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Conserved domains on  [gi|1952685370|ref|XP_038301370|]
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muskelin isoform X5 [Canis lupus familiaris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 7-180 5.81e-109

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


:

Pssm-ID: 284099  Cd Length: 197  Bit Score: 328.32  E-value: 5.81e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370   7 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKE 86
Cdd:pfam06588  23 NILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYGGRDGEEMRELLCGGLKNDSNME 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370  87 TFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA 165
Cdd:pfam06588 103 TFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMVREGEAIRLCLKHFRQCGYLDI 182

                         170
                  ....*....|....*
gi 1952685370 166 FESLQKKTKIALEHP 180
Cdd:pfam06588 183 FEILQKRTSDKIEHP 197
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
257-532 2.66e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 257 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 336
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 337 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 416
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 417 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 496
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952685370 497 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 532
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 7-180 5.81e-109

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 328.32  E-value: 5.81e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370   7 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKE 86
Cdd:pfam06588  23 NILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYGGRDGEEMRELLCGGLKNDSNME 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370  87 TFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA 165
Cdd:pfam06588 103 TFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMVREGEAIRLCLKHFRQCGYLDI 182

                         170
                  ....*....|....*
gi 1952685370 166 FESLQKKTKIALEHP 180
Cdd:pfam06588 183 FEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
257-532 2.66e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 257 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 336
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 337 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 416
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 417 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 496
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952685370 497 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 532
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
Kelch_3 pfam13415
Galactose oxidase, central domain;
255-307 3.79e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952685370 255 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 307
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 280-448 1.34e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 280 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 359
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 360 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 439
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1952685370 440 NRCLYVFGG 448
Cdd:PLN02153  137 ENHVYVFGG 145
Kelch smart00612
Kelch domain;
258-284 1.32e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.32e-03
                           10        20
                   ....*....|....*....|....*..
gi 1952685370  258 VYLFGGWDGTQDLADFWAYSVKENQWT 284
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 145-175 8.04e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 8.04e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1952685370  145 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 175
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 7-180 5.81e-109

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 328.32  E-value: 5.81e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370   7 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKE 86
Cdd:pfam06588  23 NILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYGGRDGEEMRELLCGGLKNDSNME 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370  87 TFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA 165
Cdd:pfam06588 103 TFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEMVREGEAIRLCLKHFRQCGYLDI 182

                         170
                  ....*....|....*
gi 1952685370 166 FESLQKKTKIALEHP 180
Cdd:pfam06588 183 FEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
257-532 2.66e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 257 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 336
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 337 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 416
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 417 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 496
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952685370 497 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 532
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
Kelch_3 pfam13415
Galactose oxidase, central domain;
255-307 3.79e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952685370 255 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 307
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 14-125 6.23e-07

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 48.98  E-value: 6.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370  14 NDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETftlkhk 93
Cdd:pfam00754  20 GDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYVTSYKIEYSLDGENWTTVKDEKIPGNNDNNT------ 93

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1952685370  94 IDEQMFPC----RFIKIVPlLSWGPSFNFSIWyVEL 125
Cdd:pfam00754  94 PVTNTFDPpikaRYVRIVP-TSWNGGNGIALR-AEL 127
PLN02153 PLN02153
epithiospecifier protein
 280-448 1.34e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 280 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 359
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 360 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 439
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1952685370 440 NRCLYVFGG 448
Cdd:PLN02153  137 ENHVYVFGG 145
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 243-287 4.49e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 4.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1952685370 243 MRGGHQMVidVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCIS 287
Cdd:pfam01344   1 RRSGAGVV--VVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
PLN02153 PLN02153
epithiospecifier protein
 258-349 4.68e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 258 VYLFGGWDGTQDLADFWAYSVKENQWTCISRdTEKENGPSARSCHKMCIDiqRRQIYTLGRYLDSSVRNSKSLKSDFYRY 337
Cdd:PLN02153   88 LYIFGGRDEKREFSDFYSYDTVKNEWTFLTK-LDEEGGPEARTFHSMASD--ENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                          90
                  ....*....|..
gi 1952685370 338 DIDTNTWMLLSE 349
Cdd:PLN02153  165 NIADGKWVQLPD 176
PLN02193 PLN02193
nitrile-specifier protein
 257-359 1.06e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 257 TVYLFGGWDGTQDLADFWAYSVKENQWTCIsrdTEKENGPSARSCHKMCIDiqRRQIYTLGRYldSSVRNSKSLKSdfyr 336
Cdd:PLN02193  230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAAD--EENVYVFGGV--SATARLKTLDS---- 298

                          90       100
                  ....*....|....*....|....*.
gi 1952685370 337 YDIDTNTWMLLS---EDTAADGGPKL 359
Cdd:PLN02193  299 YNIVDKKWFHCStpgDSFSIRGGAGL 324
PLN02153 PLN02153
epithiospecifier protein
 344-531 2.34e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 344 WMLLSEDTAADGGPKLvfDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLLredSCNAGP 423
Cdd:PLN02153    9 WIKVEQKGGKGPGPRC--SHGIAVVGDK--LYSFGGE-LKPNEHIDKD---------LYVFDFNTHTWSIA---PANGDV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 424 EDIqSRIGHCMLfhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRATIDPelNEIHVL 503
Cdd:PLN02153   72 PRI-SCLGVRMV--AVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFL---TKLDEEGGPEARTFHSMASDE--NHVYVF 143

                         170       180
                  ....*....|....*....|....*...
gi 1952685370 504 SGLSKDKEKREENVRNSFWIYDIVRNSW 531
Cdd:PLN02153  144 GGVSKGGLMKTPERFRTIEAYNIADGKW 171
Kelch_4 pfam13418
Galactose oxidase, central domain;
244-287 4.49e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1952685370 244 RGGHQMVIdVQTETVYLFGG--WDGTQdLADFWAYSVKENQWTCIS 287
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGegEDGTL-LSDLWVFDLSTNEWTRLG 45
PLN02193 PLN02193
nitrile-specifier protein
 356-531 5.78e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 356 GPKLVFDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLlredSCNAGPEDIQSRIGHCML 435
Cdd:PLN02193  162 GPGLRCSHGIAQVGNK--IYSFGGE-FTPNQPIDKH---------LYVFDLETRTWSI----SPATGDVPHLSCLGVRMV 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952685370 436 fhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRAtidpELNEIHVLSGLSKdkekree 515
Cdd:PLN02193  226 --SIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAA----DEENVYVFGGVSA------- 289

                         170
                  ....*....|....*..
gi 1952685370 516 NVR-NSFWIYDIVRNSW 531
Cdd:PLN02193  290 TARlKTLDSYNIVDKKW 306
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 429-466 1.02e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1952685370 429 RIGHCMLFHskNRCLYVFGGQRSKTYLNDFFSYDVDSD 466
Cdd:pfam01344   2 RSGAGVVVV--GGKIYVIGGFDGNQSLNSVEVYDPETN 37
Kelch smart00612
Kelch domain;
258-284 1.32e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.32e-03
                           10        20
                   ....*....|....*....|....*..
gi 1952685370  258 VYLFGGWDGTQDLADFWAYSVKENQWT 284
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 145-175 8.04e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 8.04e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1952685370  145 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 175
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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