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Conserved domains on  [gi|1952723897|ref|XP_038315067|]
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ataxin-2 isoform X2 [Canis lupus familiaris]

Protein Classification

PABP-interacting PAM2 motif-containing protein( domain architecture ID 10627809)

PABP-interacting PAM2 motif-containing protein similar to human polyadenylate-binding protein-interacting protein 2 (PAIP2) that acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.36e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.36e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723897    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.88e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.88e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723897  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 664-1006 5.40e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  664 PKPSTTPTSPRPQAQPSP--SMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  736 PNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 814
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  815 PAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPNAT 874
Cdd:PHA03247  2831 PTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PDQP 2905

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  875 LHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfp 954
Cdd:PHA03247  2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA-- 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1952723897  955 taqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1006
Cdd:PHA03247  2984 ----------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.43e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


:

Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.43e-03
                           10
                   ....*....|....*.
gi 1952723897  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.36e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.36e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723897    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.88e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.88e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723897  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 664-1006 5.40e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  664 PKPSTTPTSPRPQAQPSP--SMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  736 PNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 814
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  815 PAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPNAT 874
Cdd:PHA03247  2831 PTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PDQP 2905

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  875 LHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfp 954
Cdd:PHA03247  2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA-- 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1952723897  955 taqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1006
Cdd:PHA03247  2984 ----------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 665-837 4.50e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.80  E-value: 4.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  665 KPSTTPTSPRPQAQPSPSM-----------VGHQQPAPVyTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYR 733
Cdd:pfam09770  169 KAAAPAPAPQPAAQPASLPapsrkmmsleeVEAAMRAQA-KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  734 AVPNMPQQRQEQHHQ-SAMMHPASAAGPPIVATPPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPV---IQGNA 809
Cdd:pfam09770  248 QQPQQPQQHPGQGHPvTILQRPQSPQPDPAQPSIQ-------PQAQQFHQQPPPVPVQPTQILQNPNRLSAArvgYPQNP 320

                          170       180
                   ....*....|....*....|....*...
gi 1952723897  810 RMMAPPAHAQPGLVSSSATQYGAHEQTH 837
Cdd:pfam09770  321 QPGVQPAPAHQAHRQQGSFGRQAPIITH 348
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 672-785 6.43e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 46.72  E-value: 6.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  672 SPRPQAQPSPS-MVGHQQPAPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQEQHHQS 749
Cdd:TIGR01628  379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1952723897  750 AMMHPASAagPPIVATPPAYSTQyvaySPQQFPNQP 785
Cdd:TIGR01628  452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.43e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.43e-03
                           10
                   ....*....|....*.
gi 1952723897  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.36e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.36e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723897    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.88e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.88e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723897  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 664-1006 5.40e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  664 PKPSTTPTSPRPQAQPSP--SMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQ------PLYPIPMTPMPVNQAKTYRAV 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarqasPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  736 PNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAP 814
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPP 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  815 PAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPNAT 874
Cdd:PHA03247  2831 PTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PDQP 2905

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  875 LHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSfp 954
Cdd:PHA03247  2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA-- 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1952723897  955 taqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1006
Cdd:PHA03247  2984 ----------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-1027 1.29e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  665 KPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQe 744
Cdd:PHA03247  2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR- 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  745 qhhQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQP---- 820
Cdd:PHA03247  2667 ---ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPappa 2743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  821 ---GLVSSSATQYGAHEQTHAMYACPKLPYNKETSPS-----FYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQ 892
Cdd:PHA03247  2744 vpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPrrltrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  893 QSqhGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqnSFPTAQQTVFTIHPSHVQPAY 972
Cdd:PHA03247  2824 PA--GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP--ARPPVRRLARPAVSRSTESFA 2899

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1952723897  973 TNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSAlQPIPVS 1027
Cdd:PHA03247  2900 LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT-DPAGAG 2953
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 665-837 4.50e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.80  E-value: 4.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  665 KPSTTPTSPRPQAQPSPSM-----------VGHQQPAPVyTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYR 733
Cdd:pfam09770  169 KAAAPAPAPQPAAQPASLPapsrkmmsleeVEAAMRAQA-KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  734 AVPNMPQQRQEQHHQ-SAMMHPASAAGPPIVATPPaystqyvAYSPQQFPNQPLVQHVPHYQSQHPHVYSPV---IQGNA 809
Cdd:pfam09770  248 QQPQQPQQHPGQGHPvTILQRPQSPQPDPAQPSIQ-------PQAQQFHQQPPPVPVQPTQILQNPNRLSAArvgYPQNP 320

                          170       180
                   ....*....|....*....|....*...
gi 1952723897  810 RMMAPPAHAQPGLVSSSATQYGAHEQTH 837
Cdd:pfam09770  321 QPGVQPAPAHQAHRQQGSFGRQAPIITH 348
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 672-785 6.43e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 46.72  E-value: 6.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  672 SPRPQAQPSPS-MVGHQQPAPVYTQpvcfAPNMMYP-VPVSPGVQPLYPIPMTPMPVNQAKTYravPNMPQQRQEQHHQS 749
Cdd:TIGR01628  379 QPRMRQLPMGSpMGGAMGQPPYYGQ----GPQQQFNgQPLGWPRMSMMPTPMGPGGPLRPNGL---APMNAVRAPSRNAQ 451

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1952723897  750 AMMHPASAagPPIVATPPAYSTQyvaySPQQFPNQP 785
Cdd:TIGR01628  452 NAAQKPPM--QPVMYPPNYQSLP----LSQDLPQPQ 481
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 743-1007 8.45e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 8.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  743 QEQHHQSAMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 817
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  818 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 890
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  891 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQP 970
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQP 326

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1952723897  971 AytnPPHMAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 1007
Cdd:pfam09770  327 A---PAHQAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 662-950 1.07e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.62  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  662 SQPKPSTTPTSPRPQAQPSPsmvGHQQPAPVYT-QPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPVNQAKTYRAVPNMPQ 740
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPLQQ-PVQPQQPYYAPAAEQPAQQPY 420

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  741 QRQEQHHQSAMMHPASAAGPPIVATPPaystqyvayspQQFPNQPLVQHVPHYQSQHPHVySPVIQgnarmmaPPAHAQP 820
Cdd:PRK10263   421 YAPAPEQPAQQPYYAPAPEQPVAGNAW-----------QAEEQQSTFAPQSTYQTEQTYQ-QPAAQ-------EPLYQQP 481

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  821 GLVsssatqygahEQTHAMYACPKLPYNKETSPSFYFaisTGSLAQQYAHPNATLHP-HTPHPQPSATPTGQQQSQHGGS 899
Cdd:PRK10263   482 QPV----------EQQPVVEPEPVVEETKPARPPLYY---FEEVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKAPS 548

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1952723897  900 HPAPSPVQHHQHQAAQALHLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 950
Cdd:PRK10263   549 VAAVPPVEAAAAVSPLASGV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 658-1030 1.25e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  658 PRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPvytqpvcfAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPN 737
Cdd:PRK07764   400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAP--------APAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPA 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  738 MPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQpLVQHVPHYQ-------SQHPHVYSpvIQGNAR 810
Cdd:PRK07764   472 AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPE-ILAAVPKRSrktwailLPEATVLG--VRGDTL 548

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  811 MMAppaHAQPGLVSSSATQYGA-------HEQTHAMYAcpklpYNKETSPSFYFAISTGSLAQQYAHPNatlhPHTPHPQ 883
Cdd:PRK07764   549 VLG---FSTGGLARRFASPGNAevlvtalAEELGGDWQ-----VEAVVGPAPGAAGGEGPPAPASSGPP----EEAARPA 616

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  884 PSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHL----------ASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSF 953
Cdd:PRK07764   617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHhpkhvavpdaSDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGA 696

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  954 PTAQQTVFTIHPSHVQPAYTNPPHMAHVPQA-----HVQSGMVPSHPTAHAPMMLMTT--QPPGGPQAALAQSALQPIPV 1026
Cdd:PRK07764   697 APAQPAPAPAATPPAGQADDPAAQPPQAAQGasapsPAADDPVPLPPEPDDPPDPAGApaQPPPPPAPAPAAAPAAAPPP 776


                   ....
gi 1952723897 1027 STTA 1030
Cdd:PRK07764   777 SPPS 780
PHA03378 PHA03378
EBNA-3B; Provisional
 647-930 1.31e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 1.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  647 STLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVytQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPV 726
Cdd:PHA03378   583 SQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL--RPIPMRPLRMQPITFNVLVFPTPHQPPQVEIT 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  727 NQAKTYRAVPNMPQQRQEQHHqsAMMHPASAAgPPIVATPPAYSTQyvAYSPQQFPnqplvqhVPHYQSQHPHVYSPVIQ 806
Cdd:PHA03378   661 PYKPTWTQIGHIPYQPSPTGA--NTMLPIQWA-PGTMQPPPRAPTP--MRPPAAPP-------GRAQRPAAATGRARPPA 728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  807 GNARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYACPKlpynketspsfyfaistgslaqqyahPNATLHPHTPHPQPSA 886
Cdd:PHA03378   729 AAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARP--------------------------PAAAPGAPTPQPPPQA 782

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1952723897  887 TPTGQQQSQHGgshPAPSPVQHHQHQAAQALHLASPQQQSAIYH 930
Cdd:PHA03378   783 PPAPQQRPRGA---PTPQPPPQAGPTSMQLMPRAAPGQQGPTKQ 823
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 663-903 5.72e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.87  E-value: 5.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  663 QPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFA-PNMMYPVPVSP--------GVQPLYPIPMTPMPVNQAKtyr 733
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyEKYKEPEPIPDlqvdaslwGVAPKKAAAPAPAPQPAAQ--- 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  734 AVPNMPQQR-----QEQHHQ-SAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvysPVIQG 807
Cdd:pfam09770  183 PASLPAPSRkmmslEEVEAAmRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQP----QQHPG 258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  808 NARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYACPKLPynketSPSfyfaistgslaQQYAHPN------ATLHPHTPH 881
Cdd:pfam09770  259 QGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPV-----QPT-----------QILQNPNrlsaarVGYPQNPQP 322

                          250       260
                   ....*....|....*....|..
gi 1952723897  882 PQPSATPTGQQQSQHGGSHPAP 903
Cdd:pfam09770  323 GVQPAPAHQAHRQQGSFGRQAP 344
PHA03247 PHA03247
large tegument protein UL36; Provisional
 670-1033 1.71e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  670 PTSPRPQAQPSPsmvghqqpAPVYTQPvcfaPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQeqhhQS 749
Cdd:PHA03247  2551 PPPPLPPAAPPA--------APDRSVP----PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPA----PP 2614

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  750 AMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAH----AQPGLVSS 825
Cdd:PHA03247  2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRprrrAARPTVGS 2694

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  826 SATQYGAHEQthamyacPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTP----HPQPSATPTGQQQSQHGGSHP 901
Cdd:PHA03247  2695 LTSLADPPPP-------PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpaGPATPGGPARPARPPTTAGPP 2767

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  902 APSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPTAQQTVFTIHPSHVQPAYTNPPHMAHV 981
Cdd:PHA03247  2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1952723897  982 PQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFP 1033
Cdd:PHA03247  2848 PSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA 2899
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.43e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.43e-03
                           10
                   ....*....|....*.
gi 1952723897  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
650-745 6.43e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 6.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  650 NPNAKEFN---PRSFSQPKPSTTPtSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPgvqplyPIPMTPMpv 726
Cdd:PRK14971   391 QPSAAAAAspsPSQSSAAAQPSAP-QSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKE------EKKIPVS-- 461

                           90
                   ....*....|....*....
gi 1952723897  727 NQAKTYRAVPNMPQQRQEQ 745
Cdd:PRK14971   462 KVSSLGPSTLRPIQEKAEQ 480
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 710-803 8.13e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 8.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  710 SPGVQPLYPiPMTPMPVNQAKTYRAVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYST--QYVAYSPQ-QFPNQPL 786
Cdd:PRK10263   746 TPIVEPVQQ-PQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpqQPVAPQPQyQQPQQPV 824

                           90
                   ....*....|....*..
gi 1952723897  787 VQHVPHYQSQHPHVYSP 803
Cdd:PRK10263   825 APQPQYQQPQQPVAPQP 841
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 606-976 8.71e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 8.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  606 NTEHKRGPEVTSQGVQTSSPGCKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVG 685
Cdd:pfam03154  127 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  686 HQQPAPVYTQPVCFAPNMMYPV-------------------PVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQEQh 746
Cdd:pfam03154  207 PPQGSPATSQPPNQTQSTAAPHtliqqtptlhpqrlpsphpPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTG- 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  747 hQSAMMHPASAAGPPIVAT------PPAYSTQyVAYSPQQFPNQPLVQhvPHYQSQHPHVYSPVIQGNARM---MAPPAH 817
Cdd:pfam03154  286 -PSHMQHPVPPQPFPLTPQssqsqvPPGPSPA-APGQSQQRIHTPPSQ--SQLQSQQPPREQPLPPAPLSMphiKPPPTT 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  818 AQPGLVSSSATQYGAHEQTHAMYacpKLPYNKETSPSFYFAISTGSLAQQYAHPNA-TLHPHT-PHPQPSATPTGQQQSQ 895
Cdd:pfam03154  362 PIPQLPNPQSHKHPPHLSGPSPF---QMNSNLPPPPALKPLSSLSTHHPPSAHPPPlQLMPQSqQLPPPPAQPPVLTQSQ 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723897  896 hggSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPTAQQTVFTIHPSHVQPAYTNP 975
Cdd:pfam03154  439 ---SLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLP 515


                   .
gi 1952723897  976 P 976
Cdd:pfam03154  516 P 516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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