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Conserved domains on  [gi|1952677280|ref|XP_038523974|]
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interferon alpha-1/2-like [Canis lupus familiaris]

Protein Classification

alpha/beta interferon family protein( domain architecture ID 10444641)

alpha/beta interferon family protein produces antiviral and antiproliferative response in cell

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 13-113 1.01e-48

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


:

Pssm-ID: 459689  Cd Length: 160  Bit Score: 152.73  E-value: 1.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952677280  13 MTQKVFHLFCPDTSSAPWNMTLLEALCSGLSEQLDDLEACPLQEAGLAETPLMHEDSTL--RTYFQRISLYLQDKNHSPC 90
Cdd:pfam00143  58 MLQQIFNLFSTNHSSAAWNETLLEQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLalKKYFQRIHLYLKEKEYSSC 137

                          90       100
                  ....*....|....*....|...
gi 1952677280  91 AWEMVRAEIGRSFFSSTTLQERI 113
Cdd:pfam00143 138 AWEVVRVEIRRCFSFINRLTERL 160
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 13-113 1.01e-48

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 152.73  E-value: 1.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952677280  13 MTQKVFHLFCPDTSSAPWNMTLLEALCSGLSEQLDDLEACPLQEAGLAETPLMHEDSTL--RTYFQRISLYLQDKNHSPC 90
Cdd:pfam00143  58 MLQQIFNLFSTNHSSAAWNETLLEQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLalKKYFQRIHLYLKEKEYSSC 137

                          90       100
                  ....*....|....*....|...
gi 1952677280  91 AWEMVRAEIGRSFFSSTTLQERI 113
Cdd:pfam00143 138 AWEVVRVEIRRCFSFINRLTERL 160
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 11-106 1.44e-45

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 144.40  E-value: 1.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952677280  11 LVMTQKVFHLFCPDTSSAPWNMTLLEALCSGLSEQLDDLEACPLQEAGLAETP-LMHEDSTLRTYFQRISLYLQDKNHSP 89
Cdd:cd00095    56 HEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQQLNHLETCLEQEMGEEETPgPRNTHLHLRKYFQRIQLYLKEKKYSP 135

                          90
                  ....*....|....*..
gi 1952677280  90 CAWEMVRAEIGRSFFSS 106
Cdd:cd00095   136 CAWEVVRAEIMRNFSSI 152
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 11-103 5.17e-45

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 141.68  E-value: 5.17e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952677280   11 LVMTQKVFHLFCPDTSSAPWNMTLLEALCSGLSEQLDDLEACPLQEAGLAETPLMH-EDSTLRTYFQRISLYLQDKNHSP 89
Cdd:smart00076  24 HEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEETPLTRnTHLALKKYFQRIQLYLKEKKYSP 103

                           90
                   ....*....|....
gi 1952677280   90 CAWEMVRAEIGRSF 103
Cdd:smart00076 104 CAWEVVRVEIRRNF 117
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 13-113 1.01e-48

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 152.73  E-value: 1.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952677280  13 MTQKVFHLFCPDTSSAPWNMTLLEALCSGLSEQLDDLEACPLQEAGLAETPLMHEDSTL--RTYFQRISLYLQDKNHSPC 90
Cdd:pfam00143  58 MLQQIFNLFSTNHSSAAWNETLLEQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLalKKYFQRIHLYLKEKEYSSC 137

                          90       100
                  ....*....|....*....|...
gi 1952677280  91 AWEMVRAEIGRSFFSSTTLQERI 113
Cdd:pfam00143 138 AWEVVRVEIRRCFSFINRLTERL 160
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 11-106 1.44e-45

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 144.40  E-value: 1.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952677280  11 LVMTQKVFHLFCPDTSSAPWNMTLLEALCSGLSEQLDDLEACPLQEAGLAETP-LMHEDSTLRTYFQRISLYLQDKNHSP 89
Cdd:cd00095    56 HEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQQLNHLETCLEQEMGEEETPgPRNTHLHLRKYFQRIQLYLKEKKYSP 135

                          90
                  ....*....|....*..
gi 1952677280  90 CAWEMVRAEIGRSFFSS 106
Cdd:cd00095   136 CAWEVVRAEIMRNFSSI 152
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 11-103 5.17e-45

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 141.68  E-value: 5.17e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952677280   11 LVMTQKVFHLFCPDTSSAPWNMTLLEALCSGLSEQLDDLEACPLQEAGLAETPLMH-EDSTLRTYFQRISLYLQDKNHSP 89
Cdd:smart00076  24 HEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEETPLTRnTHLALKKYFQRIQLYLKEKKYSP 103

                           90
                   ....*....|....
gi 1952677280   90 CAWEMVRAEIGRSF 103
Cdd:smart00076 104 CAWEVVRVEIRRNF 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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