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Conserved domains on  [gi|1953304897|ref|XP_038547286|]
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probable cytosolic iron-sulfur protein assembly protein CIAO1 [Canis lupus familiaris]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 1.11e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.11e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  17 SRCWFLAWNPTGTLLASCGGDRRVRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpdneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200   162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953304897 257 DVAWCQlTGALATACGDD-AIRVFeedpSSDPQQPTFSLtahlpQAHSQDVNCVAWNPKEQgLLASCSDDGEVAFWK 332
Cdd:cd00200   224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 1.11e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.11e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  17 SRCWFLAWNPTGTLLASCGGDRRVRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpdneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200   162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953304897 257 DVAWCQlTGALATACGDD-AIRVFeedpSSDPQQPTFSLtahlpQAHSQDVNCVAWNPKEQgLLASCSDDGEVAFWK 332
Cdd:cd00200   224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
7-331 1.65e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 1.65e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897   7 LLGRVPAHPDSRCWFLAWNPTGTLLASCGGDRRVRIWGTEgdSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTC 86
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  87 IWkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLA 166
Cdd:COG2319   188 LW--DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 167 SASYDDTVKLYREEEDDWVccATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWrqylpDNEQGvacsgsdpswKCICT 246
Cdd:COG2319   263 SGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW-----DLATG----------KLLRT 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 247 LSGfHSRTIYDVAWCQLTGALATACGDDAIRVFeeDPSSDPQQPTFsltahlpQAHSQDVNCVAWNPKEQgLLASCSDDG 326
Cdd:COG2319   326 LTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTL-------TGHTGAVTSVAFSPDGR-TLASGSADG 394


                  ....*
gi 1953304897 327 EVAFW 331
Cdd:COG2319   395 TVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 3.84e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 3.84e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1953304897  183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.26e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1953304897 184 WVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 22-123 1.04e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  22 LAWNPT-GTLLASCGGDRRVRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420   80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1953304897  93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420  160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 1.11e-72

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.11e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  17 SRCWFLAWNPTGTLLASCGGDRRVRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpdneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200   162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953304897 257 DVAWCQlTGALATACGDD-AIRVFeedpSSDPQQPTFSLtahlpQAHSQDVNCVAWNPKEQgLLASCSDDGEVAFWK 332
Cdd:cd00200   224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
7-331 1.65e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 1.65e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897   7 LLGRVPAHPDSRCWFLAWNPTGTLLASCGGDRRVRIWGTEgdSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTC 86
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  87 IWkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLA 166
Cdd:COG2319   188 LW--DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 167 SASYDDTVKLYREEEDDWVccATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWrqylpDNEQGvacsgsdpswKCICT 246
Cdd:COG2319   263 SGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW-----DLATG----------KLLRT 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 247 LSGfHSRTIYDVAWCQLTGALATACGDDAIRVFeeDPSSDPQQPTFsltahlpQAHSQDVNCVAWNPKEQgLLASCSDDG 326
Cdd:COG2319   326 LTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTL-------TGHTGAVTSVAFSPDGR-TLASGSADG 394


                  ....*
gi 1953304897 327 EVAFW 331
Cdd:COG2319   395 TVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
7-222 7.95e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.35  E-value: 7.95e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897   7 LLGRVPAHPDsRCWFLAWNPTGTLLASCGGDRRVRIWGTEGDSWICksvLSEGHQRTVRKVAWSPCGNYLASASFDATTC 86
Cdd:COG2319   196 LLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  87 IWkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLA 166
Cdd:COG2319   272 LW--DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGKTLA 346

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953304897 167 SASYDDTVKLYreEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWR 222
Cdd:COG2319   347 SGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
23-331 7.88e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.76  E-value: 7.88e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  23 AWNPTGTLLASCGGDRRVRIWGTEGDSWIcksVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTLE 102
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALL---LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL--DAAAGALLATLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 103 GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYreEED 182
Cdd:COG2319    76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--DLA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWrqylpdneqgvacsgSDPSWKCICTLSGfHSRTIYDVAWC- 261
Cdd:COG2319   151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---------------DLATGKLLRTLTG-HTGAVRSVAFSp 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953304897 262 --QLtgaLATACGDDAIRVFeeDPSSDPQQPTFsltahlpQAHSQDVNCVAWNPKEQgLLASCSDDGEVAFW 331
Cdd:COG2319   215 dgKL---LASGSADGTVRLW--DLATGKLLRTL-------TGHSGSVRSVAFSPDGR-LLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
8-135 1.12e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 1.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897   8 LGRVPAHPDSRCWFLAWNPTGTLLASCGGDRRVRIWgtEGDSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTCI 87
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1953304897  88 WkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD 135
Cdd:COG2319   357 W--DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 3.84e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 3.84e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1953304897  183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.26e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1953304897 184 WVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 2.47e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1953304897   94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 2.73e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.73e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1953304897  95 FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-177 4.17e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1953304897  141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 22-123 1.04e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  22 LAWNPT-GTLLASCGGDRRVRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420   80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1953304897  93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420  160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
PTZ00420 PTZ00420
coronin; Provisional
 98-182 1.40e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.87  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  98 VTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDEEDEY-------ECvsVLNSHTQDVKHVVWHP-SQELLASA 168
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESvkeikdpQC--ILKGHKKKISIIDWNPmNYYIMCSS 144

                          90
                  ....*....|....
gi 1953304897 169 SYDDTVKLYREEED 182
Cdd:PTZ00420  145 GFDSFVNIWDIENE 158
PTZ00420 PTZ00420
coronin; Provisional
 190-260 2.52e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 2.52e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953304897 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRqyLPDNEQGVAcSGSDPswkcICTLSGfHSRTIYDVAW 260
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWE--IPHNDESVK-EIKDP----QCILKG-HKKKISIIDW 133
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-89 3.65e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.65e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1953304897   49 SWICKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
141-177 3.89e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1953304897 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-337 1.50e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPDneqgvacsgsdpswkCICTLSGfHSRTIYDVAWCqltg 265
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---------------LLRTLKG-HTGPVRDVAAS---- 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953304897 266 alatacgddairvfeedpssdpqqptfsltahlpqAHSQdvncvawnpkeqgLLASCSDDGEVAFWKYQRPE 337
Cdd:cd00200    61 -----------------------------------ADGT-------------YLASGSSDKTIRLWDLETGE 84
PTZ00421 PTZ00421
coronin; Provisional
 103-242 1.74e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897 103 GHENEVKSVAWAPSGNL-LATCSRDKSVWVWEVDEEDEYECVSV----LNSHTQDVKHVVWHPS-QELLASASYDDTVKL 176
Cdd:PTZ00421   73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNISDpivhLQGHTKKVGIVSFHPSaMNVLASAGADMVVNV 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953304897 177 YREEEDdwVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRqylPDNEQGVACSGSDPSWK 242
Cdd:PTZ00421  153 WDVERG--KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID---PRDGTIVSSVEAHASAK 213
WD40 pfam00400
WD domain, G-beta repeat;
58-88 1.75e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1953304897  58 EGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 23-135 3.91e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.72  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  23 AWNPTGTLLASCGG--DRRVRIWGTEGDSwICKsvLSEGHQRTVRkvaWSPCGNYLASASF---DATTCIWkkNQDDFEC 97
Cdd:pfam08662  66 AWSPNGKEFAVIYGymPAKVSFFDLKGNV-IHS--FGEQPRNTIF---WSPFGRLVLLAGFgnlAGDIEFW--DVVNKKK 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1953304897  98 VTTLEgHENEVkSVAWAPSGNLLATCSR------DKSVWVWEVD 135
Cdd:pfam08662 138 IATAE-ASNAT-LCEWSPDGRYFLTATTaprlrvDNGFKIWHYN 179
PTZ00421 PTZ00421
coronin; Provisional
 43-165 4.02e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.19  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953304897  43 WG--TEGDSWICKSVLSE--GHQRTVRKVAWSPCG-NYLASASFDATTCIWKKNQDdfECVTTLEGHENEVKSVAWAPSG 117
Cdd:PTZ00421  103 WGipEEGLTQNISDPIVHlqGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERG--KAVEVIKCHSDQITSLEWNLDG 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1953304897 118 NLLATCSRDKSVWVweVDEEDEYECVSVLNSHTQDVKHVVWHPSQELL 165
Cdd:PTZ00421  181 SLLCTTSKDKKLNI--IDPRDGTIVSSVEAHASAKSQRCLWAKRKDLI 226
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 300-332 4.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.26e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1953304897  300 QAHSQDVNCVAWNPKEQgLLASCSDDGEVAFWK 332
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 4-43 1.43e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.43e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1953304897    4 SLVLLGRVPAHpDSRCWFLAWNPTGTLLASCGGDRRVRIW 43
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
300-331 4.38e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.38e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1953304897 300 QAHSQDVNCVAWNPKEQgLLASCSDDGEVAFW 331
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
7-43 4.64e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1953304897   7 LLGRVPAHpDSRCWFLAWNPTGTLLASCGGDRRVRIW 43
Cdd:pfam00400   3 LLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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