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Conserved domains on  [gi|1952768664|ref|XP_038402467|]
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myocardin-related transcription factor B isoform X1 [Canis lupus familiaris]

Protein Classification

SAP domain-containing protein( domain architecture ID 13233135)

SAP (SAF-A/B, Acinus and PIAS) domain-containing protein may bind DNA or RNA and act as a transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 420-453 2.92e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.92e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1952768664  420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 453
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
160-185 1.37e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 1.37e-05
                            10        20
                    ....*....|....*....|....*.
gi 1952768664   160 DDLNEKIAQRPGPMELVEKNILPVDS 185
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 117-140 1.64e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.64e-04
                           10        20
                   ....*....|....*....|....
gi 1952768664  117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
DUF2130 super family cl38307
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 585-620 2.48e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


The actual alignment was detected with superfamily member pfam09903:

Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.48e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1952768664  585 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 620
Cdd:pfam09903    3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 218-430 8.53e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 8.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  218 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV-SSAKPGPALV 296
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGDVR 2863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  297 K----QSHPKNPNDKHRSKKCKEPKPRVKKLKYHQYIPPDQKGEKSEPQmdsnyarLLQQQQLFLQLQILSQQQQHYNYQ 372
Cdd:PHA03247  2864 RrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPPPPP 2936

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  373 TILPAPLKPLNDKNS---------NTGNSALNNTTPNTPRQNTSAP---VRKPGPLPSSLDDLKVSELKT 430
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGagepsgavpQPWLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
RPEL super family cl29414
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 73-97 1.83e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


The actual alignment was detected with superfamily member smart00707:

Pssm-ID: 475195  Cd Length: 26  Bit Score: 36.69  E-value: 1.83e-03
                            10        20
                    ....*....|....*....|....*
gi 1952768664    73 VLQLRLQQRRTREQLVDQGIMPPLK 97
Cdd:smart00707    2 VLNRKLSQRPTREELEERNILKELS 26
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 771-898 2.88e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  771 QTPAQAGIQTQPQTATATLSSGLAQTVPQKQDTFTP-HVLSQPQQvrkvfTNSASNTVLPYQRAPTPGVQQPFVNKTPPS 849
Cdd:pfam09770  227 AQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPvTILQRPQS-----PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1952768664  850 VLQSRNAPLPSLQNGPATSNKPASPPPPQQCVVQHSLFGSPVPKTKDPP 898
Cdd:pfam09770  302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 420-453 2.92e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.92e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1952768664  420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 453
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
420-451 7.74e-09

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 52.10  E-value: 7.74e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1952768664   420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLK 451
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
160-185 1.37e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 1.37e-05
                            10        20
                    ....*....|....*....|....*.
gi 1952768664   160 DDLNEKIAQRPGPMELVEKNILPVDS 185
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 161-184 3.10e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.49  E-value: 3.10e-05
                           10        20
                   ....*....|....*....|....
gi 1952768664  161 DLNEKIAQRPGPMELVEKNILPVD 184
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 117-140 1.64e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.64e-04
                           10        20
                   ....*....|....*....|....
gi 1952768664  117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
DUF2130 pfam09903
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 585-620 2.48e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.48e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1952768664  585 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 620
Cdd:pfam09903    3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
581-620 2.67e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 44.94  E-value: 2.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1952768664  581 ELDAAEKDRKLQEKEKQIEELKRKLEQ-EQKLV-EVLKMQLE 620
Cdd:COG4487    167 SLKVAEYEKQLKDMQEQIEELKRKKEQgSTQLQgEVLELEFE 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 218-430 8.53e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 8.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  218 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV-SSAKPGPALV 296
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGDVR 2863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  297 K----QSHPKNPNDKHRSKKCKEPKPRVKKLKYHQYIPPDQKGEKSEPQmdsnyarLLQQQQLFLQLQILSQQQQHYNYQ 372
Cdd:PHA03247  2864 RrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPPPPP 2936

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  373 TILPAPLKPLNDKNS---------NTGNSALNNTTPNTPRQNTSAP---VRKPGPLPSSLDDLKVSELKT 430
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGagepsgavpQPWLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
73-97 1.83e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 1.83e-03
                            10        20
                    ....*....|....*....|....*
gi 1952768664    73 VLQLRLQQRRTREQLVDQGIMPPLK 97
Cdd:smart00707    2 VLNRKLSQRPTREELEERNILKELS 26
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 771-898 2.88e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  771 QTPAQAGIQTQPQTATATLSSGLAQTVPQKQDTFTP-HVLSQPQQvrkvfTNSASNTVLPYQRAPTPGVQQPFVNKTPPS 849
Cdd:pfam09770  227 AQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPvTILQRPQS-----PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1952768664  850 VLQSRNAPLPSLQNGPATSNKPASPPPPQQCVVQHSLFGSPVPKTKDPP 898
Cdd:pfam09770  302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
117-140 3.24e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.92  E-value: 3.24e-03
                            10        20
                    ....*....|....*....|....
gi 1952768664   117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:smart00707    2 VLNRKLSQRPTREELEERNILKEL 25
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 7-303 5.65e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 5.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664    7 LDAEDELGPLAHLAPSPQSEAVAHEFQELSLQPSQHLPPLNERKNGSVVFWESGLQSPLLTQSVSMVLQLRLQQRRTREQ 86
Cdd:COG3266     61 LIRLLSEAVDLGALASAALLLALASLALLGILLLALLALLLDLLLLADLLRAAALLLLKLLLLLLTLLLLVLLLLLALLL 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664   87 LVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKI 166
Cdd:COG3266    141 ALLLDLPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALLLLLLASALGEAV 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  167 A----QRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPQTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESP 242
Cdd:COG3266    221 AaaaeLAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVA 300

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952768664  243 SPVTT-NTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVlPTNTVSSAKPGPALVKQSHPKN 303
Cdd:COG3266    301 LPAAPaAAAAAAAPAEAAAPQPTAAKPVVTETAAPAAPA-PEAAAAAAAPAAPAVAKKLAAD 361
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 588-628 7.35e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.87  E-value: 7.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1952768664  588 DRKLQEKEKQIEELKRK---LEQEQKLVEVLKMQLEVEKRGQRQ 628
Cdd:cd16269    190 DQALTEKEKEIEAERAKaeaAEQERKLLEEQQRELEQKLEDQER 233
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 420-453 2.92e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.92e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1952768664  420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 453
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
420-451 7.74e-09

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 52.10  E-value: 7.74e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1952768664   420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLK 451
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
160-185 1.37e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 1.37e-05
                            10        20
                    ....*....|....*....|....*.
gi 1952768664   160 DDLNEKIAQRPGPMELVEKNILPVDS 185
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 161-184 3.10e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.49  E-value: 3.10e-05
                           10        20
                   ....*....|....*....|....
gi 1952768664  161 DLNEKIAQRPGPMELVEKNILPVD 184
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 117-140 1.64e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.64e-04
                           10        20
                   ....*....|....*....|....
gi 1952768664  117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
DUF2130 pfam09903
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 585-620 2.48e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.48e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1952768664  585 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 620
Cdd:pfam09903    3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
581-620 2.67e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 44.94  E-value: 2.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1952768664  581 ELDAAEKDRKLQEKEKQIEELKRKLEQ-EQKLV-EVLKMQLE 620
Cdd:COG4487    167 SLKVAEYEKQLKDMQEQIEELKRKKEQgSTQLQgEVLELEFE 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 218-430 8.53e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 8.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  218 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV-SSAKPGPALV 296
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGDVR 2863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  297 K----QSHPKNPNDKHRSKKCKEPKPRVKKLKYHQYIPPDQKGEKSEPQmdsnyarLLQQQQLFLQLQILSQQQQHYNYQ 372
Cdd:PHA03247  2864 RrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPPPPP 2936

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  373 TILPAPLKPLNDKNS---------NTGNSALNNTTPNTPRQNTSAP---VRKPGPLPSSLDDLKVSELKT 430
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGagepsgavpQPWLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 207-306 9.24e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 9.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  207 SFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTntpaqftPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV 286
Cdd:PTZ00449   580 EFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDI-------PKSPKRPESPKSPKRPPPPQRPSSPERPEGPK 652

                           90       100
                   ....*....|....*....|
gi 1952768664  287 SSAKPGPAlvkqSHPKNPND 306
Cdd:PTZ00449   653 IIKSPKPP----KSPKPPFD 668
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
73-97 1.83e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 1.83e-03
                            10        20
                    ....*....|....*....|....*
gi 1952768664    73 VLQLRLQQRRTREQLVDQGIMPPLK 97
Cdd:smart00707    2 VLNRKLSQRPTREELEERNILKELS 26
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 771-898 2.88e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  771 QTPAQAGIQTQPQTATATLSSGLAQTVPQKQDTFTP-HVLSQPQQvrkvfTNSASNTVLPYQRAPTPGVQQPFVNKTPPS 849
Cdd:pfam09770  227 AQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPvTILQRPQS-----PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1952768664  850 VLQSRNAPLPSLQNGPATSNKPASPPPPQQCVVQHSLFGSPVPKTKDPP 898
Cdd:pfam09770  302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
117-140 3.24e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.92  E-value: 3.24e-03
                            10        20
                    ....*....|....*....|....
gi 1952768664   117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:smart00707    2 VLNRKLSQRPTREELEERNILKEL 25
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 7-303 5.65e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 5.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664    7 LDAEDELGPLAHLAPSPQSEAVAHEFQELSLQPSQHLPPLNERKNGSVVFWESGLQSPLLTQSVSMVLQLRLQQRRTREQ 86
Cdd:COG3266     61 LIRLLSEAVDLGALASAALLLALASLALLGILLLALLALLLDLLLLADLLRAAALLLLKLLLLLLTLLLLVLLLLLALLL 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664   87 LVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKI 166
Cdd:COG3266    141 ALLLDLPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALLLLLLASALGEAV 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  167 A----QRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPQTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESP 242
Cdd:COG3266    221 AaaaeLAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVA 300

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952768664  243 SPVTT-NTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVlPTNTVSSAKPGPALVKQSHPKN 303
Cdd:COG3266    301 LPAAPaAAAAAAAPAEAAAPQPTAAKPVVTETAAPAAPA-PEAAAAAAAPAAPAVAKKLAAD 361
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 209-318 5.92e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 5.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  209 DEDSSDALSPDQPASQESQ--GSAASPSEPKVSESPSPVTTNTPAQFTPVS--PAVPEFLKTPPTDQPPTRSTAPVLPTN 284
Cdd:PTZ00449   526 DKEGEEGEHEDSKESDEPKegGKPGETKEGEVGKKPGPAKEHKPSKIPTLSkkPEFPKDPKHPKDPEEPKKPKRPRSAQR 605

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1952768664  285 TVSsaKPGPALVKQSH-PKNPNDKHRSKKCKEPKP 318
Cdd:PTZ00449   606 PTR--PKSPKLPELLDiPKSPKRPESPKSPKRPPP 638
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
147-300 6.31e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 40.36  E-value: 6.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  147 QATQMKLKRARlADDLNEKIAQRPGPmelveKNILPVDSSVKEAIIGVGKEDYPQTQGDFSFDEDSSDALSPDQPASQES 226
Cdd:PRK12727    49 ELVQRALETAR-SDTPATAAAPAPAP-----QAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPR 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952768664  227 QGSAASPSEPKVSESPS------PVTTNTPAQFTPVSPAVPE-----FLKTPPTDQPPTRSTAPVLPTNTVSSAKPGPAL 295
Cdd:PRK12727   123 QAPAAAPVRAASIPSPAaqalahAAAVRTAPRQEHALSAVPEqlfadFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAH 202


                   ....*
gi 1952768664  296 VKQSH 300
Cdd:PRK12727   203 AAYAQ 207
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 588-628 7.35e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.87  E-value: 7.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1952768664  588 DRKLQEKEKQIEELKRK---LEQEQKLVEVLKMQLEVEKRGQRQ 628
Cdd:cd16269    190 DQALTEKEKEIEAERAKaeaAEQERKLLEEQQRELEQKLEDQER 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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