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Conserved domains on  [gi|1953265508|ref|XP_038510011|]
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lung adenoma susceptibility protein 2 isoform X1 [Canis lupus familiaris]

Protein Classification

LAS2 domain-containing protein( domain architecture ID 11239280)

LAS2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 162-236 1.32e-32

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


:

Pssm-ID: 464872  Cd Length: 75  Bit Score: 119.50  E-value: 1.32e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1953265508 162 SWDTEKKQNFQEPSTPLCKDNVITPVIYTNINGRHRGRLKNPKLVNKTNKCISEPSLSFSKKLSFKDSAEHSCEK 236
Cdd:pfam15792   1 SLDIEKNPNFQEPSTPMGKDNLVTPVVYTNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSFKDSSPCSLEK 75
LAS2 super family cl24379
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 329-395 4.06e-11

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


The actual alignment was detected with superfamily member pfam15792:

Pssm-ID: 464872  Cd Length: 75  Bit Score: 59.03  E-value: 4.06e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953265508 329 LINECKCDSEHSH-CQCENPVLP-----GPTKKPFSGDKIELLILKAKRNLEHCSEELPKSTK-KDDSPCSLDK 395
Cdd:pfam15792   2 LDIEKNPNFQEPStPMGKDNLVTpvvytNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSfKDSSPCSLEK 75
 
Name Accession Description Interval E-value
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 162-236 1.32e-32

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 119.50  E-value: 1.32e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1953265508 162 SWDTEKKQNFQEPSTPLCKDNVITPVIYTNINGRHRGRLKNPKLVNKTNKCISEPSLSFSKKLSFKDSAEHSCEK 236
Cdd:pfam15792   1 SLDIEKNPNFQEPSTPMGKDNLVTPVVYTNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSFKDSSPCSLEK 75
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 329-395 4.06e-11

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 59.03  E-value: 4.06e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953265508 329 LINECKCDSEHSH-CQCENPVLP-----GPTKKPFSGDKIELLILKAKRNLEHCSEELPKSTK-KDDSPCSLDK 395
Cdd:pfam15792   2 LDIEKNPNFQEPStPMGKDNLVTpvvytNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSfKDSSPCSLEK 75
 
Name Accession Description Interval E-value
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 162-236 1.32e-32

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 119.50  E-value: 1.32e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1953265508 162 SWDTEKKQNFQEPSTPLCKDNVITPVIYTNINGRHRGRLKNPKLVNKTNKCISEPSLSFSKKLSFKDSAEHSCEK 236
Cdd:pfam15792   1 SLDIEKNPNFQEPSTPMGKDNLVTPVVYTNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSFKDSSPCSLEK 75
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 329-395 4.06e-11

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 59.03  E-value: 4.06e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953265508 329 LINECKCDSEHSH-CQCENPVLP-----GPTKKPFSGDKIELLILKAKRNLEHCSEELPKSTK-KDDSPCSLDK 395
Cdd:pfam15792   2 LDIEKNPNFQEPStPMGKDNLVTpvvytNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSfKDSSPCSLEK 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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