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Conserved domains on  [gi|1953357146|ref|XP_038516408|]
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alpha-2,8-sialyltransferase 8B isoform X1 [Canis lupus familiaris]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467715  Cd Length: 278  Bit Score: 611.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSG 170
Cdd:cd23987     1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 171 CGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKE 250
Cdd:cd23987    81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987   161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1953357146 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987   241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 611.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSG 170
Cdd:cd23987     1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 171 CGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKE 250
Cdd:cd23987    81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987   161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1953357146 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987   241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 111-363 8.29e-102

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 301.45  E-value: 8.29e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 111 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ 190
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 191 EYGRDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLRSLNG--SILWIPAFMARGGKERVEWVNELILKHHVNV- 266
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 267 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 343
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 1953357146 344 SPHTMPLEFKALKSLHEQGA 363
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 611.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSG 170
Cdd:cd23987     1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 171 CGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKE 250
Cdd:cd23987    81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987   161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1953357146 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987   241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 518.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSG 170
Cdd:cd23969     1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 171 CGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKE 250
Cdd:cd23969    81 CGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKFVERLRQLGDSILWIPAFVSKGGEE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23969   161 HVQWTNEIILKHKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYH 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1953357146 331 YYDSLKYGYtsQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23969   241 YYDNRKYLT--TARPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 91-367 4.57e-175

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 487.92  E-value: 4.57e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSG 170
Cdd:cd23988     1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 171 CGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKE 250
Cdd:cd23988    81 CGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23988   161 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1953357146 331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLT 367
Cdd:cd23988   241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLT 277
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 95-368 3.59e-112

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 328.45  E-value: 3.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  95 RIRKQILKFLDAEKDISVLKGTlKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQE 174
Cdd:cd23963     5 KFRKELERLLNTRKLFLTQKNT-PLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 175 IDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEW 254
Cdd:cd23963    84 IDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 255 VNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVhIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDS 334
Cdd:cd23963   164 AARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDD 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1953357146 335 LKYGYTSqaSPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23963   243 LSPSTKN--KVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 111-363 8.29e-102

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 301.45  E-value: 8.29e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 111 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ 190
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 191 EYGRDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLRSLNG--SILWIPAFMARGGKERVEWVNELILKHHVNV- 266
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 267 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 343
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 1953357146 344 SPHTMPLEFKALKSLHEQGA 363
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 89-368 8.94e-99

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 294.69  E-value: 8.94e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  89 NQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMN-VSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLL 167
Cdd:cd23970     2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFsISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 168 NSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARG 247
Cdd:cd23970    82 NSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 248 GKERVEWVNELILKH--HVNVRTAYPSlRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQN 325
Cdd:cd23970   162 SATVTRTLVDFFVEHrgQLKVQLAWPG-NIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGT 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1953357146 326 PVKYHYYDSL--KYGYTSQASpHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23970   241 PLPYHYYDKKgtKFTTKWQES-HQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 120-366 1.26e-70

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 222.13  E-value: 1.26e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 120 GDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVqEYGRDVGLK 199
Cdd:cd23971    30 GSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSK 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 200 TDLVTMNPSVIQRAFEDLVNatWREKLLQRLRSLNGSILWIPAFMARGGKE---RVEWVNELIlKHHVNVRTAYPS-LRL 275
Cdd:cd23971   109 TNLVTANPSILREKFHNLKK--RRRPFVERMKVYGNALLLLPAFSYTSNTEpslRALYTLEDF-GSPQKVLFFNPEyLRN 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 276 LHAvrgYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 355
Cdd:cd23971   186 LSR---YWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVL----PKKGVHAMPEEFLRY 258

                         250
                  ....*....|.
gi 1953357146 356 KSLHEQGALKL 366
Cdd:cd23971   259 LKLHSQGVLRL 269
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 97-368 1.51e-59

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 193.89  E-value: 1.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146  97 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKnKHFRTCAIVGNSGVLLNSGCGQEID 176
Cdd:cd23989     7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQID 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 177 THSFVIRCNLAPV-QEYGRDVGLKTDLVTMNPSVIQRAFEDLVnatW-REKLLQRLRSLNGSILWIPAFMARGGKERVEW 254
Cdd:cd23989    86 RADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNLL---WsRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 255 VNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDS 334
Cdd:cd23989   163 VYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDN 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1953357146 335 LkygyTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23989   243 V----LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 120-366 1.01e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 170.79  E-value: 1.01e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 120 GDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPV-QEYGRDVGL 198
Cdd:cd23990    30 GTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 199 KTDLVTMNPSVIQRAFEDLvnATWREKLLQRLRSLNGSILWIPAFMARGGKE---RVEWVNElILKHHVNVRTAYPslRL 275
Cdd:cd23990   110 KTDVVTINPSIITERFHKL--EKWRRPFYEVLQVYENASVVLPAFYNTRNTDvsiRVKYVLD-DFESQQAVYYFHP--QY 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 276 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 355
Cdd:cd23990   185 LLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVK----PRPGFHAMPSEIFNF 260

                         250
                  ....*....|.
gi 1953357146 356 KSLHEQGALKL 366
Cdd:cd23990   261 LHMHSRGILRV 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 132-366 9.01e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 168.39  E-value: 9.01e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 132 TMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ-EYGRDVGLKTDLVTMNPSVI 210
Cdd:cd23991    42 KILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGgNISKDVGSKTNLVTANPSII 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 211 QRAFEDLVNAtwREKLLQRLRSLNGSILWIPAFMAR----------------GGKERVEWVNELILKHhvnvrtaypslr 274
Cdd:cd23991   122 SIKYAKLNER--RKPFLETVSVYGDAFLLLPAFSYRsntalsfkvyytledfKAKQKVIFFHPIYLKH------------ 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 275 LLHavrgYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSL--KYGYtsqaspHTMPLEF 352
Cdd:cd23991   188 LAQ----FWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQlpKPGF------HSMPKEF 257

                         250
                  ....*....|....
gi 1953357146 353 KALKSLHEQGALKL 366
Cdd:cd23991   258 YQLLQLHSKGILKL 271
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 157-358 5.97e-36

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 129.79  E-value: 5.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLlqrlrsLNGS 236
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPL------EEEV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 237 ILWIPAFMARGGKERV-----EWVNELILKHHVNvrtaypslRLLHAVRGYW----LTNKVHIKRPTTGLLMYTLATRFC 307
Cdd:cd19952    75 VLILSRAAAADFKRLKrrkkrHDNAVLLLTDPAP--------DLLSYVRKRLeklgLKSFFGGNAPSSGLLAVLLALQLC 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1953357146 308 NQIYLYGFWPFPLDQNQNPvkYHYYDslKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd19952   147 DSVDLYGFGVDSGHAPKVP--YHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 156-366 9.22e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 102.34  E-value: 9.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 156 TCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNP-SVIQRAFEDLV---NATW-----REKL 226
Cdd:cd23964    84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPeSLHNSLLKHVPqdkDTKYlfipfKIRD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 227 LQRLRS-LNGSIlwIPAFMARGGKERvewvneLILKHHVNVRTaypsLRLLHA-----VRGYWLtNKVHIKRPTTGLLMY 300
Cdd:cd23964   164 YDYLDAvLSGKP--VPDGCDKGKRPP------PLFGPKLNATN----VRLLHPdfiryLFNRWL-NSSTSYRPTTGALML 230

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953357146 301 TLATRFCNQIYLYGF---WPFPLdqnqnpvkyHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23964   231 LTALHTCDQVSVYGFgydPRFSL---------HYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 125-336 2.41e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.42  E-value: 2.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 125 YIFDRDST-MNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLV 203
Cdd:cd23968    15 STLRKTTSpFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 204 TMNpSVI----QRAFEDlvnatwreKLLQRlrslNGSIL-WIPAFMARGGKERVEWVNELILKHHVNVRTAYPSLRL-LH 277
Cdd:cd23968    95 LIN-SQIlskpEFNFLT--------DPLYR----NVTLLvWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFyLI 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953357146 278 AVRGYW-------LTNKVHIKR--PTTGLLMYTLATRFCNQIYLYGFWPfPLDQNQnpvKYHYYDSLK 336
Cdd:cd23968   162 DPRFLWrlwdilqEYTPEKIKPnpPSSGFIGIVLMLHLCDWVDVYEYVP-SVRQTD---RCHYYDVEK 225
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 134-366 4.37e-20

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 88.88  E-value: 4.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 134 NVSQNLYDLLPRTSPLKNK---HFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNP--S 208
Cdd:cd23966    54 EVLEKLFQVVPGENPYRTRdpnRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPesA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 209 VIQRAFEDLVNATWREKLLQRLRSL--NGSILW----IPAFMaRGGKERVEWVNELILKHhvnvrtaypslrllhaVRGY 282
Cdd:cd23966   134 VDLDPGVHLVLVPFKVLDLQWLISAltTGEITRtytpVKRFI-KADKDKVLVINPAFIKY----------------VHDN 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 283 WLTNkvHIKRPTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHTMPLEFKALKSLHEQ 361
Cdd:cd23966   197 WTEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGN--WHHYWEKNRSaGAFRKTGVHDADFESDIIKKLAKE 269


                  ....*
gi 1953357146 362 GALKL 366
Cdd:cd23966   270 GKIRV 274
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 155-358 7.24e-20

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 86.58  E-value: 7.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 155 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNP-SVIQRAFEDLVNAT------------ 221
Cdd:cd23967     3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPeSAFRDPEEYDSDWLlvlvpfksmdll 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 222 WREKLLQRlRSLNGSILWI--PAFMARGGKERVEWVNELILKhhvnvRTAYPSLRLLHAvrgywltNKVHIKRPTTGLLM 299
Cdd:cd23967    83 WLQAVIKG-KKPNGKGGFWkkIATSVPKPPKKIRILNPYILQ-----EAAFDLIGLPMN-------GKQGKNVPTTGIIA 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953357146 300 YTLATRFCNQIYLYGFwPFPLDQNQNPvkYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23967   150 IVMALHYCDEVDIAGF-GYDPSDPNAP--LHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 148-335 8.05e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 87.62  E-value: 8.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 148 PLKnKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAfedlvnatwrekLL 227
Cdd:cd23976    10 PLK-MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRI------------LR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 228 QRLRSLNGS-----ILWIPA-FMARGGKERVewVNELILKHHVnvrtaYPSLRLLHAVRGYWLTNKVHIKRPT------- 294
Cdd:cd23976    77 NRNELLNVSqgtvfIFWGPSnYMRRDGKGLV--YNNLQLMNQI-----LPKLKVYTITRHKMLQFDELFKRETgkdrkis 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1953357146 295 -----TGLLMYTLATRFCNQIYLYGFWP--FPLDQNQNPVKYHYYDSL 335
Cdd:cd23976   150 ntwlsTGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPS 197
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 155-358 1.39e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 85.87  E-value: 1.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 155 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPsviQRAFEDLVNATWREKLLQRLRSLN 234
Cdd:cd23982     3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYP---ESAQFDPGIENDPDTLLVLVPFKP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 235 GSILWIPAFMARGGKERVEWVNELILKHHVN---VRTAYP------SLRLLHaVRGywltNKVHIKRPTTGLLMYTLATR 305
Cdd:cd23982    80 LDFYWLYEILSNEKRVRKGFWKQPPRIWDANpkqIRILNPyytyvaATKLLQ-VPG----QRKKKQKPTTGLLAITLALH 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1953357146 306 FCNQIYLYGFwPFPLDQNQN-PVkyHYYDslkyGYTS---QASPHTMPLEFKALKSL 358
Cdd:cd23982   155 LCDEVHIAGF-GYPDNGNSNqPI--HYYN----QITLksmANSGHNLNAEAQAIQRL 204
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 152-334 5.54e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 77.05  E-value: 5.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 152 KHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVI---QRAFedLVNATWREKLLq 228
Cdd:cd23985    43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQLVtteKHKF--LKDSLYNEGIL- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 229 rlrslngsILWIPAFMArggKERVEWVNelilKHHVNVRTAYPSLRLLHAVRGYWLTNKV---------------HIKR- 292
Cdd:cd23985   120 --------IVWDPAPYH---SDIPEWYK----NPDYNFFENYKTYRRLNPNQPFYILHPQmqwelwdiiqenspeEIQPn 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1953357146 293 -PTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNPVkYHYYDS 334
Cdd:cd23985   185 pPSSGMLGIILMMTLCDQVDVYEFLP---SKRKTDV-CHYYQK 223
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 155-337 1.88e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 74.59  E-value: 1.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 155 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDlvnatwREKLLQRLRSLN 234
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRN------AILLLAGTRAPT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 235 GSILWIPAF-MARGGKERVEWVNELILKH-HVNVRTAYPSlRLLHAVR-------------GYWLtnkvhikrpTTGLLM 299
Cdd:cd23965    76 VVVFWGPETkMNKDGAGKYNLLRSLSKKYpDVEFYSLTPE-KMDYADElfeketgksriksGTWL---------STGWFT 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1953357146 300 YTLATRFCNQIYLYGFWP------FPLDQnqnpVKYHYYDSLKY 337
Cdd:cd23965   146 MLLALDVCDEIKVYGMVPenycreHPNSK----VPYHYYEPGGL 185
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 127-366 1.22e-14

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 73.37  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 127 FDRDSTMNVSQNLYDLLPRTSPLKNK---HFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLV 203
Cdd:cd23979    50 FKPHNTKEVLSKLFQIIPGENPYRSWdpsRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHH 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 204 TMNPsviQRAFEDLVNATWrekLLQRLRSLNgsILWIPAFMARG---------------GKERVEWVNELILKHhvnvrt 268
Cdd:cd23979   130 FMYP---ESAKNLPANVSF---VLVPFKTLD--LLWITSALSTGqirftyapvkqflrvDKDKVQIYNPAFFKY------ 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 269 aypslrllhaVRGYWLTNkvHIKRPTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHT 347
Cdd:cd23979   196 ----------IHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGFGA---DSRGN--WHHYWENNRYaGEFRKTGVHD 258

                         250
                  ....*....|....*....
gi 1953357146 348 MPLEFKALKSLHEQGALKL 366
Cdd:cd23979   259 ADFEAHIIDMLAKAGKIKV 277
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 155-358 2.05e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 71.32  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 155 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDL--------------VTMNPSVIQRAF--EDLv 218
Cdd:cd23984     3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFrlcypesifsdpshYDPNTTVVLIPFkpHDL- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 219 naTWREKLLQRlRSLNGSILW-IPAFMARGGKERVEWVNELILKhhvnvRTAYpslRLLHAVRGYWLTNKVhiKRPTTGL 297
Cdd:cd23984    82 --RWLLDLLMG-KKVSAKGFWkKPALNLIYKPNQIRILNPFILR-----IAAY---ELLHFPKRFPKEKKP--KHPTTGI 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953357146 298 LMYTLATRFCNQIYLYGFwPFPLDQNQNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23984   149 IAITLALHICNEVHIAGF-KYDFSNLNSTL--HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 157-366 1.19e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 71.01  E-value: 1.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLV-----TMNPSVIqrAFEDL-VNATWREKLLQ-- 228
Cdd:cd23972    85 CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvnTMKNSLI--SYWNLgFTRTPQGQDLQyi 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 229 ----RLRS---LNGSILWIPafMARGGKERVEWVNELILKHHVN-VRTAYPSlrLLHAVRGYWLTNKV------HIKRPT 294
Cdd:cd23972   163 fipsDIRDyvmLRSAILGVP--VPEGLDKGDRPHKYFGPEASAKkFKLLHPD--FISYLTDRFLKSKLlnthygHLYMPS 238

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953357146 295 TGLLMYTLATRFCNQIYLYGFwpfpLDQNQNPVKYHYYDSLKYGYTSQASpHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23972   239 TGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKKKPLVFYAN-HDMLLEAALWRRLHKAGILQL 305
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 153-358 1.61e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 69.00  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 153 HFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLvTMN-----PSVIQRAFEDLVNAT------ 221
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTI-RMTypegaPKSEQEYDPTSLFVAvlfksv 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 222 ---WREKLLQRLRSLNGSILW--------IPAfmargGKERVEWVNELILKHHVNVRTAYPSLRllhavRGYWLTNKVHi 290
Cdd:cd23983    80 dfaWLKAMVKKEPLSFWSRLFfwkevadsIPL-----KPSQFRILNPLIIKETALDILQYPEPQ-----SRLWGWDKNV- 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953357146 291 krPTTGLLMYTLATRFCNQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23983   149 --PTLGVTAVVLATHLCDEVSLAG---FGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 155-358 2.09e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 68.41  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 155 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLvtmnpsviqrafedlvNATWREKLLQRLRSLN 234
Cdd:cd23981     3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTL----------------RITYPEGAIQKPEQYE 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 235 GSILWIPAfmarGGK-ERVEWVNELILKHHVN--------VRTAYP----SLRLLHAvrgYWL-----------TNKVHI 290
Cdd:cd23981    67 KDSLFVLA----GFKwQDFKWLKYIVYKEKVSasdgfwksVATRVPrephEIRILNP---YFIqeaafsfiglpFNNGLM 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953357146 291 KR---PTTGLLMYTLATRFCNQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23981   140 GRgniPTLGSVAITMALHNCDEVAVAG---FGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 156-366 3.56e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 69.40  E-value: 3.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 156 TCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTdlvtmnpSVIQRAFEDLVNATW--REKLLQRLRSL 233
Cdd:cd23973    85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRT-------SFYVHTAHSITSSLMilQKRGFKNIPQD 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 234 NGsilwIPAFMARGGKERVEWVNELILKHHVN---VRTAYP-----------SLRLLHA-----VRGYWLTNKV------ 288
Cdd:cd23973   158 KD----IKYILFPEGPRDYQWLEALLKNKTIPsgaYYGRRPrsyfsgdftedKYLVLHPdflryVKNRFLRSKTlkgkyw 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 289 HIKRPTTGLLMYTLATRFCNQIYLYGFwpfpldQNQNPVKY--HYYDsLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23973   234 AIYRPTTGAFLLLTALHLCDTVSAYGF------ITEDYRKYpdHYYD-KKKTKLVFYINHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 131-366 4.33e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 69.40  E-value: 4.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 131 STMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVT------ 204
Cdd:cd23974    61 NLLNSSANGQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTfstntl 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 205 MN------------PSVIQRAFEDLVNATWREKLLQRLRSLNGSIlwipafmARG---GKERVEWVNELILKHHVNVR-- 267
Cdd:cd23974   141 MNslrayagvgfngPPQSKETRYIFLPDHDRDYLLVKAALTHTPI-------DRGrdkSKRPSKYFGKDVTAEKFKIYhp 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 268 --TAYPSLRLLHAvrGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFwpfpLDQNQNPVKYHYYDSlKYGYTSQASP 345
Cdd:cd23974   214 dfIRYLRNRFLWS--PILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDK-TYHKVVFYAN 286

                         250       260
                  ....*....|....*....|.
gi 1953357146 346 HTMPLEFKALKSLHEQGALKL 366
Cdd:cd23974   287 HDLRLEMQLWQKLHKAGLIKL 307
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 155-315 1.16e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 67.60  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 155 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKtdlvTMNPSVIQRAFEDLVNATwrEKLLQRLRSLN 234
Cdd:cd23980    82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSK----TTHHFVYPESFRELAQNV--SMILVPFKTLD 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 235 gsILWIPAFMARG----------GKERVEwvNELILKHHvnvrtayPSlrLLHAVRGYWLTNkvHIKRPTTGLLMYTLAT 304
Cdd:cd23980   156 --LEWVISATTTGtishtyvpvpRKIKVK--KEKILIYH-------PA--FIKYVFDRWLQG--HGRYPSTGILSVIFSL 220

                         170
                  ....*....|.
gi 1953357146 305 RFCNQIYLYGF 315
Cdd:cd23980   221 HVCDEVDLYGF 231
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 147-334 1.34e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 67.17  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 147 SPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLV-NATWREK 225
Cdd:cd23986    42 SKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIdSSLYKDV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 226 LLqrlrslngsILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPS--LRLLHAvRGYW---------LTNKVHIKRPT 294
Cdd:cd23986   122 IL---------VAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNqpFYILHP-KFIWqlwdiiqenTQEKIQPNPPS 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1953357146 295 TGLLMYTLATRFCNQIYLYGFwpFPLDQNQNPVKYH--YYDS 334
Cdd:cd23986   192 SGFIGILIMMSMCREVHVYEY--IPSVRQTDLCHYHerYYDA 231
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 157-333 3.64e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 56.40  E-value: 3.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEdlvnatwREKLLQRLRSLNGS 236
Cdd:cd23978     4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLR-------RPQEFLNRTPETTL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 237 ILW-IPAFMARGGKERVEWVNELILKHHVNVRTAYPSLR-------LLHAVRGY-------WLtnkvhikrpTTGLLMYT 301
Cdd:cd23978    77 IFWgPPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRrmrqfddLFRGETGRdrkkshsWL---------STGWFTMV 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1953357146 302 LATRFCNQIYLYGFWPFP-LDQNQNPVK--YHYYD 333
Cdd:cd23978   148 IAVELCDNVHVYGMVPPNyCSKRPTPKKmpYHYYE 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 155-336 1.01e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 55.25  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 155 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDL-VTMNPSVIQRafedLVNATWrekLLQRLRSl 233
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLrVVSHTSVPLL----LRNQGY---FFQQSRD- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953357146 234 NGSILWIPA-FMARGGKERVewvnelilkHHVNVRTA--YPSLRLLHAVRGYWL---------TNKVHIKRPT---TGLL 298
Cdd:cd23977    74 TKYVIWGPErNMDRDGGGKT---------YRALLTLAkmYPHLQVYTLTEEKMAycdgvfqneTGKNRMKSGSflsTGWF 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1953357146 299 MYTLATRFCNQIYLYGFW--PFPLDQNQNPVKYHYYDSLK 336
Cdd:cd23977   145 TMILALELCEEILVYGMVsdSYCRNKNHSSVPYHYYEKGR 184
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 157-202 3.64e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 47.62  E-value: 3.64e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1953357146 157 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDL 202
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTI 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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