NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1955865626|ref|XP_038890729|]
View 

aquaporin TIP1-3 [Benincasa hispida]

Protein Classification

TIP-type aquaporin( domain architecture ID 10010587)

TIP (tonoplast intrinsic protein)-type aquaporin is a water channel required to facilitate the transport of water from the vacuolar compartment to the cytoplasm

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|11473620|8849412
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 1-247 4.22e-142

aquaporin TIP; Provisional


:

Pssm-ID: 177664  Cd Length: 252  Bit Score: 398.39  E-value: 4.22e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626   1 MPIQKFTLGTPGEVSQPDAIKAAFAEFFSMIIFVFAGQGSGLAFDKLTDGGSATPSGLIMASLAHAFALFVAVSVGANIS 80
Cdd:PLN00027    1 MPIRRIAIGTPGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAVSVGANIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  81 GGHVNPAVTFGALVGGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKVTPAFALSTGVSVWNAFIFEAVMTFGLVYTVY 160
Cdd:PLN00027   81 GGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 161 ATAIDPKRENLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFIS 240
Cdd:PLN00027  161 ATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFIG 240


                  ....*..
gi 1955865626 241 DSVHEPL 247
Cdd:PLN00027  241 STTHEQL 247
 
Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 1-247 4.22e-142

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 398.39  E-value: 4.22e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626   1 MPIQKFTLGTPGEVSQPDAIKAAFAEFFSMIIFVFAGQGSGLAFDKLTDGGSATPSGLIMASLAHAFALFVAVSVGANIS 80
Cdd:PLN00027    1 MPIRRIAIGTPGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAVSVGANIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  81 GGHVNPAVTFGALVGGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKVTPAFALSTGVSVWNAFIFEAVMTFGLVYTVY 160
Cdd:PLN00027   81 GGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 161 ATAIDPKRENLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFIS 240
Cdd:PLN00027  161 ATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFIG 240


                  ....*..
gi 1955865626 241 DSVHEPL 247
Cdd:PLN00027  241 STTHEQL 247
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 13-234 9.50e-77

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 231.44  E-value: 9.50e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  13 EVSQPDAIKAAFAEFFSMIIFVFAGQGSGLAFDKLTDggSATPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGA 92
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVS--SLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  93 LVGGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKVTP---AFALSTGVSVWNAFIFEAVMTFGLVYTVYATAIDPKRE 169
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAglfANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1955865626 170 NLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFY 234
Cdd:pfam00230 159 SLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 21-237 9.96e-64

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 198.63  E-value: 9.96e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  21 KAAFAEFFSMIIFVFAGQGSGLAFDKLTDggsaTPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNISL 100
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG----ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 101 FRSIMYWIVQLLGSVVACFLLKFATGGKVTPAFA------------LSTGVSVWNAFIFEAVMTFGLVYTVYATAIDPKR 168
Cdd:cd00333    77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGannivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1955865626 169 ENLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTW---SWSHHWVYWLGPMAGAAIAAIFYDTL 237
Cdd:cd00333   157 PPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 25-234 5.44e-53

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 170.94  E-value: 5.44e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  25 AEFFSMIIFVFAGQGSGLAFDKLTDGGSATPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNISLFRSI 104
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 105 MYWIVQLLGSVVACFLLKFATGGKVTPAFALST----GVSVWNAFIFEAVMTFGLVYTVYATAIDPKRENLGIIAPISIG 180
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGsasaGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1955865626 181 FIVGANILVGGAFDGASMNPAVSFGPAVVTWS--WSHHWVYWLGPMAGAAIAAIFY 234
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 20-238 5.89e-44

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 147.97  E-value: 5.89e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  20 IKAAFAEFFSMIIFVFAGQGSGLAFdkltdGGSATPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNIS 99
Cdd:COG0580     3 MKRLLAEFLGTFILVLLGCGVVAVL-----AGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 100 LFRSIMYWIVQLLGSVVACFLLKF-------ATGGKVTPAFALST----GVSVWNAFIFEAVMTFGLVYTVYATAIDPKr 168
Cdd:COG0580    78 WKDVLPYIIAQLLGAFLGAALVYLiygghfdATEDGGAKLGVFATspaiGYSLGAAFLTEIIGTFVLVFVILGITDKRA- 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1955865626 169 eNLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVV------TWSWSHHWVYWLGPMAGAAIAAIFYDTLF 238
Cdd:COG0580   157 -APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
 
Name Accession Description Interval E-value
PLN00027 PLN00027
aquaporin TIP; Provisional
 1-247 4.22e-142

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 398.39  E-value: 4.22e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626   1 MPIQKFTLGTPGEVSQPDAIKAAFAEFFSMIIFVFAGQGSGLAFDKLTDGGSATPSGLIMASLAHAFALFVAVSVGANIS 80
Cdd:PLN00027    1 MPIRRIAIGTPGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAVSVGANIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  81 GGHVNPAVTFGALVGGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKVTPAFALSTGVSVWNAFIFEAVMTFGLVYTVY 160
Cdd:PLN00027   81 GGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 161 ATAIDPKRENLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFIS 240
Cdd:PLN00027  161 ATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIFIG 240


                  ....*..
gi 1955865626 241 DSVHEPL 247
Cdd:PLN00027  241 STTHEQL 247
PLN00166 PLN00166
aquaporin TIP2; Provisional
 5-249 1.22e-81

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 245.23  E-value: 1.22e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626   5 KFTLGTPGEVSQPDAIKAAFAEFFSMIIFVFAGQGSGLAFDKLTDGGSATPSGLIMASLAHAFALFVAVSVGANISGGHV 84
Cdd:PLN00166    3 KIEFGSLGDSFSVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  85 NPAVTFGALVGGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKVTPAFALSTGVSVWNAFIFEAVMTFGLVYTVYATAI 164
Cdd:PLN00166   83 NPAVTLGLAIGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 165 DPKRENLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFISDSVH 244
Cdd:PLN00166  163 DPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVFIGSYAA 242


                  ....*
gi 1955865626 245 EPLTQ 249
Cdd:PLN00166  243 APTSE 247
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 13-234 9.50e-77

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 231.44  E-value: 9.50e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  13 EVSQPDAIKAAFAEFFSMIIFVFAGQGSGLAFDKLTDggSATPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGA 92
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVS--SLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  93 LVGGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKVTP---AFALSTGVSVWNAFIFEAVMTFGLVYTVYATAIDPKRE 169
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAglfANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1955865626 170 NLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFY 234
Cdd:pfam00230 159 SLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
PLN00167 PLN00167
aquaporin TIP5; Provisional
 13-235 2.50e-64

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 201.29  E-value: 2.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  13 EVSQPDAIKAAFAEFFSMIIFVFAGQGSGLAFDKLTDGGSATPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGA 92
Cdd:PLN00167   15 QSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGM 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  93 LVGGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKVTPAFALSTGVSVWNAFIFEAVMTFGLVYTVYAtAIDPKRENLG 172
Cdd:PLN00167   95 AVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYA-AGDPRRGLLG 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1955865626 173 IIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYD 235
Cdd:PLN00167  174 AIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYD 236
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 21-237 9.96e-64

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 198.63  E-value: 9.96e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  21 KAAFAEFFSMIIFVFAGQGSGLAFDKLTDggsaTPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNISL 100
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG----ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 101 FRSIMYWIVQLLGSVVACFLLKFATGGKVTPAFA------------LSTGVSVWNAFIFEAVMTFGLVYTVYATAIDPKR 168
Cdd:cd00333    77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGannivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1955865626 169 ENLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVTW---SWSHHWVYWLGPMAGAAIAAIFYDTL 237
Cdd:cd00333   157 PPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 25-234 5.44e-53

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 170.94  E-value: 5.44e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  25 AEFFSMIIFVFAGQGSGLAFDKLTDGGSATPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNISLFRSI 104
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 105 MYWIVQLLGSVVACFLLKFATGGKVTPAFALST----GVSVWNAFIFEAVMTFGLVYTVYATAIDPKRENLGIIAPISIG 180
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGsasaGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1955865626 181 FIVGANILVGGAFDGASMNPAVSFGPAVVTWS--WSHHWVYWLGPMAGAAIAAIFY 234
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 20-238 5.89e-44

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 147.97  E-value: 5.89e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  20 IKAAFAEFFSMIIFVFAGQGSGLAFdkltdGGSATPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNIS 99
Cdd:COG0580     3 MKRLLAEFLGTFILVLLGCGVVAVL-----AGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 100 LFRSIMYWIVQLLGSVVACFLLKF-------ATGGKVTPAFALST----GVSVWNAFIFEAVMTFGLVYTVYATAIDPKr 168
Cdd:COG0580    78 WKDVLPYIIAQLLGAFLGAALVYLiygghfdATEDGGAKLGVFATspaiGYSLGAAFLTEIIGTFVLVFVILGITDKRA- 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1955865626 169 eNLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVV------TWSWSHHWVYWLGPMAGAAIAAIFYDTLF 238
Cdd:COG0580   157 -APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00026 PLN00026
aquaporin NIP; Provisional
 25-253 1.28e-22

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 93.77  E-value: 1.28e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  25 AEFFSMIIFVFAGQGSGLAFDKLtdGGSATPSGLimASLAHAFALFVAVSVGaNISGGHVNPAVTFGALVGGNISLFRSI 104
Cdd:PLN00026   76 AEFVGTFILIFAATAGPIVNQKY--DGAETLIGN--AACAGLAVMIVILSTG-HISGAHLNPSLTIAFAALRHFPWKHVP 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 105 MYWIVQLLGSVVACFLLK-----FATGGKVTPAfalstgVSVWNAFIFEAVMTFGLVYTVYATAIDPKRenLGIIAPISI 179
Cdd:PLN00026  151 AYIAAQVSASICASFALKgvfhpFMSGGVTVPS------VSTGQAFALEFIITFNLLFVVTAVATDTRA--VGELAGIAV 222

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1955865626 180 GFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFISDSVHEPLTQYNDF 253
Cdd:PLN00026  223 GATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREEDGDPPRPVRSF 296
PLN00184 PLN00184
aquaporin NIP1; Provisional
 25-253 3.99e-20

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 87.00  E-value: 3.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  25 AEFFSMIIFVFAGQGSgLAFDKLTDGGSATPSGLIMASLAhafaLFVAVSVGANISGGHVNPAVTFGALVGGNISLFRSI 104
Cdd:PLN00184   59 AEVLGTYFLVFTGCAS-VVVNMQNDNVVTLPGIAIVWGLT----IMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVP 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 105 MYWIVQLLGSVVACFLLKFATG-------GKVTPAFALSTGVSVWNAFIFEAVMTFGLVYTVYATAIDPKRenLGIIAPI 177
Cdd:PLN00184  134 AYVISQVIGSTLAAATLRLLFGldhdvcsGKHDVFIGSSPVGSDLQAFVMEFIVTFYLMFIISGVATDNRA--IGELAGL 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1955865626 178 SIGFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFISDSVHEPLTQYNDF 253
Cdd:PLN00184  212 AIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDKPLREITKSGSF 287
PRK05420 PRK05420
aquaporin Z; Provisional
 21-242 4.81e-20

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 85.40  E-value: 4.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  21 KAAFAEFFSMIIFVFAGQGSGL---AFDKLtdggsatpsGLIMASLAHAFALFV---AVSVGaNISGGHVNPAVTFGALV 94
Cdd:PRK05420    3 KKLAAEFFGTFWLVFGGCGSAVlaaAFPEL---------GIGFLGVALAFGLTVltmAYAVG-HISGGHFNPAVSVGLWA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  95 GGNISLFRSIMYWIVQLLGSVVACFLLKFATGGKvtPAFALST--------------GVSVWNAFIFEAVMTFGLVYTVY 160
Cdd:PRK05420   73 GGRFPAKELVPYIIAQVVGGIAAAAVLYLIASGK--AGFDLAGsgfasngygehspgGYSLLAALVCEVVLTAFFLLVIL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 161 AtAIDpKRENLGiIAPISIGFIVGANILVGGAFDGASMNPAVSFGPA--VVTWSWSHHWVYWLGPMAGAAIAAIFYDTLF 238
Cdd:PRK05420  151 G-ATD-KRAPAG-FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVAlfVGGWALEQLWLFWVAPIVGAIIGGLIYRLLL 227


                  ....
gi 1955865626 239 ISDS 242
Cdd:PRK05420  228 EKDD 231
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 25-253 5.77e-20

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 86.50  E-value: 5.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  25 AEFFSMIIFVFAGQGSgLAFDKLTdGGSATPSGLimaSLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNISLFRSI 104
Cdd:PLN00182   47 AEMIGTYFIIFSGCGV-VVVNVLY-GGTITFPGI---CVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 105 MYWIVQLLGSVVACFLLKFATggKVTP-AFALSTGV-SVWNAFIFEAVMTFGLVYTVYATAIDPKRenLGIIAPISIGFI 182
Cdd:PLN00182  122 LYIGAQLTGSLLASLTLRLMF--NVTPeAFFGTTPTdSSGQALVAEIIISFLLMFVISGVATDSRA--VGELAGIAVGMT 197

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1955865626 183 VGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFISDSVHEPLTQYNDF 253
Cdd:PLN00182  198 IILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIRFTDKPLRELTKSASF 268
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 20-239 3.82e-18

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 81.44  E-value: 3.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  20 IKAAFAEFFSMIIFVFAGQGSgLAFDKLTDGgsatPSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNIS 99
Cdd:PLN00183   45 ARMVLAEMVGTFILMFCVCGI-IASTQLSGG----EVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 100 LFRSIMYWIVQLLGSVVACFLLKFATGGKvTPAFALSTGVSVWNAFIFEAVMTFGLVYtvYATAIDPKRENLGIIAPISI 179
Cdd:PLN00183  120 WSKVPLYITAQTVGSVLATYVGVSVYGVK-ADLMTTKPAQGCSSAFWVEFIATFIVMF--LAASLTSQPQSLGHLSGFVI 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 180 GFIVGANILVGGAFDGASMNPAVSFGPAVVTWSWSHHWVYWLGPMAGAAIAAIFYDTLFI 239
Cdd:PLN00183  197 GIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLLRL 256
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 25-239 2.45e-10

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 59.37  E-value: 2.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626  25 AEFFSMIIFVFAGQGSGLAFdkLTDGGSatpSGLIMASLAHAFALFVAVSVGANISGGHVNPAVTFGALVGGNISLFRSI 104
Cdd:PTZ00016   55 AEFLGTFVLLFFGEGVVATT--HTVGNN---GDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 105 MYWIVQLLGSVVA------CF-----------LLKFATGGKVTPAFALSTGVSVWNAFIFEAVMTFGLVYTVYATaIDPK 167
Cdd:PTZ00016  130 GYFVAQLLGAFVGaacvygLYygffkdhgipeLPWETMANGFAGVFATYPREGNFYAIFSELILTAILLLVILAI-TDPN 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955865626 168 RENLGIIAPISIGFIVGANILVGGAFDGASMNPAVSFGPAVVT---W---SWSHH----WVYWLGPMAGAAIAAIFYDTL 237
Cdd:PTZ00016  209 NCPAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSailWgseVFTKDnyyfWVPLVAPFVGAVLGMFLYDKF 288


                  ..
gi 1955865626 238 FI 239
Cdd:PTZ00016  289 IP 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH