57e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 9.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199 1032 FSTSSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1111
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958661199 1112 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1162
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 306-457 1.33e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.04  E-value: 1.33e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  306 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 384
Cdd:cd00110      1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661199  385 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 457
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 731-881 4.46e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.80  E-value: 4.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  731 TISFRTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcqwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 809
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  810 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLEYDQPLYVG--------SAELKRRPFVGCLRAMRLN 881
Cdd:cd00110     74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
FA58C super family cl25480
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 66-111 6.70e-12

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


The actual alignment was detected with superfamily member cd00057:

Pssm-ID: 330301 [Multi-domain]  Cd Length: 143  Bit Score: 64.30  E-value: 6.70e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958661199   66 TFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYG 111
Cdd:cd00057    100 VFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 539-560 1.41e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.41e-05
                           10        20
                   ....*....|....*....|..
gi 1958661199  539 SGNYTIDPDGSGPLKPFVVYCD 560
Cdd:NF040941    14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1248-1266 1.75e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.75e-05
                            10
                    ....*....|....*....
gi 1958661199  1248 FYLQNHRYKGSYHTNEPKA 1266
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 528-602 7.65e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member cd00087:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 215  Bit Score: 42.61  E-value: 7.65e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958661199  528 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 602
Cdd:cd00087      5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 488-517 2.15e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.15e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958661199  488 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 517
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 119-274 3.94e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 119.83  E-value: 3.94e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  119 LYFDGDDAISYRFQRGASQSLwdVFAFSFKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSspiqprpGHTTVS 197
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958661199  198 AGGVLNDLSWHYVRVDRYGREANLTLDGYVH-RFVLNGDFERLNLENEIFIGGLVGAARKN-LAYRHNFRGCIENVIYN 274
Cdd:cd00110     73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
143-275 9.55e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.21  E-value: 9.55e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   143 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVsaggvlNDLSWHYVRVDRYGREANL 221
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661199   222 TLDGYVH-RFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 275
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 147-276 4.99e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.59  E-value: 4.99e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  147 FKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIqprpghTTVSAGGVLNDLSWHYVRVDRYGREANLTLDGY 226
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958661199  227 VHRFVLN-GDFERLNLENEIFIGGLVGAAR-KNLAYRHNFRGCIENVIYNRI 276
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1162 9.57e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 9.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199 1032 FSTSSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1111
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958661199 1112 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1162
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1027-1162 1.51e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.97  E-value: 1.51e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  1027 EVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1105
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958661199  1106 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1162
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1016-1160 4.08e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 105.58  E-value: 4.08e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199 1016 YRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1094
Cdd:cd00110     12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661199 1095 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1160
Cdd:cd00110     90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 306-457 1.33e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.04  E-value: 1.33e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  306 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 384
Cdd:cd00110      1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661199  385 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 457
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 731-881 4.46e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.80  E-value: 4.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  731 TISFRTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcqwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 809
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  810 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLEYDQPLYVG--------SAELKRRPFVGCLRAMRLN 881
Cdd:cd00110     74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
329-459 1.02e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 97.80  E-value: 1.02e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   329 VSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 408
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1958661199   409 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 459
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 333-459 1.12e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.49  E-value: 1.12e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  333 FRTWDLTGLLLFSRlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 412
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958661199  413 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 459
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 757-883 1.48e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.48e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  757 FRTSAPSGVFLENMGGpfcqwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 836
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958661199  837 HRPWVLRPMPLQTYIwLEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 883
Cdd:pfam02210   73 GQTVVSSLPPGESLL-LNLNGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
752-883 3.31e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.56  E-value: 3.31e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   752 DVSFYFRTSAPSGVFLENMGGPfcqwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 831
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   832 RLRVDHRPWVLRPMPLQTYIwLEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 883
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTI-LNLDGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 66-111 6.70e-12

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 64.30  E-value: 6.70e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958661199   66 TFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYG 111
Cdd:cd00057    100 VFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 66-112 2.24e-10

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 59.83  E-value: 2.24e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958661199    66 TFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYGC 112
Cdd:smart00231   95 VFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 69-109 5.20e-06

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 47.06  E-value: 5.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958661199   69 GNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGI 109
Cdd:pfam00754   87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 539-560 1.41e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.41e-05
                           10        20
                   ....*....|....*....|..
gi 1958661199  539 SGNYTIDPDGSGPLKPFVVYCD 560
Cdd:NF040941    14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1248-1266 1.75e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.75e-05
                            10
                    ....*....|....*....
gi 1958661199  1248 FYLQNHRYKGSYHTNEPKA 1266
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 528-602 7.65e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 42.61  E-value: 7.65e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958661199  528 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 602
Cdd:cd00087      5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 488-517 2.15e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.15e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958661199  488 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 517
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
525-569 3.84e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.20  E-value: 3.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958661199  525 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 569
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 486-520 8.68e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 8.68e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958661199  486 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGVTC 520
Cdd:cd00054      3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 524-583 8.86e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 39.18  E-value: 8.86e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958661199   524 LYKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIRENR-AWTVVRHdrlwttRVTGS 583
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGgGWTVIQR------RMDGS 53
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 119-274 3.94e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 119.83  E-value: 3.94e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  119 LYFDGDDAISYRFQRGASQSLwdVFAFSFKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSspiqprpGHTTVS 197
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958661199  198 AGGVLNDLSWHYVRVDRYGREANLTLDGYVH-RFVLNGDFERLNLENEIFIGGLVGAARKN-LAYRHNFRGCIENVIYN 274
Cdd:cd00110     73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
143-275 9.55e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.21  E-value: 9.55e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   143 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVsaggvlNDLSWHYVRVDRYGREANL 221
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661199   222 TLDGYVH-RFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 275
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 147-276 4.99e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.59  E-value: 4.99e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  147 FKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIqprpghTTVSAGGVLNDLSWHYVRVDRYGREANLTLDGY 226
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958661199  227 VHRFVLN-GDFERLNLENEIFIGGLVGAAR-KNLAYRHNFRGCIENVIYNRI 276
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1032-1162 9.57e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 9.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199 1032 FSTSSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1111
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958661199 1112 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1162
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1027-1162 1.51e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.97  E-value: 1.51e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  1027 EVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1105
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958661199  1106 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1162
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1016-1160 4.08e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 105.58  E-value: 4.08e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199 1016 YRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1094
Cdd:cd00110     12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661199 1095 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1160
Cdd:cd00110     90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 306-457 1.33e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.04  E-value: 1.33e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  306 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 384
Cdd:cd00110      1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958661199  385 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 457
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 731-881 4.46e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.80  E-value: 4.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  731 TISFRTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcqwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 809
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  810 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLEYDQPLYVG--------SAELKRRPFVGCLRAMRLN 881
Cdd:cd00110     74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
329-459 1.02e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 97.80  E-value: 1.02e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   329 VSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 408
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1958661199   409 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 459
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 333-459 1.12e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.49  E-value: 1.12e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  333 FRTWDLTGLLLFSRlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 412
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958661199  413 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 459
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 757-883 1.48e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.48e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  757 FRTSAPSGVFLENMGGpfcqwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 836
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958661199  837 HRPWVLRPMPLQTYIwLEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 883
Cdd:pfam02210   73 GQTVVSSLPPGESLL-LNLNGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
752-883 3.31e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.56  E-value: 3.31e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   752 DVSFYFRTSAPSGVFLENMGGPfcqwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 831
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199   832 RLRVDHRPWVLRPMPLQTYIwLEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 883
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTI-LNLDGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
147-275 5.64e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 84.29  E-value: 5.64e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  147 FKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSSPIqprpghtTVSAGGVLNDLSWHYVRVDRYGREANLTLDG 225
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqTERDFLALELRDGRLEVSYDLGSGAA-------VVRSGDKLNDGKWHSVELERNGRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958661199  226 ---YVHRFVLNGDFErLNLENEIFIGGL--VGAARKNLAYRHNFRGCIENVIYNR 275
Cdd:pfam00054   74 earPTGESPLGATTD-LDVDGPLYVGGLpsLGVKKRRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
333-462 8.09e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 8.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  333 FRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDveGAEV 412
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSY-DLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG--EARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958661199  413 RVSYPL----LIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVN 462
Cdd:pfam00054   78 TGESPLgattDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 66-111 6.70e-12

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 64.30  E-value: 6.70e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958661199   66 TFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYG 111
Cdd:cd00057    100 VFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
Laminin_G_1 pfam00054
Laminin G domain;
1032-1162 3.11e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199 1032 FSTSSAPAVLLYVSSFV-RDYMAVLIKeDGTLQLRYQLGTSPyVYQLTTRPVTDGQPHSVNITRVYRNLFIQVD--YFPL 1108
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELR-DGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVDgeARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958661199 1109 TEQKFSllVDSQLDSPKALYLGRvMETGVIDPEIQRyNTPGFSGCLSGVRFNNV 1162
Cdd:pfam00054   79 GESPLG--ATTDLDVDGPLYVGG-LPSLGVKKRRLA-ISPSFDGCIRDVIVNGK 128
Laminin_G_1 pfam00054
Laminin G domain;
757-886 5.30e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 61.56  E-value: 5.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958661199  757 FRTSAPSGVFLENMGGPFcqwrRPYVRVELNTSRdVVFAFDIGNGDEnLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 836
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE----RDFLALELRDGR-LEVSYDLGSGAA-VVRSGD--KLNDGKWHSVELERNGRSGTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958661199  837 HRPWVLRPMPLQTYIWLEYDQPLYVGSA----ELKRR-----PFVGCLRAMRLNGVTLN 886
Cdd:pfam00054   73 GEARPTGESPLGATTDLDVDGPLYVGGLpslgVKKRRlaispSFDGCIRDVIVNGKPLD 131
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 66-112 2.24e-10

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 59.83  E-value: 2.24e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1958661199    66 TFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGIYGC 112
Cdd:smart00231   95 VFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 69-109 5.20e-06

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 47.06  E-value: 5.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958661199   69 GNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGI 109
Cdd:pfam00754   87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 539-560 1.41e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.32  E-value: 1.41e-05
                           10        20
                   ....*....|....*....|..
gi 1958661199  539 SGNYTIDPDGSGPLKPFVVYCD 560
Cdd:NF040941    14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1248-1266 1.75e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.51  E-value: 1.75e-05
                            10
                    ....*....|....*....
gi 1958661199  1248 FYLQNHRYKGSYHTNEPKA 1266
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 528-602 7.65e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 42.61  E-value: 7.65e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958661199  528 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 602
Cdd:cd00087      5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 488-517 2.15e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.15e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958661199  488 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 517
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
525-569 3.84e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.20  E-value: 3.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958661199  525 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 569
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 486-520 8.68e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 8.68e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958661199  486 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGVTC 520
Cdd:cd00054      3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 524-583 8.86e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 39.18  E-value: 8.86e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958661199   524 LYKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIRENR-AWTVVRHdrlwttRVTGS 583
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGgGWTVIQR------RMDGS 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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