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Conserved domains on  [gi|1953289927|ref|XP_038541183|]
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nicotinate phosphoribosyltransferase isoform X1 [Canis lupus familiaris]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 15-525 0e+00

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PLN02885:

Pssm-ID: 473867 [Multi-domain]  Cd Length: 545  Bit Score: 615.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSGTEVPPDPMLAPAASPGPKVDLTARVEAWLD--G 252
Cdd:PLN02885  172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 253 VCAHLGLGVQEPHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIR 332
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 333 GVFRTVSARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDP 412
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 413 EKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelRVW---PHGAREACTVRPAGVEPLLRL-WVQQGQLC-EPL 487
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCyWDGSSGKPrEEL 489

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1953289927 488 PSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 525
Cdd:PLN02885  490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-525 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 615.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSGTEVPPDPMLAPAASPGPKVDLTARVEAWLD--G 252
Cdd:PLN02885  172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 253 VCAHLGLGVQEPHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIR 332
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 333 GVFRTVSARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDP 412
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 413 EKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelRVW---PHGAREACTVRPAGVEPLLRL-WVQQGQLC-EPL 487
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCyWDGSSGKPrEEL 489

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1953289927 488 PSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 525
Cdd:PLN02885  490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-525 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 566.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSgtevppdpmlapaaspgpkvdltarveawldgvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFD---------------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 255 ahlglgvqephrGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYrAVGIRLDSGDLLQQAQEIRGV 334
Cdd:TIGR01513 203 ------------NELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 335 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEK 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 415 QTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelrvwphgarEACTVRPAGVEPLLRLWVQQGQLCEPLPSLAESR 494
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDLNQ----------EKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1953289927 495 AFAQLSLSRLSPEHKRLEWPALYQVALSDKL 525
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-398 1.89e-160

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 459.35  E-value: 1.89e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570     1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDcSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570    79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSgtevppdpmlapaaspgpkvdltarveawldgvc 254
Cdd:cd01570   157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFD---------------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 255 ahlglgvqephrGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIRGV 334
Cdd:cd01570   203 ------------DELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953289927 335 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLV 398
Cdd:cd01570   271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-532 3.60e-133

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 394.13  E-value: 3.60e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  16 LLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488     6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  96 LRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488    84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 176 PDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSfsgtevppdpmlapaaspgpkvdltarveawldgvca 255
Cdd:COG1488   162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 256 hlglgvqepHRGERAAFVAYALAFPQAFQGLLDTYSVQrSGLPNflAVALAlGELG--YRAVGIRLDSGDLLQQAQEIRg 333
Cdd:COG1488   205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQAR- 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 334 vfrtvsarfQMPW---LESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGG----QPRM 406
Cdd:COG1488   271 ---------ELLDeagLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVI 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 407 KLTEDPEKQTLPGSKAAFRlLGPEGSLLLDVLQLAEEPPPQAGqelrvwphgareactvrpagvEPLLRLWVQQGQLCEP 486
Cdd:COG1488   342 KLSETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYE 399

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1953289927 487 LPSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKLRALVDRL 532
Cdd:COG1488   400 LPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.12e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 156.52  E-value: 1.12e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  16 LLTDLYQATMALGYWRAGRaREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1953289927  96 LRALDCSDVTVrALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-525 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 615.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSGTEVPPDPMLAPAASPGPKVDLTARVEAWLD--G 252
Cdd:PLN02885  172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 253 VCAHLGLGVQEPHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIR 332
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 333 GVFRTVSARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDP 412
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 413 EKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelRVW---PHGAREACTVRPAGVEPLLRL-WVQQGQLC-EPL 487
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCyWDGSSGKPrEEL 489

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1953289927 488 PSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 525
Cdd:PLN02885  490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-525 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 566.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSgtevppdpmlapaaspgpkvdltarveawldgvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFD---------------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 255 ahlglgvqephrGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYrAVGIRLDSGDLLQQAQEIRGV 334
Cdd:TIGR01513 203 ------------NELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 335 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEK 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 415 QTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelrvwphgarEACTVRPAGVEPLLRLWVQQGQLCEPLPSLAESR 494
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDLNQ----------EKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1953289927 495 AFAQLSLSRLSPEHKRLEWPALYQVALSDKL 525
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-398 1.89e-160

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 459.35  E-value: 1.89e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570     1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDcSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570    79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSgtevppdpmlapaaspgpkvdltarveawldgvc 254
Cdd:cd01570   157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFD---------------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 255 ahlglgvqephrGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIRGV 334
Cdd:cd01570   203 ------------DELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953289927 335 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLV 398
Cdd:cd01570   271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
 15-525 1.11e-145

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 426.88  E-value: 1.11e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASvlPPDTDPAFFE 94
Cdd:PRK09243   10 ALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRS--LGIFDEDFLD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRRAQ 174
Cdd:PRK09243   88 YLRNFRFT-GDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAG-GRPLLEFGSRRAQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSfsgtevppdpmlapaaspgpkvdltarveawldgvc 254
Cdd:PRK09243  166 GPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQA------------------------------------ 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 255 ahlglgvqepHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGElGYRAVGIRLDSGDLLQQAQEIRgv 334
Cdd:PRK09243  210 ----------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKELGD-GIELGGVRIDSGDLAYLSKKVR-- 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 335 frtvsARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGG----QPRMKLTE 410
Cdd:PRK09243  277 -----KMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGVYKLVAIEGeggmIPKIKLSN 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 411 DPEKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPpqaGQELRVW-PHGAREACTVRPAGVEPLLRLWVQQGQLCEPLPS 489
Cdd:PRK09243  352 SPEKVTTPGRKQVYRIYDKGGKAEADVITLADEEE---EEPLKMFhPVHTYKSKTVKNFDAEPLLVPVMENGKRVYELPS 428

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1953289927 490 LAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 525
Cdd:PRK09243  429 LEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-532 3.60e-133

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 394.13  E-value: 3.60e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  16 LLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488     6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  96 LRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488    84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 176 PDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSfsgtevppdpmlapaaspgpkvdltarveawldgvca 255
Cdd:COG1488   162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 256 hlglgvqepHRGERAAFVAYALAFPQAFQGLLDTYSVQrSGLPNflAVALAlGELG--YRAVGIRLDSGDLLQQAQEIRg 333
Cdd:COG1488   205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQAR- 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 334 vfrtvsarfQMPW---LESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGG----QPRM 406
Cdd:COG1488   271 ---------ELLDeagLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVI 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 407 KLTEDPEKQTLPGSKAAFRlLGPEGSLLLDVLQLAEEPPPQAGqelrvwphgareactvrpagvEPLLRLWVQQGQLCEP 486
Cdd:COG1488   342 KLSETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYE 399

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1953289927 487 LPSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKLRALVDRL 532
Cdd:COG1488   400 LPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
 16-534 9.13e-102

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 313.61  E-value: 9.13e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  16 LLTDLYQATMALGYWRAGRAReQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLP-PDTDPAFFE 94
Cdd:PRK12484    6 LLTDLYEVTMANAYLREGMSA-PATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQfSEEFLAWLA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRaLDCSdvtVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLiAGPEKRLLEMGLRRAQ 174
Cdd:PRK12484   85 GLR-FTGD---VRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVL-AAAGRPVVDFGARRAH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 175 GPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFsgtevpPDpmlapaaspgpkvdltarveawldgvc 254
Cdd:PRK12484  160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF------PD--------------------------- 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 255 ahlglgvqephrgERAAFVAYALAFPQAFQGLLDTYSVQRsGLPNFLAVALALGElGYRAVGIRLDSGDLLQQAQEIRGV 334
Cdd:PRK12484  207 -------------EVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAI 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 335 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTedPEK 414
Cdd:PRK12484  272 LDAAG-------LEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVLDSAYKLVAYEGRGVTKLS--SGK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 415 QTLPGSKAAFRLLGPEGSlLLDVLQLAEEPPpqagqelrvwphgareactvrPAGVEPLLRLWVQQGQLCEPLPSLAESR 494
Cdd:PRK12484  343 VTYPGRKQVFRLYEHGTA-CGDVIGLHTENI---------------------PDGREPLLVPVMTNGRRIQHAPTLDGAR 400

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1953289927 495 AFAQLSLSRLSPEHKRLEWPALYQVALSDKLRALVDRLGA 534
Cdd:PRK12484  401 DWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTA 440
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
 15-396 2.75e-97

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 298.80  E-value: 2.75e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  15 PLLTDLYQATMALGYWrAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPpdtDPAFFE 94
Cdd:cd01567     1 LLDTDLYKLTMMQAYL-YPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLI---FGEFFL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAG-----------PEK 163
Cdd:cd01567    77 YLLFLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGglletkdnleeLGF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 164 RLLEMGLRRAQGPDGGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSGTEVppdpmlapaaspgpkvdlt 243
Cdd:cd01567   157 KLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALEE------------------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 244 arveawldgvcahlglgvqephrgerAAFVAYALAFPQAFQGLL----DTYSVQRsGLPNFLAVALALGElGYRAVGIRL 319
Cdd:cd01567   218 --------------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRL 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953289927 320 DSGDLLQQAQEIRGVFRTVSArfqmpWLESISIAVSNNID-EKELARL-AQEGSEVNVIGIGTNVVTCPRQPSLGCVYK 396
Cdd:cd01567   270 DSGDPVELIKKVRKHLDELGI-----DLNKKKIIISGDLDtEEAIELLlEQGASPNDAFGVGTSLTNDLGRPPLGFVYK 343
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
 19-396 5.35e-54

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 183.98  E-value: 5.35e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  19 DLYQATMALGYwraGRAREQAEFELFFRGCPFGgafaLAAGLRDCVRFLRAFRLRDadvqflasvlppdtdpaffehlra 98
Cdd:cd00516     1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRFPG------------------------ 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  99 ldcsDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIA-GPEKRLLEMGLRRAQgPD 177
Cdd:cd00516    50 ----PLVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkGANTKVHDFGTRKTT-PG 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 178 GGLTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFsgtevppdpmlapaaspgpkvdltarveawldgvcahl 257
Cdd:cd00516   125 LRLLEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 258 glgvqephrGERAAFVAYALAFPQAFQGLLDTYSvqrSGLPNFLAVALALgelgyRAVGIRLDSGDL--LQQAQEIRGVF 335
Cdd:cd00516   167 ---------GELAAVKALRRWLPELFIALIDVEV---DTLEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKAR 229

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953289927 336 rtvsARFQMPWLESISIAVSNNIDEKELARLAQEGseVNVIGIGTNVVTCprqPSLGCVYK 396
Cdd:cd00516   230 ----AHLDGKGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---PPLDIVLK 281
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.12e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 156.52  E-value: 1.12e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  16 LLTDLYQATMALGYWRAGRaREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1953289927  96 LRALDCSDVTVrALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 421-528 1.02e-30

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 115.36  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 421 KAAFRLLGPEGSLLLDVLQLAEEPPPQAGQELRVW-PHGAREACTVRPAGVEPLLRLWVQQGQLCEPLPSLAESRAFAQL 499
Cdd:pfam17956   2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFhPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81

                          90       100
                  ....*....|....*....|....*....
gi 1953289927 500 SLSRLSPEHKRLEWPALYQVALSDKLRAL 528
Cdd:pfam17956  82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
NAPRTase_B cd01571
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ...
 94-407 2.27e-26

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238805 [Multi-domain]  Cd Length: 302  Bit Score: 108.90  E-value: 2.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  94 EHLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRR- 172
Cdd:cd01571    43 EVLALLEGLPVKVYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAG-DKPVISFGDRRd 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 173 --AQGPDGGLTAstysYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSGtevppdpmlapaaspgpkvdltARVEAWl 250
Cdd:cd01571   122 hpAIQPMDGRAA----YIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGG----------------------DQVEAW- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 251 dgvcahlglgvqephrgeraafVAYALAFPQAFQ--GLLDTYSVQRsglpnfLAVALALGELGYRAVGIRLDSgdllqqA 328
Cdd:cd01571   175 ----------------------KAFDETYPEDVPriALIDTFNDEK------EEALKAAKALGDKLDGVRLDT------P 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 329 QEIRGVFRTVSARFQmpW------LESISIAVSNNIDEKELARLAQEGseVNVIGIGTNVVTCprqPSLGCVYKLVSVGG 402
Cdd:cd01571   221 SSRRGVFRYLIREVR--WaldirgYKHVKIFVSGGLDEEDIKELEDVG--VDAFGVGTAISKA---PPVDFTMDIVEVNG 293


                  ....*
gi 1953289927 403 QPRMK 407
Cdd:cd01571   294 QPIAK 298
PRK08662 PRK08662
nicotinate phosphoribosyltransferase; Reviewed
 103-380 1.92e-21

nicotinate phosphoribosyltransferase; Reviewed


Pssm-ID: 236328 [Multi-domain]  Cd Length: 343  Bit Score: 95.71  E-value: 1.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 103 DVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRR---AQGPdgg 179
Cdd:PRK08662   69 PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAG-DKPVLSFGARHvhpAIAP--- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 180 lTASTYSYLGGFDGSSNVLAGQLRGVPLAGTLAHSFVTSFSGTevppdpmlapaaspgpkvdltarVEAWLdgvcahlgl 259
Cdd:PRK08662  145 -MMDRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIFGDQ-----------------------VEAWK--------- 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 260 gvqephrgeraafvAYALAFPQAFQ--GLLDTYSVQRSglpNFLAVALALGElgyRAVGIRLDSgdllqqAQEIRGVFRT 337
Cdd:PRK08662  192 --------------AFDEVVPPDVPriALVDTFKDERE---EALRAAEALGD---RLDGVRLDT------PSSRRGNFRK 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1953289927 338 ----VSARFQMPWLESISIAVSNNIDEKELARLAQegsEVNVIGIGT 380
Cdd:PRK08662  246 ivreVRWTLDIRGYEHVKIFVSGGLDPERIRELRD---VVDGFGVGT 289
PncB_like cd01401
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ...
 14-416 3.50e-11

Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.


Pssm-ID: 238695 [Multi-domain]  Cd Length: 377  Bit Score: 64.96  E-value: 3.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  14 RPLL-TDLYQATMALGYWRAgRAREQAEFELFFRGCPFGGAFALAAgLRDCVRFLRAFRLRDADVQFLASVLPPDTdPAF 92
Cdd:cd01401     1 RSLLdTDLYKLTMQQAVLHH-YPDVQVTYEFTNRSPEDFLEEAAEA-LREQIDHLANLRFSEEELAYLRRSLPFLK-PDY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  93 FEHLRA--LDCSDVTVRA-LPEGSLAfpnvplLQVSGPLLVVQLLETPLLCLVS--YASLIATNA--------------- 152
Cdd:cd01401    78 LDYLELfrLNPEEVVVRLdTGKGQLD------IRISGPWKDTILYEVPLLAIVSevYFRFRDADWdyeeqlekleekler 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 153 --ARLRLIAGPEKRLLEMGLRRAQGPD------GGLTASTYSYLGgfdGSSNVLAGQLRGVPLAGTLAHSFVTSFSGtev 224
Cdd:cd01401   152 llEEAKRRDLNGFRFSDFGTRRRFSYEvqetvlKGLKQAAPGYLT---GTSNVHFAMKYGLTPIGTVAHEWFMAHQA--- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 225 ppdpmLAPAASPGPKVDLtarvEAWLDGVCAHLGLgvqephrgeraafvayalafpqafqGLLDTYsvqrsGLPNFLAVA 304
Cdd:cd01401   226 -----LTGDLKDSQKAAL----ERWVREYGGDLGI-------------------------ALTDTF-----GTDAFLRDF 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 305 LAlgELGYRAVGIRLDSGDllqqaqEIRGVFRTVSarfqmpWLESISIA-------VSNNID-EK--ELARLAQEGseVN 374
Cdd:cd01401   267 DL--YFAKLFDGVRHDSGD------PFEWGEKAIA------HYEKLGIDpktktlvFSDGLDvEKalELYEYFKGR--IK 330

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1953289927 375 VI-GIGTN----VVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEKQT 416
Cdd:cd01401   331 VSfGIGTNltndFGNKEKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
 14-416 6.79e-11

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 64.01  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  14 RPLL-TDLYQATMALGYWRAGRaREQAEFELFFRGcpfGGAFA--LAAGLRDCVRFLRAFRLRDADVQFLAS--VLPPDt 88
Cdd:PRK05321   10 RSLLdTDFYKLTMQQAVLHHYP-DAQVEYEFICRN---DEVDLaeYIDEIREQLDHLCTLRLTDDELDYLRGlpFFKPD- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  89 dpaFFEHLRA--LDCSDVTVRAlPEGSLAfpnvplLQVSGPLLVVQLLETPLLCLVS-----YASLIATNA---ARL--- 155
Cdd:PRK05321   85 ---FLDWLRLfrLNPYEVTVSI-DDGQLD------IRIEGPWLETILWEVPLLAIISelyfrARSPEVLYAqakRRLwek 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 156 --RLIAGPEK---RLLEMGLRRaqgpdggltasTYSYL--------------GGFDGSSNVLAGQLRGVPLAGTLAHSFv 216
Cdd:PRK05321  155 ieLLKALPDLsgfKIADFGTRR-----------RFSFEwqeevvealkeglpGAFVGTSNVHLAMKLGLTPIGTMAHEW- 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 217 tsfsgtevppdPMLAPAASPGPKVDLTARVEAWLDGVCAHLGlgvqephrgeraafVAyalafpqafqgLLDTYsvqrsG 296
Cdd:PRK05321  223 -----------FMAHQALGPRLRDSQYAALEDWVREYRGDLG--------------IA-----------LTDTI-----G 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 297 LPNFLA-VALALGELgYraVGIRLDSGDLLQQAQEIrgvfrtvsarfqMPWLESISI------AV-SNNID-EKELARLA 367
Cdd:PRK05321  262 MDAFLRdFDLYFAKL-F--DGLRHDSGDPIEWGEKA------------IAHYEKLGIdprtktLVfSDGLDfDKALELYR 326

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1953289927 368 QEGSEVNVI-GIGTNvVTC--PRQPSLGCVYKLVSVGGQPRMKLTEDPEKQT 416
Cdd:PRK05321  327 HFKGRIKLSfGIGTN-LTNdfPGVKPLNIVIKLVECNGRPVAKLSDSPGKTM 377
PRK09198 PRK09198
putative nicotinate phosphoribosyltransferase; Provisional
 104-222 7.60e-04

putative nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 236407 [Multi-domain]  Cd Length: 463  Bit Score: 42.19  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927 104 VTVRALPEGSLAFPNVPLLQVSG--PLL--VVQLLETPLLCLVSYASLIATNAARLRLIAgpeKRLLEmglrraqgpdgg 179
Cdd:PRK09198   98 LRIKAVPEGSVVPVHNVLMTIENtdPEFfwLPNYLETLLLRNVWYPSTVATISWEYKQLI---RQYLE------------ 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1953289927 180 LTASTYSYLG------GFDGSSNVLAGQLrgvplaGTLAHsfVTSFSGT 222
Cdd:PRK09198  163 KTADDLDFLPfqlhdfGARGMSSLESAAL------GGAAH--LVSFLGT 203
nadV PHA02594
nicotinamide phosphoribosyl transferase; Provisional
 42-150 7.61e-03

nicotinamide phosphoribosyl transferase; Provisional


Pssm-ID: 222898 [Multi-domain]  Cd Length: 470  Bit Score: 38.86  E-value: 7.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953289927  42 ELFFRGCPFGGAF---ALAAGLRDCVRFLRAFRLRDADVQF----LASVLPPDTDPAffEHLRA---LDCSDVTVRALPE 111
Cdd:PHA02594   31 YVMFYLEPRGGKFfdkVVVFGIQYFVKKYFFEPITMEVVEEahelVKAHLGKDVFNR--EHWEAlhdLGYLPIEVRAVPE 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1953289927 112 GSLAFPNVPLLQV----SGPLLVVQLLETPLLCLVSYASLIAT 150
Cdd:PHA02594  109 GTVVPVKVPVLTIenthPDFFWLAGYLETVILRGVWYPSTVAT 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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