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Conserved domains on  [gi|1953030506|ref|XP_038431024|]
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ataxin-2 isoform X5 [Canis lupus familiaris]

Protein Classification

PABP-interacting PAM2 motif-containing protein( domain architecture ID 10627809)

PABP-interacting PAM2 motif-containing protein similar to human polyadenylate-binding protein-interacting protein 2 (PAIP2) that acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.33e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.33e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953030506    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.67e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.67e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953030506  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 664-982 4.05e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 4.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  664 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  736 KVPNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 814
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  815 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 874
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  875 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 954
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340
                   ....*....|....*....|....*...
gi 1953030506  955 fptaqqtvftihPSHVQPAYTNPPHMAH 982
Cdd:PHA03247  2984 ------------PSREAPASSTPPLTGH 2999
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.50e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


:

Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.50e-03
                           10
                   ....*....|....*.
gi 1953030506  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.33e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.33e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953030506    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.67e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.67e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953030506  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 664-982 4.05e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 4.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  664 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  736 KVPNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 814
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  815 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 874
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  875 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 954
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340
                   ....*....|....*....|....*...
gi 1953030506  955 fptaqqtvftihPSHVQPAYTNPPHMAH 982
Cdd:PHA03247  2984 ------------PSREAPASSTPPLTGH 2999
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 645-803 1.34e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 49.03  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  645 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 724
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  725 PVNQaktyrAGKVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 798
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 1953030506  799 HPHVY 803
Cdd:TIGR01628  514 FPLVE 518
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 745-985 9.37e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.10  E-value: 9.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  745 QEQHHQSAMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 819
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  820 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 892
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  893 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQ----NSFPTAQQTVFTIHPS 968
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNrlsaARVGYPQNPQPGVQPA 327

                          250
                   ....*....|....*..
gi 1953030506  969 HVQPAYTNPPHMAHVPQ 985
Cdd:pfam09770  328 PAHQAHRQQGSFGRQAP 344
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.50e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.50e-03
                           10
                   ....*....|....*.
gi 1953030506  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.33e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.33e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953030506    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.67e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.67e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953030506  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 664-982 4.05e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 4.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  664 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  736 KVPNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 814
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  815 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 874
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  875 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 954
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340
                   ....*....|....*....|....*...
gi 1953030506  955 fptaqqtvftihPSHVQPAYTNPPHMAH 982
Cdd:PHA03247  2984 ------------PSREAPASSTPPLTGH 2999
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 645-803 1.34e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 49.03  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  645 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 724
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  725 PVNQaktyrAGKVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 798
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 1953030506  799 HPHVY 803
Cdd:TIGR01628  514 FPLVE 518
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 662-952 2.14e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.46  E-value: 2.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  662 SQPKPSTTPTSPRPQAQPSPsmvGHQQPAPVYT-QPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPVNQAktyragkvPNM 740
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPLQQ-PVQPQQPYYA--------PAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  741 PQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYspqqfPNQPLVQHVPHYQSQHPHVySPVIQgnarmmaPPAHA 820
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE-----EQQSTFAPQSTYQTEQTYQ-QPAAQ-------EPLYQ 479

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  821 QPGLVsssatqygahEQTHAMYACPKLPYNKETSPSFYFaisTGSLAQQYAHPNATLHP-HTPHPQPSATPTGQQQSQHG 899
Cdd:PRK10263   480 QPQPV----------EQQPVVEPEPVVEETKPARPPLYY---FEEVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKA 546

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953030506  900 GSHPAPSPVQHHQHQAAQALHLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 952
Cdd:PRK10263   547 PSVAAVPPVEAAAAVSPLASGV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
PHA03378 PHA03378
EBNA-3B; Provisional
 647-932 8.47e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 8.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  647 STLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVytQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPV 726
Cdd:PHA03378   583 SQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL--RPIPMRPLRMQPITFNVLVFPTPHQPPQVEIT 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  727 NQAKTYraGKVPNMPQQRQEQHHqsAMMHPASAAgPPIVATPPAYSTQyvAYSPQQFPnqplvqhVPHYQSQHPHVYSPV 806
Cdd:PHA03378   661 PYKPTW--TQIGHIPYQPSPTGA--NTMLPIQWA-PGTMQPPPRAPTP--MRPPAAPP-------GRAQRPAAATGRARP 726

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  807 IQGNARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYACPKlpynketspsfyfaistgslaqqyahPNATLHPHTPHPQP 886
Cdd:PHA03378   727 PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARP--------------------------PAAAPGAPTPQPPP 780

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1953030506  887 SATPTGQQQSQHGgshPAPSPVQHHQHQAAQALHLASPQQQSAIYH 932
Cdd:PHA03378   781 QAPPAPQQRPRGA---PTPQPPPQAGPTSMQLMPRAAPGQQGPTKQ 823
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 745-985 9.37e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.10  E-value: 9.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  745 QEQHHQSAMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 819
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  820 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 892
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  893 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQ----NSFPTAQQTVFTIHPS 968
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNrlsaARVGYPQNPQPGVQPA 327

                          250
                   ....*....|....*..
gi 1953030506  969 HVQPAYTNPPHMAHVPQ 985
Cdd:pfam09770  328 PAHQAHRQQGSFGRQAP 344
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-957 2.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  665 KPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQr 744
Cdd:PHA03247  2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR- 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  745 qeqhhQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGL 824
Cdd:PHA03247  2667 -----ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP 2741

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  825 VSSSATqygaheqthamyacPKLPYNKETSPSfyfaistgslAQQYAHPNATLHPHTP--HPQPSAT-PTGQQQSQHGGS 901
Cdd:PHA03247  2742 PAVPAG--------------PATPGGPARPAR----------PPTTAGPPAPAPPAAPaaGPPRRLTrPAVASLSESRES 2797

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1953030506  902 HPAPSPVQHHQHQAAQALHLASPQQQSaiyhAGLAPTPPSMTPASNTQSPQNSFPT 957
Cdd:PHA03247  2798 LPSPWDPADPPAAVLAPAAALPPAASP----AGPLPPPTSAQPTAPPPPPGPPPPS 2849
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.50e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.50e-03
                           10
                   ....*....|....*.
gi 1953030506  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 710-805 6.54e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 6.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  710 SPGVQPLYPIPMTPMPVNQaktYRAGKVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYST--QYVAYSPQ-QFPNQ 786
Cdd:PRK10263   746 TPIVEPVQQPQQPVAPQQQ---YQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpqQPVAPQPQyQQPQQ 822

                           90
                   ....*....|....*....
gi 1953030506  787 PLVQHVPHYQSQHPHVYSP 805
Cdd:PRK10263   823 PVAPQPQYQQPQQPVAPQP 841
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 643-898 9.14e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.02  E-value: 9.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  643 QVRKSTLNPNAKEFNP--RSFSQPKPSTTPTSPRPQAQPSPSMVG---HQQPAPVytqpvcfaPNM-----MYPVPVSPG 712
Cdd:pfam09770   99 QVRFNRQQPAARAAQSsaQPPASSLPQYQYASQQSQQPSKPVRTGyekYKEPEPI--------PDLqvdasLWGVAPKKA 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  713 VQPLYPIPMTPMPVNQAKTYRagKV--------------PNMPQQRQEQHHQSAMMHPASAAgPPIVATPPAYSTQYVAY 778
Cdd:pfam09770  171 AAPAPAPQPAAQPASLPAPSR--KMmsleeveaamraqaKKPAQQPAPAPAQPPAAPPAQQA-QQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  779 SPQQFPNQPLVQHVPHYQSQHPHvySPVIQGNARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPsfy 858
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQ--SPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQP--- 322

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1953030506  859 faiSTGSLAQQYAHPNATLHPHTP----HPQPSATPTGQQQSQH 898
Cdd:pfam09770  323 ---GVQPAPAHQAHRQQGSFGRQApiitHPQQLAQLSEEEKAAY 363
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 606-960 9.66e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  606 NTEHKRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVG 685
Cdd:pfam03154  127 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  686 HQQPAPVYTQPVCFAPNMMYPV-------------------PVSPGVQPLYPIPMTPMPVNQAKTYraGKVPNMPQQRQE 746
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTAAPHtliqqtptlhpqrlpsphpPLQPMTQPPPPSQVSPQPLPQPSLH--GQMPPMPHSLQT 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  747 QhhQSAMMHPASAAGPPIVAT------PPAYSTQyVAYSPQQFPNQPLVQhvPHYQSQHPHVYSPVIQGNARM---MAPP 817
Cdd:pfam03154  285 G--PSHMQHPVPPQPFPLTPQssqsqvPPGPSPA-APGQSQQRIHTPPSQ--SQLQSQQPPREQPLPPAPLSMphiKPPP 359

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953030506  818 AHAQPGLVSSSATQYGAHEQTHAMYacpKLPYNKETSPSFYFAISTGSLAQQYAHPNA-TLHPHT-PHPQPSATPTGQQQ 895
Cdd:pfam03154  360 TTPIPQLPNPQSHKHPPHLSGPSPF---QMNSNLPPPPALKPLSSLSTHHPPSAHPPPlQLMPQSqQLPPPPAQPPVLTQ 436

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1953030506  896 SQhggSHPAPSpvqhhQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQ-SPQNSFPTAQQ 960
Cdd:pfam03154  437 SQ---SLPPPA-----ASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPtSTSSAMPGIQP 494
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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