NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1952715164|ref|XP_038313207|]
View 

solute carrier family 22 member 13 isoform X2 [Canis lupus familiaris]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 102-449 2.66e-114

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17374:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 339.27  E-value: 2.66e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 102 RFNETQPCEAGWEYPEHGPLSLQN-EFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGL 180
Cdd:cd17374     1 SEADTEPCVDGWVYDRSKFTSTIVtEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 181 STAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAP 260
Cdd:cd17374    81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 261 VLLLFFYFWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYV 340
Cdd:cd17374   161 FFLFFLYSWWLP-----------------------------------------------------------KRTLILSFV 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 341 WFVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTV 420
Cdd:cd17374   182 WFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTV 261

                         330       340
                  ....*....|....*....|....*....
gi 1952715164 421 LAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:cd17374   262 LAVLGKGSSAAAFTISYVYTAELFPTVLR 290
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 102-449 2.66e-114

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 339.27  E-value: 2.66e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 102 RFNETQPCEAGWEYPEHGPLSLQN-EFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGL 180
Cdd:cd17374     1 SEADTEPCVDGWVYDRSKFTSTIVtEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 181 STAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAP 260
Cdd:cd17374    81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 261 VLLLFFYFWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYV 340
Cdd:cd17374   161 FFLFFLYSWWLP-----------------------------------------------------------KRTLILSFV 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 341 WFVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTV 420
Cdd:cd17374   182 WFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTV 261

                         330       340
                  ....*....|....*....|....*....
gi 1952715164 421 LAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:cd17374   262 LAVLGKGSSAAAFTISYVYTAELFPTVLR 290
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-449 3.33e-108

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 329.28  E-value: 3.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164  12 GDFNRFQVRLLILLSIPNFLSAFYMFAQVFMIQDEAHYCSVawvkNHTLNLSAAEQLTLSVPLDAAGSPEPCLMFRPPPD 91
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRL----PDAANLSSRCELNLTLPRLPDGRPESCLRFMVDQW 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164  92 NASLE------DILSHRFNETQPCEAGWEYPEHGPLS-LQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGR 164
Cdd:TIGR00898  77 ANPSLlgceplKLSDLGLAATEPCLDGWEYSYDTFSStIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 165 RATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLA 244
Cdd:TIGR00898 157 KKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 245 YGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIQKVASVNKRKLSPELLSqLVAEKTGPSG----N 320
Cdd:TIGR00898 237 YFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLS-LSLEKDLSSSkkqyS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 321 ALDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLG 400
Cdd:TIGR00898 316 FLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLA 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1952715164 401 GLMCIAIIFVPADLPVVVTVLAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:TIGR00898 396 GVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVR 444
Sugar_tr pfam00083
Sugar (and other) transporter;
142-449 8.35e-20

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 91.56  E-value: 8.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVP---SFELYMVLRFAVATAVAGYTFSNVTLLTEWVG 218
Cdd:pfam00083  53 SIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAP 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 219 PLWRTRAVVLAQCAFSVGEMALAGLAYGIRN------WRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIQ 292
Cdd:pfam00083 133 KKLRGALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 293 KV--ASVNKRKLSPELLSqLVAEKTGPSGNALDLFRHPQLWKMTLILCYVWFV------DSLGYYG--LSLQVGdFGLDI 362
Cdd:pfam00083 213 KLrgVPDVDRELDEIKDS-LEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFqqltgiNAIFYYSttIFENLG-LSDSF 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 363 YLTqLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIaIIFVPADL----PVVVTVLAVVGKFATASGFTIS-- 436
Cdd:pfam00083 291 LVT-IIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFV-ILGIVALLgvskSDWAGIVAIVFIALFIAFFAMGwg 368

                         330
                  ....*....|....*.
gi 1952715164 437 ---YVYSAELFPTIIR 449
Cdd:pfam00083 369 pvpWVIVSELFPLSVR 384
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
142-449 5.95e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.94  E-value: 5.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:COG2814    52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEMA---LAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWALPESARwlltqgrveearqviqkvasv 297
Cdd:COG2814   132 RGRALGLLGAGLGLGPALgplLGGLLADLFGWRWvFLVNAVLALLALLLLLRLLPESRP--------------------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 298 nkrklspellsqlvAEKTGPSGNALDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGD-FGLD---IYLTQLIFGAVE 373
Cdd:COG2814   191 --------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSasaAGLLLALFGLGG 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952715164 374 VPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPAdLPVVVTVLAVVGkFATASGFTISYVYSAELFPTIIR 449
Cdd:COG2814   257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS-LWLLLLALFLLG-FGFGLLFPLLQALVAELAPPEAR 330
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 142-278 3.30e-12

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 67.68  E-value: 3.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:PRK11551   57 SAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRL 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952715164 222 RTRAVVLAQCAFSVGEmALAG----LAYGIRNWRH-FQMAGTAPVLLLFFYFWALPESARWL 278
Cdd:PRK11551  137 RGTAVSLMYCGVPFGG-ALASvigvLAAGDAAWRHiFYVGGVGPLLLVPLLMRWLPESRAFA 197
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 102-449 2.66e-114

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 339.27  E-value: 2.66e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 102 RFNETQPCEAGWEYPEHGPLSLQN-EFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGL 180
Cdd:cd17374     1 SEADTEPCVDGWVYDRSKFTSTIVtEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 181 STAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAP 260
Cdd:cd17374    81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 261 VLLLFFYFWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYV 340
Cdd:cd17374   161 FFLFFLYSWWLP-----------------------------------------------------------KRTLILSFV 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 341 WFVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTV 420
Cdd:cd17374   182 WFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTV 261

                         330       340
                  ....*....|....*....|....*....
gi 1952715164 421 LAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:cd17374   262 LAVLGKGSSAAAFTISYVYTAELFPTVLR 290
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-449 3.33e-108

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 329.28  E-value: 3.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164  12 GDFNRFQVRLLILLSIPNFLSAFYMFAQVFMIQDEAHYCSVawvkNHTLNLSAAEQLTLSVPLDAAGSPEPCLMFRPPPD 91
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRL----PDAANLSSRCELNLTLPRLPDGRPESCLRFMVDQW 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164  92 NASLE------DILSHRFNETQPCEAGWEYPEHGPLS-LQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGR 164
Cdd:TIGR00898  77 ANPSLlgceplKLSDLGLAATEPCLDGWEYSYDTFSStIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 165 RATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLA 244
Cdd:TIGR00898 157 KKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 245 YGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIQKVASVNKRKLSPELLSqLVAEKTGPSG----N 320
Cdd:TIGR00898 237 YFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLS-LSLEKDLSSSkkqyS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 321 ALDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLG 400
Cdd:TIGR00898 316 FLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLA 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1952715164 401 GLMCIAIIFVPADLPVVVTVLAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:TIGR00898 396 GVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVR 444
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 122-449 4.89e-78

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 245.95  E-value: 4.89e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 122 SLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATA 201
Cdd:cd17317    12 TIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 202 VAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPesarwlltq 281
Cdd:cd17317    92 SAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP--------- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 282 grveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYVWFVDSLGYYGLSLQVGDFGLD 361
Cdd:cd17317   163 --------------------------------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLGGN 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 362 IYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGKFATASGFTISYVYSA 441
Cdd:cd17317   193 LYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTA 272


                  ....*...
gi 1952715164 442 ELFPTIIR 449
Cdd:cd17317   273 ELYPTVVR 280
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 105-450 8.64e-71

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 227.30  E-value: 8.64e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 105 ETQPCEAGWEYPEHG-PLSLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTA 183
Cdd:cd17446     2 ATEPCTDGWVYDKSEfPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 184 FVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPlwRTRAVV--LAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPV 261
Cdd:cd17446    82 FSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPT--RVRAVVgtLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 262 LLLFFYFWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYVW 341
Cdd:cd17446   160 FIFFLYSWWFP-----------------------------------------------------------RITFCLSLVW 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 342 FVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVL 421
Cdd:cd17446   181 FSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQTVRTAL 260

                         330       340
                  ....*....|....*....|....*....
gi 1952715164 422 AVVGKFATASGFTISYVYSAELFPTIIRR 450
Cdd:cd17446   261 AVFGKGCLAASFNCVYLYTGELYPTVIRQ 289
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 104-450 1.57e-52

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 179.93  E-value: 1.57e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 104 NETQPCEAGWEYpEHGPLS--LQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLS 181
Cdd:cd17447     3 LPVVPCQNGWVY-DHSTFSstIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 182 TAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPV 261
Cdd:cd17447    82 SAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 262 LLLFFYFWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYVW 341
Cdd:cd17447   162 APGIITWWWVP-----------------------------------------------------------KISLCTGIVW 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 342 FVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVL 421
Cdd:cd17447   183 FGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVRTVI 262

                         330       340
                  ....*....|....*....|....*....
gi 1952715164 422 AVVGKFATASGFTISYVYSAELFPTIIRR 450
Cdd:cd17447   263 AVLGKGFSEAAFTTVFLYTSELYPTVLRQ 291
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 108-449 9.71e-46

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 161.75  E-value: 9.71e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 108 PCEAGWEYPEHGPlSLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPS 187
Cdd:cd17379     7 PCQDGWVYNTPRS-SIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 188 FELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLLFFY 267
Cdd:cd17379    86 YPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLLY 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 268 FWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYVWFVDSLG 347
Cdd:cd17379   166 YWFIP-----------------------------------------------------------KHTFILMYAWFTSAVV 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 348 YYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGKF 427
Cdd:cd17379   187 YQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPDLHWLKTTIACVGRL 266

                         330       340
                  ....*....|....*....|..
gi 1952715164 428 ATASGFTISYVYSAELFPTIIR 449
Cdd:cd17379   267 GITMAFEIVCLVNTELYPTFLR 288
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 108-449 2.37e-43

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 155.68  E-value: 2.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 108 PCEAGWEYPE-HGPLSLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVP 186
Cdd:cd17375     7 SCSDGFVYDQsKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 187 SFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLLFF 266
Cdd:cd17375    87 DYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFIL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 267 YFWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYVWFVDSL 346
Cdd:cd17375   167 CCWMLP-----------------------------------------------------------KRTITVWLIWFTGSL 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 347 GYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGK 426
Cdd:cd17375   188 GYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMTGK 267

                         330       340
                  ....*....|....*....|...
gi 1952715164 427 FATASGFTISYVYSAELFPTIIR 449
Cdd:cd17375   268 FAIAIAFGLIYLYTAELYPTIVR 290
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 122-451 3.63e-40

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 147.23  E-value: 3.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 122 SLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATA 201
Cdd:cd17377    26 SIVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVM 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 202 VAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPesarwlltq 281
Cdd:cd17377   106 NGGMSLVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIP--------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 282 GRveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwkmTLILCYVWFVDSLGYYGLSLQVGDFGLD 361
Cdd:cd17377   177 GR--------------------------------------------------TLILMYVWFVCSLVYYGLTLNAGDLGGN 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 362 IYLTQLIFGAVEVPARYSSIFMM--QWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVL------AVVGKFATASGF 433
Cdd:cd17377   207 IYLNLALSGLVELPAYPLCIYLInqKWSGRRRTLAGFLFLGGIACLLVMFVPEKKDSGVFAVvnstslSLLGKLTISAAF 286

                         330
                  ....*....|....*...
gi 1952715164 434 TISYVYSAELFPTIIRRA 451
Cdd:cd17377   287 NIVYIYTSELYPTVVRNA 304
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 105-449 6.19e-36

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 135.67  E-value: 6.19e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 105 ETQPCEAGWEYPEHGPLS-LQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTA 183
Cdd:cd17376     4 EQEPCLDGWEYSQDVYLStIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 184 FVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFS-VGEMALAGLAYGIRNWRHFQMAGTAPVL 262
Cdd:cd17376    84 FSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCIFYaIGYMLLPLFAYFIRDWRMLLLALTLPGV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 263 LLFFYFWALPesarwlltqgrveearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwKMTLILCYVWF 342
Cdd:cd17376   164 LCVPLWWFIP-----------------------------------------------------------ITTIMSLLLWM 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 343 VDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLA 422
Cdd:cd17376   185 AISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALV 264

                         330       340
                  ....*....|....*....|....*..
gi 1952715164 423 VVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:cd17376   265 MLGKFGITAAFSMVYVYTAELYPTVVR 291
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 113-451 1.40e-35

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 134.41  E-value: 1.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 113 WEYPEHGplSLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCD-WIGRRATILVQLFLFAIFGLSTAFVPSFELY 191
Cdd:cd17378    13 WDGGSKV--SIVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 192 MVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAY-GIRNWRHFQMAGTAPVLLLffyfwa 270
Cdd:cd17378    91 AFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYlNGSSWRVLYFWTSIPALIY------ 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 271 lpeSARWLLTQGRVeearqviqkvasvnkrklspellsqlvaektgpsgnaldlfrhpqlwkmtLILCYVWFVDSLGYYG 350
Cdd:cd17378   165 ---CILVYLFARRL--------------------------------------------------LAVMVIGFGIGMVYYG 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 351 LSLQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLA-VVGKFAT 429
Cdd:cd17378   192 IPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALeLVGFFGA 271

                         330       340
                  ....*....|....*....|..
gi 1952715164 430 ASGFTISYVYSAELFPTIIRRA 451
Cdd:cd17378   272 AGAFNLLYIYTVELFPTCVRNA 293
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 142-449 1.06e-22

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 99.35  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:TIGR00895  59 SAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRF 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGeMALAGLAYGIR----NWRH-FQMAGTAPVLLLFFYFWALPESARWLLTQgRVEEARQVIQKVAS 296
Cdd:TIGR00895 139 RGTAVGLMFCGYPIG-AAVGGFLAGWLipvfGWRSlFYVGGIAPLLLLLLLMRFLPESIDFLVSK-RPETVRRIVNAIAP 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 297 VNKRKLSPELLSQLVAEKTGPSgnALDLFRHPQLWKMTLILCYVWFVDSLGYYGLS----LQVGDFGLDIYLTQLIFGAV 372
Cdd:TIGR00895 217 QMQAEAQSALPEQKSTQGTKRS--VFKALFQGKTARITVLLWLLYFMLLVGVYFLTnwlpKLMVELGFSLSLAATGGALF 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 373 EVPARYSSIF---MMQWLGRKwsQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:TIGR00895 295 NFGGVIGSIIfgwLADRLGPR--VTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIR 372
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 104-272 8.42e-22

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 96.00  E-value: 8.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 104 NETQPCEAGWEYPEHGPL--SLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLS 181
Cdd:cd17443     3 NLAVLCTGGWPFSAAAGLgsNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 182 TAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPV 261
Cdd:cd17443    83 VALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPL 162

                         170
                  ....*....|.
gi 1952715164 262 LLLFFYfWALP 272
Cdd:cd17443   163 LLLLLY-WCFP 172
Sugar_tr pfam00083
Sugar (and other) transporter;
142-449 8.35e-20

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 91.56  E-value: 8.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVP---SFELYMVLRFAVATAVAGYTFSNVTLLTEWVG 218
Cdd:pfam00083  53 SIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAP 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 219 PLWRTRAVVLAQCAFSVGEMALAGLAYGIRN------WRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIQ 292
Cdd:pfam00083 133 KKLRGALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 293 KV--ASVNKRKLSPELLSqLVAEKTGPSGNALDLFRHPQLWKMTLILCYVWFV------DSLGYYG--LSLQVGdFGLDI 362
Cdd:pfam00083 213 KLrgVPDVDRELDEIKDS-LEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFqqltgiNAIFYYSttIFENLG-LSDSF 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 363 YLTqLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIaIIFVPADL----PVVVTVLAVVGKFATASGFTIS-- 436
Cdd:pfam00083 291 LVT-IIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFV-ILGIVALLgvskSDWAGIVAIVFIALFIAFFAMGwg 368

                         330
                  ....*....|....*.
gi 1952715164 437 ---YVYSAELFPTIIR 449
Cdd:pfam00083 369 pvpWVIVSELFPLSVR 384
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 109-269 2.11e-18

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 85.98  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 109 CEAGWEYpeHGPLSLQN----EFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAF 184
Cdd:cd17445     8 CDAGWNY--TGLPGLTNnivtEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 185 VPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLL 264
Cdd:cd17445    86 AASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQGTITAPLSLF 165


                  ....*
gi 1952715164 265 FFYFW 269
Cdd:cd17445   166 LCYGC 170
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 142-449 7.26e-18

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 85.05  E-value: 7.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17371    41 TVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARH 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEMALAGLAY-------GIRNWRHFQMAGTAPVLLLFFYFWALPESARWlltqgrvEEARQviqkv 294
Cdd:cd17371   121 RGKALGYVQSGWAVGWLLATLLAAllfpllpPEIAWRVLFLLGALPALLVLFIRRFVKEPPQW-------QAARA----- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 295 asvnkrklspellsqlvAEKTGPSGNALDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGDF----------GLDIYL 364
Cdd:cd17371   189 -----------------ARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYltgerglsfeGSAGYL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 365 TQLIFGAveVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGKFATA--SGFTIsyvYSAE 442
Cdd:cd17371   252 VVTILGG--FLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGpfSGMGA---YLTE 326


                  ....*..
gi 1952715164 443 LFPTIIR 449
Cdd:cd17371   327 LFPTAVR 333
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 142-449 7.61e-18

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 84.58  E-value: 7.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17316    43 AAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEMALAGLAYGIRN-------WRHFQMAGTAPVLLLFFyfwalpesarwlltqgrveearqviqkv 294
Cdd:cd17316   123 RGFALGLLQSGWALGALLAALVASLLIPllsgdwgWRILFLIGALPALLALL---------------------------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 295 asvnkrklspellsqlvaektgpsgnaldlfrhpqLWKMTLILCYVWFVDSLGYYGLSL-------QVGDFGLD-IYLTQ 366
Cdd:cd17316   175 -----------------------------------LRRRTLLLILLWFFISFGYYGLTTflptylqTVLGLSPAtSSLYL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 367 LIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGKFATASGFTISYVYSAELFPT 446
Cdd:cd17316   220 LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT 299


                  ...
gi 1952715164 447 IIR 449
Cdd:cd17316   300 EVR 302
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
142-449 5.95e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.94  E-value: 5.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:COG2814    52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEMA---LAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWALPESARwlltqgrveearqviqkvasv 297
Cdd:COG2814   132 RGRALGLLGAGLGLGPALgplLGGLLADLFGWRWvFLVNAVLALLALLLLLRLLPESRP--------------------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 298 nkrklspellsqlvAEKTGPSGNALDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGD-FGLD---IYLTQLIFGAVE 373
Cdd:COG2814   191 --------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSasaAGLLLALFGLGG 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952715164 374 VPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPAdLPVVVTVLAVVGkFATASGFTISYVYSAELFPTIIR 449
Cdd:COG2814   257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS-LWLLLLALFLLG-FGFGLLFPLLQALVAELAPPEAR 330
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 147-407 1.33e-16

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 81.47  E-value: 1.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 147 GLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAV 226
Cdd:cd17358    53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 227 VLAQCAFSVGEMALAGLAYGIrNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIQKV--ASVNKRKLSP 304
Cdd:cd17358   133 SLNQLLVNIGILLGYVLGSFL-PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLrgKDADISKEAA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 305 ELLSQLVAEKTGPSGNALDLFRHPQLWK-----MTLILCYVWF-VDSLGYYGLS-LQVGDFGLDIYLTQLIFGAVEVPAR 377
Cdd:cd17358   212 EIQEELAELEKEAKESSFSDLFQRKYLKplvigLGLMLFQQLSgINAVIFYASSiFDEAGSGLDPNTATIIIGVVQVVGT 291

                         250       260       270
                  ....*....|....*....|....*....|
gi 1952715164 378 YSSIFMMQWLGRKWSQMLSLVLGGLMCIAI 407
Cdd:cd17358   292 LVATLLVDRLGRRPLLLVSAIGMGIGLLAL 321
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 126-274 1.95e-16

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 80.25  E-value: 1.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 126 EFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGY 205
Cdd:cd17373    16 KWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGI 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952715164 206 TFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPES 274
Cdd:cd17373    96 ILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSIFPKN 164
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 126-273 3.70e-15

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 76.43  E-value: 3.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 126 EFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGY 205
Cdd:cd17444    27 KWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGI 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952715164 206 TFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPE 273
Cdd:cd17444   107 ILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCIFPK 174
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 142-449 6.13e-15

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 76.61  E-value: 6.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLF---AIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVG 218
Cdd:TIGR00879  78 SIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFvigAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 219 PLWRTRAVVLAQCAFSVGEMALAGLAYGIR------NWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIQ 292
Cdd:TIGR00879 158 KALRGALTSLYQLAITFGILVAYGFGSGKVslnntlGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLA 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 293 KVASVN-------KRKLSPELLSQLVAEKTGPSGNALDLFRHPQLWKMTLILCYVWF-----VDSLGYYGLSL--QVGDF 358
Cdd:TIGR00879 238 RLRGTSgedkellDELELIDIKRSIEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFqqftgINAIMYYSPTIfeNAGVS 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 359 GLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVlGGLMC---IAIIFVPADLPVVVTVLAVVGKF--ATASGF 433
Cdd:TIGR00879 318 TDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAA-GMAIClfvLGILGASFVTGSSKSSGNVAIVFilLFIAFF 396

                         330       340
                  ....*....|....*....|.
gi 1952715164 434 TIS-----YVYSAELFPTIIR 449
Cdd:TIGR00879 397 AMGwgpvpWVIVSEIFPLSLR 417
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 143-357 6.68e-14

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 73.42  E-value: 6.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 143 VYMaGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAG-----YTFSNVTLLTE-- 215
Cdd:cd17438    43 VYL-GMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGslpivFAYFSEFLAREkr 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 216 -----WVGPLWRTRAVVLAQCAFSV----GEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEE 286
Cdd:cd17438   122 gehlsWLCMFWMIGGLYASAMAWSIiphyGWGFSMGTNYHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDE 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952715164 287 ARQVIQKVASVNKR-KLSPELLSQLVAEKTgpsgnaldlfrhpqlwKMTLILCYVWFVDSLGYYGLSLQVGD 357
Cdd:cd17438   202 AWMILKNIHDTNMRaKGTPEKVFTVSNIKR----------------KNTLFLAVVWFTMAFSYYGLTVWFPD 257
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
142-271 1.21e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.82  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:COG2271    52 SAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKE 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952715164 222 RTRAVVLAQCAFSVGEMALAGLAYGI---RNWRH-FQMAGTAPVLLLFFYFWAL 271
Cdd:COG2271   132 RGRALGIFNAGGPLGGALAPPLLGWLlaaFGWRAaFLILGLPGLLLALLRFWLL 185
MFS_1 pfam07690
Major Facilitator Superfamily;
142-411 1.62e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 71.30  E-value: 1.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:pfam07690  39 TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEM---ALAGLAYGIRNWRHFqMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIqkvasvn 298
Cdd:pfam07690 119 RGRALGLVSAGFGLGAAlgpLLGGLLASLFGWRAA-FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 299 krklspellsqlvaektgpsGNALDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGDFGLD---IYLTQLIFGAVEVP 375
Cdd:pfam07690 191 --------------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSallAGLLLGLGGLLGAI 250

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952715164 376 ARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVP 411
Cdd:pfam07690 251 GRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 142-265 2.29e-13

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 71.08  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17365    41 SAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARR 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1952715164 222 RTRAVVLAQCAFSVGeMALAGL-------AYGirnWRHFQMAGTAPVLLLF 265
Cdd:cd17365   121 RSLAVTLMFCGYPLG-AALGGFlaaalipAFG---WRSVFLLGGVPPLILL 167
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 143-357 2.63e-13

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 71.60  E-value: 2.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 143 VYMaGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAG-----YTFSNVTLLTE-- 215
Cdd:cd17439    43 VYL-GMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGsipivFSYFSEFLAQEkr 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 216 -----WVGPLWRTRAVVLAQCAFSV----GEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEE 286
Cdd:cd17439   122 gehlsWLCMFWMIGGIYASAMAWAIiphyGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDE 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952715164 287 ARQVIQKVASVNKR-KLSPELLSQLVAEKTgpsgnaldlfrhpqlwKMTLILCYVWFVDSLGYYGLSLQVGD 357
Cdd:cd17439   202 AWMVLKQVHDTNMRaKGHPERVFSVTHIKR----------------RITLMMMAVWFTMSFSYYGLTVWFPD 257
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 143-357 2.66e-13

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 71.93  E-value: 2.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 143 VYMaGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAG-----YTFSNVTLLTE-- 215
Cdd:TIGR01299 211 VYL-GMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGaipivFSYFAEFLAQEkr 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 216 -----WVGPLWRTRAVVLAQCAFSV----GEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEE 286
Cdd:TIGR01299 290 gehlsWLCMFWMIGGIYAAAMAWAIiphyGWSFQMGSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDE 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 287 ARQVI--------------QKVASVNKRKlSPELLSQLV------------------AEKTGPSGNALDLFrHPQLWKMT 334
Cdd:TIGR01299 370 AWMILklihdtnmrakghpEKVFSVNHIK-TIHQEDELIeiesdtgtwyqrcfvralSEGGGIWGNFLRCF-NPEVREIT 447

                         250       260
                  ....*....|....*....|...
gi 1952715164 335 LILCYVWFVDSLGYYGLSLQVGD 357
Cdd:TIGR01299 448 IKLMGVWFTLSFGYYGLSVWFPD 470
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 142-409 1.38e-12

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 69.21  E-value: 1.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLF----AIFGLSTAFvPSFELYMVLRFAVATAvAGYTFSNVTLLTEWV 217
Cdd:cd17357    56 SIFFIGGAIGSFISAFLANRFGRKNGLLISNALLvvssLLMFLSKSA-KSPELLIFGRFLVGIA-CGLSTGFVPMYLQEI 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 218 GPL-WRTRAVVLAQCAFSVGEM--ALAGLAY---GIRNWRHFQMAGTAPVLLLFFYFWALPESARWLL-TQGRVEEARQV 290
Cdd:cd17357   134 SPSeLRGALGSLTQIGVTLGILlgQVFGLPSvlgTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEEAEKS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 291 IQKVASVNKRKLSPELLSQLVAEKTGPSGNA--LDLFRHPQLWKMTLILCYVWF------VDSLGYYGLSLqVGDFGLD- 361
Cdd:cd17357   214 LKFLRGIEDDVDQELEEIKKESEQMGDQKQVslMQLLRDPSLRLPLLLVLVVSAsqqfsgINAIFFYSTFI-FENAGFSp 292

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1952715164 362 ---IYLTQLIfGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIF 409
Cdd:cd17357   293 qlaEWANLGI-GIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSV 342
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 142-278 3.30e-12

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 67.68  E-value: 3.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:PRK11551   57 SAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRL 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1952715164 222 RTRAVVLAQCAFSVGEmALAG----LAYGIRNWRH-FQMAGTAPVLLLFFYFWALPESARWL 278
Cdd:PRK11551  137 RGTAVSLMYCGVPFGG-ALASvigvLAAGDAAWRHiFYVGGVGPLLLVPLLMRWLPESRAFA 197
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 143-352 3.97e-12

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 67.90  E-value: 3.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 143 VYMaGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAG-----YTFSNVTLLTE-- 215
Cdd:cd17363    43 VYL-GMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGsipivFSYFAEFLAREkr 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 216 -----WVGPLWRTRAVVLAQCAFSV----GEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEE 286
Cdd:cd17363   122 gehlsWLCMFWMIGGLYASAMAWAIiphyGWGFSMGTAYQFHSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDE 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952715164 287 ARQVIQKVASVNKR-KLSPEllsqlvaektgpsgnalDLFRHPQLWKM-TLILCYVWFVDSLGYYGLS 352
Cdd:cd17363   202 AWMILKQVHDTNMRaKGHPE-----------------RVFTVSHIKRMnTLFLAIVWFTMSFSYYGLT 252
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 142-449 4.84e-12

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 67.17  E-value: 4.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSnVTLLTEWVGPLW 221
Cdd:cd17372    41 SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQL-ASWYLEFLPAKS 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEMALAGLAYGIR---NWRHFQMAGTAP-VLLLFFYFWaLPESAR--WLLTQGRVEEARQVIQKVA 295
Cdd:cd17372   120 RGTWMVLFSVFWTVGTIFEASLAWLVMprlGWRWLLAFSSVPsSLLLVFYRW-TPKTTLllWVIWFGNAFAYYGVVLLTT 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 296 SVNKRKLspellsqlvaektgpsgnaldlfrhpqlwkmtliLCYVWFVDSLGYYGLSLQVGDFGLDIYLTQLIFGAVEVP 375
Cdd:cd17372   199 ELNNSHN----------------------------------VCGSKSDSDSGESPTEKQCRNSNDVDYRDVFIATFAEFP 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952715164 376 ARYSSIFMMQWLGRKWSQMLSLVlgglmCIAIIFVPADL---PVVVTVLAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:cd17372   245 GLLISAAMIDRLGRKASMASMLF-----TCCIFLLLLLIcqsPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVR 316
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 142-357 2.74e-11

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 65.32  E-value: 2.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAG-----YTFSNVTLLTE- 215
Cdd:cd17440    41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGavptvFSYFAEVLAREk 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 216 ------WVGPLWRTRAVVLAQCAFSV----GEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVE 285
Cdd:cd17440   121 rgehlsWLCMFWMIGGIYASAMAWAIiphyGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHD 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952715164 286 EARQVIQKVASVNKRKlspellsqlvaektgpSGNALDLFRHPQLWK-MTLILCYVWFVDSLGYYGLSLQVGD 357
Cdd:cd17440   201 EAWMILKQIHDTNMRA----------------RGQPEKVFTVNRIKKdNTIKLTIVWLTLSFGYYGLSVWFPD 257
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 142-283 3.71e-11

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 64.51  E-value: 3.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17359    43 SSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952715164 222 RTRAVVLAQCAFSVGEMALAGLAYGIRN-----------WRHFQMAGTAPVLLLFFYFWALPESARWLLTQGR 283
Cdd:cd17359   123 RGRLVSLNQLMIVFGQLLAYIVNYLIANaggadwlgaegWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK 195
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 139-449 4.01e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 64.37  E-value: 4.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 139 TSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVG 218
Cdd:cd06174    35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 219 PLWRTRAVVLAQCAFSVGeMALAGLAYGIR------NWRHFQMAGTAPVLLLFFYFWALPESARWlltqgrveearqviq 292
Cdd:cd06174   115 ERERGRALGLLQAFGSVG-GILGPLLGGILasslgfGWRAVFLIAAALALLAAILLLLVVPDPPE--------------- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 293 kvasvnkrklspellSQLVAEKTGPSGNALDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGDFGLDIYLT------- 365
Cdd:cd06174   179 ---------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsvavagl 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 366 -QLIFGAVEVPARYSSIFMMQ-WLGRKWSQMLSLVLGGLMCIAIIFvpADLPVVVTVLAVVGKFATASGFTISYVYSAEL 443
Cdd:cd06174   244 lLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLL--APSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321


                  ....*.
gi 1952715164 444 FPTIIR 449
Cdd:cd06174   322 FPPEIR 327
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 142-291 6.71e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 62.91  E-value: 6.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:COG0477    56 SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARE 135

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1952715164 222 RTRAVVLAQCAFSVGeMALAGLAYGI----RNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVI 291
Cdd:COG0477   136 RGRALGLWGAAIGLG-LALGPLLGGLlvaaLGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLL 208
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 142-449 2.94e-10

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 61.75  E-value: 2.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSnVTLLTEWVGPLW 221
Cdd:cd17441    41 SVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQS-VTLYAEFLPMKS 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVG---EMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPESARwlltqgrveearqviqkvasvn 298
Cdd:cd17441   120 RAKCILLIEVFWALGtvfEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESAR---------------------- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 299 krklspellsqlvaektgpsgnaldlfrhpqlWKMTLILCYVWFVDSLGYYGLSL------QVGD--------------- 357
Cdd:cd17441   178 --------------------------------YWTTILLWFIWFSNAFSYYGLVLlttelfQAGDvcsgssgkkvegkcs 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 358 -----FGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLmCIAIIFVPADLPVVVTVLAVVGKFaTASG 432
Cdd:cd17441   226 leceyLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMALCFFVFSF-CTLLLFSCVGRFSLTVLLFIARAF-ISGG 303

                         330
                  ....*....|....*..
gi 1952715164 433 FTISYVYSAELFPTIIR 449
Cdd:cd17441   304 FQAAYVYTPEVYPTATR 320
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 142-272 5.87e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 60.64  E-value: 5.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17324    41 SAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952715164 222 RTRAVVLAQCAFSVGEMA---LAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWALP 272
Cdd:cd17324   121 RGRAIGLVFSGLTLGLVLgrpLGGLLGQLLGWRAaFLAIAVLALLAALLLWRLLP 175
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
142-446 5.90e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 60.66  E-value: 5.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:COG2223    47 AIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEMA---LAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWALPESARwlltqgrveearqviqkvasv 297
Cdd:COG2223   127 RGLALGLAAGGGNLGAAVaafLAPLLIAAFGWRNaFLILGILLLVVAVLAWLFLRDPPA--------------------- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 298 nkrklspellsQLVAEKTGPSGNALDLFRHPQLWKMTLILcyvwFVDSLGYYGLSLQVGDFGLDIY--------LTQLIF 369
Cdd:COG2223   186 -----------GAAAAAKASLRDQLEALRDPRFWLLSLLY----FGTFGSFIGFSSWLPPYLVDQFglsaatagLLAALF 250

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952715164 370 GAVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGkFATASGFTISYVYSAELFPT 446
Cdd:COG2223   251 ALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLG-LALGGGNGAVFALVPDIFPT 326
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 146-449 5.99e-10

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 61.28  E-value: 5.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 146 AGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVP---SFELYMVL---RFAVATAVAG-YTFSNvTLLTEWVG 218
Cdd:TIGR00887  67 IGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPgssPKSVMATLcfwRFWLGVGIGGdYPLSA-IITSEFAT 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 219 PLWRTR--AVVLAQCAFS--VGEMALAGLAYGIRN----------------------WRHFQMAGTAPVLLLFFYFWALP 272
Cdd:TIGR00887 146 KKWRGAmmAAVFAMQGFGilAGAIVALIVLAGFKHsleaaadeasctgscvpavdymWRILIGFGAVPALLALYFRLTIP 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 273 ESARWLLTQGR-VEEARQVIQKVASVnKRKLSPELLSQLVAEKTGPSGNALDLFRHPQLWKMTLIL---CYVWFVDSLGY 348
Cdd:TIGR00887 226 ETPRYTADVAKdVEQAASDMSAVLQV-KIEAEPDEVEKASTAVEVPKASWSDFFTHFFKWRHGKHLlgtAGSWFLLDIAF 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 349 YGLSLQVGD------------------FGLDIYLTQLIFG-AVEVPARYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIF 409
Cdd:TIGR00887 305 YGVNLNQKVilsaigysppaatnnayeELYKTAVGNLIIAlAGTVPGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGF 384

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1952715164 410 VPADLPV--VVTVLAVVGKFATASGFTISYVYSAELFPTIIR 449
Cdd:TIGR00887 385 AYNHLSThgFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYR 426
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
141-411 9.61e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 60.25  E-value: 9.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 141 QSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVAtavAGYTFSNVTLLTE--WVG 218
Cdd:COG0738    49 LFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLG---LGLGLLDVAANPYvaALG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 219 PLWRTRAVVLAQCAFSVGEMALAGLAYGI------RNWRH--FQMAGTAPVLLLFFYFWALPEsarwlltqgrveearqv 290
Cdd:COG0738   126 PETAASRLNLLHAFFSLGALLGPLLGGLLillglsLSWHLpyLILAVLLLLLALLFLRSKLPE----------------- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 291 iqkvasvnkrklspelLSQLVAEKTGPSGNALDLFRHPQLWKMTL-ILCYV--------WFVDSL-GYYGLSLQVGDFGL 360
Cdd:COG0738   189 ----------------IEEEEEEAAGSAASLKSLLKNPRLLLGGLaIFLYVgaegaigdWLPLYLkDVLGLSEATAALGL 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1952715164 361 DIYLTQLIFGavevpaRYSSIFMMQWLGRKWSQMLSLVLGGLMCIAIIFVP 411
Cdd:COG0738   253 SLFWGGMTIG------RFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP 297
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 142-449 6.01e-09

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 57.65  E-value: 6.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAI-FGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPL 220
Cdd:cd17356    52 SIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKH 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 221 WRTRAVVLAQCAFSVGEMALAGLAYGIRN------WRHFQMAGTAPVLLLFFYFWALPESARWLltqgrveearqviqkv 294
Cdd:cd17356   132 IRGTLVSLYQLAITIGILVAYCINYGTHKldgsaqWRIPLGLQIVWGLLLLIGMFFLPESPRWL---------------- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 295 asvnkRKLSPELLSQLVAEKTGpsgnaldlfrhpqlwkmtlilcyvwfVDSLGYYGLSL--QVGDFGLDIYLTQLIFGAV 372
Cdd:cd17356   196 -----YRTILGIMLQLFQQLTG--------------------------INYFFYYGTTIfqSTGLTGSSPLLTSIILYIV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 373 EVPARYSSIFMMQWLGRKwsqmLSLVLGG------LMCIAIIFVPADLPVVVTVLAVVGKFATASGFT------------ 434
Cdd:cd17356   245 NFVSTIPGLFFVDKFGRR----TCLLIGAagmsicLFIYAAVGVRYLIPNPQSGTSNKSAGNGMIVFIclfifsfattwg 320

                         330
                  ....*....|....*.
gi 1952715164 435 -ISYVYSAELFPTIIR 449
Cdd:cd17356   321 pIAWVYVAEVFPLRVR 336
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 140-211 1.01e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 56.81  E-value: 1.01e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952715164 140 SQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRF------AVATAVAGYTFSNVT 211
Cdd:cd17323    39 GVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFlqgffgSSPLAIGAGTIADLF 116
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 121-274 2.16e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 55.66  E-value: 2.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 121 LSLQNEFNLVCDrKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVAT 200
Cdd:cd17315    21 LYIAKDLGFGLS-TSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGL 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952715164 201 AVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALA----GLAYGIRNWRHFQMA-GTAPVLLLFFYFWALPES 274
Cdd:cd17315   100 GVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYllglALSLSPPGWWRLMFAlAAVPALLQLLLMFFLPES 178
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 121-277 3.02e-08

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 55.35  E-value: 3.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 121 LSLQNEFNLVCDRKHLKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVAT 200
Cdd:cd17360    21 LYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 201 AVAgytFSNVT---LLTEWVGPLWRTRAVVLAQCAFSVGEMalagLAYGIR--------NWRHFQMAGTAPVLLLFFYFW 269
Cdd:cd17360   101 GVG---IASMTvplYIAEAAPPRIRGRLVTINVLFITGGQF----VAYVINgafsylpgGWRWMLGLAAVPAVLQFIGLL 173


                  ....*...
gi 1952715164 270 ALPESARW 277
Cdd:cd17360   174 FLPESPRW 181
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 142-204 3.35e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 55.27  E-value: 3.35e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAG 204
Cdd:cd17320    41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA 103
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 139-277 1.09e-07

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 53.90  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 139 TSQSVYmaGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVG 218
Cdd:cd17362    45 VSGSLL--GALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSP 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952715164 219 PLWRTRAVVLAQCAFSVGEMALAGLAYGIRN----WRHFQMAGTAPVLLLFFYFWALPESARW 277
Cdd:cd17362   123 SHIRGLLVSLKELFIVLGILLGYVSGYAFADvvggWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 142-411 1.16e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17325    38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 222 RTRAVVLAQCAFSVGEMA---LAGLAYGIRNWRhfqmagtAPvlllfFYFWALPESARWLLTQGRVEEARQVIQKVASVN 298
Cdd:cd17325   118 RGRAMGIFSSAIGLGFLIgplLGGLLADALGYR-------AP-----FLVCAALALLALVLALLLLPEPRPPPNKRAVSA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 299 KRKLSPELLsqlvaektgpsgnaldLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGD-FGLDIYLTQLIFGAVEVPAR 377
Cdd:cd17325   186 ARLRSGLRL----------------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASA 249

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1952715164 378 YSSIFMMQW---LGRKWSQMLSLVLGGLMCIAIIFVP 411
Cdd:cd17325   250 LSQPPAGKLsdrIGRKPLILIGLLLSAVALLLLPLAT 286
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 147-449 1.30e-07

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 53.27  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 147 GLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTfSNVTLLTEWVGPLWRTRAV 226
Cdd:cd17442    48 GYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHS-QGLIIKTEFLPTKYRGYML 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 227 VLAQCAFSVGEMALAGLAYGI---RNWRHFQMAGTAPVLLLFFYFWALPESA--RWLLTQGRVEEARQVIQKvasvnkrk 301
Cdd:cd17442   127 PLSQIFWLAGSLLIIGLASVViptLGWRWLIRFASIPGIILIVVFKFIPRTTlqIWVIWLGISFAYYGVILA-------- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 302 lSPELLsqlvaEKTGPSGNALDLFRHPQLWKMTLILCYVWFvdslgyyglslqvgdFGLDIYLTQLIFGAVEVPARYSSI 381
Cdd:cd17442   199 -SSELL-----ERNLLCGSDPSDEEAGIKHIESESPCYCHM---------------FNPSDYQTMIISTLGEIALNPLNI 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952715164 382 FMMQWLGRKWSQMLSLVLGGLMCIAIIFVPADLPVVVTVLAVVGkfATASGFTISYVYSAELFPTIIR 449
Cdd:cd17442   258 LGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRA--LVSANFNTVYIYTAEVYPTTMR 323
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 142-276 1.46e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 53.34  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17474    41 TAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGE 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1952715164 222 RTRAVVLAQCAFSVGEMA--LAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWALPESAR 276
Cdd:cd17474   121 RAKAMGLYEAALGLGIAVgpLLGGLLAAISWRYpFFLLAALIPVAFLAILFLLPEPKE 178
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
140-202 1.68e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 52.97  E-value: 1.68e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952715164 140 SQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAV 202
Cdd:PRK11043   46 SLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGV 108
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 149-277 4.30e-07

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 52.02  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 149 LAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVaGYTFSNVTLLTEWVGPL-WRTRAVV 227
Cdd:cd17437    46 LVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGV-GFALMIAPVYTAEVAPAsSRGFLTS 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1952715164 228 LAQCAFSVGEM-------ALAGLAYGIrNWRHFQMAGTAPVLLLFFYFWALPESARW 277
Cdd:cd17437   125 FPEIFINIGILlgyvsnyAFSGLPLHV-GWRLMLGVGAVPSLFLAIGVLAMPESPRW 180
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 142-272 6.56e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 51.03  E-value: 6.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17319    45 SAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARE 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952715164 222 RTRAVVLAQCAFSVGEM---ALAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWALP 272
Cdd:cd17319   125 RGRATGLFNSGAPLGAAigpPLSGWLLLLFGWRWaFIIEGLLGLLLAVLWWFYLR 179
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 152-312 7.98e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.03  E-value: 7.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 152 SLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTE-WVGPL------WRTR 224
Cdd:cd17473    52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDyFEGEErakmlgLQSA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 225 AVVLAQCAFSVGEMALAGLaygirNWRHFQMAGTAPVLLLFFYFWALPESARwlltqGRVEEARQVIQKVASVNKRKLSP 304
Cdd:cd17473   132 AMSLGGVVFLLLGGALAEI-----GWRAPFLVYLLALPVLILVLLFLPEPAR-----KSKSAASPGAATAAALPWKRVLP 201


                  ....*...
gi 1952715164 305 ELLSQLVA 312
Cdd:cd17473   202 IYFLAFLA 209
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 140-203 1.03e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 50.46  E-value: 1.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1952715164 140 SQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVA 203
Cdd:TIGR00710  45 TLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAS 108
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 139-411 2.08e-06

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 49.55  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 139 TSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVG 218
Cdd:cd17327    45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 219 PLWRTRAVVLAQCAFSVGEMALAGLAYG---------IRNWRH-FQMAGTAPVLLLFFYFWALPE--SARWLLTQgrvEE 286
Cdd:cd17327   125 REEQAKRIAFFYAAAGLGSIFGGLLAYGvfkilgvggLAGWRWlFIIEGLITIIIGLVIFFWLPDnpSKAWFLTE---EE 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 287 ARQVIQKVASVNKRKLSPELLSQLVaektgpsgnaLDLFRHPQLWKMTLILCYVWFVDSLGYYGLSLQVGDFGLDIYLTQ 366
Cdd:cd17327   202 KELAVERLRANQTGKGDQKFKWKQI----------KEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTN 271

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1952715164 367 L---IFGAVEVPARYSSIFMMQWLGRKWSQML---SLVLGGlmCIAIIFVP 411
Cdd:cd17327   272 LlsvPIGALGAVSLLIAALLSDRFKKRGLFAIfacVLALVG--SIILLAAP 320
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
139-243 3.39e-06

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 49.17  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 139 TSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRF----------AVATAVAGYTF- 207
Cdd:PRK15402   52 TSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFlqgiglcfigAVGYAAIQESFe 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1952715164 208 -----------SNVTLLTEWVGPL----------WRTRAVVLAQCAFsvgeMALAGL 243
Cdd:PRK15402  132 eadaikitalmANVALLAPLLGPLvgaalihvlpWRGMFVLFAALAA----LSFFGL 184
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
136-202 5.08e-06

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 48.67  E-value: 5.08e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952715164 136 LKETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAV 202
Cdd:PRK15403   52 LAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSI 118
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 151-292 5.29e-06

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 48.54  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 151 GSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRAVVLAQ 230
Cdd:PRK03893   71 GGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLI 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952715164 231 CAFSVGEMaLAGLAYGI----RNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEARQVIQ 292
Cdd:PRK03893  151 SGFSIGAV-VAAQVYSLvvpvWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVD 215
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 142-269 4.06e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 4.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:cd17325   242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952715164 222 RTRAVVLAQCAFSVGEMA---LAGLAYGIRNWRH-FQMAGTAPVLLLFFYFW 269
Cdd:cd17325   322 RGTAMGLFNTAFSLGMVLgplLGGFLYDAFGFATpFLAAAALLLLAAVLFLL 373
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
142-197 4.63e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 45.29  E-value: 4.63e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFA 197
Cdd:PRK11102   33 SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFL 88
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
142-236 4.87e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLW 221
Cdd:COG2814   250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329

                          90
                  ....*....|....*
gi 1952715164 222 RTRAVVLAQCAFSVG 236
Cdd:COG2814   330 RGRASGLYNSAFFLG 344
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 141-276 1.44e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 43.76  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 141 QSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPL 220
Cdd:cd17328    40 QTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952715164 221 WRTRAVVLAQCAFSVGemALAGLAYG------IRNWR-HFQMAGTAPVLLLFFYFWALPESAR 276
Cdd:cd17328   120 KRTRALGVFYFAIPLG--SGLGYVVGglvaqaTGGWRwAFRVTGVLGVLLAILLLLFVREPPR 180
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
142-276 5.70e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRR--ATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGP 219
Cdd:COG2271   223 SLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK 302

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1952715164 220 LWRTRAVVLAQCAFSVGEM---ALAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWALPESAR 276
Cdd:COG2271   303 KARGTASGLVNTFGFLGGAlgpLLVGYLLDATGYQAaFLLLAALALLAALLALLLLRETRK 363
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 121-275 9.22e-04

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 41.33  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 121 LSLQNEFNLVCDRKhlkETSQSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVAT 200
Cdd:cd17436    25 LQLQTDFSLSCFEQ---EALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGF 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952715164 201 AVAGYTFSNVTLLTEWVGPLWRTRAVVLAQCAFSVGEMALAGLAYGIRN----WRHFQMAGTAPVLLLFFYFWALPESA 275
Cdd:cd17436   102 AISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNvltgWRYMFGLAIIPAAIQFASILLLPKKP 180
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 142-287 1.94e-03

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 40.25  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFaIFGLSTaFVPSFELYMVLRFAVATAVAGYTFSNVT--LLTEWVGP 219
Cdd:cd17433    48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPF-IAGFTV-ITAAQNVWMLYVGRLLTGLASGVTSLVVpvYISEIAHP 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952715164 220 LWRTRAVVLAQCAFSVGEMaLAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALPESARWLLTQGRVEEA 287
Cdd:cd17433   126 RVRGTLGSCVQLMVVIGIM-GAYLAGLVLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEA 192
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 142-406 2.22e-03

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 40.29  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQlFLFAI-----FGLSTAFvPSFELYMVLRFAVATAvAGYTFSNVTL-LTE 215
Cdd:cd17432    57 SIFPLGGLFGSLLVGPLVIRLGRKGTLLLN-NIFAIvaailMGLSKIA-KSFEMIIVGRFLVGIN-AGISLNVVPMyLGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 216 WVGPLWRTRAVVLAQCAFSVGemALAGLAYGIRN-------WRH-FQMAGTAPVLLLFFYFWaLPESARWLLTQ-GRVEE 286
Cdd:cd17432   134 SAPKNLRGAVGLVPAIFITLG--ILLGQVLGLREllgneegWPLlLALTGVPALLQLLTLPF-FPESPRYLLIEkGDEEA 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 287 ARQVIQKVASvnKRKLSPEL---LSQLVAEKTGPSGNALDLFRHPQL-WKMTLI--------LCYvwfVDSLGYYGLS-- 352
Cdd:cd17432   211 ARKALQRLRG--KEDVDDEMeemLEEQRAEKGVGTVSVLELFRDRSVrWQLISIivlmagqqLCG---INAIYFYADSif 285

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1952715164 353 LQVGDFGLDIYLTQLIFGAVEVPARYSSIFMMQWLGRKwsqmlSLVLGG--LMCIA 406
Cdd:cd17432   286 LEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRR-----PLLIGGfgLMAVW 336
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 146-270 3.59e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 146 AGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPLWRTRA 225
Cdd:cd06173   255 VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1952715164 226 V----VLAQCAFSVGeMALAGLAYGIRNWRH-FQMAGTAPVLLLFFYFWA 270
Cdd:cd06173   335 FsvynALNSGAMPLG-ALLAGLLADALGLSAvFLLAGALLLLAALLLLLL 383
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 141-272 5.73e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 38.64  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 141 QSVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAGYTFSNVTLLTEWVGPL 220
Cdd:COG0477   144 GAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLL 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1952715164 221 WRTRAVVLAQCAFSVGEMALAGLAYGIRNWRHFQMAGTAPVLLLFFYFWALP 272
Cdd:COG0477   224 LLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALL 275
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
142-204 6.20e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 6.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952715164 142 SVYMAGLLAGSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMvlrFAVATAVAG 204
Cdd:COG2211   271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWL---LLVLAALAG 330
emrD PRK11652
multidrug transporter EmrD;
141-204 9.32e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 38.35  E-value: 9.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1952715164 141 QSVYMAGLLA---GSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRF--AVATAVAG 204
Cdd:PRK11652   46 QAVMAAYLLTyglSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAiqGLGTGVGG 114
PRK12307 PRK12307
MFS transporter;
151-277 9.49e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 38.37  E-value: 9.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952715164 151 GSLIFGPLCDWIGRRATILVQLFLFAIFGLSTAFVPSFELYMVLRFAVATAVAG-YTFSNVTLLTEWVGPLwRTRAVVLA 229
Cdd:PRK12307   69 GGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGeYACASTYAVESWPKHL-KSKASAFL 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1952715164 230 QCAFSVGEMALAGL------AYGirnWRHFQMAGTAPVLLLFFYFWALPESARW 277
Cdd:PRK12307  148 VSGFGIGNIIAAYFmpsfaeAYG---WRAAFFVGLLPVLLVIYIRARAPESKEW 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH