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Conserved domains on  [gi|1953361240|ref|XP_038517992|]
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leucine-rich repeat LGI family member 2 [Canis lupus familiaris]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
111-170 1.57e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.57e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953361240 111 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 141-216 1.38e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.25  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953361240  141 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNDVPSFDYEC 216
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 267-306 8.00e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953361240 267 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 306
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 453-493 9.54e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1953361240 453 QFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 493
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 408-449 1.29e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 408 KFVPHSDIPNMeDVLAVKSFRMQNALYLSLTRFIGDSRVMRW 449
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 312-357 1.87e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1953361240 312 KFVKFQDIEVSRiskPNDIELFQIEDETFFIIADSSkaGLSTVYKW 357
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 220-260 3.19e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 220 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 260
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 361-402 4.02e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.91  E-value: 4.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 361 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 402
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 500-539 1.17e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 36.68  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953361240 500 FKKFKEIYVQAPRCFTAVSTDRRDFFFASSFKGKTKIFEH 539
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
111-170 1.57e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.57e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953361240 111 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-171 4.29e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.29e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953361240 103 DDAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPRDvFSDLDSLIELDLRGNKFE 171
Cdd:COG4886   175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 141-216 1.38e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.25  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953361240  141 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNDVPSFDYEC 216
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 267-306 8.00e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953361240 267 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 306
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 453-493 9.54e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1953361240 453 QFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 493
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 408-449 1.29e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 408 KFVPHSDIPNMeDVLAVKSFRMQNALYLSLTRFIGDSRVMRW 449
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 312-357 1.87e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1953361240 312 KFVKFQDIEVSRiskPNDIELFQIEDETFFIIADSSkaGLSTVYKW 357
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 220-260 3.19e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 220 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 260
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-168 3.23e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 3.23e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953361240 112 LEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPR--DVFSDLDSLIELDLRGN 168
Cdd:cd21340   122 LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 361-402 4.02e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.91  E-value: 4.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 361 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 402
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRRCT smart00082
Leucine rich repeat C-terminal domain;
168-217 1.53e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.53e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1953361240  168 NKFECDCKAKWLYLWLKMTNSTVS--DVLCIGPPEYQEKKLNDVPSFDYeCT 217
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEFK-CP 51
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 500-539 1.17e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 36.68  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953361240 500 FKKFKEIYVQAPRCFTAVSTDRRDFFFASSFKGKTKIFEH 539
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
133-156 1.49e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.49e-03
                           10        20
                   ....*....|....*....|....
gi 1953361240  133 LRDLTHLSLANNHIKALPRDVFSD 156
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
111-170 1.57e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.57e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953361240 111 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
98-146 1.62e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 1.62e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1953361240  98 FTVIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHI 146
Cdd:pfam13855  13 LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-171 4.29e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.29e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953361240 103 DDAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPRDvFSDLDSLIELDLRGNKFE 171
Cdd:COG4886   175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-171 5.93e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 5.93e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953361240 104 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrdVFSDLDSLIELDLRGNKFE 171
Cdd:COG4886   199 EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-171 7.87e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 7.87e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953361240 104 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrDVFSDLDSLIELDLRGNKFE 171
Cdd:COG4886   130 EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQIT 195
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 141-216 1.38e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.25  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953361240  141 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNDVPSFDYEC 216
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 267-306 8.00e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953361240 267 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 306
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-181 8.72e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 8.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953361240 104 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrDVFSDLDSLIELDLRGNKFE------CDCKA- 176
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTdlpeelGNLTNl 184


                  ....*
gi 1953361240 177 KWLYL 181
Cdd:COG4886   185 KELDL 189
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-200 1.44e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953361240 104 DAFAGLFHLEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPrdVFSDLDSLIELDLRGNKFEcDCKAKWLYLWL 183
Cdd:COG4886   222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-DLKLKELELLL 296

                          90
                  ....*....|....*..
gi 1953361240 184 KMTNSTVSDVLCIGPPE 200
Cdd:COG4886   297 GLNSLLLLLLLLNLLEL 313
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 453-493 9.54e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.54e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1953361240 453 QFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 493
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 408-449 1.29e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 408 KFVPHSDIPNMeDVLAVKSFRMQNALYLSLTRFIGDSRVMRW 449
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 312-357 1.87e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1953361240 312 KFVKFQDIEVSRiskPNDIELFQIEDETFFIIADSSkaGLSTVYKW 357
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 220-260 3.19e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.19e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 220 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 260
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-168 3.23e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 3.23e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953361240 112 LEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPR--DVFSDLDSLIELDLRGN 168
Cdd:cd21340   122 LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 361-402 4.02e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.91  E-value: 4.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953361240 361 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 402
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRRCT smart00082
Leucine rich repeat C-terminal domain;
168-217 1.53e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.53e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1953361240  168 NKFECDCKAKWLYLWLKMTNSTVS--DVLCIGPPEYQEKKLNDVPSFDYeCT 217
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEFK-CP 51
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 136-168 2.97e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 2.97e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1953361240 136 LTHLSLANNHIKALPrdVFSDLDSLIELDLRGN 168
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 500-539 1.17e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 36.68  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953361240 500 FKKFKEIYVQAPRCFTAVSTDRRDFFFASSFKGKTKIFEH 539
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
133-156 1.49e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.49e-03
                           10        20
                   ....*....|....*....|....
gi 1953361240  133 LRDLTHLSLANNHIKALPRDVFSD 156
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
133-156 1.49e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.49e-03
                           10        20
                   ....*....|....*....|....
gi 1953361240  133 LRDLTHLSLANNHIKALPRDVFSD 156
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-169 4.57e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 4.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953361240 114 YLFieGNKIETISrnAFRGLRDLTHLSLANNHIKALprDVFSDLDSLIELDLRGNK 169
Cdd:cd21340    30 YLY--DNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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