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Conserved domains on  [gi|1952977301|ref|XP_038411467|]
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protein tilB homolog isoform X1 [Canis lupus familiaris]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 26-162 2.44e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 2.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  26 LSLHQQEIERLEHIDkWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEGLTKLDLTVNFI----- 100
Cdd:cd21340     7 LYLNDKNITKIDNLS-LCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRIsvveg 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301 101 -------------------GE-------------------------LSSIK--------------------------TLQ 110
Cdd:cd21340    86 lenltnleelhienqrlppGEkltfdprslaalsnslrvlnisgnnIDSLEplaplrnleqldasnnqisdleelldLLS 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952977301 111 HNIHLKELFLMGNPCADFDGYRQFVVATLQRLKWLDGKEIERSERiQALQNF 162
Cdd:cd21340   166 SWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER-QFLKRL 216
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 26-162 2.44e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 2.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  26 LSLHQQEIERLEHIDkWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEGLTKLDLTVNFI----- 100
Cdd:cd21340     7 LYLNDKNITKIDNLS-LCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRIsvveg 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301 101 -------------------GE-------------------------LSSIK--------------------------TLQ 110
Cdd:cd21340    86 lenltnleelhienqrlppGEkltfdprslaalsnslrvlnisgnnIDSLEplaplrnleqldasnnqisdleelldLLS 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952977301 111 HNIHLKELFLMGNPCADFDGYRQFVVATLQRLKWLDGKEIERSERiQALQNF 162
Cdd:cd21340   166 SWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER-QFLKRL 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-146 2.95e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 2.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  22 SLEELSLHQQEIERL-EHIDKwCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEGLTKLDLTVN 98
Cdd:COG4886   114 NLESLDLSGNQLTDLpEELAN-LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1952977301  99 FIGELSsiKTLQHNIHLKELFLMGNPCADFDGyrqfVVATLQRLKWLD 146
Cdd:COG4886   193 QITDLP--EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR_9 pfam14580
Leucine-rich repeat;
1-162 9.49e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.77  E-value: 9.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301   1 MGRITEDLIRRNAEHNDCIifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  81 I-ENL-EGCEGLTKLDLTVNFIGELSSIKTLQHNIHLKELFLMGNPCADFDGYRQFVVATLQRLKWLDGKEIERSERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158


                  ....
gi 1952977301 159 LQNF 162
Cdd:pfam14580 159 EKMF 162
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 26-162 2.44e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.68  E-value: 2.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  26 LSLHQQEIERLEHIDkWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEGLTKLDLTVNFI----- 100
Cdd:cd21340     7 LYLNDKNITKIDNLS-LCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRIsvveg 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301 101 -------------------GE-------------------------LSSIK--------------------------TLQ 110
Cdd:cd21340    86 lenltnleelhienqrlppGEkltfdprslaalsnslrvlnisgnnIDSLEplaplrnleqldasnnqisdleelldLLS 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952977301 111 HNIHLKELFLMGNPCADFDGYRQFVVATLQRLKWLDGKEIERSERiQALQNF 162
Cdd:cd21340   166 SWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER-QFLKRL 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-146 2.95e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 2.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  22 SLEELSLHQQEIERL-EHIDKwCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEGLTKLDLTVN 98
Cdd:COG4886   114 NLESLDLSGNQLTDLpEELAN-LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1952977301  99 FIGELSsiKTLQHNIHLKELFLMGNPCADFDGyrqfVVATLQRLKWLD 146
Cdd:COG4886   193 QITDLP--EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-169 2.98e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEGLTKLDLTVNFIG 101
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952977301 102 ELsSIKTLQHNIHLKELFLMGNPCADFDGYRQFVVATLQRLKWLDGKEIERSERIQALQNFPVIEQQI 169
Cdd:COG4886   286 DL-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
LRR_9 pfam14580
Leucine-rich repeat;
1-162 9.49e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.77  E-value: 9.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301   1 MGRITEDLIRRNAEHNDCIifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK 80
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  81 I-ENL-EGCEGLTKLDLTVNFIGELSSIKTLQHNIHLKELFLMGNPCADFDGYRQFVVATLQRLKWLDGKEIERSERIQA 158
Cdd:pfam14580  79 IgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158


                  ....
gi 1952977301 159 LQNF 162
Cdd:pfam14580 159 EKMF 162
LRR_8 pfam13855
Leucine rich repeat;
46-98 1.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1952977301  46 LKILYLQNNLIGKIENVS--KLKKLEYLNLALNNIEKIEN--LEGCEGLTKLDLTVN 98
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 46-86 2.25e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.16  E-value: 2.25e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1952977301  46 LKILYLQNNLIGKIENVSKLKKLEYLNLALNN-IEKIENLEG 86
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-146 9.63e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 9.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  46 LKILYLQNNligkiENVSKLKKLEYLNLALNNIEKI-ENLEGCEGLTKLDLTVNFIGELSSikTLQHNIHLKELFLMGNP 124
Cdd:COG4886    98 LTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQ 170

                          90       100
                  ....*....|....*....|..
gi 1952977301 125 CADFDGyrqfVVATLQRLKWLD 146
Cdd:COG4886   171 LTDLPE----ELGNLTNLKELD 188
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 46-127 1.59e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  46 LKILYLQNNLIGK------IENVSKLKKLEYLNLALNNI------EKIENLEGCEGLTKLDLTVNFIGELSSI---KTLQ 110
Cdd:COG5238   210 VTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIgdegviALAEALKNNTTVETLYLSGNQIGAEGAIalaKALQ 289

                          90
                  ....*....|....*..
gi 1952977301 111 HNIHLKELFLMGNPCAD 127
Cdd:COG5238   290 GNTTLTSLDLSVNRIGD 306
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-127 1.78e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  49 LYLQNNLIGK------IENVSKLKKLEYLNLALNNI------EKIENLEGCEGLTKLDLTVNFIGELSSI---KTLQHNI 113
Cdd:COG5238   269 LYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAQGAIalaKALQENT 348

                          90
                  ....*....|....
gi 1952977301 114 HLKELFLMGNPCAD 127
Cdd:COG5238   349 TLHSLDLSDNQIGD 362
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-111 2.32e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 2.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1952977301  66 KKLEYLNLALNNIEKIENLEGCEGLTKLDLTVNFIgeLSSIKTLQH 111
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 22-123 1.02e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  22 SLEELSLHQQEIERLEHIDkwcrdlkilyLQNNLIGK------IENVSKLKKLEYLNLALNNIEK------IENLEGCEG 89
Cdd:COG5238   224 GAEILAEALKGNKSLTTLD----------LSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTT 293

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1952977301  90 LTKLDLTVNFIGELSSI---KTLQHNIHLKELFLMGN 123
Cdd:COG5238   294 LTSLDLSVNRIGDEGAIalaEGLQGNKTLHTLNLAYN 330
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 20-127 1.40e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  20 IFSLEELSLHQQEIERlEHIDKWCR-------DLKILYLQNNLIGK------IENVSKLKKLEYLNLALNNI--EKIENL 84
Cdd:cd00116   107 SSSLQELKLNNNGLGD-RGLRLLAKglkdlppALEKLVLGRNRLEGascealAKALRANRDLKELNLANNGIgdAGIRAL 185

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952977301  85 egCEGLT------KLDLTVNFIGELSSIK---TLQHNIHLKELFLMGNPCAD 127
Cdd:cd00116   186 --AEGLKancnleVLDLNNNGLTDEGASAlaeTLASLKSLEVLNLGDNNLTD 235
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 46-145 1.71e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  46 LKILYLQNNLIGK------IENVSKLKKLEYLNLALNNI------EKIENLEGCEGLTKLDLTVNFIGEL---SSIKTLQ 110
Cdd:COG5238   322 LHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIgdegaiALAKYLEGNTTLRELNLGKNNIGKQgaeALIDALQ 401

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952977301 111 HNiHLKELFLMGNPCADfdGYRQFVVATLQRLKWL 145
Cdd:COG5238   402 TN-RLHTLILDGNLIGA--EAQQRLEQLLERIKSV 433
LRR_8 pfam13855
Leucine rich repeat;
67-124 2.04e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  67 KLEYLNLALNNIEKI--ENLEGCEGLTKLDLTVNFIGELSSiKTLQHNIHLKELFLMGNP 124
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
22-78 2.25e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952977301  22 SLEELSLHQQEIERLEhiDKW---CRDLKILYLQNNLIGKIENVS--KLKKLEYLNLALNNI 78
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAfkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-146 2.67e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952977301  23 LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNiekieNLEGCEGLTKLDLTVNFIGE 102
Cdd:COG4886    53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTD 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1952977301 103 LSsiKTLQHNIHLKELFLMGNPCADFDgyrqFVVATLQRLKWLD 146
Cdd:COG4886   128 LP--EELANLTNLKELDLSNNQLTDLP----EPLGNLTNLKSLD 165
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-123 2.70e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1952977301  65 LKKLEYLNLALNNIEKIENLEGCEGLTKLDLTVNFIgelSSIKTLQHNIHLKELFLMGN 123
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKI---TKIENLEFLTNLTHLYLQNN 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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