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Conserved domains on  [gi|1953268825|ref|XP_038511327|]
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LOW QUALITY PROTEIN: serine palmitoyltransferase 1 isoform X1 [Canis lupus familiaris]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 1-472 3.74e-169

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02822:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 481  Bit Score: 485.02  E-value: 3.74e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822    8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  70 VPPISK----DHPALNYniVSGPpshNIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVH 145
Cdd:PLN02822   82 IPPITEemrpEPPVLES--AAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVH 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 146 LDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQE 225
Cdd:PLN02822  157 LDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 226 MEDqknpRKARVTRRFIVAEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISA 305
Cdd:PLN02822  237 AEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITA 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 306 NMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGISGLKV 385
Cdd:PLN02822  313 AMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSI 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 386 VGESLSPAFHLQLKDSTGSREKDVKLLQEIVNHCMDRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTDEELERAAR 462
Cdd:PLN02822  393 GSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASE 469

                         490
                  ....*....|
gi 1953268825 463 TIKEVAQAVL 472
Cdd:PLN02822  470 SLKRVAASVL 479
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 1-472 3.74e-169

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 485.02  E-value: 3.74e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822    8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  70 VPPISK----DHPALNYniVSGPpshNIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVH 145
Cdd:PLN02822   82 IPPITEemrpEPPVLES--AAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVH 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 146 LDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQE 225
Cdd:PLN02822  157 LDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 226 MEDqknpRKARVTRRFIVAEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISA 305
Cdd:PLN02822  237 AEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITA 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 306 NMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGISGLKV 385
Cdd:PLN02822  313 AMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSI 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 386 VGESLSPAFHLQLKDSTGSREKDVKLLQEIVNHCMDRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTDEELERAAR 462
Cdd:PLN02822  393 GSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASE 469

                         490
                  ....*....|
gi 1953268825 463 TIKEVAQAVL 472
Cdd:PLN02822  470 SLKRVAASVL 479
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 1.47e-80

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 254.98  E-value: 1.47e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  84 IVSGPPSHNIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAII 163
Cdd:COG0156    23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 164 YSYGFATIASAIPAYSKRGDIVFVDRA--ACfaIQKGLQASRSDIKLFKHNDMADLERLLKEqemedqknPRKARvtRRF 241
Cdd:COG0156   103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 242 IVAEGLY-MnTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGFCCG 320
Cdd:COG0156   171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGLE-DRVDIIMGTLSKALGSSGGFVAG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 321 RSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGIsGLKvVGESLSPAFHLQLKD 400
Cdd:COG0156   249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIVGD 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953268825 401 StgsrekdvKLLQEIVNHCMDRSIALTQARYlekeekclppPS-------IRVVVTVEQTDEELERAARTIKEVAQA 470
Cdd:COG0156   327 A--------ERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 3.80e-78

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 247.47  E-value: 3.80e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454     1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 178 YSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEqemedqkNPRKARvtRRFIVAEGLYMNTGTICPL 257
Cdd:cd06454    81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHFGISIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454   152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 338 SASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGIsGLKVVGESLSPAFHLQLKDStgsrekdvKLLQEIVN 417
Cdd:cd06454   231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGDDP--------AKAVAFSD 301

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1953268825 418 HCMDRSIALTQARY---LEKEEKclpppsIRVVVTVEQTDEELERAARTIKEV 467
Cdd:cd06454   302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 6.18e-25

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 105.47  E-value: 6.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  98 KKCVNFASFNFLGLLdnprVKAAALASLKkygVGTCGPRGFYGTFDVHLDLEDRLAKFM--------KTEEAIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDT----LPAVAKAEKD---ALAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 170 TIASAIPAYSK-RGDIVFVDRAACFAIQKGLQASRSDIKLFK-------HNDMADLERLLKEQemedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 242 IVAEGLYMNTGTICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsiDDIDLISAN-MENSLASIG-- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLA--EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 316 -GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGIsGLKVVGeSLSPAF 394
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 395 HLQLkdstGSREKDVKLLQEIVNHCmdrSIALTQARYLEKeekclpPPSIRVVVTVeQTDEELERAARTI 464
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 1-472 3.74e-169

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 485.02  E-value: 3.74e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822    8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  70 VPPISK----DHPALNYniVSGPpshNIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVH 145
Cdd:PLN02822   82 IPPITEemrpEPPVLES--AAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVH 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 146 LDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQE 225
Cdd:PLN02822  157 LDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 226 MEDqknpRKARVTRRFIVAEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISA 305
Cdd:PLN02822  237 AEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITA 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 306 NMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGISGLKV 385
Cdd:PLN02822  313 AMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSI 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 386 VGESLSPAFHLQLKDSTGSREKDVKLLQEIVNHCMDRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTDEELERAAR 462
Cdd:PLN02822  393 GSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASE 469

                         490
                  ....*....|
gi 1953268825 463 TIKEVAQAVL 472
Cdd:PLN02822  470 SLKRVAASVL 479
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 101-472 5.89e-114

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 341.11  E-value: 5.89e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 101 VNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK 180
Cdd:PLN03227    1 LNFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 181 RGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEMEDQKNPRKARVTRRFIVAEGLYMNTGTICPLPEL 260
Cdd:PLN03227   81 RGDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQVRAQDVALKRKPTDQRRFLVVEGLYKNTGTLAPLKEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 261 VKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGIS-IDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSA 339
Cdd:PLN03227  161 VALKEEFHYRLILDESFSFGTLGKSGRGSLEHAGLKpMVHAEIVTFSLENAFGSVGGMTVGSEEVVDHQRLSGSGYCFSA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 340 SLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGIS---------GLKVVGESLSPAFHLQLKDSTGSREKD-V 409
Cdd:PLN03227  241 SAPPFLAKADATATAGELAGPQLLNRLHDSIANLYSTLTNSShpyalklrnRLVITSDPISPIIYLRLSDQEATRRTDeT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953268825 410 KLLQEIVNHCMDRSIALTQAR-YLEKEEKCLPPPSIRVVVTVEQTDEELERAARTIKEVAQAVL 472
Cdd:PLN03227  321 LILDQIAHHSLSEGVAVVSTGgHVKKFLQLVPPPCLRVVANASHTREDIDKLLTVLGEAVEAIL 384
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 1.47e-80

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 254.98  E-value: 1.47e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  84 IVSGPPSHNIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAII 163
Cdd:COG0156    23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 164 YSYGFATIASAIPAYSKRGDIVFVDRA--ACfaIQKGLQASRSDIKLFKHNDMADLERLLKEqemedqknPRKARvtRRF 241
Cdd:COG0156   103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 242 IVAEGLY-MnTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGFCCG 320
Cdd:COG0156   171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGLE-DRVDIIMGTLSKALGSSGGFVAG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 321 RSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGIsGLKvVGESLSPAFHLQLKD 400
Cdd:COG0156   249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIVGD 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953268825 401 StgsrekdvKLLQEIVNHCMDRSIALTQARYlekeekclppPS-------IRVVVTVEQTDEELERAARTIKEVAQA 470
Cdd:COG0156   327 A--------ERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 3.80e-78

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 247.47  E-value: 3.80e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454     1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 178 YSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEqemedqkNPRKARvtRRFIVAEGLYMNTGTICPL 257
Cdd:cd06454    81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHFGISIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454   152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 338 SASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGIsGLKVVGESLSPAFHLQLKDStgsrekdvKLLQEIVN 417
Cdd:cd06454   231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGDDP--------AKAVAFSD 301

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1953268825 418 HCMDRSIALTQARY---LEKEEKclpppsIRVVVTVEQTDEELERAARTIKEV 467
Cdd:cd06454   302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
PLN02483 PLN02483
serine palmitoyltransferase
 96-471 1.29e-54

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 189.97  E-value: 1.29e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  96 NGKKCVNFASFNFLGLLD-----NPRVkaaaLASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFAT 170
Cdd:PLN02483   98 KTRRCLNLGSYNYLGFAAadeycTPRV----IESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYAT 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 171 IASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEMEDQknPRKARVTRRFIV-AEGLYM 249
Cdd:PLN02483  174 NSTIIPALIGKGGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLREQIAEGQ--PRTHRPWKKIIViVEGIYS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 250 NTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISANMENSLASIGGFCCGRSFVIDHQR 329
Cdd:PLN02483  252 MEGELCKLPEIVAVCKKYKAYVYLDEAHSIGAVGKTGRGVCELLGVDPADVDIMMGTFTKSFGSCGGYIAGSKELIQYLK 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 330 LSGQGYCFSASL-PPLLAAAAIEALNIMEE---NPGifsvlKEKCKRIHK-------ALQGIsGLKVVGESLSPAFHLQL 398
Cdd:PLN02483  332 RTCPAHLYATSMsPPAVQQVISAIKVILGEdgtNRG-----AQKLAQIREnsnffrsELQKM-GFEVLGDNDSPVMPIML 405

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953268825 399 ----KDSTGSREkdvkllqeivnhCMDRSIALTQARYlekeeKCLPP--PSIRVVVTVEQTDEELERAARTIKEVAQAV 471
Cdd:PLN02483  406 ynpaKIPAFSRE------------CLKQNVAVVVVGF-----PATPLllARARICISASHSREDLIKALEVISEVGDLV 467
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 84-343 2.22e-47

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 168.07  E-value: 2.22e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  84 IVSGPPSHNI-VVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAI 162
Cdd:PRK06939   27 VITSPQGADItVADGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMASVRFICGTQDLHKELEEKLAKFLGTEDAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 163 IYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQemedqknpRKARVTRRFI 242
Cdd:PRK06939  107 LYSSCFDANGGLFETLLGKEDAIISDALNHASIIDGVRLCKAKRYRYANNDMADLEAQLKEA--------KEAGARHKLI 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 243 VAEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLA-SIGGFCCGR 321
Cdd:PRK06939  179 ATDGVFSMDGDIAPLPEICDLADKYDALVMVDDSHAVGFVGENGRGTVEHFGVM-DRVDIITGTLGKALGgASGGYTAGR 257

                         250       260
                  ....*....|....*....|..
gi 1953268825 322 SFVIDHQRLSGQGYCFSASLPP 343
Cdd:PRK06939  258 KEVIDWLRQRSRPYLFSNSLAP 279
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 84-343 3.75e-47

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 167.26  E-value: 3.75e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  84 IVSGPPSHNIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAII 163
Cdd:PRK05958   25 PREGGAGRWLVVDGRRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRLVTGNSPAHEALEEELAEWFGAERALL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 164 YSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLkeqemedqknpRKARVTRRFIV 243
Cdd:PRK05958  105 FSSGYAANLAVLTALAGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVDALEALL-----------AKWRAGRALIV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 244 AEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsIDDIDLIS-ANMENSLASIGGFCCGRS 322
Cdd:PRK05958  174 TESVFSMDGDLAPLAELVALARRHGAWLLVDEAHGTGVLGPQGRGLAAEAGL-AGEPDVILvGTLGKALGSSGAAVLGSE 252

                         250       260
                  ....*....|....*....|.
gi 1953268825 323 FVIDHQRLSGQGYCFSASLPP 343
Cdd:PRK05958  253 TLIDYLINRARPFIFTTALPP 273
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 98-343 2.65e-30

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 121.88  E-value: 2.65e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:PRK13392   46 RRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAGAGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALST 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 178 YSKR--GDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEMEDQKnprkarvtrrFIVAEGLYMNTGTIC 255
Cdd:PRK13392  126 LGKLlpGCVILSDALNHASMIEGIRRSGAEKQVFRHNDLADLEEQLASVDPDRPK----------LIAFESVYSMDGDIA 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 256 PLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGY 335
Cdd:PRK13392  196 PIEAICDLADRYNALTYVDEVHAVGLYGARGGGIAERDGL-MDRIDMIQGTLAKAFGCLGGYIAASADLIDFVRSFAPGF 274


                  ....*...
gi 1953268825 336 CFSASLPP 343
Cdd:PRK13392  275 IFTTALPP 282
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 6.18e-25

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 105.47  E-value: 6.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  98 KKCVNFASFNFLGLLdnprVKAAALASLKkygVGTCGPRGFYGTFDVHLDLEDRLAKFM--------KTEEAIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDT----LPAVAKAEKD---ALAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 170 TIASAIPAYSK-RGDIVFVDRAACFAIQKGLQASRSDIKLFK-------HNDMADLERLLKEQemedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 242 IVAEGLYMNTGTICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsiDDIDLISAN-MENSLASIG-- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLA--EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 316 -GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLKEKCKRIHKALQGIsGLKVVGeSLSPAF 394
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 395 HLQLkdstGSREKDVKLLQEIVNHCmdrSIALTQARYLEKeekclpPPSIRVVVTVeQTDEELERAARTI 464
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
101-343 4.10e-18

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 86.22  E-value: 4.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 101 VNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK 180
Cdd:PRK07179   57 IILQSNDYLNLSGHPDIIKAQIAALQEEGDSLVMSAVFLHDDSPKPQFEKKLAAFTGFESCLLCQSGWAANVGLLQTIAD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 181 RGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLkeqemedqknprkarvtRRF----IVAEGLYMNTGTICP 256
Cdd:PRK07179  137 PNTPVYIDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQI-----------------ERHgpgiIVVDSVYSTTGTIAP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 257 LPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYC 336
Cdd:PRK07179  200 LADIVDIAEEFGCVLVVDESHSLGTHGPQGAGLVAELGLT-SRVHFITASLAKAFAGRAGIITCPRELAEYVPFVSYPAI 278


                  ....*..
gi 1953268825 337 FSASLPP 343
Cdd:PRK07179  279 FSSTLLP 285
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 98-459 1.44e-17

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 85.11  E-value: 1.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:PLN02955  102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAANMAAMVA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 178 YSKRGDIVFVD-------RAACF-------AIQKGLQ-ASR---SDIKLFKHNDMADLERLLKEQEMEdqknprkarvtR 239
Cdd:PLN02955  182 IGSVASLLAASgkplkneKVAIFsdalnhaSIIDGVRlAERqgnVEVFVYRHCDMYHLNSLLSSCKMK-----------R 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 240 RFIVAEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGF-- 317
Cdd:PLN02955  251 KVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCE-ADVDLCVGTLSKAAGCHGGFia 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 318 CCGRSFVIDHQRlsGQGYCFSASLP-PLLAAAAIealnimeenpGIFSVLKEKCKRIH-----KALQGISGLKVVgeslS 391
Cdd:PLN02955  330 CSKKWKQLIQSR--GRSFIFSTAIPvPMAAAAYA----------AVVVARKEKWRRKAiwervKEFKALSGVDIS----S 393

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953268825 392 PAFHLQLkdstGSREKdvkllqeivnhcmdrsiALTQARYLEK--------EEKCLPPPS--IRVVVTVEQTDEELER 459
Cdd:PLN02955  394 PIISLVV----GNQEK-----------------ALKASRYLLKsgfhvmaiRPPTVPPNScrLRVTLSAAHTTEDVKK 450
PRK07505 PRK07505
hypothetical protein; Provisional
 97-317 7.55e-17

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 82.33  E-value: 7.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825  97 GKKCVNFASFNFLGLLDNPRVKAAALASLKKYGV-GTCGPRGFYgTFDVHLDLEDRLAKFMKTEEAIIYSYGFAT----- 170
Cdd:PRK07505   45 GHTFVNFVSCSYLGLDTHPAIIEGAVDALKRTGSlHLSSSRTRV-RSQILKDLEEALSELFGASVLTFTSCSAAHlgilp 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 171 -IASAIPAYSKRGDIVFvDRAA--CFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEmedqknprkarvtRRFIVAEGL 247
Cdd:PRK07505  124 lLASGHLTGGVPPHMVF-DKNAhaSLNILKGICADETEVETIDHNDLDALEDICKTNK-------------TVAYVADGV 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953268825 248 YmNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRG-VTEHFGISIDDIDLISANMENSLASIGGF 317
Cdd:PRK07505  190 Y-SMGGIAPVKELLRLQEKYGLFLYIDDAHGLSIYGKNGEGyVRSELDYRLNERTIIAASLGKAFGASGGV 259
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 101-294 2.75e-16

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 80.21  E-value: 2.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 101 VNFASFNFLGLLDNPRVKAAALASLKKY-------GVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIAS 173
Cdd:PRK05937    7 IDFVTNDFLGFSRSDTLVHEVEKRYRLYcrqfphaQLGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953268825 174 AIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQemedqknpRKARVTRRFIVAEGLYMNTGT 253
Cdd:PRK05937   87 LCAHLSSVTDYVLWDEQVHISVVYSLSVISGWHQSFRHNDLDHLESLLESC--------RQRSFGRIFIFVCSVYSFKGT 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1953268825 254 ICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFG 294
Cdd:PRK05937  159 LAPLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGFCHSLG 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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