NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958792361|ref|XP_038936082|]
View 

regulator of G-protein signaling 22 isoform X3 [Rattus norvegicus]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 10246704)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 832-961 5.83e-67

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188681  Cd Length: 130  Bit Score: 221.20  E-value: 5.83e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  832 FNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 911
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958792361  912 LLSGGWGKILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 961
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1005-1127 1.31e-63

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188680  Cd Length: 123  Bit Score: 211.48  E-value: 1.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361 1005 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCEESIIHKKITTIINCFINSCIPPALQIDIPVEQAQKII 1084
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958792361 1085 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMS 1127
Cdd:cd08725     81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 663-765 4.39e-44

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08727:

Pssm-ID: 470619  Cd Length: 116  Bit Score: 155.28  E-value: 4.39e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  663 VENRAGFFFTKFCENSGNK-------------AYHQLFYQETLEPFKVCKQAQYLFATYIAPSASLDVGLHPEEKKDIYI 729
Cdd:cd08727      1 LENRAGNFFTQFCEKSGNKlwknavyfwfdlqEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958792361  730 KIQPPFEDLFDTAEEFILLNLLEPWTQMVMSDQVSY 765
Cdd:cd08727     81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 832-961 5.83e-67

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 221.20  E-value: 5.83e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  832 FNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 911
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958792361  912 LLSGGWGKILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 961
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1005-1127 1.31e-63

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 211.48  E-value: 1.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361 1005 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCEESIIHKKITTIINCFINSCIPPALQIDIPVEQAQKII 1084
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958792361 1085 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMS 1127
Cdd:cd08725     81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 663-765 4.39e-44

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 155.28  E-value: 4.39e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  663 VENRAGFFFTKFCENSGNK-------------AYHQLFYQETLEPFKVCKQAQYLFATYIAPSASLDVGLHPEEKKDIYI 729
Cdd:cd08727      1 LENRAGNFFTQFCEKSGNKlwknavyfwfdlqEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958792361  730 KIQPPFEDLFDTAEEFILLNLLEPWTQMVMSDQVSY 765
Cdd:cd08727     81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 832-955 1.55e-08

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 53.77  E-value: 1.55e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  832 FNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYikNKYLNKKyffgprSPASLHQQNQIM 911
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLAPG------SPKEINLDSDLR 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958792361  912 -LLSGGwgkiLHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 955
Cdd:pfam00615   74 eEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1001-1115 2.77e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 50.35  E-value: 2.77e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  1001 FRKALLNPVIARQFQRFvaLKGDLLENGVLFWQEVQKFKDLCHShceeSIIHKKITTIINCFINSCIPPALQIDI-PVEQ 1079
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKAEDD----EERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 1958792361  1080 AQKIIEHRkELGPYVFREAQMTIFGVL-FKFWPQFCE 1115
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYELLeKDSFPRFLE 111
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 831-955 4.17e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 49.96  E-value: 4.17e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361   831 TFNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYIKnkylnkkyFFGPRSPASLHQQNQI 910
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDK--------FLSPNAPKEVNLDSDL 72

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 1958792361   911 M--LLSGgwgkILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 955
Cdd:smart00315   73 RekIEEN----LESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 832-961 5.83e-67

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 221.20  E-value: 5.83e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  832 FNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 911
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958792361  912 LLSGGWGKILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 961
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1005-1127 1.31e-63

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 211.48  E-value: 1.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361 1005 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCEESIIHKKITTIINCFINSCIPPALQIDIPVEQAQKII 1084
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958792361 1085 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMS 1127
Cdd:cd08725     81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 663-765 4.39e-44

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 155.28  E-value: 4.39e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  663 VENRAGFFFTKFCENSGNK-------------AYHQLFYQETLEPFKVCKQAQYLFATYIAPSASLDVGLHPEEKKDIYI 729
Cdd:cd08727      1 LENRAGNFFTQFCEKSGNKlwknavyfwfdlqEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958792361  730 KIQPPFEDLFDTAEEFILLNLLEPWTQMVMSDQVSY 765
Cdd:cd08727     81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 836-955 9.75e-17

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 77.43  E-value: 9.75e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  836 LNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIfKDQKQREAKSIYIKNKYLNKKYFFGPRSPASLhqQNQIMLlsg 915
Cdd:cd07440      1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTT-SSDEELKSKAKEIYDKYISKDAPKEINIPESI--REEIEE--- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958792361  916 gwgKILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 955
Cdd:cd07440     75 ---NLEEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLY 111
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 832-955 1.55e-08

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 53.77  E-value: 1.55e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  832 FNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYikNKYLNKKyffgprSPASLHQQNQIM 911
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLAPG------SPKEINLDSDLR 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958792361  912 -LLSGGwgkiLHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 955
Cdd:pfam00615   74 eEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1001-1115 2.77e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 50.35  E-value: 2.77e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  1001 FRKALLNPVIARQFQRFvaLKGDLLENGVLFWQEVQKFKDLCHShceeSIIHKKITTIINCFINSCIPPALQIDI-PVEQ 1079
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKAEDD----EERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 1958792361  1080 AQKIIEHRkELGPYVFREAQMTIFGVL-FKFWPQFCE 1115
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYELLeKDSFPRFLE 111
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 831-955 4.17e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 49.96  E-value: 4.17e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361   831 TFNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYIKnkylnkkyFFGPRSPASLHQQNQI 910
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDK--------FLSPNAPKEVNLDSDL 72

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 1958792361   911 M--LLSGgwgkILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 955
Cdd:smart00315   73 RekIEEN----LESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 836-1018 4.78e-06

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 48.30  E-value: 4.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  836 LNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYiknkylnKKYFFGPRSPASLHQQNQIMLLSG 915
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIV-------KRYFHGQDPPGVLLQCEAIIIREI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  916 GWGKILHEqldaSVLVEIQKHVLNRLENVWLPLF---LSSEQFASRQKIKIRMKDIADELLLQR-HDRKIGVWkpveSKW 991
Cdd:cd08728     74 AMMKVVTT----SMLLSIQHLVSKSLEERWFKKYqdtFPDCPHEVEPDEEIKVPLKPTKLKAPHvISSQKRAW----EIF 145

                          170       180
                   ....*....|....*....|....*..
gi 1958792361  992 ISSSCEIIAFRKALLNPVIARQFQRFV 1018
Cdd:cd08728    146 ISFIRSFIKFRRFMVNREIRQEFEDYL 172
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 1005-1120 1.48e-03

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 39.68  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361 1005 LLNPVIARQFQRFVALKGDLlENgVLFWQEVQKFKDLCHShceESIIHKKITTIINCFINSciPPALQIDIPvEQAQKII 1084
Cdd:cd07440      1 LRDPYGLEYFRQFLKSEHCE-EN-LEFWLAVEKFKKTTSS---DEELKSKAKEIYDKYISK--DAPKEINIP-ESIREEI 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958792361 1085 EHR---KELGPYVFREAQMTIFGVLFK-FWPQFCEFRKNL 1120
Cdd:cd07440     73 EENleePYPDPDCFDEAQEHILNLLEKdSYPRFLKSDLYL 112
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 832-953 1.97e-03

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 39.27  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958792361  832 FNDLLNNKLEFEHFRQFLESHSSSIDLMCWIDIEQFRRIIFKDQKQREAKSIYikNKYLNKKyffGPRSpASLHQQNQIM 911
Cdd:cd08709      1 FDELLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSPQKLTSKAKKIY--TDFIEKE---APKE-INIDFQTKTL 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958792361  912 LLSGgwgkilHEQLDASVLVEIQKHVLNRLENVWLPLFLSSE 953
Cdd:cd08709     75 IAQN------IQEATSGCFTAAQKRVYSLMENNSYPRFLESE 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH