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Conserved domains on  [gi|1952977850|ref|XP_038411672|]
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nicotinate phosphoribosyltransferase isoform X2 [Canis lupus familiaris]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 15-515 0e+00

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PLN02885:

Pssm-ID: 473867 [Multi-domain]  Cd Length: 545  Bit Score: 588.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLG----------GQLRGVPLAGTLAHSFVTSFSGTEVPPDPMLAPAASPGPKVDLTARVEAWLD--G 242
Cdd:PLN02885  172 GPDGGISASKYCYLGgfdatsnveaGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 243 VCAHLGLGVQEPHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIR 322
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 323 GVFRTVSARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDP 402
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 403 EKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelRVW---PHGAREACTVRPAGVEPLLRL-WVQQGQLC-EPL 477
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCyWDGSSGKPrEEL 489

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1952977850 478 PSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 515
Cdd:PLN02885  490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-515 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 588.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLG----------GQLRGVPLAGTLAHSFVTSFSGTEVPPDPMLAPAASPGPKVDLTARVEAWLD--G 242
Cdd:PLN02885  172 GPDGGISASKYCYLGgfdatsnveaGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 243 VCAHLGLGVQEPHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIR 322
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 323 GVFRTVSARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDP 402
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 403 EKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelRVW---PHGAREACTVRPAGVEPLLRL-WVQQGQLC-EPL 477
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCyWDGSSGKPrEEL 489

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1952977850 478 PSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 515
Cdd:PLN02885  490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-515 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 538.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSFSGtevppdpmlapaaspgpkvdltarveawldgvc 244
Cdd:TIGR01513 157 GPDAALKAARAAYIGGadgtsnvlagRLYGIPVSGTMAHSFVMSFDN--------------------------------- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 245 ahlglgvqephrgERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYrAVGIRLDSGDLLQQAQEIRGV 324
Cdd:TIGR01513 204 -------------ELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 325 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEK 404
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 405 QTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelrvwphgarEACTVRPAGVEPLLRLWVQQGQLCEPLPSLAESR 484
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDLNQ----------EKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1952977850 485 AFAQLSLSRLSPEHKRLEWPALYQVALSDKL 515
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-388 1.80e-149

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 431.23  E-value: 1.80e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570     1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDcSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570    79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSFSgtevppdpmlapaaspgpkvdltarveawldgvc 244
Cdd:cd01570   157 GPDAALSAARAAYIGGfdgtsnvlagKLYGIPVSGTMAHSFVQAFD---------------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 245 ahlglgvqephrGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIRGV 324
Cdd:cd01570   203 ------------DELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1952977850 325 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLV 388
Cdd:cd01570   271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-522 4.58e-122

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 365.62  E-value: 4.58e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  16 LLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488     6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  96 LRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488    84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 176 PDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSfsgtevppdpmlapaaspgpkvdltarveawldgvca 245
Cdd:COG1488   162 LEAAVAAARAAYLAGfagtsnvlagRYYGIPSVGTMAHSFVQA------------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 246 hlglgvqepHRGERAAFVAYALAFPQAFQGLLDTYSVQrSGLPNflAVALAlGELG--YRAVGIRLDSGDLLQQAQEIRg 323
Cdd:COG1488   205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQAR- 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 324 vfrtvsarfQMPW---LESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGG----QPRM 396
Cdd:COG1488   271 ---------ELLDeagLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVI 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 397 KLTEDPEKQTLPGSKAAFRlLGPEGSLLLDVLQLAEEPPPQAGqelrvwphgareactvrpagvEPLLRLWVQQGQLCEP 476
Cdd:COG1488   342 KLSETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYE 399

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1952977850 477 LPSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKLRALVDRL 522
Cdd:COG1488   400 LPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.19e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 156.13  E-value: 1.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  16 LLTDLYQATMALGYWRAGRaREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1952977850  96 LRALDCSDVTVrALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-515 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 588.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885   12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885   92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLG----------GQLRGVPLAGTLAHSFVTSFSGTEVPPDPMLAPAASPGPKVDLTARVEAWLD--G 242
Cdd:PLN02885  172 GPDGGISASKYCYLGgfdatsnveaGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 243 VCAHLGLGVQEPHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIR 322
Cdd:PLN02885  252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 323 GVFRTVSARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDP 402
Cdd:PLN02885  332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 403 EKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelRVW---PHGAREACTVRPAGVEPLLRL-WVQQGQLC-EPL 477
Cdd:PLN02885  412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCyWDGSSGKPrEEL 489

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1952977850 478 PSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 515
Cdd:PLN02885  490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-515 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 538.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSFSGtevppdpmlapaaspgpkvdltarveawldgvc 244
Cdd:TIGR01513 157 GPDAALKAARAAYIGGadgtsnvlagRLYGIPVSGTMAHSFVMSFDN--------------------------------- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 245 ahlglgvqephrgERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYrAVGIRLDSGDLLQQAQEIRGV 324
Cdd:TIGR01513 204 -------------ELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 325 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEK 404
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 405 QTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPPQAGQelrvwphgarEACTVRPAGVEPLLRLWVQQGQLCEPLPSLAESR 484
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDLNQ----------EKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1952977850 485 AFAQLSLSRLSPEHKRLEWPALYQVALSDKL 515
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-388 1.80e-149

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 431.23  E-value: 1.80e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570     1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDcSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570    79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSFSgtevppdpmlapaaspgpkvdltarveawldgvc 244
Cdd:cd01570   157 GPDAALSAARAAYIGGfdgtsnvlagKLYGIPVSGTMAHSFVQAFD---------------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 245 ahlglgvqephrGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGELGYRAVGIRLDSGDLLQQAQEIRGV 324
Cdd:cd01570   203 ------------DELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1952977850 325 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLV 388
Cdd:cd01570   271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
 15-515 2.40e-134

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 397.60  E-value: 2.40e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASvlPPDTDPAFFE 94
Cdd:PRK09243   10 ALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRS--LGIFDEDFLD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRRAQ 174
Cdd:PRK09243   88 YLRNFRFT-GDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAG-GRPLLEFGSRRAQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSfsgtevppdpmlapaaspgpkvdltarveawldgvc 244
Cdd:PRK09243  166 GPDAAVWAARAAYIGGfdatsnvlagKRYGIPVSGTMAHSFVQA------------------------------------ 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 245 ahlglgvqepHRGERAAFVAYALAFPQAFQGLLDTYSVQRSGLPNFLAVALALGElGYRAVGIRLDSGDLLQQAQEIRgv 324
Cdd:PRK09243  210 ----------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKELGD-GIELGGVRIDSGDLAYLSKKVR-- 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 325 frtvsARFQMPWLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGG----QPRMKLTE 400
Cdd:PRK09243  277 -----KMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGVYKLVAIEGeggmIPKIKLSN 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 401 DPEKQTLPGSKAAFRLLGPEGSLLLDVLQLAEEPPpqaGQELRVW-PHGAREACTVRPAGVEPLLRLWVQQGQLCEPLPS 479
Cdd:PRK09243  352 SPEKVTTPGRKQVYRIYDKGGKAEADVITLADEEE---EEPLKMFhPVHTYKSKTVKNFDAEPLLVPVMENGKRVYELPS 428

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1952977850 480 LAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKL 515
Cdd:PRK09243  429 LEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-522 4.58e-122

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 365.62  E-value: 4.58e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  16 LLTDLYQATMALGYWRAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488     6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  96 LRALDCSdVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488    84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 176 PDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSfsgtevppdpmlapaaspgpkvdltarveawldgvca 245
Cdd:COG1488   162 LEAAVAAARAAYLAGfagtsnvlagRYYGIPSVGTMAHSFVQA------------------------------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 246 hlglgvqepHRGERAAFVAYALAFPQAFQGLLDTYSVQrSGLPNflAVALAlGELG--YRAVGIRLDSGDLLQQAQEIRg 323
Cdd:COG1488   205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQAR- 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 324 vfrtvsarfQMPW---LESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGG----QPRM 396
Cdd:COG1488   271 ---------ELLDeagLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVI 341

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 397 KLTEDPEKQTLPGSKAAFRlLGPEGSLLLDVLQLAEEPPPQAGqelrvwphgareactvrpagvEPLLRLWVQQGQLCEP 476
Cdd:COG1488   342 KLSETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYE 399

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1952977850 477 LPSLAESRAFAQLSLSRLSPEHKRLEWPALYQVALSDKLRALVDRL 522
Cdd:COG1488   400 LPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
 16-524 7.45e-94

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 292.81  E-value: 7.45e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  16 LLTDLYQATMALGYWRAGRAReQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLP-PDTDPAFFE 94
Cdd:PRK12484    6 LLTDLYEVTMANAYLREGMSA-PATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQfSEEFLAWLA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRaLDCSdvtVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLiAGPEKRLLEMGLRRAQ 174
Cdd:PRK12484   85 GLR-FTGD---VRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVL-AAAGRPVVDFGARRAH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 175 GPDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSFsgtevpPDpmlapaaspgpkvdltarveawldgvc 244
Cdd:PRK12484  160 GTDAACYVARASYLAGaagtsnvlaaRQYGIPASGTMAHSFVEAF------PD--------------------------- 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 245 ahlglgvqephrgERAAFVAYALAFPQAFQGLLDTYSVQRsGLPNFLAVALALGElGYRAVGIRLDSGDLLQQAQEIRGV 324
Cdd:PRK12484  207 -------------EVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAI 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 325 FRTVSarfqmpwLESISIAVSNNIDEKELARLAQEGSEVNVIGIGTNVVTCPRQPSLGCVYKLVSVGGQPRMKLTedPEK 404
Cdd:PRK12484  272 LDAAG-------LEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVLDSAYKLVAYEGRGVTKLS--SGK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 405 QTLPGSKAAFRLLGPEGSlLLDVLQLAEEPPpqagqelrvwphgareactvrPAGVEPLLRLWVQQGQLCEPLPSLAESR 484
Cdd:PRK12484  343 VTYPGRKQVFRLYEHGTA-CGDVIGLHTENI---------------------PDGREPLLVPVMTNGRRIQHAPTLDGAR 400

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1952977850 485 AFAQLSLSRLSPEHKRLEWPALYQVALSDKLRALVDRLGA 524
Cdd:PRK12484  401 DWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTA 440
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
 15-386 8.12e-88

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 273.76  E-value: 8.12e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  15 PLLTDLYQATMALGYWrAGRAREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPpdtDPAFFE 94
Cdd:cd01567     1 LLDTDLYKLTMMQAYL-YPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLI---FGEFFL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  95 HLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAG-----------PEK 163
Cdd:cd01567    77 YLLFLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGglletkdnleeLGF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 164 RLLEMGLRRAQGPDGGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSFSGTEVppdpmlapaaspgpkvdlt 233
Cdd:cd01567   157 KLHDFGTRRRHSPEAALSGGRAALIGGfggtsnvaaaKKLGIPPIGTMAHSWIQAFGALEE------------------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 234 arveawldgvcahlglgvqephrgerAAFVAYALAFPQAFQGLL----DTYSVQRsGLPNFLAVALALGElGYRAVGIRL 309
Cdd:cd01567   218 --------------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRL 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952977850 310 DSGDLLQQAQEIRGVFRTVSArfqmpWLESISIAVSNNID-EKELARL-AQEGSEVNVIGIGTNVVTCPRQPSLGCVYK 386
Cdd:cd01567   270 DSGDPVELIKKVRKHLDELGI-----DLNKKKIIISGDLDtEEAIELLlEQGASPNDAFGVGTSLTNDLGRPPLGFVYK 343
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
 19-386 3.06e-46

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 163.18  E-value: 3.06e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  19 DLYQATMALGYwraGRAREQAEFELFFRGCPFGgafaLAAGLRDCVRFLRAFRLRDadvqflasvlppdtdpaffehlra 98
Cdd:cd00516     1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRFPG------------------------ 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  99 ldcsDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIA-GPEKRLLEMGLRRAQgPD 177
Cdd:cd00516    50 ----PLVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkGANTKVHDFGTRKTT-PG 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 178 GGLTASTYSYLGG----------QLRGVPLAGTLAHSFVTSFsgtevppdpmlapaaspgpkvdltarveawldgvcahl 247
Cdd:cd00516   125 LRLLEKYAVLIGGgdghrnglsdAILIKDNHGTMAHSIIQAF-------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 248 glgvqephrGERAAFVAYALAFPQAFQGLLDTYSvqrSGLPNFLAVALALgelgyRAVGIRLDSGDL--LQQAQEIRGVF 325
Cdd:cd00516   167 ---------GELAAVKALRRWLPELFIALIDVEV---DTLEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKAR 229

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1952977850 326 rtvsARFQMPWLESISIAVSNNIDEKELARLAQEGseVNVIGIGTNVVTCprqPSLGCVYK 386
Cdd:cd00516   230 ----AHLDGKGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---PPLDIVLK 281
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.19e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 156.13  E-value: 1.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  16 LLTDLYQATMALGYWRAGRaREQAEFELFFRGCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1952977850  96 LRALDCSDVTVrALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 411-518 9.44e-31

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 115.36  E-value: 9.44e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 411 KAAFRLLGPEGSLLLDVLQLAEEPPPQAGQELRVW-PHGAREACTVRPAGVEPLLRLWVQQGQLCEPLPSLAESRAFAQL 489
Cdd:pfam17956   2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFhPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81

                          90       100
                  ....*....|....*....|....*....
gi 1952977850 490 SLSRLSPEHKRLEWPALYQVALSDKLRAL 518
Cdd:pfam17956  82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
NAPRTase_B cd01571
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ...
 94-397 3.81e-20

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238805 [Multi-domain]  Cd Length: 302  Bit Score: 90.80  E-value: 3.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  94 EHLRALDCSDVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLRR- 172
Cdd:cd01571    43 EVLALLEGLPVKVYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAG-DKPVISFGDRRd 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 173 --AQGPDGGLTAstysYLGG----------QLRGVPLAGTLAHSFVTSFSGtevppdpmlapaaspgpkvdltARVEAWl 240
Cdd:cd01571   122 hpAIQPMDGRAA----YIGGcdgvstvlgaELLGEKPSGTMPHALIQIFGG----------------------DQVEAW- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 241 dgvcahlglgvqephrgeraafVAYALAFPQAFQ--GLLDTYSVQRsglpnfLAVALALGELGYRAVGIRLDSgdllqqA 318
Cdd:cd01571   175 ----------------------KAFDETYPEDVPriALIDTFNDEK------EEALKAAKALGDKLDGVRLDT------P 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 319 QEIRGVFRTVSARFQmpW------LESISIAVSNNIDEKELARLAQEGseVNVIGIGTNVVTCprqPSLGCVYKLVSVGG 392
Cdd:cd01571   221 SSRRGVFRYLIREVR--WaldirgYKHVKIFVSGGLDEEDIKELEDVG--VDAFGVGTAISKA---PPVDFTMDIVEVNG 293


                  ....*
gi 1952977850 393 QPRMK 397
Cdd:cd01571   294 QPIAK 298
PRK08662 PRK08662
nicotinate phosphoribosyltransferase; Reviewed
 103-370 1.65e-15

nicotinate phosphoribosyltransferase; Reviewed


Pssm-ID: 236328 [Multi-domain]  Cd Length: 343  Bit Score: 77.99  E-value: 1.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 103 DVTVRALPEGSLAFPNVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGpEKRLLEMGLR----------- 171
Cdd:PRK08662   69 PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAG-DKPVLSFGARhvhpaiapmmd 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 172 RAQ---GPDGgltAStySYLGGQLRGVPLAGTLAHSFVTSFSGTevppdpmlapaaspgpkvdltarVEAWLdgvcahlg 248
Cdd:PRK08662  148 RAAyigGCDG---VS--GVLGAELLGIEPSGTMPHALILIFGDQ-----------------------VEAWK-------- 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 249 lgvqephrgeraafvAYALAFPQAFQ--GLLDTYSVQRSglpNFLAVALALGElgyRAVGIRLDSgdllqqAQEIRGVFR 326
Cdd:PRK08662  192 ---------------AFDEVVPPDVPriALVDTFKDERE---EALRAAEALGD---RLDGVRLDT------PSSRRGNFR 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1952977850 327 T----VSARFQMPWLESISIAVSNNIDEKELARLAQegsEVNVIGIGT 370
Cdd:PRK08662  245 KivreVRWTLDIRGYEHVKIFVSGGLDPERIRELRD---VVDGFGVGT 289
PncB_like cd01401
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ...
 14-406 1.38e-08

Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.


Pssm-ID: 238695 [Multi-domain]  Cd Length: 377  Bit Score: 56.87  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  14 RPLL-TDLYQATMALGYWRAgRAREQAEFELFFRGCPFGGAFALAAgLRDCVRFLRAFRLRDADVQFLASVLPPDTdPAF 92
Cdd:cd01401     1 RSLLdTDLYKLTMQQAVLHH-YPDVQVTYEFTNRSPEDFLEEAAEA-LREQIDHLANLRFSEEELAYLRRSLPFLK-PDY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  93 FEHLRA--LDCSDVTVRA-LPEGSLAfpnvplLQVSGPLLVVQLLETPLLCLVS--YASLIATNA--------------- 152
Cdd:cd01401    78 LDYLELfrLNPEEVVVRLdTGKGQLD------IRISGPWKDTILYEVPLLAIVSevYFRFRDADWdyeeqlekleekler 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 153 --ARLRLIAGPEKRLLEMGLRRAQGPD------GGLTASTYSYLGG-------QLRGVPLAGTLAHSFVTSFSGtevppd 217
Cdd:cd01401   152 llEEAKRRDLNGFRFSDFGTRRRFSYEvqetvlKGLKQAAPGYLTGtsnvhfaMKYGLTPIGTVAHEWFMAHQA------ 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 218 pmLAPAASPGPKVDLtarvEAWLDGVCAHLGLgvqephrgeraafvayalafpqafqGLLDTYsvqrsGLPNFLAVALAl 297
Cdd:cd01401   226 --LTGDLKDSQKAAL----ERWVREYGGDLGI-------------------------ALTDTF-----GTDAFLRDFDL- 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 298 gELGYRAVGIRLDSGDllqqaqEIRGVFRTVSarfqmpWLESISIA-------VSNNID-EK--ELARLAQEGseVNVI- 366
Cdd:cd01401   269 -YFAKLFDGVRHDSGD------PFEWGEKAIA------HYEKLGIDpktktlvFSDGLDvEKalELYEYFKGR--IKVSf 333

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1952977850 367 GIGTN----VVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEKQT 406
Cdd:cd01401   334 GIGTNltndFGNKEKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
 14-406 4.98e-08

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 55.15  E-value: 4.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  14 RPLL-TDLYQATMALGYWRAGRaREQAEFELFFRGcpfGGAFA--LAAGLRDCVRFLRAFRLRDADVQFLAS--VLPPDt 88
Cdd:PRK05321   10 RSLLdTDFYKLTMQQAVLHHYP-DAQVEYEFICRN---DEVDLaeYIDEIREQLDHLCTLRLTDDELDYLRGlpFFKPD- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  89 dpaFFEHLRA--LDCSDVTVRAlPEGSLAfpnvplLQVSGPLLVVQLLETPLLCLVS-----YASLIATNA---ARL--- 155
Cdd:PRK05321   85 ---FLDWLRLfrLNPYEVTVSI-DDGQLD------IRIEGPWLETILWEVPLLAIISelyfrARSPEVLYAqakRRLwek 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 156 --RLIAGPEK---RLLEMGLRRaqgpdggltasTYSY-------------LGGQLRG---VPLA--------GTLAHSFv 206
Cdd:PRK05321  155 ieLLKALPDLsgfKIADFGTRR-----------RFSFewqeevvealkegLPGAFVGtsnVHLAmklgltpiGTMAHEW- 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 207 tsfsgtevppdPMLAPAASPGPKVDLTARVEAWLDGVCAHLGlgvqephrgeraafVAyalafpqafqgLLDTYsvqrsG 286
Cdd:PRK05321  223 -----------FMAHQALGPRLRDSQYAALEDWVREYRGDLG--------------IA-----------LTDTI-----G 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 287 LPNFLA-VALALGELgYraVGIRLDSGDLLQQAQEIrgvfrtvsarfqMPWLESISI------AV-SNNID-EKELARLA 357
Cdd:PRK05321  262 MDAFLRdFDLYFAKL-F--DGLRHDSGDPIEWGEKA------------IAHYEKLGIdprtktLVfSDGLDfDKALELYR 326

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952977850 358 QEGSEVNVI-GIGTNvVTC--PRQPSLGCVYKLVSVGGQPRMKLTEDPEKQT 406
Cdd:PRK05321  327 HFKGRIKLSfGIGTN-LTNdfPGVKPLNIVIKLVECNGRPVAKLSDSPGKTM 377
PRK09198 PRK09198
putative nicotinate phosphoribosyltransferase; Provisional
 104-212 1.91e-04

putative nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 236407 [Multi-domain]  Cd Length: 463  Bit Score: 44.12  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850 104 VTVRALPEGSLAFPNVPLLQVSG--PLL--VVQLLETPLLCLVSYASLIATNAARLRLIAgpeKRLLEmglrraqgpdgg 179
Cdd:PRK09198   98 LRIKAVPEGSVVPVHNVLMTIENtdPEFfwLPNYLETLLLRNVWYPSTVATISWEYKQLI---RQYLE------------ 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1952977850 180 LTASTYSYLGGQL-----RGVP-----LAGTLAHsfVTSFSGT 212
Cdd:PRK09198  163 KTADDLDFLPFQLhdfgaRGMSslesaALGGAAH--LVSFLGT 203
nadV PHA02594
nicotinamide phosphoribosyl transferase; Provisional
 42-150 7.42e-03

nicotinamide phosphoribosyl transferase; Provisional


Pssm-ID: 222898 [Multi-domain]  Cd Length: 470  Bit Score: 38.86  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977850  42 ELFFRGCPFGGAF---ALAAGLRDCVRFLRAFRLRDADVQF----LASVLPPDTDPAffEHLRA---LDCSDVTVRALPE 111
Cdd:PHA02594   31 YVMFYLEPRGGKFfdkVVVFGIQYFVKKYFFEPITMEVVEEahelVKAHLGKDVFNR--EHWEAlhdLGYLPIEVRAVPE 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1952977850 112 GSLAFPNVPLLQV----SGPLLVVQLLETPLLCLVSYASLIAT 150
Cdd:PHA02594  109 GTVVPVKVPVLTIenthPDFFWLAGYLETVILRGVWYPSTVAT 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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