NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1953014407|ref|XP_038424304|]
View 

polycomb protein EED isoform X1 [Canis lupus familiaris]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-463 2.35e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYV 309
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG----------------------------HTDWV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 310 DCVRWLGD--LILS------------KSGRAI--LHSHQQCMKD-PVSPNLRRHLSC--ENAIVCWkpgkmedDIDKIKP 370
Cdd:cd00200   139 NSVAFSPDgtFVASssqdgtiklwdlRTGKCVatLTGHTGEVNSvAFSPDGEKLLSSssDGTIKLW-------DLSTGKC 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 371 sesnvtiLGRFDYSQCDIWYMRFSmdFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSIL 450
Cdd:cd00200   212 -------LGTLRGHENGVNSVAFS--PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRL 276

                         330
                  ....*....|...
gi 1953014407 451 IAVCDDASIWRWD 463
Cdd:cd00200   277 ASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-463 2.35e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYV 309
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG----------------------------HTDWV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 310 DCVRWLGD--LILS------------KSGRAI--LHSHQQCMKD-PVSPNLRRHLSC--ENAIVCWkpgkmedDIDKIKP 370
Cdd:cd00200   139 NSVAFSPDgtFVASssqdgtiklwdlRTGKCVatLTGHTGEVNSvAFSPDGEKLLSSssDGTIKLW-------DLSTGKC 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 371 sesnvtiLGRFDYSQCDIWYMRFSmdFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSIL 450
Cdd:cd00200   212 -------LGTLRGHENGVNSVAFS--PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRL 276

                         330
                  ....*....|...
gi 1953014407 451 IAVCDDASIWRWD 463
Cdd:cd00200   277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-464 1.37e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 1.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319    89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319   160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 268 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWLGDlilsksGRAILHShqqcmkdpvspnlrrhl 347
Cdd:COG2319   236 GKLL----------------------------RTLTGHSGSVRSVAFSPD------GRLLASG----------------- 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 348 SCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakct 427
Cdd:COG2319   265 SADGTVRLW-------DLATGEL-------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR---- 324

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1953014407 428 TLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWDR 464
Cdd:COG2319   325 TLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 6.86e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1953014407  179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 3.43e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953014407 180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 167-269 1.70e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 167 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 241
Cdd:PTZ00420   51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                          90       100       110
                  ....*....|....*....|....*....|
gi 1953014407 242 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 269
Cdd:PTZ00420  131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-463 2.35e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYV 309
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG----------------------------HTDWV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 310 DCVRWLGD--LILS------------KSGRAI--LHSHQQCMKD-PVSPNLRRHLSC--ENAIVCWkpgkmedDIDKIKP 370
Cdd:cd00200   139 NSVAFSPDgtFVASssqdgtiklwdlRTGKCVatLTGHTGEVNSvAFSPDGEKLLSSssDGTIKLW-------DLSTGKC 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 371 sesnvtiLGRFDYSQCDIWYMRFSmdFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSIL 450
Cdd:cd00200   212 -------LGTLRGHENGVNSVAFS--PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRL 276

                         330
                  ....*....|...
gi 1953014407 451 IAVCDDASIWRWD 463
Cdd:cd00200   277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-464 1.37e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 1.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319    89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319   160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 268 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWLGDlilsksGRAILHShqqcmkdpvspnlrrhl 347
Cdd:COG2319   236 GKLL----------------------------RTLTGHSGSVRSVAFSPD------GRLLASG----------------- 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 348 SCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakct 427
Cdd:COG2319   265 SADGTVRLW-------DLATGEL-------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR---- 324

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1953014407 428 TLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWDR 464
Cdd:COG2319   325 TLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
162-463 2.68e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 2.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRS 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWlgdlils 321
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLATGELL----------------------------RTLTGHSGGVNSVAF------- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 322 ksgrailhshqqcmkdpvSPNLRRHLSC--ENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQ 399
Cdd:COG2319   297 ------------------SPDGKLLASGsdDGTVRLW-------DLATGKL-------LRTLTGHTGAVRSVAFSPD--G 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953014407 400 KMLALGNQVGKLYVWDLEVedphKAKCTTLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWD 463
Cdd:COG2319   343 KTLASGSDDGTVRLWDLAT----GELLRTLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
83-269 1.23e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407  83 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNTshpl 162
Cdd:COG2319   195 KLLRTLT-GHTGAVRSVAF---SPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGH-----SGSVRSVAFSPDGRL---- 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 242
Cdd:COG2319   261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSV 336

                         170       180
                  ....*....|....*....|....*..
gi 1953014407 243 DYDLLGEKIMSCGMDHSLKLWRINSKR 269
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
83-269 3.24e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 3.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407  83 KCVNSLKEdHNQPLFGVQFnwhSKEGDPLvfATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshp 161
Cdd:COG2319   153 KLLRTLTG-HSGAVTSVAF---SPDGKLL--ASGSDdGTVRLWDLATGKLLRTLTGHTGA-----VRSVAFSPDGKL--- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 162 lLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFGgveGHRDEVLS 241
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNS 293

                         170       180
                  ....*....|....*....|....*...
gi 1953014407 242 ADYDLLGEKIMSCGMDHSLKLWRINSKR 269
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWDLATGK 321
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-264 1.75e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 1.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407  81 SFKCVNSLKeDHNQPLFGVQFNWHSKegdplvFATVGS--NRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNT 158
Cdd:cd00200   124 TGKCLTTLR-GHTDWVNSVAFSPDGT------FVASSSqdGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEK 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 159 shplLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDE 238
Cdd:cd00200   192 ----LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNS 263

                         170       180
                  ....*....|....*....|....*.
gi 1953014407 239 VLSADYDLLGEKIMSCGMDHSLKLWR 264
Cdd:cd00200   264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
83-267 2.97e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407  83 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshpl 162
Cdd:COG2319   237 KLLRTLT-GHSGSVRSVAF---SPDGRLLASGS-ADGTVRLWDLATGELLRTLTGHSGG-----VNSVAFSPDGKL---- 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 242
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSV 378

                         170       180
                  ....*....|....*....|....*
gi 1953014407 243 DYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319   379 AFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-269 4.29e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 4.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 148 YTCAWtydsNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVA 227
Cdd:cd00200    97 SSVAF----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVA 171

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1953014407 228 IFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269
Cdd:cd00200   172 TL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
162-463 5.52e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 5.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRWL--GDLI 319
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG----------------------------HSGAVTSVAFSpdGKLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 320 LS------------KSGRAI--LHSHQqcmkDPV-----SPNlRRHL---SCENAIVCWkpgkmedDIDKIKPsesnVTI 377
Cdd:COG2319   178 ASgsddgtvrlwdlATGKLLrtLTGHT----GAVrsvafSPD-GKLLasgSADGTVRLW-------DLATGKL----LRT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 378 LGRFDYSqcdIWYMRFSMDfwQKMLALGNQVGKLYVWDLEvedpHKAKCTTLTHHkcGAAIRQTSFSRDSSILIAVCDDA 457
Cdd:COG2319   242 LTGHSGS---VRSVAFSPD--GRLLASGSADGTVRLWDLA----TGELLRTLTGH--SGGVNSVAFSPDGKLLASGSDDG 310


                  ....*.
gi 1953014407 458 SIWRWD 463
Cdd:COG2319   311 TVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-276 7.20e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 7.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407  81 SFKCVNSLkEDHNQPLFGVQFNWHskegDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWtydsNTSH 160
Cdd:cd00200    82 TGECVRTL-TGHTSYVSSVAFSPD----GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW-----VNSVAF----SPDG 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 161 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVL 240
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTL---RGHENGVN 223

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1953014407 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276
Cdd:cd00200   224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 6.86e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1953014407  179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 3.43e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953014407 180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 167-269 1.70e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 167 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 241
Cdd:PTZ00420   51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                          90       100       110
                  ....*....|....*....|....*....|
gi 1953014407 242 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 269
Cdd:PTZ00420  131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
PTZ00421 PTZ00421
coronin; Provisional
 183-262 9.43e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.34  E-value: 9.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953014407 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIfggVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262
Cdd:PTZ00421  118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV---IKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH