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Conserved domains on  [gi|1952723891|ref|XP_038315066|]
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ataxin-2 isoform X1 [Canis lupus familiaris]

Protein Classification

PABP-interacting PAM2 motif-containing protein( domain architecture ID 10627809)

PABP-interacting PAM2 motif-containing protein similar to human polyadenylate-binding protein-interacting protein 2 (PAIP2) that acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.37e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.37e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723891    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.89e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.89e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723891  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 664-1008 8.67e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 8.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  664 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  736 KVPNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 814
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  815 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 874
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  875 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 954
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1952723891  955 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1008
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.50e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


:

Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.50e-03
                           10
                   ....*....|....*.
gi 1952723891  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.37e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.37e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723891    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.89e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.89e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723891  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 664-1008 8.67e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 8.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  664 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  736 KVPNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 814
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  815 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 874
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  875 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 954
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1952723891  955 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1008
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 645-803 1.48e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 49.03  E-value: 1.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  645 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 724
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  725 PVNQaktyrAGKVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 798
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 1952723891  799 HPHVY 803
Cdd:TIGR01628  514 FPLVE 518
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 745-1009 8.11e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 8.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  745 QEQHHQSAMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 819
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  820 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 892
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  893 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQP 972
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQP 326

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1952723891  973 AytnPPHMAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 1009
Cdd:pfam09770  327 A---PAHQAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.50e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.50e-03
                           10
                   ....*....|....*.
gi 1952723891  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 3-76 1.37e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 86.84  E-value: 1.37e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723891    3 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSVESSSG--PKREEIMESILFKCSDFVVVQFK 76
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 144-205 7.89e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 7.89e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952723891  144 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 205
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 664-1008 8.67e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 8.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  664 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 735
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  736 KVPNMPQQRQEQHHQSAMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 814
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  815 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 874
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  875 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 954
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1952723891  955 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1008
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 645-803 1.48e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 49.03  E-value: 1.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  645 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 724
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  725 PVNQaktyrAGKVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 798
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 1952723891  799 HPHVY 803
Cdd:TIGR01628  514 FPLVE 518
PHA03247 PHA03247
large tegument protein UL36; Provisional
 659-1027 3.05e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  659 RSFSQPKPSTTPTSP-------RPQAQPSPSM----VGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVN 727
Cdd:PHA03247  2566 RSVPPPRPAPRPSEPavtsrarRPDAPPQSARprapVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  728 QAKTYRAGKVPNMPQQRQEQHhQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVI 807
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRR-ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  808 QGNARMMAPPAHAQP-------GLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFyfAISTGSLAQQYAHPNATLHPH 880
Cdd:PHA03247  2725 PAAARQASPALPAAPappavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR--RLTRPAVASLSESRESLPSPW 2802

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  881 TPHPQPSATPtGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAP----------TPPSMTPASNTQS 950
Cdd:PHA03247  2803 DPADPPAAVL-APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrppsRSPAAKPAAPARP 2881

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  951 PQNSFP----TAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPI 1026
Cdd:PHA03247  2882 PVRRLArpavSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ 2961


                   .
gi 1952723891 1027 P 1027
Cdd:PHA03247  2962 P 2962
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 745-1009 8.11e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 8.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  745 QEQHHQSAMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 819
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  820 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 892
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  893 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQP 972
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQP 326

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1952723891  973 AytnPPHMAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 1009
Cdd:pfam09770  327 A---PAHQAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 662-952 4.05e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 4.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  662 SQPKPSTTPTSPRPQAQPSPsmvGHQQPAPVYT-QPVCFAPNMMYPVPVSPGVQPLYPiPMTPMPVNQAktyragkvPNM 740
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPLQQ-PVQPQQPYYA--------PAA 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  741 PQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYspqqfPNQPLVQHVPHYQSQHPHVySPVIQgnarmmaPPAHA 820
Cdd:PRK10263   413 EQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE-----EQQSTFAPQSTYQTEQTYQ-QPAAQ-------EPLYQ 479

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  821 QPGLVsssatqygahEQTHAMYACPKLPYNKETSPSFYFaisTGSLAQQYAHPNATLHP-HTPHPQPSATPTGQQQSQHG 899
Cdd:PRK10263   480 QPQPV----------EQQPVVEPEPVVEETKPARPPLYY---FEEVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKA 546

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1952723891  900 GSHPAPSPVQHHQHQAAQALHLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 952
Cdd:PRK10263   547 PSVAAVPPVEAAAAVSPLASGV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 658-1032 5.84e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 5.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  658 PRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPvytqpvcfAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKV 737
Cdd:PRK07764   400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAP--------APAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPA 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  738 PNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAySTQYVAYSPQQFPNqpLVQHVPHYQ-------SQHPHVYSpvIQGN 810
Cdd:PRK07764   472 AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA-GADDAATLRERWPE--ILAAVPKRSrktwailLPEATVLG--VRGD 546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  811 ARMMAppaHAQPGLVSSSATQYGA-------HEQTHAMYAcpklpYNKETSPSFYFAISTGSLAQQYAHPNatlhPHTPH 883
Cdd:PRK07764   547 TLVLG---FSTGGLARRFASPGNAevlvtalAEELGGDWQ-----VEAVVGPAPGAAGGEGPPAPASSGPP----EEAAR 614

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  884 PQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHL----------ASPQQQSAIYHAGLAPTPPSMTPASNTQSPQN 953
Cdd:PRK07764   615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHhpkhvavpdaSDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPA 694

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  954 SFPTAQQTVFTIHPSHVQPAYTNPPHMAHVPQA-----HVQSGMVPSHPTAHAPMMLMTT--QPPGGPQAALAQSALQPI 1026
Cdd:PRK07764   695 GAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGasapsPAADDPVPLPPEPDDPPDPAGApaQPPPPPAPAPAAAPAAAP 774


                   ....*.
gi 1952723891 1027 PVSTTA 1032
Cdd:PRK07764   775 PPSPPS 780
PHA03378 PHA03378
EBNA-3B; Provisional
 647-932 1.79e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  647 STLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVytQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPV 726
Cdd:PHA03378   583 SQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL--RPIPMRPLRMQPITFNVLVFPTPHQPPQVEIT 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  727 NQAKTYraGKVPNMPQQRQEQHHqsAMMHPASAAgPPIVATPPAYSTQyvAYSPQQFPnqplvqhVPHYQSQHPHVYSPV 806
Cdd:PHA03378   661 PYKPTW--TQIGHIPYQPSPTGA--NTMLPIQWA-PGTMQPPPRAPTP--MRPPAAPP-------GRAQRPAAATGRARP 726

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  807 IQGNARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYACPKlpynketspsfyfaistgslaqqyahPNATLHPHTPHPQP 886
Cdd:PHA03378   727 PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARP--------------------------PAAAPGAPTPQPPP 780

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1952723891  887 SATPTGQQQSQHGgshPAPSPVQHHQHQAAQALHLASPQQQSAIYH 932
Cdd:PHA03378   781 QAPPAPQQRPRGA---PTPQPPPQAGPTSMQLMPRAAPGQQGPTKQ 823
PHA03247 PHA03247
large tegument protein UL36; Provisional
 659-1035 2.59e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  659 RSFSQPKPSTTPTS---PRPQAQPSPsmvGHQQPAPVYTQPVCFA--PNMMY---------------PVPVSP------- 711
Cdd:PHA03247  2487 RFPFAAGAAPDPGGggpPDPDAPPAP---SRLAPAILPDEPVGEPvhPRMLTwirgleelasddagdPPPPLPpaappaa 2563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  712 ---GVQPLYPIPMTPMPVNQAKTYR--------AGKVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSP 780
Cdd:PHA03247  2564 pdrSVPPPRPAPRPSEPAVTSRARRpdappqsaRPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  781 QQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAH----AQPGLVSSSATQYGAHEQthamyacPKLPYNKETSPS 856
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRprrrAARPTVGSLTSLADPPPP-------PPTPEPAPHALV 2716

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  857 FYFAISTGSLAQQYAHPNATLHPHTP----HPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYH 932
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  933 AGLAPTPPSMTPASNTQSPQNSFPTAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPG 1012
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876

                          410       420
                   ....*....|....*....|...
gi 1952723891 1013 GPQAALAQSALQPIPVSTTAHFP 1035
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFA 2899
PHA03247 PHA03247
large tegument protein UL36; Provisional
 651-1029 5.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  651 PNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSmvghqqpapvytqpvcfapnmmyPVPVSPGVQPLYPIPMTPMPVNQAK 730
Cdd:PHA03247  2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS-----------------------PAANEPDPHPPPTVPPPERPRDDPA 2657

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  731 TYRAGKvpnmpqqrqeQHHQSAMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGN 810
Cdd:PHA03247  2658 PGRVSR----------PRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA 2727

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  811 ARMMAPPAHAQP-------GLVSSSATQYGAHEQTHAMYACPKLPYNKETSPS-----FYFAISTGSLAQQYAHPNATLH 878
Cdd:PHA03247  2728 ARQASPALPAAPappavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPrrltrPAVASLSESRESLPSPWDPADP 2807

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  879 PHTPHPQPSATPTGQQQSqhGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqnSFPTA 958
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP--ARPPV 2883

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1952723891  959 QQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSAlQPIPVS 1029
Cdd:PHA03247  2884 RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT-DPAGAG 2953
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 645-660 5.50e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.50e-03
                           10
                   ....*....|....*.
gi 1952723891  645 RKSTLNPNAKEFNPRS 660
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 710-805 9.33e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.07  E-value: 9.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723891  710 SPGVQPLYPIPMTPMPVNQaktYRAGKVPNMPQQRQEQHHQSAMMHPASAAGPPIVATPPAYST--QYVAYSPQ-QFPNQ 786
Cdd:PRK10263   746 TPIVEPVQQPQQPVAPQQQ---YQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQpqQPVAPQPQyQQPQQ 822

                           90
                   ....*....|....*....
gi 1952723891  787 PLVQHVPHYQSQHPHVYSP 805
Cdd:PRK10263   823 PVAPQPQYQQPQQPVAPQP 841
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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