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leucine-rich repeat LGI family member 2 [Canis lupus familiaris]
LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)
LRR_8 and EPTP domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
LRR_8 | pfam13855 | Leucine rich repeat; |
111-170 | 1.57e-13 | ||
Leucine rich repeat; : Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 65.24 E-value: 1.57e-13
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PCC super family | cl28216 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
141-216 | 1.38e-09 | ||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. The actual alignment was detected with superfamily member TIGR00864: Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 61.25 E-value: 1.38e-09
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
267-306 | 8.00e-09 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. : Pssm-ID: 461033 Cd Length: 41 Bit Score: 51.32 E-value: 8.00e-09
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
453-493 | 9.54e-08 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. : Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 9.54e-08
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
408-449 | 1.29e-07 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. : Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.85 E-value: 1.29e-07
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
312-357 | 1.87e-07 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. : Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.46 E-value: 1.87e-07
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
220-260 | 3.19e-06 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. : Pssm-ID: 461033 Cd Length: 41 Bit Score: 44.00 E-value: 3.19e-06
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
361-402 | 4.02e-05 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. : Pssm-ID: 461033 Cd Length: 41 Bit Score: 40.91 E-value: 4.02e-05
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
500-539 | 1.17e-03 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. : Pssm-ID: 461033 Cd Length: 41 Bit Score: 36.68 E-value: 1.17e-03
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Name | Accession | Description | Interval | E-value | ||
LRR_8 | pfam13855 | Leucine rich repeat; |
111-170 | 1.57e-13 | ||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 65.24 E-value: 1.57e-13
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
103-171 | 4.29e-11 | ||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.95 E-value: 4.29e-11
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
141-216 | 1.38e-09 | ||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 61.25 E-value: 1.38e-09
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
267-306 | 8.00e-09 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 51.32 E-value: 8.00e-09
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
453-493 | 9.54e-08 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 9.54e-08
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
408-449 | 1.29e-07 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.85 E-value: 1.29e-07
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
312-357 | 1.87e-07 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.46 E-value: 1.87e-07
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
220-260 | 3.19e-06 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 44.00 E-value: 3.19e-06
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
112-168 | 3.23e-05 | ||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.16 E-value: 3.23e-05
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
361-402 | 4.02e-05 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 40.91 E-value: 4.02e-05
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
168-217 | 1.53e-04 | ||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.72 E-value: 1.53e-04
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
500-539 | 1.17e-03 | ||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 36.68 E-value: 1.17e-03
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LRR | smart00370 | Leucine-rich repeats, outliers; |
133-156 | 1.49e-03 | ||
Leucine-rich repeats, outliers; Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 36.18 E-value: 1.49e-03
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Name | Accession | Description | Interval | E-value | |||
LRR_8 | pfam13855 | Leucine rich repeat; |
111-170 | 1.57e-13 | |||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 65.24 E-value: 1.57e-13
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LRR_8 | pfam13855 | Leucine rich repeat; |
98-146 | 1.62e-12 | |||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 1.62e-12
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
103-171 | 4.29e-11 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.95 E-value: 4.29e-11
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
104-171 | 5.93e-10 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 61.49 E-value: 5.93e-10
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
104-171 | 7.87e-10 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 61.10 E-value: 7.87e-10
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
141-216 | 1.38e-09 | |||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 61.25 E-value: 1.38e-09
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
267-306 | 8.00e-09 | |||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 51.32 E-value: 8.00e-09
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
104-181 | 8.72e-09 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.64 E-value: 8.72e-09
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
104-200 | 1.44e-08 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 56.87 E-value: 1.44e-08
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
453-493 | 9.54e-08 | |||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 48.23 E-value: 9.54e-08
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
408-449 | 1.29e-07 | |||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.85 E-value: 1.29e-07
|
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
312-357 | 1.87e-07 | |||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 47.46 E-value: 1.87e-07
|
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
220-260 | 3.19e-06 | |||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 44.00 E-value: 3.19e-06
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
112-168 | 3.23e-05 | |||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.16 E-value: 3.23e-05
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
361-402 | 4.02e-05 | |||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 40.91 E-value: 4.02e-05
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
168-217 | 1.53e-04 | |||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.72 E-value: 1.53e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
136-168 | 2.97e-04 | |||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 38.38 E-value: 2.97e-04
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EPTP | pfam03736 | EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ... |
500-539 | 1.17e-03 | |||
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold. Pssm-ID: 461033 Cd Length: 41 Bit Score: 36.68 E-value: 1.17e-03
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LRR | smart00370 | Leucine-rich repeats, outliers; |
133-156 | 1.49e-03 | |||
Leucine-rich repeats, outliers; Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 36.18 E-value: 1.49e-03
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LRR_TYP | smart00369 | Leucine-rich repeats, typical (most populated) subfamily; |
133-156 | 1.49e-03 | |||
Leucine-rich repeats, typical (most populated) subfamily; Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 36.18 E-value: 1.49e-03
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
114-169 | 4.57e-03 | |||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 38.61 E-value: 4.57e-03
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Blast search parameters | ||||
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