PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1953273919 604 SCQGGLPKEACMDISSPGCQPPAQRLCQPVPPSPACQLVLHQVLKgGSGTYC 655
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953273919 367 RALVVTHTYLESGPITAQVVLQAAIPLTSCGSS------PVPVTTDG-----HAPT-AEIPGTTAGRVPTAEVISTTPGq 434
Cdd:pfam05109 401 KTLIITRTATNATTTTHKVIFSKAPESTTTSPTlnttgfAAPNTTTGlpsstHVPTnLTAPASTGPTVSTADVTSPTPA- 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953273919 435 vptAEPSGATAVQMTTTEVTGTTLAQMPTTegigTTPEQVPTSEVISTTLAETTGTTPEGSTAEPsgTTGEQVTTKESVE 514
Cdd:pfam05109 480 ---GTTSGASPVTPSPSPRDNGTESKAPDM----TSPTSAVTTPTPNATSPTPAVTTPTPNATSP--TLGKTSPTSAVTT 550

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1953273919 515 PTA-GEGPTPETKGPDTNLFVPTEGITGSQSALLDGT 550
Cdd:pfam05109 551 PTPnATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1953273919 604 SCQGGLPKEACMDISSPGCQPPAQRLCQPVPPSPACQLVLHQVLKgGSGTYC 655
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953273919 328 LRNHPLTFALRLHDPSGylsGADLSYTWDFGDHTGTLiSRALVVTHTYLESGPITAQVVLQAAIPLTSCGSSPVPV 403
Cdd:cd00146    10 VAELGASVTFSASDSSG---GSIVSYKWDFGDGEVSS-SGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953273919 367 RALVVTHTYLESGPITAQVVLQAAIPLTSCGSS------PVPVTTDG-----HAPT-AEIPGTTAGRVPTAEVISTTPGq 434
Cdd:pfam05109 401 KTLIITRTATNATTTTHKVIFSKAPESTTTSPTlnttgfAAPNTTTGlpsstHVPTnLTAPASTGPTVSTADVTSPTPA- 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953273919 435 vptAEPSGATAVQMTTTEVTGTTLAQMPTTegigTTPEQVPTSEVISTTLAETTGTTPEGSTAEPsgTTGEQVTTKESVE 514
Cdd:pfam05109 480 ---GTTSGASPVTPSPSPRDNGTESKAPDM----TSPTSAVTTPTPNATSPTPAVTTPTPNATSP--TLGKTSPTSAVTT 550

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1953273919 515 PTA-GEGPTPETKGPDTNLFVPTEGITGSQSALLDGT 550
Cdd:pfam05109 551 PTPnATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953273919  304 ITDQVPFSVSvSQLQALDGGNKH--FLRNHPLTF-ALRLHDPSGYLsgadlsYTWDFGDHTGTLISRALVVTHTYLESGP 380
Cdd:TIGR00864 1075 ISQQINMSVR-AILPRVAIGTEDglLLAGKPADFeAHPLPSPGGIH------YEWDFGDGSALLQGRQPAAAHTFAKRGP 1147

                   ....*
gi 1953273919  381 ITAQV 385
Cdd:TIGR00864 1148 FHVCL 1152

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1953273919 604 SCQGGLPKEACMDISSPGCQPPAQRLCQPVPPSPACQLVLHQVLKgGSGTYC 655
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953273919 328 LRNHPLTFALRLHDPSGylsGADLSYTWDFGDHTGTLiSRALVVTHTYLESGPITAQVVLQAAIPLTSCGSSPVPV 403
Cdd:cd00146    10 VAELGASVTFSASDSSG---GSIVSYKWDFGDGEVSS-SGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953273919 367 RALVVTHTYLESGPITAQVVLQAAIPLTSCGSS------PVPVTTDG-----HAPT-AEIPGTTAGRVPTAEVISTTPGq 434
Cdd:pfam05109 401 KTLIITRTATNATTTTHKVIFSKAPESTTTSPTlnttgfAAPNTTTGlpsstHVPTnLTAPASTGPTVSTADVTSPTPA- 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953273919 435 vptAEPSGATAVQMTTTEVTGTTLAQMPTTegigTTPEQVPTSEVISTTLAETTGTTPEGSTAEPsgTTGEQVTTKESVE 514
Cdd:pfam05109 480 ---GTTSGASPVTPSPSPRDNGTESKAPDM----TSPTSAVTTPTPNATSPTPAVTTPTPNATSP--TLGKTSPTSAVTT 550

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1953273919 515 PTA-GEGPTPETKGPDTNLFVPTEGITGSQSALLDGT 550
Cdd:pfam05109 551 PTPnATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1953273919 351 LSYTWDFGDhtGTlISRALVVTHTYLESGPITAQVV 386
Cdd:pfam18911  35 LSYRWDFGD--GT-TATGANVSHTYAAPGTYTVTLT 67