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2-oxoglutarate dehydrogenase, mitochondrial isoform X1 [Salvelinus namaycush]
Protein Classification
2-oxoglutarate dehydrogenase family protein ( domain architecture ID 11426267 )
2-oxoglutarate dehydrogenase family protein, such as 2-oxoglutarate dehydrogenase subunit E1 that catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
47-1008
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1310.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 47 FL N G TSSN Y V EE M Y YSW LEDP K SV HK SW DI FF RN - ANAGATPGK AH Q ---- SPLS LA GQPQAQSLVG A Q in VEKLVEDHL 121
Cdd:COG0567 11 FL S G ANAA Y I EE L Y EQY LEDP D SV DP SW RA FF DG l PDVPGARDF AH S pire EFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 122 A V QS LI R AY QI RGH HV A Q LDPLG IMD ---- AD LD ahvpndiitssdk LG FYGL D E S DLD K VF rl P T TTFI G GTET vl P LR 197
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRE rpyv PE LD ------------- PA FYGL T E A DLD T VF -- N T GSLL G LETA -- T LR 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 198 EII RR L EMA YC QH IGVE F M F I N D LDQCQ WI R E KF E KP - GVMQ F TL EEK RTL L ARMVRSTR FE E FL QR K WSSE KRF G LEG C 276
Cdd:COG0567 152 EII AA L KET YC GS IGVE Y M H I S D PEEKR WI Q E RL E ST r NRPS F SA EEK KRI L EKLTAAEG FE K FL HT K YVGQ KRF S LEG G 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 277 ESLIPAL KTI I DKSS E K GV EN IV M GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D 356
Cdd:COG0567 232 ESLIPAL DEL I ERAG E L GV KE IV I GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 357 - RNIT LSL MA NPSHLE A V D PVV Q G KTK A E Q FYC GDT EGH KV MS IL M HGDAAFAGQGVVYET FHL S D L PS Y S T H GT V H V V V 435
Cdd:COG0567 309 g GKVH LSL AF NPSHLE I V N PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQGVVYET LNM S Q L RG Y R T G GT I H I V I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 436 NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN A DDPEAVV Y V CNV A AEW R AT F H KDVV V DLVCYRR L GHNE M DEP M FT 515
Cdd:COG0567 389 NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAVV F V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FT 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 516 QPLMYK Q IKK QKGVMQK Y GE KL I AEG AVSRQ E YE E EIAK Y DKICE E AHVRS K d E KILHIKH WL DSP W PGFFN L DG qp KSL 595
Cdd:COG0567 469 QPLMYK K IKK HPTTREI Y AD KL V AEG VITAE E AD E MVDE Y RAALD E GFEVV K - E YKPNKAD WL EGD W SPYRR L GE -- DWD 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 596 TCPT TG LTE E E L IHI G QVASSV P v E D F TI H GGLSR IL KA R GE M I - KNRTV DW ALG E YM A FG SLL K EG IH VRLSGQD VE RG 674
Cdd:COG0567 546 DPVD TG VPL E K L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GMA E AL A YA SLL D EG YP VRLSGQD SG RG 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 675 TFSHRH H VLHDQ NVDKRV c I P M NH VAPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQF 754
Cdd:COG0567 625 TFSHRH A VLHDQ KTGETY - V P L NH LSEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQF 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 755 I CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdmlpsitddfairqlhdc N WI V V N CSN P GNF FH V L 834
Cdd:COG0567 704 I SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D ------------------- N MQ V C N PTT P AQY FH L L 764
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 835 RRQ ILA PFRKPLIV F TPKSLLRH PD A R S NFD E MLP G T e FQ RL I P D SGPV tq N P AG VKR I V F C T GKVYY E L TK ER KAH G ME 914
Cdd:COG0567 765 RRQ MKR PFRKPLIV M TPKSLLRH KL A V S SLE E LAE G S - FQ EV I D D TDEL -- D P KK VKR V V L C S GKVYY D L LE ER RER G RD 841
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 915 D m VAI A R M EQL S PFP FDLVK AE SK KYPNA - DL VWCQEE H KN Q G YYDYVKP R MRTTIERAKPVW YAGRP PA A A PATG NKKA 993
Cdd:COG0567 842 D - VAI V R I EQL Y PFP EEELA AE LA KYPNA k EV VWCQEE P KN M G AWYFIQH R LEEVLPKGQRLR YAGRP AS A S PATG YMSV 920
970
....*....|....*
gi 1955726232 994 H LV E L K NFLDT A FDL 1008
Cdd:COG0567 921 H KA E Q K ALVEE A LGI 935
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
47-1008
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1310.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 47 FL N G TSSN Y V EE M Y YSW LEDP K SV HK SW DI FF RN - ANAGATPGK AH Q ---- SPLS LA GQPQAQSLVG A Q in VEKLVEDHL 121
Cdd:COG0567 11 FL S G ANAA Y I EE L Y EQY LEDP D SV DP SW RA FF DG l PDVPGARDF AH S pire EFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 122 A V QS LI R AY QI RGH HV A Q LDPLG IMD ---- AD LD ahvpndiitssdk LG FYGL D E S DLD K VF rl P T TTFI G GTET vl P LR 197
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRE rpyv PE LD ------------- PA FYGL T E A DLD T VF -- N T GSLL G LETA -- T LR 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 198 EII RR L EMA YC QH IGVE F M F I N D LDQCQ WI R E KF E KP - GVMQ F TL EEK RTL L ARMVRSTR FE E FL QR K WSSE KRF G LEG C 276
Cdd:COG0567 152 EII AA L KET YC GS IGVE Y M H I S D PEEKR WI Q E RL E ST r NRPS F SA EEK KRI L EKLTAAEG FE K FL HT K YVGQ KRF S LEG G 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 277 ESLIPAL KTI I DKSS E K GV EN IV M GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D 356
Cdd:COG0567 232 ESLIPAL DEL I ERAG E L GV KE IV I GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 357 - RNIT LSL MA NPSHLE A V D PVV Q G KTK A E Q FYC GDT EGH KV MS IL M HGDAAFAGQGVVYET FHL S D L PS Y S T H GT V H V V V 435
Cdd:COG0567 309 g GKVH LSL AF NPSHLE I V N PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQGVVYET LNM S Q L RG Y R T G GT I H I V I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 436 NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN A DDPEAVV Y V CNV A AEW R AT F H KDVV V DLVCYRR L GHNE M DEP M FT 515
Cdd:COG0567 389 NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAVV F V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FT 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 516 QPLMYK Q IKK QKGVMQK Y GE KL I AEG AVSRQ E YE E EIAK Y DKICE E AHVRS K d E KILHIKH WL DSP W PGFFN L DG qp KSL 595
Cdd:COG0567 469 QPLMYK K IKK HPTTREI Y AD KL V AEG VITAE E AD E MVDE Y RAALD E GFEVV K - E YKPNKAD WL EGD W SPYRR L GE -- DWD 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 596 TCPT TG LTE E E L IHI G QVASSV P v E D F TI H GGLSR IL KA R GE M I - KNRTV DW ALG E YM A FG SLL K EG IH VRLSGQD VE RG 674
Cdd:COG0567 546 DPVD TG VPL E K L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GMA E AL A YA SLL D EG YP VRLSGQD SG RG 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 675 TFSHRH H VLHDQ NVDKRV c I P M NH VAPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQF 754
Cdd:COG0567 625 TFSHRH A VLHDQ KTGETY - V P L NH LSEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQF 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 755 I CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdmlpsitddfairqlhdc N WI V V N CSN P GNF FH V L 834
Cdd:COG0567 704 I SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D ------------------- N MQ V C N PTT P AQY FH L L 764
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 835 RRQ ILA PFRKPLIV F TPKSLLRH PD A R S NFD E MLP G T e FQ RL I P D SGPV tq N P AG VKR I V F C T GKVYY E L TK ER KAH G ME 914
Cdd:COG0567 765 RRQ MKR PFRKPLIV M TPKSLLRH KL A V S SLE E LAE G S - FQ EV I D D TDEL -- D P KK VKR V V L C S GKVYY D L LE ER RER G RD 841
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 915 D m VAI A R M EQL S PFP FDLVK AE SK KYPNA - DL VWCQEE H KN Q G YYDYVKP R MRTTIERAKPVW YAGRP PA A A PATG NKKA 993
Cdd:COG0567 842 D - VAI V R I EQL Y PFP EEELA AE LA KYPNA k EV VWCQEE P KN M G AWYFIQH R LEEVLPKGQRLR YAGRP AS A S PATG YMSV 920
970
....*....|....*
gi 1955726232 994 H LV E L K NFLDT A FDL 1008
Cdd:COG0567 921 H KA E Q K ALVEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
47-1007
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1268.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 47 FL N G TSSN Y V EE M Y YSW L E DP K SV HKS W DI FF RNANAG A TPGKAHQSPL S LAGQPQAQSLVG A Q invekl VEDHLA V QS L 126
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L K DP D SV DEE W RA FF DGLPGV A PDVAHSAVRE S FRRLAKPARVSS A V ------ SDPQVK V LQ L 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 127 I R AY QI RGH HV A Q LDPLG IM ---- DAD LD ahvpndiitssdk LG FYGL D E S DLD KV F rl P T TTFIG G T ET V l P LREII RR 202
Cdd:PRK09404 87 I N AY RF RGH LA A N LDPLG LW krpd VPE LD ------------- PA FYGL T E A DLD RT F -- N T GSLAL G K ET A - T LREII EA 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 203 L EMA YC QH IGVE F M F I N D LDQCQ W IREKF E KPGV m Q F TL EEK RTL L A R MVRSTR FE E FL QR K WSSE KRF G LEG C ESLIP A 282
Cdd:PRK09404 151 L KKT YC GS IGVE Y M H I S D PEERR W LQQRI E SGRP - S F SA EEK KAI L E R LTAAEG FE R FL HT K FVGQ KRF S LEG G ESLIP M 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 283 L KT II DKSSEK GV EN IV M GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR ri N R V TD - RNIT 360
Cdd:PRK09404 230 L DE II RRAGKL GV KE IV I GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS -- D R E TD g GEVH 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 361 LSL MA NPSHLE A V D PVV Q G KTK A E Q FYC GD - TEGH KV MS IL M HGDAAFAGQGVV Y ET FH LS D L PS Y S T H GT V H V V V NNQI 439
Cdd:PRK09404 307 LSL AF NPSHLE I V N PVV E G SVR A R Q DRR GD g QDRK KV LP IL I HGDAAFAGQGVV A ET LN LS Q L RG Y R T G GT I H I V I NNQI 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 440 GFTT D P RMA RS S PY P TDVA RV V N APIFHVN A DDPEAVV YVCNV A A E W R AT F H KDVV V DLVCYRR L GHNE M DEP M FTQPLM 519
Cdd:PRK09404 387 GFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAVV FATRL A L E Y R QK F K KDVV I DLVCYRR H GHNE G DEP S FTQPLM 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 520 YK Q IKK QKGVMQK Y GE KL I AEG AVSRQ E YE E EIAK Y DKICEEAHVRS K DEK ilh IKH WL DSP W PGFFNLDGQPK sltc PT 599
Cdd:PRK09404 467 YK K IKK HPTTREL Y AD KL V AEG VITEE E AD E MVNE Y RDALDAGFEVV K EWR --- PAD WL AGD W SPYLGHEWDDP ---- VD 539
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 600 TG LTE E E L IHIGQVASS VP v E D F TI H GGLSR IL KA R G EM IK - NRTV DW ALG E YM AF G SLL K EG IH VRLSGQD VE RGTFSH 678
Cdd:PRK09404 540 TG VPL E R L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GMA E AL AF A SLL D EG YP VRLSGQD SG RGTFSH 618
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 679 RH H VLHDQ NVDKRV c IP M NH VAPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T AQ CI IDQFI CP G 758
Cdd:PRK09404 619 RH A VLHDQ KTGETY - IP L NH LSEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G AQ VV IDQFI SS G 697
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 759 QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdmlpsitddfairqlhdc N WI V V N CSN P GNF FH V LRRQ I 838
Cdd:PRK09404 698 EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D ------------------- N MQ V C N PTT P AQY FH L LRRQ A 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 839 L A PFRKPL I V F TPKSLLRHP D A R S NFD E MLP G T e FQ RL I P D SGPV tq N P AG VKR I V F C T GKVYY E L TKE R KAH G ME D m VA 918
Cdd:PRK09404 759 L R PFRKPL V V M TPKSLLRHP L A V S SLE E LAE G S - FQ PV I G D IDEL -- D P KK VKR V V L C S GKVYY D L LEA R RKR G ID D - VA 834
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 919 I A R M EQL S PFP FDLVK AE SK KYPNA - DL VWCQEE H KNQG YYDYVKPRMRTTIERAKPVW YAGRP PA A A PA T G NKKA H LVE 997
Cdd:PRK09404 835 I V R I EQL Y PFP HEELA AE LA KYPNA k EV VWCQEE P KNQG AWYFIQHHLEEVLPEGQKLR YAGRP AS A S PA V G YMSL H KKQ 914
970
....*....|
gi 1955726232 998 LKNFLDT A FD 1007
Cdd:PRK09404 915 QEALVED A LG 924
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
47-1006
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 978.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 47 F L N G TSSN Y V EE M Y YSW L E DP K SV HK SW DIF F RNANAGATPGKAHQ SP L ----- S LA GQ - PQAQSLVG aqi NVEKL V EDH 120
Cdd:TIGR00239 1 Y L S G ANQS Y I EE L Y EDY L T DP D SV DA SW RST F DQLPGPGPAPDQFH SP T rsyfr R LA KD a SRGSVTIS --- DPDTN V SQV 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 121 LAV Q s LIRAY QI RGH HV A Q LDPLG IMDA D LDAHVP ndiitssdk L G FYGL D E S DL DKV F RLPTTTFIGGTETV L PLR E II 200
Cdd:TIGR00239 78 KVL Q - LIRAY RF RGH LH A N LDPLG LKQQ D KVPELD --------- L S FYGL T E A DL QET F NIGSFVSGKDATMK L SNL E LL 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 201 RR L EMA YC QH IG V E F M F I NDLDQCQ W IREKF E KPGVM QF TL EEK RTL L A R MVRSTR FE E FL QR K WSSE KRF G LEG CES L I 280
Cdd:TIGR00239 148 QA L KQT YC GS IG A E Y M H I TSTEEKR W LQQRI E SGERA QF NS EEK KRF L S R LTAAEG FE R FL GA K FPGA KRF S LEG LDA L V 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 281 P A LK T II DK S SEK G VENI V M GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHRRIN r VTDRNI 359
Cdd:TIGR00239 228 P M LK E II RH S VNS G TRDV V L GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSSDFT - TDGKLV 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 360 T L S L MA NPSHLE A V D PVV Q G K T K A EQFYCG D - T E GH KV MS IL M HGDAAFAGQGVV Y ET FHL S D L PS YS TH GT V H VVV NNQ 438
Cdd:TIGR00239 307 H L A L AF NPSHLE I V S PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQGVV Q ET LNM S K L RG YS VG GT I H III NNQ 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 439 IGFTT D P RM ARS S PY PT D V A RVVN APIFHVNADDPEAV VYVCNV A A E W R A TF HK DV VV DLV C YRR L GHNE M DEP MF TQPL 518
Cdd:TIGR00239 387 IGFTT N P LD ARS T PY CS D L A KMIQ APIFHVNADDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE A DEP SA TQPL 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 519 MY KQ IKK QKGVMQK Y GE KL IA EG AVSRQEYE E EIAK Y DKIC E E A hvrsk D EKILHIKHWLDSPWPGFFN L D g QPKSLTC P 598
Cdd:TIGR00239 467 MY QK IKK HPTPRKV Y AD KL VS EG VATEEDVT E MVNL Y RDAL E A A ----- D CVVPSWREMNTASFTWSPE L N - HEWDEEY P 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 599 TT g LTEEE L IHIGQVA S S VP v E DFTI H GGLSR I LKA R GEMIK -- NRTV DW ALG E YM AF GS L LKE GI H VRLSG Q D V ERGTF 676
Cdd:TIGR00239 541 NK - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GGA E NL AF AT L VDD GI P VRLSG E D S ERGTF 618
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 677 SH RH H VLHDQ N v DKRVCI P MN H VAPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T AQ CI IDQFI C 756
Cdd:TIGR00239 619 FQ RH A VLHDQ S - NGSTYT P LQ H LHNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G AQ VV IDQFI S 697
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 757 P G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdmlpsitddfairqlhdc N WI V VNCSN P GNF FH V LRR 836
Cdd:TIGR00239 698 S G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ ------------------- N MQ V CVPTT P AQV FH I LRR 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 837 Q I L APF R K PL I V FT PKSLLRHP D A R S NFD E MLP GT e FQ RL I P -- DSGPVTQN P A GVKR I V F C T GKVYY E L TKE R KAH G ME 914
Cdd:TIGR00239 759 Q A L RGM R R PL V V MS PKSLLRHP L A V S SLE E LAE GT - FQ PV I G ei EESGLSLD P E GVKR L V L C S GKVYY D L HEQ R RKN G QK 837
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 915 D m VAI A R M EQL S PFP FDL VK AESKK YPN - ADL VWCQEE HK N Q G YYD Y VK P RM R TT I ERAKP V W YAGRP PA A A PA T G NKKA 993
Cdd:TIGR00239 838 D - VAI V R I EQL Y PFP HKA VK EVLQQ YPN l KEI VWCQEE PL N M G AWY Y SQ P HL R EV I PEGVS V R YAGRP AS A S PA V G YMSL 916
970
....*....|...
gi 1955726232 994 H LVELKNF L DT A F 1006
Cdd:TIGR00239 917 H QKQQQDL L ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
257-520
3.61e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 520.93
E-value: 3.61e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 257 FE E FL QR K WSSE KRFGLEG C ESLIPAL KTI ID KSS E K GVE NI V M GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 334
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A ESLIPAL DEL ID RAA E L GVE EV V I GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 335 EGSGDVKYHLG MYHR R INRV t DRNIT LSL MA NPSHLEAV D PVV Q GKT K A E Q F Y C GD T E GH KV MS IL M HGDAAFAGQGVVY 414
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEAV N PVV M GKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQGVVY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 415 ET FH LS D LP S Y S T H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN A DDPEAVV YVCNV A A E W R AT F H KDV 494
Cdd:cd02016 160 ET LN LS N LP G Y T T G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAVV RATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 1955726232 495 V V DLVCYRR L GHNE M DEP M FTQPLMY 520
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
249-575
2.71e-96
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 306.56
E-value: 2.71e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 249 A RM VRST R F E EFLQRKWSSEKRF G LEGCESLIP A LKTI I DKSS E K G v EN I VM G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 328
Cdd:pfam00676 1 R RM MTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I IP G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 329 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L S lmanpshle A VD P VVQ G KTK A EQF ycgdt E G H K VMS I LMH GD A A f A 408
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L G --------- A QV P LGA G IAL A AKY ----- R G K K EVA I TLY GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 409 G QG VVY E TFHLSD L PSYST hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NAD DP E AV VYVCNV AAE WRA 488
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQASKF AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 489 T FHKDVVVD LV C YR RL GH NEM D E P MFTQ - PLM Y KQIK K Q K GVM Q KYG E K L IAE G AV S RQ E YEEEIAKYD K IC EEA HVRSK 567
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEVR K K K DPI Q RFK E H L VSK G VW S EE E LKAIEKEVR K EV EEA FKKAE 292
....*...
gi 1955726232 568 DEKIL H IK 575
Cdd:pfam00676 293 SAPEP H PE 300
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
710-856
9.93e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.16
E-value: 9.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 710 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 788
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1955726232 789 E - RFLQM cnddpdmlpsitddfairqlhd CNWI VV NC S N P GNFFHV LR RQ I LAP f RKPL I VFTP KSL L R 856
Cdd:smart00861 91 E a LLRAI ---------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
47-1008
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1310.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 47 FL N G TSSN Y V EE M Y YSW LEDP K SV HK SW DI FF RN - ANAGATPGK AH Q ---- SPLS LA GQPQAQSLVG A Q in VEKLVEDHL 121
Cdd:COG0567 11 FL S G ANAA Y I EE L Y EQY LEDP D SV DP SW RA FF DG l PDVPGARDF AH S pire EFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 122 A V QS LI R AY QI RGH HV A Q LDPLG IMD ---- AD LD ahvpndiitssdk LG FYGL D E S DLD K VF rl P T TTFI G GTET vl P LR 197
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRE rpyv PE LD ------------- PA FYGL T E A DLD T VF -- N T GSLL G LETA -- T LR 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 198 EII RR L EMA YC QH IGVE F M F I N D LDQCQ WI R E KF E KP - GVMQ F TL EEK RTL L ARMVRSTR FE E FL QR K WSSE KRF G LEG C 276
Cdd:COG0567 152 EII AA L KET YC GS IGVE Y M H I S D PEEKR WI Q E RL E ST r NRPS F SA EEK KRI L EKLTAAEG FE K FL HT K YVGQ KRF S LEG G 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 277 ESLIPAL KTI I DKSS E K GV EN IV M GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D 356
Cdd:COG0567 232 ESLIPAL DEL I ERAG E L GV KE IV I GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 357 - RNIT LSL MA NPSHLE A V D PVV Q G KTK A E Q FYC GDT EGH KV MS IL M HGDAAFAGQGVVYET FHL S D L PS Y S T H GT V H V V V 435
Cdd:COG0567 309 g GKVH LSL AF NPSHLE I V N PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQGVVYET LNM S Q L RG Y R T G GT I H I V I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 436 NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN A DDPEAVV Y V CNV A AEW R AT F H KDVV V DLVCYRR L GHNE M DEP M FT 515
Cdd:COG0567 389 NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAVV F V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FT 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 516 QPLMYK Q IKK QKGVMQK Y GE KL I AEG AVSRQ E YE E EIAK Y DKICE E AHVRS K d E KILHIKH WL DSP W PGFFN L DG qp KSL 595
Cdd:COG0567 469 QPLMYK K IKK HPTTREI Y AD KL V AEG VITAE E AD E MVDE Y RAALD E GFEVV K - E YKPNKAD WL EGD W SPYRR L GE -- DWD 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 596 TCPT TG LTE E E L IHI G QVASSV P v E D F TI H GGLSR IL KA R GE M I - KNRTV DW ALG E YM A FG SLL K EG IH VRLSGQD VE RG 674
Cdd:COG0567 546 DPVD TG VPL E K L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GMA E AL A YA SLL D EG YP VRLSGQD SG RG 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 675 TFSHRH H VLHDQ NVDKRV c I P M NH VAPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQF 754
Cdd:COG0567 625 TFSHRH A VLHDQ KTGETY - V P L NH LSEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQF 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 755 I CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdmlpsitddfairqlhdc N WI V V N CSN P GNF FH V L 834
Cdd:COG0567 704 I SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D ------------------- N MQ V C N PTT P AQY FH L L 764
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 835 RRQ ILA PFRKPLIV F TPKSLLRH PD A R S NFD E MLP G T e FQ RL I P D SGPV tq N P AG VKR I V F C T GKVYY E L TK ER KAH G ME 914
Cdd:COG0567 765 RRQ MKR PFRKPLIV M TPKSLLRH KL A V S SLE E LAE G S - FQ EV I D D TDEL -- D P KK VKR V V L C S GKVYY D L LE ER RER G RD 841
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 915 D m VAI A R M EQL S PFP FDLVK AE SK KYPNA - DL VWCQEE H KN Q G YYDYVKP R MRTTIERAKPVW YAGRP PA A A PATG NKKA 993
Cdd:COG0567 842 D - VAI V R I EQL Y PFP EEELA AE LA KYPNA k EV VWCQEE P KN M G AWYFIQH R LEEVLPKGQRLR YAGRP AS A S PATG YMSV 920
970
....*....|....*
gi 1955726232 994 H LV E L K NFLDT A FDL 1008
Cdd:COG0567 921 H KA E Q K ALVEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
47-1007
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1268.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 47 FL N G TSSN Y V EE M Y YSW L E DP K SV HKS W DI FF RNANAG A TPGKAHQSPL S LAGQPQAQSLVG A Q invekl VEDHLA V QS L 126
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L K DP D SV DEE W RA FF DGLPGV A PDVAHSAVRE S FRRLAKPARVSS A V ------ SDPQVK V LQ L 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 127 I R AY QI RGH HV A Q LDPLG IM ---- DAD LD ahvpndiitssdk LG FYGL D E S DLD KV F rl P T TTFIG G T ET V l P LREII RR 202
Cdd:PRK09404 87 I N AY RF RGH LA A N LDPLG LW krpd VPE LD ------------- PA FYGL T E A DLD RT F -- N T GSLAL G K ET A - T LREII EA 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 203 L EMA YC QH IGVE F M F I N D LDQCQ W IREKF E KPGV m Q F TL EEK RTL L A R MVRSTR FE E FL QR K WSSE KRF G LEG C ESLIP A 282
Cdd:PRK09404 151 L KKT YC GS IGVE Y M H I S D PEERR W LQQRI E SGRP - S F SA EEK KAI L E R LTAAEG FE R FL HT K FVGQ KRF S LEG G ESLIP M 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 283 L KT II DKSSEK GV EN IV M GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR ri N R V TD - RNIT 360
Cdd:PRK09404 230 L DE II RRAGKL GV KE IV I GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS -- D R E TD g GEVH 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 361 LSL MA NPSHLE A V D PVV Q G KTK A E Q FYC GD - TEGH KV MS IL M HGDAAFAGQGVV Y ET FH LS D L PS Y S T H GT V H V V V NNQI 439
Cdd:PRK09404 307 LSL AF NPSHLE I V N PVV E G SVR A R Q DRR GD g QDRK KV LP IL I HGDAAFAGQGVV A ET LN LS Q L RG Y R T G GT I H I V I NNQI 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 440 GFTT D P RMA RS S PY P TDVA RV V N APIFHVN A DDPEAVV YVCNV A A E W R AT F H KDVV V DLVCYRR L GHNE M DEP M FTQPLM 519
Cdd:PRK09404 387 GFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAVV FATRL A L E Y R QK F K KDVV I DLVCYRR H GHNE G DEP S FTQPLM 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 520 YK Q IKK QKGVMQK Y GE KL I AEG AVSRQ E YE E EIAK Y DKICEEAHVRS K DEK ilh IKH WL DSP W PGFFNLDGQPK sltc PT 599
Cdd:PRK09404 467 YK K IKK HPTTREL Y AD KL V AEG VITEE E AD E MVNE Y RDALDAGFEVV K EWR --- PAD WL AGD W SPYLGHEWDDP ---- VD 539
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 600 TG LTE E E L IHIGQVASS VP v E D F TI H GGLSR IL KA R G EM IK - NRTV DW ALG E YM AF G SLL K EG IH VRLSGQD VE RGTFSH 678
Cdd:PRK09404 540 TG VPL E R L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GMA E AL AF A SLL D EG YP VRLSGQD SG RGTFSH 618
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 679 RH H VLHDQ NVDKRV c IP M NH VAPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T AQ CI IDQFI CP G 758
Cdd:PRK09404 619 RH A VLHDQ KTGETY - IP L NH LSEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G AQ VV IDQFI SS G 697
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 759 QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdmlpsitddfairqlhdc N WI V V N CSN P GNF FH V LRRQ I 838
Cdd:PRK09404 698 EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D ------------------- N MQ V C N PTT P AQY FH L LRRQ A 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 839 L A PFRKPL I V F TPKSLLRHP D A R S NFD E MLP G T e FQ RL I P D SGPV tq N P AG VKR I V F C T GKVYY E L TKE R KAH G ME D m VA 918
Cdd:PRK09404 759 L R PFRKPL V V M TPKSLLRHP L A V S SLE E LAE G S - FQ PV I G D IDEL -- D P KK VKR V V L C S GKVYY D L LEA R RKR G ID D - VA 834
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 919 I A R M EQL S PFP FDLVK AE SK KYPNA - DL VWCQEE H KNQG YYDYVKPRMRTTIERAKPVW YAGRP PA A A PA T G NKKA H LVE 997
Cdd:PRK09404 835 I V R I EQL Y PFP HEELA AE LA KYPNA k EV VWCQEE P KNQG AWYFIQHHLEEVLPEGQKLR YAGRP AS A S PA V G YMSL H KKQ 914
970
....*....|
gi 1955726232 998 LKNFLDT A FD 1007
Cdd:PRK09404 915 QEALVED A LG 924
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
122-1008
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1004.80
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 122 A V QS LI R AY QI RGH HV A QL DPL GI --- MDA DLD ahvpnd II T ssdklgf Y GL DES DLD KV F rl P TTT F i GG T E T v LP LR E 198
Cdd:PRK12270 388 R V ME LI H AY RV RGH LM A DT DPL EY rqr SHP DLD ------ VL T ------- H GL TLW DLD RE F -- P VGG F - GG K E R - MK LR D 450
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 199 I IRR L EMA YC QHI G V E F M F I N D LD Q CQ W IR E KF E K P GV m QF T L EE KRTL L ARMVRSTR FE E FLQ R K WSSE KRF G LEG C ES 278
Cdd:PRK12270 451 I LGV L RDS YC RTV G I E Y M H I Q D PE Q RR W LQ E RV E R P HE - KP T R EE QKRI L SKLNAAEA FE T FLQ T K YVGQ KRF S LEG G ES 529
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 279 LIP A L KTII D KSS E K G VENI V M GM P HRGRLNVLAN VIR K ELE QIF CQ F DSK L E - AADE GSGDVKYHLG --- MYHR rinr V 354
Cdd:PRK12270 530 LIP L L DAVL D QAA E H G LDEV V I GM A HRGRLNVLAN IVG K PYS QIF RE F EGN L D p RSAQ GSGDVKYHLG aeg TFTQ ---- M 605
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 355 TDRN I TL SL M ANPSHLEAVDPV VQ G KTK A E Q FYCGD - T EG HK V MS IL M HGDAAFAGQGVV Y ET FH LS D L PS Y S T H GT V H V 433
Cdd:PRK12270 606 FGDE I KV SL A ANPSHLEAVDPV LE G IVR A K Q DRLDK g E EG FT V LP IL L HGDAAFAGQGVV A ET LN LS Q L RG Y R T G GT I H I 685
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 434 VVNNQ I GFTT D P RMA RSS P Y P TDVA RVVN APIFHVN A DDPEAVV Y V CNV A A E W R AT FHKDVV V DLVCYRR L GHNE M D E P M 513
Cdd:PRK12270 686 VVNNQ V GFTT A P ESS RSS E Y A TDVA KMIQ APIFHVN G DDPEAVV R V ARL A F E Y R QR FHKDVV I DLVCYRR R GHNE G D D P S 765
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 514 F TQPLMY KQ I KKQKG V MQK Y G E K LI AE G AVSRQ E Y E EEIAK Y DKIC E EAHVRSKDEK ilhi K H wl DSPW P GFFNL D GQ P k 593
Cdd:PRK12270 766 M TQPLMY DL I DAKRS V RKL Y T E A LI GR G DITVE E A E QALRD Y QGQL E RVFNEVREAE ---- K K -- PPEP P ESVES D QG P - 838
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 594 s LTCPT T GLTE E E L IH IG QVASSV P v E D FT I H GG L SRI L KA R G EM IKNRTV DWA L GE YM AFGSLL K EG IH VRLSGQD VE R 673
Cdd:PRK12270 839 - PAGVD T AVSA E V L ER IG DAHVNL P - E G FT V H PK L KPL L EK R R EM AREGGI DWA F GE LL AFGSLL L EG TP VRLSGQD SR R 916
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 674 GTFS H RH H VL H D QNVDKRVC i P MNHVAPN Q APYT V CN S S LSEY GVL GFE L G FAMAS P N ALVLWEAQFGDF H N T AQ C IID Q 753
Cdd:PRK12270 917 GTFS Q RH A VL I D RETGEEYT - P LQNLSDD Q GKFL V YD S L LSEY AAM GFE Y G YSVER P D ALVLWEAQFGDF A N G AQ T IID E 995
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 754 FI CP G Q AKW VRQN G I VLLLPHG M EG M GP E HSSAR P ERFLQ M C NDD pdmlpsitddfairqlhdc N WI V VNC S N P G N F FH V 833
Cdd:PRK12270 996 FI SS G E AKW GQRS G V VLLLPHG Y EG Q GP D HSSAR I ERFLQ L C AEG ------------------- N MT V AQP S T P A N Y FH L 1056
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 834 LRRQ I L APF R K PL I VFTPKS L LR HPD A R S NFDEMLP G T e F QRL I P D sg P VTQNP A G V K R IVF C T GK V YY E L TKE R KAH G M 913
Cdd:PRK12270 1057 LRRQ A L SGP R R PL V VFTPKS M LR LKA A V S DVEDFTE G K - F RPV I D D -- P TVDDG A K V R R VLL C S GK L YY D L AAR R EKD G R 1133
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 914 E D m V AI A R M EQL S P F P FDLVKAESKK YPNA - DL VW C QEE HK NQG YYDYVKPRMRTTIERAKPVWYAG RP PA A A PATG NK K 992
Cdd:PRK12270 1134 D D - T AI V R V EQL Y P L P RAELREALAR YPNA t EV VW V QEE PA NQG AWPFMALNLPELLPDGRRLRRVS RP AS A S PATG SA K 1212
890
....*....|....*.
gi 1955726232 993 A H L VE LKNF LD T AF DL 1008
Cdd:PRK12270 1213 V H A VE QQEL LD E AF AR 1228
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
47-1006
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 978.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 47 F L N G TSSN Y V EE M Y YSW L E DP K SV HK SW DIF F RNANAGATPGKAHQ SP L ----- S LA GQ - PQAQSLVG aqi NVEKL V EDH 120
Cdd:TIGR00239 1 Y L S G ANQS Y I EE L Y EDY L T DP D SV DA SW RST F DQLPGPGPAPDQFH SP T rsyfr R LA KD a SRGSVTIS --- DPDTN V SQV 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 121 LAV Q s LIRAY QI RGH HV A Q LDPLG IMDA D LDAHVP ndiitssdk L G FYGL D E S DL DKV F RLPTTTFIGGTETV L PLR E II 200
Cdd:TIGR00239 78 KVL Q - LIRAY RF RGH LH A N LDPLG LKQQ D KVPELD --------- L S FYGL T E A DL QET F NIGSFVSGKDATMK L SNL E LL 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 201 RR L EMA YC QH IG V E F M F I NDLDQCQ W IREKF E KPGVM QF TL EEK RTL L A R MVRSTR FE E FL QR K WSSE KRF G LEG CES L I 280
Cdd:TIGR00239 148 QA L KQT YC GS IG A E Y M H I TSTEEKR W LQQRI E SGERA QF NS EEK KRF L S R LTAAEG FE R FL GA K FPGA KRF S LEG LDA L V 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 281 P A LK T II DK S SEK G VENI V M GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHRRIN r VTDRNI 359
Cdd:TIGR00239 228 P M LK E II RH S VNS G TRDV V L GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSSDFT - TDGKLV 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 360 T L S L MA NPSHLE A V D PVV Q G K T K A EQFYCG D - T E GH KV MS IL M HGDAAFAGQGVV Y ET FHL S D L PS YS TH GT V H VVV NNQ 438
Cdd:TIGR00239 307 H L A L AF NPSHLE I V S PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQGVV Q ET LNM S K L RG YS VG GT I H III NNQ 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 439 IGFTT D P RM ARS S PY PT D V A RVVN APIFHVNADDPEAV VYVCNV A A E W R A TF HK DV VV DLV C YRR L GHNE M DEP MF TQPL 518
Cdd:TIGR00239 387 IGFTT N P LD ARS T PY CS D L A KMIQ APIFHVNADDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE A DEP SA TQPL 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 519 MY KQ IKK QKGVMQK Y GE KL IA EG AVSRQEYE E EIAK Y DKIC E E A hvrsk D EKILHIKHWLDSPWPGFFN L D g QPKSLTC P 598
Cdd:TIGR00239 467 MY QK IKK HPTPRKV Y AD KL VS EG VATEEDVT E MVNL Y RDAL E A A ----- D CVVPSWREMNTASFTWSPE L N - HEWDEEY P 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 599 TT g LTEEE L IHIGQVA S S VP v E DFTI H GGLSR I LKA R GEMIK -- NRTV DW ALG E YM AF GS L LKE GI H VRLSG Q D V ERGTF 676
Cdd:TIGR00239 541 NK - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GGA E NL AF AT L VDD GI P VRLSG E D S ERGTF 618
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 677 SH RH H VLHDQ N v DKRVCI P MN H VAPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T AQ CI IDQFI C 756
Cdd:TIGR00239 619 FQ RH A VLHDQ S - NGSTYT P LQ H LHNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G AQ VV IDQFI S 697
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 757 P G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdmlpsitddfairqlhdc N WI V VNCSN P GNF FH V LRR 836
Cdd:TIGR00239 698 S G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ ------------------- N MQ V CVPTT P AQV FH I LRR 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 837 Q I L APF R K PL I V FT PKSLLRHP D A R S NFD E MLP GT e FQ RL I P -- DSGPVTQN P A GVKR I V F C T GKVYY E L TKE R KAH G ME 914
Cdd:TIGR00239 759 Q A L RGM R R PL V V MS PKSLLRHP L A V S SLE E LAE GT - FQ PV I G ei EESGLSLD P E GVKR L V L C S GKVYY D L HEQ R RKN G QK 837
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 915 D m VAI A R M EQL S PFP FDL VK AESKK YPN - ADL VWCQEE HK N Q G YYD Y VK P RM R TT I ERAKP V W YAGRP PA A A PA T G NKKA 993
Cdd:TIGR00239 838 D - VAI V R I EQL Y PFP HKA VK EVLQQ YPN l KEI VWCQEE PL N M G AWY Y SQ P HL R EV I PEGVS V R YAGRP AS A S PA V G YMSL 916
970
....*....|...
gi 1955726232 994 H LVELKNF L DT A F 1006
Cdd:TIGR00239 917 H QKQQQDL L ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
257-520
3.61e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 520.93
E-value: 3.61e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 257 FE E FL QR K WSSE KRFGLEG C ESLIPAL KTI ID KSS E K GVE NI V M GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 334
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A ESLIPAL DEL ID RAA E L GVE EV V I GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 335 EGSGDVKYHLG MYHR R INRV t DRNIT LSL MA NPSHLEAV D PVV Q GKT K A E Q F Y C GD T E GH KV MS IL M HGDAAFAGQGVVY 414
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEAV N PVV M GKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQGVVY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 415 ET FH LS D LP S Y S T H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN A DDPEAVV YVCNV A A E W R AT F H KDV 494
Cdd:cd02016 160 ET LN LS N LP G Y T T G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAVV RATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 1955726232 495 V V DLVCYRR L GHNE M DEP M FTQPLMY 520
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
249-575
2.71e-96
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 306.56
E-value: 2.71e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 249 A RM VRST R F E EFLQRKWSSEKRF G LEGCESLIP A LKTI I DKSS E K G v EN I VM G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 328
Cdd:pfam00676 1 R RM MTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I IP G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 329 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L S lmanpshle A VD P VVQ G KTK A EQF ycgdt E G H K VMS I LMH GD A A f A 408
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L G --------- A QV P LGA G IAL A AKY ----- R G K K EVA I TLY GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 409 G QG VVY E TFHLSD L PSYST hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NAD DP E AV VYVCNV AAE WRA 488
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQASKF AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 489 T FHKDVVVD LV C YR RL GH NEM D E P MFTQ - PLM Y KQIK K Q K GVM Q KYG E K L IAE G AV S RQ E YEEEIAKYD K IC EEA HVRSK 567
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEVR K K K DPI Q RFK E H L VSK G VW S EE E LKAIEKEVR K EV EEA FKKAE 292
....*...
gi 1955726232 568 DEKIL H IK 575
Cdd:pfam00676 293 SAPEP H PE 300
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
861-1006
7.87e-70
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 228.87
E-value: 7.87e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 861 RS NFD E ML PGT E FQR L IPD SG P V t QN P AG VKR I V F C T GKVYY E L T KER KAH G MEDM VAI A R M EQL S PFPFDL V K A E SK KY 940
Cdd:pfam16870 1 RS SLE E FT PGT H FQR V IPD PE P L - VD P EK VKR V V L C S GKVYY D L L KER EER G GIKD VAI V R I EQL Y PFPFDL L K E E LD KY 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1955726232 941 PNA - DL VWCQEE H KNQG YYDY V K PR MR T TI - E RAKPVW YAGRPP A A A PATG N K KA HL V E LKNF LD T AF 1006
Cdd:pfam16870 80 PNA a EI VWCQEE P KNQG AWSF V Q PR LE T VL n E TGHRLR YAGRPP S A S PATG S K SV HL A E QEAL LD D AF 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
642-856
3.46e-52
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 180.44
E-value: 3.46e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 642 RTVDWALGEYM A FGS L L K EGIH V RLS G Q D VER GTF SHRHHV LH D qnvdkrvcipmnhvapn Q APYT V CNSSLS E YGVL GF 721
Cdd:pfam02779 1 KKIATRKASGE A LAE L A K RDPR V VGG G A D LAG GTF TVTKGL LH P ----------------- Q GAGR V IDTGIA E QAMV GF 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 722 EL G F A MAS P N a L VLW EA Q F G DF H N taqc II D QF I CP G Q A KWVRQNG - I V LLL P H G MEGM GP E H S S ARPER FL QMCN ddpd 800
Cdd:pfam02779 64 AN G M A LHG P L - L PPV EA T F S DF L N ---- RA D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP ---- 134
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1955726232 801 mlpsitddfairqlhdc NWI VV NC S NPGNFFHV LR RQ I LAPF RKP LIVFT P KS LLR 856
Cdd:pfam02779 135 ----------------- GLK VV RP S DAAETKGL LR AA I RRDG RKP VVLRL P RQ LLR 173
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
710-856
9.93e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.16
E-value: 9.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 710 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 788
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1955726232 789 E - RFLQM cnddpdmlpsitddfairqlhd CNWI VV NC S N P GNFFHV LR RQ I LAP f RKPL I VFTP KSL L R 856
Cdd:smart00861 91 E a LLRAI ---------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
45-85
7.76e-17
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 74.87
E-value: 7.76e-17
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1955726232 45 EP FL N G TSSN Y V EE M Y YSW L E DP K SV HK SW DIF F R N ANA G A 85
Cdd:pfam16078 1 DS FL S G ANAA Y I EE L Y EQY L K DP S SV DP SW RAY F D N LDD G E 41
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
393-562
7.75e-09
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 58.28
E-value: 7.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 393 G HKVMSILMH GD A A f AGQ G VVY E TFHLS --- D LP systhg TVH V VV NN QIGFT T d P R m A R SSPYPTDVA R VVNA -- P IFH 467
Cdd:cd02000 124 G EDRVAVCFF GD G A - TNE G DFH E ALNFA alw K LP ------ VIF V CE NN GYAIS T - P T - S R QTAGTSIAD R AAAY gi P GIR 194
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955726232 468 V NAD D PE AV VYVCNV A A E W - RA T f HKDVVVDL V C YR RL GH NEM D E P M ftqpl M Y K ----- QIK K QKGVMQKYGEK LI AE G 541
Cdd:cd02000 195 V DGN D VL AV YEAAKE A V E R a RA G - GGPTLIEA V T YR LG GH STS D D P S ----- R Y R tkeev EEW K KRDPILRLRKY LI EA G 268
170 180
....*....|....*....|.
gi 1955726232 542 AVSRQ E YEEEI A KYDKIC EEA 562
Cdd:cd02000 269 ILTEE E LAAIE A EVKAEV EEA 289
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
55-103
4.04e-04
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 44.50
E-value: 4.04e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1955726232 55 Y VEEMY YSW L E DP K SV HK SW DI FF RNANA G A T PGKAHQSPLSL A GQPQA 103
Cdd:PRK12270 10 L VEEMY QQY L A DP N SV DP SW RE FF ADYGP G S T AAPTAAAAAAA A AASAP 58
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
