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Conserved domains on  [gi|1953078971|ref|XP_038396242|]
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myocardin-related transcription factor B isoform X6 [Canis lupus familiaris]

Protein Classification

SAP domain-containing protein( domain architecture ID 13233135)

SAP (SAF-A/B, Acinus and PIAS) domain-containing protein may bind DNA or RNA and act as a transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 420-453 2.50e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1953078971 420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 453
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
160-185 1.43e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.46  E-value: 1.43e-05
                           10        20
                   ....*....|....*....|....*.
gi 1953078971  160 DDLNEKIAQRPGPMELVEKNILPVDS 185
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 117-140 1.48e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|....
gi 1953078971 117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPED 24
DUF2130 super family cl38307
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 585-620 2.07e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


The actual alignment was detected with superfamily member pfam09903:

Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1953078971 585 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 620
Cdd:pfam09903   3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 218-430 6.99e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  218 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV-SSAKPGPALV 296
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGDVR 2863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  297 K----QSHPKNPNDKHRSKKCKEPKPRVKKLKYHQYIPPDQKGEKSEPQmdsnyarLLQQQQLFLQLQILSQQQQHYNYQ 372
Cdd:PHA03247  2864 RrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPPPPP 2936

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  373 TILPAPLKPLNDKNS---------NTGNSALNNTTPNTPRQNTSAP---VRKPGPLPSSLDDLKVSELKT 430
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGagepsgavpQPWLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
RPEL super family cl29414
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 73-97 1.83e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


The actual alignment was detected with superfamily member smart00707:

Pssm-ID: 475195  Cd Length: 26  Bit Score: 36.69  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....*
gi 1953078971   73 VLQLRLQQRRTREQLVDQGIMPPLK 97
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 771-898 2.51e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.56  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 771 QTPAQAGIQTQPQTATATLSSGLAQTVPQKQDTFTP-HVLSQPQQvrkvfTNSASNTVLPYQRAPTPGVQQPFVNKTPPS 849
Cdd:pfam09770 227 AQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPvTILQRPQS-----PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1953078971 850 VLQSRNAPLPSLQNGPATSNKPASPPPPQQCVVQHSLFGSPVPKTKDPP 898
Cdd:pfam09770 302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 420-453 2.50e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1953078971 420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 453
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
420-451 7.28e-09

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 52.10  E-value: 7.28e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1953078971  420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLK 451
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
160-185 1.43e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.46  E-value: 1.43e-05
                           10        20
                   ....*....|....*....|....*.
gi 1953078971  160 DDLNEKIAQRPGPMELVEKNILPVDS 185
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 161-184 2.83e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.49  E-value: 2.83e-05
                          10        20
                  ....*....|....*....|....
gi 1953078971 161 DLNEKIAQRPGPMELVEKNILPVD 184
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPED 24
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 117-140 1.48e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|....
gi 1953078971 117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPED 24
DUF2130 pfam09903
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 585-620 2.07e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1953078971 585 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 620
Cdd:pfam09903   3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
581-620 3.85e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 44.17  E-value: 3.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953078971 581 ELDAAEKDRKLQEKEKQIEELKRKLEQ-EQKLV-EVLKMQLE 620
Cdd:COG4487   167 SLKVAEYEKQLKDMQEQIEELKRKKEQgSTQLQgEVLELEFE 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 218-430 6.99e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  218 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV-SSAKPGPALV 296
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGDVR 2863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  297 K----QSHPKNPNDKHRSKKCKEPKPRVKKLKYHQYIPPDQKGEKSEPQmdsnyarLLQQQQLFLQLQILSQQQQHYNYQ 372
Cdd:PHA03247  2864 RrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPPPPP 2936

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  373 TILPAPLKPLNDKNS---------NTGNSALNNTTPNTPRQNTSAP---VRKPGPLPSSLDDLKVSELKT 430
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGagepsgavpQPWLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
73-97 1.83e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....*
gi 1953078971   73 VLQLRLQQRRTREQLVDQGIMPPLK 97
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 771-898 2.51e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.56  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 771 QTPAQAGIQTQPQTATATLSSGLAQTVPQKQDTFTP-HVLSQPQQvrkvfTNSASNTVLPYQRAPTPGVQQPFVNKTPPS 849
Cdd:pfam09770 227 AQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPvTILQRPQS-----PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1953078971 850 VLQSRNAPLPSLQNGPATSNKPASPPPPQQCVVQHSLFGSPVPKTKDPP 898
Cdd:pfam09770 302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
117-140 3.27e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.92  E-value: 3.27e-03
                           10        20
                   ....*....|....*....|....
gi 1953078971  117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKEL 25
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 7-303 5.12e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 5.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971   7 LDAEDELGPLAHLAPSPQSEAVAHEFQELSLQPSQHLPPLNERKNGSVVFWESGLQSPLLTQSVSMVLQLRLQQRRTREQ 86
Cdd:COG3266    61 LIRLLSEAVDLGALASAALLLALASLALLGILLLALLALLLDLLLLADLLRAAALLLLKLLLLLLTLLLLVLLLLLALLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  87 LVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKI 166
Cdd:COG3266   141 ALLLDLPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALLLLLLASALGEAV 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 167 A----QRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPQTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESP 242
Cdd:COG3266   221 AaaaeLAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVA 300

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953078971 243 SPVTT-NTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVlPTNTVSSAKPGPALVKQSHPKN 303
Cdd:COG3266   301 LPAAPaAAAAAAAPAEAAAPQPTAAKPVVTETAAPAAPA-PEAAAAAAAPAAPAVAKKLAAD 361
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 74-95 8.97e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 34.56  E-value: 8.97e-03
                          10        20
                  ....*....|....*....|..
gi 1953078971  74 LQLRLQQRRTREQLVDQGIMPP 95
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 588-628 9.94e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.10  E-value: 9.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1953078971 588 DRKLQEKEKQIEELKRK---LEQEQKLVEVLKMQLEVEKRGQRQ 628
Cdd:cd16269   190 DQALTEKEKEIEAERAKaeaAEQERKLLEEQQRELEQKLEDQER 233
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 420-453 2.50e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.50e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1953078971 420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 453
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
420-451 7.28e-09

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 52.10  E-value: 7.28e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1953078971  420 LDDLKVSELKTELKLRGLPVSGTKPDLIERLK 451
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
160-185 1.43e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.46  E-value: 1.43e-05
                           10        20
                   ....*....|....*....|....*.
gi 1953078971  160 DDLNEKIAQRPGPMELVEKNILPVDS 185
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 161-184 2.83e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.49  E-value: 2.83e-05
                          10        20
                  ....*....|....*....|....
gi 1953078971 161 DLNEKIAQRPGPMELVEKNILPVD 184
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPED 24
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 117-140 1.48e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|....
gi 1953078971 117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPED 24
DUF2130 pfam09903
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 585-620 2.07e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1953078971 585 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 620
Cdd:pfam09903   3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
581-620 3.85e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 44.17  E-value: 3.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1953078971 581 ELDAAEKDRKLQEKEKQIEELKRKLEQ-EQKLV-EVLKMQLE 620
Cdd:COG4487   167 SLKVAEYEKQLKDMQEQIEELKRKKEQgSTQLQgEVLELEFE 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 218-430 6.99e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  218 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV-SSAKPGPALV 296
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGDVR 2863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  297 K----QSHPKNPNDKHRSKKCKEPKPRVKKLKYHQYIPPDQKGEKSEPQmdsnyarLLQQQQLFLQLQILSQQQQHYNYQ 372
Cdd:PHA03247  2864 RrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPPPPP 2936

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  373 TILPAPLKPLNDKNS---------NTGNSALNNTTPNTPRQNTSAP---VRKPGPLPSSLDDLKVSELKT 430
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGagepsgavpQPWLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 207-306 7.09e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 207 SFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTntpaqftPVSPAVPEFLKTPPTDQPPTRSTAPVLPTNTV 286
Cdd:PTZ00449  580 EFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDI-------PKSPKRPESPKSPKRPPPPQRPSSPERPEGPK 652

                          90       100
                  ....*....|....*....|
gi 1953078971 287 SSAKPGPAlvkqSHPKNPND 306
Cdd:PTZ00449  653 IIKSPKPP----KSPKPPFD 668
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
73-97 1.83e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....*
gi 1953078971   73 VLQLRLQQRRTREQLVDQGIMPPLK 97
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 771-898 2.51e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.56  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 771 QTPAQAGIQTQPQTATATLSSGLAQTVPQKQDTFTP-HVLSQPQQvrkvfTNSASNTVLPYQRAPTPGVQQPFVNKTPPS 849
Cdd:pfam09770 227 AQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPvTILQRPQS-----PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1953078971 850 VLQSRNAPLPSLQNGPATSNKPASPPPPQQCVVQHSLFGSPVPKTKDPP 898
Cdd:pfam09770 302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
117-140 3.27e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.92  E-value: 3.27e-03
                           10        20
                   ....*....|....*....|....
gi 1953078971  117 FLKHKIRSRPDRSELVRMHILEET 140
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKEL 25
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 209-318 4.63e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 209 DEDSSDALSPDQPASQESQ--GSAASPSEPKVSESPSPVTTNTPAQFTPVS--PAVPEFLKTPPTDQPPTRSTAPVLPTN 284
Cdd:PTZ00449  526 DKEGEEGEHEDSKESDEPKegGKPGETKEGEVGKKPGPAKEHKPSKIPTLSkkPEFPKDPKHPKDPEEPKKPKRPRSAQR 605

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1953078971 285 TVSsaKPGPALVKQSH-PKNPNDKHRSKKCKEPKP 318
Cdd:PTZ00449  606 PTR--PKSPKLPELLDiPKSPKRPESPKSPKRPPP 638
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 7-303 5.12e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 5.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971   7 LDAEDELGPLAHLAPSPQSEAVAHEFQELSLQPSQHLPPLNERKNGSVVFWESGLQSPLLTQSVSMVLQLRLQQRRTREQ 86
Cdd:COG3266    61 LIRLLSEAVDLGALASAALLLALASLALLGILLLALLALLLDLLLLADLLRAAALLLLKLLLLLLTLLLLVLLLLLALLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971  87 LVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKI 166
Cdd:COG3266   141 ALLLDLPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALLLLLLASALGEAV 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 167 A----QRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPQTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESP 242
Cdd:COG3266   221 AaaaeLAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVA 300

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1953078971 243 SPVTT-NTPAQFTPVSPAVPEFLKTPPTDQPPTRSTAPVlPTNTVSSAKPGPALVKQSHPKN 303
Cdd:COG3266   301 LPAAPaAAAAAAAPAEAAAPQPTAAKPVVTETAAPAAPA-PEAAAAAAAPAAPAVAKKLAAD 361
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
147-300 5.91e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 40.36  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 147 QATQMKLKRARlADDLNEKIAQRPGPmelveKNILPVDSSVKEAIIGVGKEDYPQTQGDFSFDEDSSDALSPDQPASQES 226
Cdd:PRK12727   49 ELVQRALETAR-SDTPATAAAPAPAP-----QAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953078971 227 QGSAASPSEPKVSESPS------PVTTNTPAQFTPVSPAVPE-----FLKTPPTDQPPTRSTAPVLPTNTVSSAKPGPAL 295
Cdd:PRK12727  123 QAPAAAPVRAASIPSPAaqalahAAAVRTAPRQEHALSAVPEqlfadFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAH 202


                  ....*
gi 1953078971 296 VKQSH 300
Cdd:PRK12727  203 AAYAQ 207
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 74-95 8.97e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 34.56  E-value: 8.97e-03
                          10        20
                  ....*....|....*....|..
gi 1953078971  74 LQLRLQQRRTREQLVDQGIMPP 95
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 588-628 9.94e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.10  E-value: 9.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1953078971 588 DRKLQEKEKQIEELKRK---LEQEQKLVEVLKMQLEVEKRGQRQ 628
Cdd:cd16269   190 DQALTEKEKEIEAERAKaeaAEQERKLLEEQQRELEQKLEDQER 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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