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Conserved domains on  [gi|1952979639|ref|XP_038412417|]
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muskelin isoform X6 [Canis lupus familiaris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Muskelin_N super family cl18491
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 1-115 1.23e-63

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


The actual alignment was detected with superfamily member pfam06588:

Pssm-ID: 284099  Cd Length: 197  Bit Score: 208.91  E-value: 1.23e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639   1 MNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKY 79
Cdd:pfam06588  82 RDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMV 161

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952979639  80 REQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 115
Cdd:pfam06588 162 REGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
192-467 2.33e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 192 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 271
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 272 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 351
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 352 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 431
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952979639 432 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 467
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 114-166 9.56e-03

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 34.85  E-value: 9.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952979639  114 HPMLTDLHDKLVLKGDFDACEELIEKAVNDGL-----FNQYISQQEYKPRWSQIIPKS 166
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLernskLEFELRKQKFLELVRQGKLEE 58
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 1-115 1.23e-63

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 208.91  E-value: 1.23e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639   1 MNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKY 79
Cdd:pfam06588  82 RDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMV 161

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952979639  80 REQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 115
Cdd:pfam06588 162 REGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
192-467 2.33e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 192 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 271
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 272 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 351
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 352 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 431
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952979639 432 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 467
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
Kelch_3 pfam13415
Galactose oxidase, central domain;
190-242 3.44e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.44e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952979639 190 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 242
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 215-383 1.17e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 215 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 294
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 295 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 374
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1952979639 375 NRCLYVFGG 383
Cdd:PLN02153  137 ENHVYVFGG 145
Kelch smart00612
Kelch domain;
193-219 1.20e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.20e-03
                           10        20
                   ....*....|....*....|....*..
gi 1952979639  193 VYLFGGWDGTQDLADFWAYSVKENQWT 219
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 80-110 7.67e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 7.67e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1952979639   80 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 110
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 114-166 9.56e-03

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 34.85  E-value: 9.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952979639  114 HPMLTDLHDKLVLKGDFDACEELIEKAVNDGL-----FNQYISQQEYKPRWSQIIPKS 166
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLernskLEFELRKQKFLELVRQGKLEE 58
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 1-115 1.23e-63

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 208.91  E-value: 1.23e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639   1 MNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKY 79
Cdd:pfam06588  82 RDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMV 161

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952979639  80 REQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 115
Cdd:pfam06588 162 REGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
192-467 2.33e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 192 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 271
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 272 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 351
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 352 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 431
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952979639 432 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 467
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
Kelch_3 pfam13415
Galactose oxidase, central domain;
190-242 3.44e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.44e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952979639 190 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 242
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 215-383 1.17e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 215 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 294
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 295 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 374
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1952979639 375 NRCLYVFGG 383
Cdd:PLN02153  137 ENHVYVFGG 145
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 178-222 4.00e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 4.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1952979639 178 MRGGHQMVidVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCIS 222
Cdd:pfam01344   1 RRSGAGVV--VVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
PLN02153 PLN02153
epithiospecifier protein
 193-284 4.12e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 193 VYLFGGWDGTQDLADFWAYSVKENQWTCISRdTEKENGPSARSCHKMCIDiqRRQIYTLGRYLDSSVRNSKSLKSDFYRY 272
Cdd:PLN02153   88 LYIFGGRDEKREFSDFYSYDTVKNEWTFLTK-LDEEGGPEARTFHSMASD--ENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                          90
                  ....*....|..
gi 1952979639 273 DIDTNTWMLLSE 284
Cdd:PLN02153  165 NIADGKWVQLPD 176
PLN02193 PLN02193
nitrile-specifier protein
 192-294 9.36e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 9.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 192 TVYLFGGWDGTQDLADFWAYSVKENQWTCIsrdTEKENGPSARSCHKMCIDiqRRQIYTLGRYldSSVRNSKSLKSdfyr 271
Cdd:PLN02193  230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAAD--EENVYVFGGV--SATARLKTLDS---- 298

                          90       100
                  ....*....|....*....|....*.
gi 1952979639 272 YDIDTNTWMLLS---EDTAADGGPKL 294
Cdd:PLN02193  299 YNIVDKKWFHCStpgDSFSIRGGAGL 324
PLN02153 PLN02153
epithiospecifier protein
 279-466 2.07e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 279 WMLLSEDTAADGGPKLvfDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLLredSCNAGP 358
Cdd:PLN02153    9 WIKVEQKGGKGPGPRC--SHGIAVVGDK--LYSFGGE-LKPNEHIDKD---------LYVFDFNTHTWSIA---PANGDV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 359 EDIqSRIGHCMLfhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRATIDPelNEIHVL 438
Cdd:PLN02153   72 PRI-SCLGVRMV--AVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFL---TKLDEEGGPEARTFHSMASDE--NHVYVF 143

                         170       180
                  ....*....|....*....|....*...
gi 1952979639 439 SGLSKDKEKREENVRNSFWIYDIVRNSW 466
Cdd:PLN02153  144 GGVSKGGLMKTPERFRTIEAYNIADGKW 171
Kelch_4 pfam13418
Galactose oxidase, central domain;
179-222 4.40e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1952979639 179 RGGHQMVIdVQTETVYLFGG--WDGTQdLADFWAYSVKENQWTCIS 222
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGegEDGTL-LSDLWVFDLSTNEWTRLG 45
PLN02193 PLN02193
nitrile-specifier protein
 291-466 5.10e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 5.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 291 GPKLVFDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLlredSCNAGPEDIQSRIGHCML 370
Cdd:PLN02193  162 GPGLRCSHGIAQVGNK--IYSFGGE-FTPNQPIDKH---------LYVFDLETRTWSI----SPATGDVPHLSCLGVRMV 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979639 371 fhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRAtidpELNEIHVLSGLSKdkekree 450
Cdd:PLN02193  226 --SIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAA----DEENVYVFGGVSA------- 289

                         170
                  ....*....|....*..
gi 1952979639 451 NVR-NSFWIYDIVRNSW 466
Cdd:PLN02193  290 TARlKTLDSYNIVDKKW 306
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 364-401 9.10e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 9.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1952979639 364 RIGHCMLFHskNRCLYVFGGQRSKTYLNDFFSYDVDSD 401
Cdd:pfam01344   2 RSGAGVVVV--GGKIYVIGGFDGNQSLNSVEVYDPETN 37
Kelch smart00612
Kelch domain;
193-219 1.20e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.20e-03
                           10        20
                   ....*....|....*....|....*..
gi 1952979639  193 VYLFGGWDGTQDLADFWAYSVKENQWT 219
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 80-110 7.67e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 7.67e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1952979639   80 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 110
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 114-166 9.56e-03

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 34.85  E-value: 9.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952979639  114 HPMLTDLHDKLVLKGDFDACEELIEKAVNDGL-----FNQYISQQEYKPRWSQIIPKS 166
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLernskLEFELRKQKFLELVRQGKLEE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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